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Combination Of Vandetanib, Radiotherapy, And Irinotecan In The Lovo Human Colorectal Cancer Xenograft Model, Phyllis Wachsberger, Phd, Randy Burd, Phd, Anderson Ryan, Phd, Constantine Daskalakis, Phd, Adam Dicker Md, Phd

Bodine Journal

Purpose:

The tumor growth kinetics of the human LoVo colorectal xenograft model was assessed in response to vandetanib, an orally available receptor tyrosine kinase inhibitor, radiotherapy (RT), or irinotecan (CPT-11), as single therapies and in combination.

Methods and Materials:

LoVo cells were injected subcutaneously into the right hind limb (5x106 cells in 100μL phosphate-buffered saline) of athymic NCR NUM mice and tumors were grown to a volume of 200–300mm3 before treatment. Vandetanib was administered at 50 mg/kg daily orally for 14 days starting on Day 1. RT was given as three fractions (3x3 Gy) on Days 1, 2, and 3. …

Nuclear Factor Κb Inhibitors Alleviate And The Proteasome Inhibitor Ps-341 Exacerbates Radiation Toxicity In Zebrafish Embryos, Borbala Daroczi, Gabor Kari, Qing Ren, Adam Dicker Md, Phd, Ulrich Rodeck

Bodine Journal

Inflammatory changes are a major component of the normal tissue response to ionizing radiation, and increased nuclear factor κB (NF-κB) activity is an important mediator of inflammatory responses. Here, we used zebrafish embryos to assess the capacity of two different classes of pharmacologic agents known to target NF-κB to modify radiation toxicity in the vertebrate organism. These were proteasome inhibitors, including lactacystin, MG132, and PS-341 (Bortezomib/VELCADE), and direct inhibitors of NF-κB activity, including ethyl pyruvate (EP) and the synthetic triterpenoid CDDO-TFEA (RTA401), among others. The proteasome inhibitors either did not significantly affect radiation sensitivity of zebrafish embryos (MG132, lactacystin) or …

Bodine Journal, Table Of Contents, Volume 2, Issue 1, Fall 2009

Bodine Journal

No abstract provided.

Rhode Island State Council On The Arts (1979-1992): Booklet 01

Rhode Island State Council on the Arts (1979-1992)

No abstract provided.

Rhode Island State Council On The Arts (1979-1992): Report 08

Rhode Island State Council on the Arts (1979-1992)

No abstract provided.

Accident Rates, Phase Of Operations, And Injury Severity For Solo Students In Pursuit Of Private Pilot Certification (1994–2013), Douglas Boyd, Peter Dittmer

Journal of Aviation Technology and Engineering

Flight training accidents constitute 14% of general aviation accidents. Herein we determined the rates, injury severity, and phase of flight for primary student solo accidents/incidents (mishaps) in Cessna 172 aircraft.

Mishaps over the period spanning 1994–2013 were identified from the NTSB database. Student population data were from the FAA. Statistics employed proportion tests, Poisson distribution, and Mann-Whitney tests.

Across the study period, 598 mishaps were identified. While the mishap rate increased nearly two-fold between 1994/1997 and 2002/ 2005, a 35% decline was evident thereafter. Nevertheless, no statistical difference in mishap rates was evident between the initial and current periods. Over …

The Bates Student - Volume 147 Number 7 - November 9, 2016, Bates College

The Bates Student

No abstract provided.

Annual Financial Report, 2015-2016, University Of Arkansas, Fayetteville

Annual Financial Report

No abstract provided.

Tungstate (Vi) Sorption On Hematite: An In Situ Atr-Ftir Probe On The Mechanism, Sudipta Rakshit, Bryan Sallman, Athénais Davantés, Grégory Lefèvre

Agricultural and Environmental Sciences Faculty Research

Owing to the suspected toxicity and carcinogenicity of tungstate (VI) oxyanions [i.e. mono tungstate and several polytungstate, generally represented by W (VI)], the environmental fate of W (VI) has been widely studied. Sorption is regarded as a major mechanism by which W (VI) species are retained in the solid/water interface. Iron (hydr)oxides have been considered important environmental sinks for W (VI) species. Here we report sorption mechanisms of W (VI) on a common iron oxide mineral-hematite under environmentally relevant solution properties using in situ attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopic probes. Initial W (VI) loadings varied from 10 …

Confidence Intervals For Heritability Via Haseman-Elston Regression, Tamar Sofer

UW Biostatistics Working Paper Series

Heritability is the proportion of phenotypic variance in a population that is attributable to individual genotypes. Heritability is considered an important measure in both evolutionary biology and in medicine, and is routinely estimated and reported in genetic epidemiology studies. In population-based genome-wide association studies (GWAS), mixed models are used to estimate variance components, from which a heritability estimate is obtained. The estimated heritability is the proportion of the model's total variance that is due to the genetic relatedness matrix (kinship measured from genotypes). Current practice is to use bootstrapping, which is slow, or normal asymptotic approximation to estimate the precision …

Campus Assembly Minutes 11/09/2016, Campus Assembly

Campus Assembly

No abstract provided.

Understanding Alternative Financial Services, Robert Andrew Butgereit

Honors Capstone Projects and Theses

No abstract provided.

Minutes Of The Faculty Senate Meeting, November 9, 2016, University Of Arkansas, Fayetteville. Faculty Senate

Faculty Senate Minutes

No abstract provided.

The Lumberjack, November 9, 2016, The Lumberjack Staff

2016

The student newspaper of Humboldt State University

Spartan Daily, November 9, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 147, Issue 30

Meeting Minutes From November 9th, 2016, Rollins College Student Government Association

SGA Meeting Minutes

No abstract provided.

Prospectus, November 9, 2016, Peter Floess, Scott Wells, Matt Moss, Dylan Kleiss, Ryan Mills

Prospectus 2016

RADIO DRAMA BY COMM. STUDENTS TO AIR ON WPCD; Humans of Parkland: Thom Schnarre; Club Latino a 'family-like community'; Official: 40 to 50 buildings damaged in Oklahoma quake; Parkland Cobra soccer teams 2016; Reasons to go to China; Obama reveals private living areas of White House; Register for Parkland College Spring 2017 Classes; Google speaker is secretary, radio...and work in progress; Students from Okinawa, Japan visit Parkland

Senate Meeting, November 9, 2016, Academic Senate

Academic Senate Minutes

No abstract provided.

Volume 54, Number 13: November 09, 2016, University Of North Dakota

University Letter Archive

No abstract provided.

We Are...Marshall, November 9, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Food Banking System Helps Alleviate Hunger In Mexico, Carlos Navarro

SourceMex

No abstract provided.

The Winonan, Winona State University

The Winonan - 2010s

No abstract provided.

Place Names Beginning With The Letter D, Robert M. Rennick

Robert M. Rennick Manuscript Collection

Place names of Kentucky beginning with the letter D.

‘Crying A Few Million Tears’ For The Fallen Victims Of Huntington's Disease, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

A Qualitative Study Of Rural Nurse Practitioners' In Medically Underserved Clinics, Jama J. Bogart

Doctor of Nursing Practice Scholarly Project

Retention of nurse practitioners is a serious problem in rural medically underserved areas. This study focused on the underserved areas in southeast Kansas, southwest Missouri, and northern Oklahoma. Approximately, three million persons reside in rural medically-underserved areas of the study area. Seventy-three percent of these adults have at least two or more complex chronic medical conditions and there are only 526 nurse practitioners to care for them. Rural providers face many challenges in caring for these individuals and experience anxiety and stress while caring for them. The purpose of this research study was to explore, analyze, and describe the phenomena …

Mesenteric Vascular Dysregulation And Intestinal Inflammation Accompanies Experimental Spinal Cord Injury, Emily Swartz Besecker, Gina M. Deiter, Nicole Pironi, Timothy K. Cooper, Gregory Michael Holmes

Health Sciences Faculty Publications

Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial hypotension. Gastrointestinal (GI) tissues are critically dependent upon adequate blood flow and even brief periods of visceral hypoxia triggers GI dysmotility. The aim of this study was to test the hypothesis that T3-SCI induces visceral hypoperfusion, diminished postprandial vascular reflexes and concomitant visceral inflammation. We measured in vivo systemic arterial blood pressure and superior mesenteric artery (SMA) and duodenal blood flow in anesthetized T3-SCI rats at 3 …

Joining Forces Wellness Week Raises Awareness Of Veteran Healthcare Needs, Kendra Carter

Browse All News

No abstract provided.

Montana Kaimin, November 9-15, 2016, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Monroe, Quincy Adams, 1841-1928 (Sc 3070), Manuscripts & Folklife Archives

Manuscript Collection Finding Aids

Finding aid only for Manuscripts Small Collection 3070. Letter, 30 December 1861, to “Orissa,” from Quincy A. Monroe, serving with the 1st Ohio Light Artillery. Writing on “Cotter’s Battery” letterhead while at Camp Wood on the Green River in Kentucky, he describes troop strength in the area, the topography, Confederate fortifications at Bowling Green, and his expectations of battle.

Emu Today, November 9, 2016, Eastern Michigan University

EMU Today

No abstract provided.