Digital Commons Network^™

Temporary Nerve Block At Selected Digits Revealed Hand Motor Deficits In Grasping Tasks, Aude Cateron, Kerry Mcpartlan, Christina Gioeli, Emily Reid, Matt Turturro, Barry Hahn, Cynthia Benson, Wei Zhang

Publications and Research

Peripheral sensory feedback plays a crucial role in ensuring correct motor execution throughout hand grasp control. Previous studies utilized local anesthesia to deprive somatosensory feedback in the digits or hand, observations included sensorimotor deficits at both corticospinal and peripheral levels. However, the questions of how the disturbed and intact sensory input integrate and interact with each other to assist the motor program execution, and whether the motor coordination based on motor output variability between affected and non-affected elements (e.g., digits) becomes interfered by the local sensory deficiency, have not been answered. The current study aims to investigate the effect of …

Ocean Sprawl: Challenges And Opportunities For Biodiversity Management In A Changing World, Louise B. Firth, Antony M. Knights, Danielle Bridger, Ally J. Evans, Nova Mieszkowska, Pippa J. Moore, Nessa E. O'Connor, Emma V. Sheehan, Richard C. Thompson, Stephen J. Hawkins

School of Biological and Marine Sciences

The last few decades have seen rapid proliferation of hard artificial structures (e.g., energy infrastructure, aquaculture, coastal defences) in the marine environment: ocean sprawl. The replacement of natural, often sedimentary, substrata with hard substrata has altered the distribution of species, particularly non-indigenous species, and can facilitate the assisted migration of native species at risk from climate change. This has been likened to urbanization as a driver of global biotic homogenization in the marine environment-the process by which species invasions and extinctions increase the genetic, taxonomic, or functional similarity of communities at local, regional, and global scales. Ecological engineering research showed …

Regulatory Ecotoxicity Testing Of Nanomaterials – Proposed Modifications Of Oecd Test Guidelines Based On Laboratory Experience With Silver And Titanium Dioxide Nanoparticles, K Hund-Rinke, A Baun, D Cupi, Tf Fernandes, R Handy, Jh Kinross, Jm Navas, W Peijnenburg, K Schlich, Bj Shaw, Jj Scott-Fordsmand

School of Biological and Marine Sciences

No abstract provided.

Broadening Understandings Of Occupational Identity: Illustrations From A Research Study Of Homeless Adults., Mj Cunningham

School of Health Professions

No abstract provided.

A Holistic Approach To Dissecting Sparc Family Protein Complexity Reveals Fstl-1 As An Inhibitor Of Pancreatic Cancer Cell Growth, Katrina Viloria, Amanda Munasinghe, Sharan Asher, Roberto Bogyere, Lucy Jones, Natasha J. Hill

School of Biomedical Sciences

AbstractSPARC is a matricellular protein that is involved in both pancreatic cancer and diabetes. It belongs to a wider family of proteins that share structural and functional similarities. Relatively little is known about this extended family, but evidence of regulatory interactions suggests the importance of a holistic approach to their study. We show that Hevin, SPOCKs, and SMOCs are strongly expressed within islets, ducts, and blood vessels, suggesting important roles for these proteins in the normal pancreas, while FSTL-1 expression is localised to the stromal compartment reminiscent of SPARC. In direct contrast to SPARC, however, FSTL-1 expression is reduced in …

5-Hydroxymethylcytosine Localizes To Enhancer Elements And Is Associated With Survival In Glioblastoma Patients, Kevin C. Johnson, E. Andres Houseman, Jessica E. King, Katharine M. Von Herrmann, Camilo E. Fadu, Brock C. Christensen

Dartmouth Scholarship

Glioblastomas exhibit widespread molecular alterations including a highly distorted epigenome. Here, we resolve genome-wide 5-methylcytosine and 5-hydroxymethylcytosine in glioblastoma through parallel processing of DNA with bisulfite and oxidative bisulfite treatments. We apply a statistical algorithm to estimate 5-methylcytosine, 5-hydroxymethylcytosine and unmethylated proportions from methylation array data. We show that 5-hydroxymethylcytosine is depleted in glioblastoma compared with prefrontal cortex tissue. In addition, the genomic localization of 5-hydroxymethylcytosine in glioblastoma is associated with features of dynamic cell-identity regulation such as tissue-specific transcription and super-enhancers. Annotation of 5-hydroxymethylcytosine genomic distribution reveal significant associations with RNA regulatory processes, immune function, stem cell maintenance and …

Budd Revisited - Gambling In Great Britain 15 Years On, Daniel Waugh Mr

UNLV Gaming Research & Review Journal

In 2000, Sir Alan Budd, the noted economist was asked by the British Government to chair a review of the nation’s gambling laws. The resulting ‘The Report of the Gambling Review Body’ (referred to here as ‘The Budd Report’ or ‘Budd’) was published a year later and provided a blueprint for how gaming and betting would subsequently be regulated under a major new piece of legislation - the Gambling Act 2005 (the ‘2005 Act’ or the ‘Gambling Act’).

The work of the Gambling Review Body (the ‘Review Body’) was undertaken at considerable expense and effort – more than 200 submissions …

Severe Mortality Impact Of The 1957 Influenza Pandemic In Chile., Gerardo Chowell, Lone Simonsen, Rodrigo Fuentes, Jose Flores, Mark A Miller, Cécile Viboud

Microbiology, Immunology, and Tropical Medicine Faculty Publications

INTRODUCTION: Epidemiological studies of the 1957 influenza pandemic are scarce, particularly from lower-income settings.

METHODS: We analyzed the spatial-temporal mortality patterns of the 1957 influenza pandemic in Chile, including detailed age-specific mortality data from a large city, and investigated risk factors for severe mortality impact across regions.

RESULTS: Chile exhibited two waves of excess mortality in winter 1957 and 1959 with a cumulative excess mortality rate of 12 per 10 000, and a ~10-fold mortality difference across provinces. High excess mortality rates were associated with high baseline mortality (R(2) =41.8%; P=.02), but not with latitude (P>.7). Excess mortality rates …

Perioperative Ledipasvir-Sofosbuvir For Hcv In Liver-Transplant Recipients, Josh Levitsky, Elizabeth C. Verna, Jacqueline G. O'Leary, Natalie H. Bzowej, D Moonka, Robert H. Hyland, Sarah Arterburn, Hadas Dvory-Sobol, Diana M. Brainard, John G. Mchutchison, Norah A. Terrault

Gastroenterology Articles

No abstract provided.

Methods And Apparatus For Electrical Stimulation, Jeffrey Hargrove, William G. Mavity, Lauren R. Briggs, Robert M. Gengreau

Mechanical Engineering Patents

A method of treating a neurological condition in a patient, the method including the step of applying an electrical stimulation from conductors to the patient's head at a stimulation application site. In some embodiments, the electrical stimulation includes a composite electrical signal further comprising at least one signal form configured to provide long-term treatment of the neurological condition and at least one signal form configured to provide analgesia for short-term pain relief. The invention also provides an electrical stimulation apparatus having an electrical signal generator adapted to provide an electrical signal form configured to provide long-term treatment of a neurological …

The Weekly Challenger, November 24, 2016, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The November 24, 2016, issue of The Weekly Challenger.

How Does The Development Of Early Literacy Skills And The Partnership Between A Child’S Home And School Promote Literacy Success?, Teri Greenstein

School of Education and Leadership Student Capstone Theses and Dissertations

The research question addressed in this capstone was, How does the development of early literacy skills and the partnership between a child’s home and school promote literacy success? This capstone describes the foundational early literacy skills necessary for literacy success for students, and discusses ways that school and home can collaborate towards ensuring that students are effectively prepared for literacy learning as they begin their formal schooling. The goal of the capstone project was to provide families with tools and resources that can be used to help them develop more effective literacy learning for their children.

Trouble On The Exchanges — Does The United Owe Billions To Health Insurers?, Nicholas Bagley

Articles

Yet another bruising fight has erupted over health care reform. On September 9, 2016, the Obama administration offered to open settlement negotiations with health insurers that have sued the United States to recover billions of dollars that they claim they are owed. Congressional Republicans are incensed, believing that any settlement would illegally squander taxpayer dollars in a lastgasp effort to save the Affordable Care Act (ACA).

The Relationship Between Religiosity And Health-Promoting Behaviors In Pregnant Women, Natalie A. Cyphers, Andrea D. Clements, Glenda Lindseth

ETSU Faculty Works

Pender’s health promotion model guided this descriptive/correlational study exploring the relationship between religiosity and health-promoting behaviors of pregnant women at Pregnancy Resource Centers (PRCs). A consecutive sample included women who knew they were pregnant at least 2 months, could read/write English, and visited PRCs in eastern Pennsylvania. Participants completed self-report surveys that examined religiosity, demographics, pregnancy-related variables, services received at PRCs, and health-promoting behaviors. Women reported they “sometimes” or “often” engaged in health-promoting behaviors, Hispanic women reported fewer health-promoting behaviors than non-Hispanic women, and women who attended classes at the centers reported more frequent health-promoting behaviors than those who did …

Regional Variation In Ascaris Lumbricoides And Trichuris Trichiura Infections By Age Cohort And Sex: Effects Of Market Integration Among The Indigenous Shuar Of Amazonian Ecuador, Theresa E. Gildner, Tara J. Cepon-Robins, Melissa A. Liebert, Samuel S. Urlacher, Felicia C. Madimenos, J. Josh Snodgross, Lawrence S. Sugiyama

Publications and Research

Background: Soil-transmitted helminth (STH) infection peaks during childhood and varies by sex. The impact of market integration (MI) (increasing production for and consumption from a market-based economy) on these infection patterns, however, is unclear. In this study, STH infection is examined by sex and age among indigenous Shuar inhabiting two regions of Amazonian Ecuador: (1) the modestly market-integrated Upano Valley (UV) and (2) the more traditional Cross-Cutucú (CC) region.

Methods: Kato-Katz fecal smears were examined for parasite presence and infection intensity. Factorial ANOVAs and post hoc simple effects analyses were performed by sex to compare infection intensity between regions and …

Nucleoside-Diphosphate-Kinase Of P. Gingivalis Is Secreted From Epithelial Cells In The Absence Of A Leader Sequence Through A Pannexin-1 Interactome, Kalina Atanasova, Jungnam Lee, Joann Roberts, Kyulim Lee, David M. Ojcius, Özlem Yilmaz

All Dugoni School of Dentistry Faculty Articles

Nucleoside-diphosphate-kinases (NDKs) are leaderless, multifunctional enzymes. The mode(s) of NDK secretion is currently undefined, while extracellular translocation of bacterial NDKs is critical for avoidance of host pathogen clearance by opportunistic pathogens such as Porphyromonas gingivalis. P. gingivalis-NDK during infection inhibits extracellular-ATP (eATP)/P2X7-receptor mediated cell death in gingival epithelial cells (GECs) via eATP hydrolysis. Furthermore, depletion of pannexin-1-hemichannel (PNX1) coupled with P2X7-receptor blocks the infection-induced eATP release in GECs, and P. gingivalis-NDK impacts this pathway. Ultrastructural and confocal microscopy of P. gingivalis-co-cultured GECs or green-fluorescent-protein (GFP)-P. gingivalis-NDK transfected GECs revealed a perinuclear/cytoplasmic localization of NDK. eATP stimulation induced NDK recruitment to …

A Trial Of Unrelated Donor Marrow Transplantation For Children With Severe Sickle Cell Disease., Shalini Shenoy, Mary Eapen, Julie A. Panepinto, Brent R. Logan, Juan Wu, Allistair Abraham, Joel Brochstein, Sonali Chaudhury, Kamar Godder, Ann E. Haight, Kimberly A. Kasow, Kathryn Leung, Martin Andreansky, Monica Bhatia, Jignesh Dalal, Hilary Haines, Jennifer Jaroscak, Hillard M. Lazarus, John E. Levine, Lakshmanan Krishnamurti, David Margolis, Gail C. Megason, Lolie C. Yu, Michael A. Pulsipher, Iris Gersten, Nancy Difronzo, Mary M. Horowitz, Mark C. Walters, Naynesh Kamani

Manuscripts, Articles, Book Chapters and Other Papers

Children with sickle cell disease experience organ damage, impaired quality of life, and premature mortality. Allogeneic bone marrow transplant from an HLA-matched sibling can halt disease progression but is limited by donor availability. A Blood and Marrow Transplant Clinical Trials Network (BMT CTN) phase 2 trial conducted from 2008 to 2014 enrolled 30 children aged 4 to 19 years; 29 were eligible for evaluation. The primary objective was 1-year event-free survival (EFS) after HLA allele-matched (at HLA-A, -B, -C, and -DRB1 loci) unrelated donor transplant. The conditioning regimen included alemtuzumab, fludarabine, and melphalan. Graft-versus-host disease (GVHD) prophylaxis included calcineurin inhibitor, …

Technology-Enhanced Learning In Transnational Higher Education, N Arunasalam

School of Nursing and Midwifery

Some university schools of nursing in Australia and the UK have developed collaborative links with Malaysia to deliver part-time Transnational Higher Education (TNHE) post-registration top-up nursing degree courses. It enables nurses trained to diploma level to upgrade to a degree qualification. The views of 18 Malaysian nurses who had studied with one Australian and two UK TNHE universities were explored using a hermeneutic phenomenological approach. Participants recruited via convenience and snowball sampling methods were interviewed in English and Bahasa Malaysia (Malaysian language). Thematic analysis were used to analyse data. Findings indicated nurses' frustration with technology-enhanced teaching and learning and a …

Risk Of Medication Overuse Headache Across Classes Of Treatments For Acute Migraine, Kristian Thorlund, Christina Sun-Edelstein, Eric Druyts, Steve Kanters, Shanil Ebrahim, Rahul Bhambri, Elodie Ramos, Edward Mills, Michel Lanteri-Minet, Stewart Tepper

Dartmouth Scholarship

Background: The most commonly prescribed medications used to treat migraine acutely are single analgesics, ergots, opioids, and triptans. Due to varying mechanisms of action across drug classes, there is reason to believe that some classes may be less likely than others to elicit Medication Overuse Headache (MOH) than others. We therefore aimed to determine whether certain classes of acute migraine drugs are more likely to elicit MOH than others.

Methods: A comprehensive systematic literature was conducted to identify studies of varying designs that reported on MOH within the considered treatment classes. Only studies that reported MOH according to the International …

Influence Of Tick And Mammalian Physiological Temperatures On Borrelia Burgdorferi Biofilms, Shafiq Shaikh, Venkata Arun Timmaraju, Jason Torres, Kayla Socarras, Priyanka A. Theophilus, Eva Sapi

Biology and Environmental Science Faculty Publications

The spirochaete bacterium Borrelia burgdorferi sensu lato is the aetiologic agent of Lyme disease. Borrelia is transmitted to mammals through tick bite and is adapted to survive at tick and mammalian physiological temperatures. We have previously shown that B. burgdorferi can exist in different morphological forms, including the antibiotic-resistant biofilm form, in vitro and in vivo. B. burgdorferi forms aggregates in ticks as well as in humans, indicating potential of biofilm formation at both 23 and 37 °C. However, the role of various environmental factors that influence Borrelia biofilm formation remains unknown. In this study, we investigated the effect …

Preparing Future Leaders: An Ethnographic Study Exploring The Culture Of Succession Planning And Leader Development In Christian Higher Education, Andrew Barton

Dissertations

The purpose of this ethnographic case study was to explore the culture of succession planning and leader development at Lipscomb University, using the 5C’s: Strategies for succession planning in the academy model. In the face of unprecedented disruption and complexity, the review of literature suggested the higher education sector in the United States is largely underprepared for the upcoming exodus and shortage of leaders. With religiously-affiliated institutions accounting for more than one in five colleges and universities in the US, there were no visible studies attending to succession planning and leader development in Christian higher education. Given the important contribution …

An Ethnographic Investigation On How Chief Nursing Officers Use Transformational Leadership To Lead And Support New Nurse Graduates, Susan Pailet

Dissertations

Purpose: The purpose of this ethnographic study was to examine how chief nursing officers (CNOs) use transformational leadership to lead and support new nurse graduates based on the Transformational Leadership Skills Inventory (TLSi) tool developed by Larick and White (2012).

Methodology: The sample for this qualitative ethnographic study included 13 CNOs in 4 counties in California (Los Angeles, Orange, San Bernardino, and Riverside) working for hospitals and other healthcare settings. The data sources for this study included observations, interviews, and artifact reviews. Data were analyzed using a thematic analysis.

Findings: 8 major findings emerged: (a) CNOs participate …

State V. Kelly Appellant's Brief Dckt. 44195

Not Reported

No abstract provided.

Family Health Nursing Nur 353, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Clinical Immersion Nur 417, Joanna Burkhardt

Library Impact Statements

No abstract provided.

We Are...Marshall, November 23, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

The Family Story Of James Sumler, James Aaron Sumler

Your Family in History: HIST 550/700

The Family History of James Aaron Sumler

23 November 2016

James Aaron Sumler authored this family history as part of the course requirements for HIST 813 Seminar in American History: Family History offered in the Fall Semester of 2016. It was submitted to the Pittsburg State University Digital Commons. Please contact the author directly with any questions or comments: [email protected]

Practicum In Family Health Nursing Nur 354, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Medical-Surgical Nursing 3: Care Of The Adult With Complex Clinical Illnesses Nur 413, Joanna Burkhardt

Library Impact Statements

No abstract provided.

State V. Fenton Clerk's Record Dckt. 44546

Idaho Supreme Court Records & Briefs, All

No abstract provided.