Digital Commons Network^™

The Humoral Theory Of Transplantation: Epitope Analysis And The Pathogenicity Of Hla Antibodies., Edward J Filippone, John Farber

Department of Medicine Faculty Papers

Central to the humoral theory of transplantation is production of antibodies by the recipient against mismatched HLA antigens in the donor organ. Not all mismatches result in antibody production, however, and not all antibodies are pathogenic. Serologic HLA matching has been the standard for solid organ allocation algorithms in current use. Antibodies do not recognize whole HLA molecules but rather polymorphic residues on the surface, called epitopes, which may be shared by multiple serologic HLA antigens. Data are accumulating that epitope analysis may be a better way to determine organ compatibility as well as the potential immunogenicity of given HLA …

Comparative Efficacy Of Nebivolol And Metoprolol To Prevent Tachycardia-Induced Cardiomyopathy In A Porcine Model, Alireza Nazeri, Macarthur A Elayda, Ana Maria Segura, Raymond F Stainback, Joanna Nathan, Vei-Vei Lee, Christina Bove, Luiz Sampaio, Brian Grace, Ali Massumi, Mehdi Razavi

The Texas Heart Institute Journal

Chronic tachycardia is a well-known cause of nonischemic cardiomyopathy. We hypothesized that nebivolol, a β-blocker with nitric oxide activity, would be superior to a pure β-blocker in preventing tachycardia-induced cardiomyopathy in a porcine model.

Fifteen healthy Yucatan pigs were randomly assigned to receive nebivolol, metoprolol, or placebo once a day. All pigs underwent dual-chamber pacemaker implantation. The medication was started the day after the pacemaker implantation. On day 7 after implantation, each pacemaker was set at atrioventricular pace (rate, 170 beats/min), and the pigs were observed for another 7 weeks. Transthoracic echocardiograms, serum catecholamine levels, and blood chemistry data were …

Sickle Cell Disease With Cyanotic Congenital Heart Disease: Long-Term Outcomes In 5 Children, Glen J Iannucci, Olufolake A Adisa, Matthew E Oster, Michael Mcconnell, William T Mahle

The Texas Heart Institute Journal

Sickle cell disease is a risk factor for cerebrovascular accidents in the pediatric population. This risk is compounded by hypoxemia. Cyanotic congenital heart disease can expose patients to prolonged hypoxemia. To our knowledge, the long-term outcome of patients who have combined sickle cell and cyanotic congenital heart disease has not been reported. We retrospectively reviewed patient records at our institution and identified 5 patients (3 girls and 2 boys) who had both conditions. Their outcomes were uniformly poor: 4 died (age range, 12 mo-17 yr); 3 had documented cerebrovascular accidents; and 3 developed ventricular dysfunction. The surviving patient had developmental …

Endovascular Treatment Of Superior Vena Cava Syndrome Via Balloon-In-Balloon Catheter Technique With A Palmaz Stent, Wassim Shatila, Abdelkader Almanfi, Mehran Massumi, Kathryn G Dougherty, Dhaval R Parekh, Neil E Strickman

The Texas Heart Institute Journal

Superior vena cava syndrome is a well-known disease entity that carries substantial rates of morbidity and mortality. Although most cases of superior vena cava syndrome are secondary to a malignant process, additional causes (such as mediastinal fibrosis, pacemaker lead implantation, or central venous catheter placement) have been reported. Multiple treatment options include percutaneous transluminal angioplasty, stent implantation, thrombolysis, mechanical thrombectomy, and venous grafting. We present a case of superior vena cava syndrome in a symptomatic 30-year-old woman who obtained complete relief of obstruction and marked symptomatic improvement through venoplasty and stenting, aided by our use of a balloon-in-balloon catheter system.

"Eyeing" The Cause Of Heart Failure: Visible Telltale Clues, Herbert L Fred, Manoj Thangam

The Texas Heart Institute Journal

No abstract provided.

Aspirin Resistance Predicts Adverse Cardiovascular Events In Patients With Symptomatic Peripheral Artery Disease, Tilak Pasala, Jennifer Soo Hoo, Mary Kate Lockhart, Rehan Waheed, Prasanna Sengodan, Jeffrey Alexander, Sanjay Gandhi

The Texas Heart Institute Journal

Antiplatelet therapy reduces the risk of myocardial infarction, stroke, and vascular death in patients who have symptomatic peripheral artery disease. However, a subset of patients who take aspirin continues to have recurrent cardiovascular events. There are few data on cardiovascular outcomes in patients with peripheral artery disease who manifest aspirin resistance.

Patients with peripheral artery disease on long-term aspirin therapy (≥4 wk) were tested for aspirin responsiveness by means of the VerifyNow Aspirin Assay. The mean follow-up duration was 22.6 ± 8.3 months. The primary endpoint was a composite of death, myocardial infarction, or ischemic stroke. Secondary endpoints were the …

Peering Below The Diffraction Limit: Robust And Specific Sorting Of Viruses With Flow Cytometry, Shea T. Lance, David J. Sukovich, Kenneth M. Stedman, Adam R. Abate

Biology Faculty Publications and Presentations

Background: Viruses are incredibly diverse organisms and impact all forms of life on Earth; however, individual virions are challenging to study due to their small size and mass, precluding almost all direct imaging or molecular analysis. Moreover, like microbes, the overwhelming majority of viruses cannot be cultured, impeding isolation, replication, and study of interesting new species. Here, we introduce PCR-activated virus sorting, a method to isolate specific viruses from a heterogeneous population. Specific sorting opens new avenues in the study of uncultivable viruses, including recovering the full genomes of viruses based on genetic fragments in metagenomes, or identifying the …

The Privacy Policymaking Of State Attorneys General, Danielle K. Citron

Faculty Scholarship

Accounts of privacy law have focused on legislation, federal agencies, and the self-regulation of privacy professionals. Crucial agents of regulatory change, however, have been ignored: the state attorneys general. This article is the first in-depth study of the privacy norm entrepreneurship of state attorneys general. Because so little has been written about this phenomenon, I engaged with primary sources — first interviewing state attorneys general and current and former career staff, and then examining documentary evidence received through FOIA requests submitted to AG offices around the country.

Much as Justice Louis Brandeis imagined states as laboratories of the law, offices …

Real Talk: Developing A Computer-Delivered Sexual Health Program For Black Men Who Have Sex With Men, Charles H. Klein, Carmela Lomonaco

Anthropology Faculty Publications and Presentations

HIV disproportionately affects Black men who have sex with men (MSM), yet there are few evidence-based programs that respond to the diverse realities of Black MSM communities. This article examines the development of Real Talk, a new harm reduction-based, sexual health intervention for Black MSM. We first analyze the key themes from our formative research: (1) stigma, discrimination, and intersectionalities in the lives of Black MSM, (2) the importance of safe spaces and community provided by health promotion programs, and (3) moving beyond condoms in sexual health messaging. We then describe our agile design product development process and present an …

Qualitative Collective Case Study Of Targeted Violence Preparedness At Institutions Of Higher Education, Tim Gunter

Doctoral Dissertations and Projects

An increase in targeted violence incidents (TVIs), primarily active shooter events, at institutions of higher education (IHEs) has exposed gaps in campus security plan preparation and exercises. The purpose of this qualitative collective case study was to discover barriers to and best practices of universities and colleges conducting security preparedness activities for TVIs. The theory that guided this study was vested interest theory which predicts how attitudes will influence behavior in a commitment to preparedness fundamentals. The setting for this study was two institutions of higher education along the East Coast of the United States. Data collection techniques included site …

A Phenomenological Study Exploring Factors That Contribute To Academic Persistence For Nontraditional Undergraduate African American Male Degree-Completers From Bible Colleges In The Southeast, Rodney Phillips

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to understand factors that contribute to college persistence for nontraditional undergraduate African American male four-year degree completers from select evangelical Bible colleges in the southeastern United States. An ecological and adult resiliency theoretical framework guided the research. Three research questions framed this study: (a) How do nontraditional undergraduate African American male four-year degree completers from select evangelical Bible colleges describe persistence? (b) What type of experiences do participants understand as having contributed to their persistence at Bible colleges? (c) What specific factors do participants identify as having contributed to their persistence at …

The Impact Of Sports Participation On The Academic Achievement Of African American Girls, Sarita Singleton

Doctoral Dissertations and Projects

Although there are several educational benefits resulting from participation in high school sports, African American students do not always experience the positive outcomes that other populations share. The purpose of this causal comparative study was to investigate the effect of athletic participation on the academic achievement of African American high school female students. The sample consisted of 100 female African American 12th-grade students. Descriptive statistics were collected and analyzed. Analysis involved archival data to determine the grade point averages and graduation rates of student athletes and non-athletes in two urban high schools in Georgia. The study sought to determine if …

Physical Education, Art, And Music Teachers' Lived Experiences With Students Who Have Adhd Or Adhd Symptoms, Kellie Henry

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to discover the lived experiences of teaching students with ADHD for art, music, and physical education teachers at elementary schools. The theories guiding this study are Zentall’s (1975) Optimal Stimulation Theory and Ajzen’s (1991) Theory of Planned Behavior as they explain how teachers’ attitudes and use of stimulation in the classroom affects the central phenomenon. This transcendental phenomenological study was based on actual descriptions of elementary special area teachers’ lived experiences with students who have ADHD. The design included a review of the literature, epoche, phenomenological reduction, imaginative variation, and synthesis of …

Community College Alumni Engagement: Exploring The Relationship Of Social Media To Alumni Giving, Amy Hall

Doctoral Dissertations and Projects

Community colleges have begun to rely more heavily on private funding sources like alumni donations to support their overall fiscal health. This correlational study tested the theory of planned behavior as it relates to level of engagement through social media for community college alumni and alumni giving behavior for Virginia’s community colleges. More specifically, it attempted to determine whether a relationship exists between alumni use of their alma mater’s Facebook page and engagement behaviors. Survey data were gathered from participating colleges and from a randomly drawn sample of alumni of Virginia’s 23 community colleges (N=4,100) using the Virginia Community College …

To College They Go: A Multiple Case Study Of Seven Homeschooled Graduates' Transition From Home To College, Shellie Fink-Glass

Doctoral Dissertations and Projects

The purpose of this multiple case study was to explore and capture how Pennsylvania homeschooled graduates transitioned from their homeschooled academic environment to a collegiate one. This research was founded on the need for further research addressing homeschoolers and their transition into college. Existing literature falls short which not only documents the first-hand, personal experiences taken directly from homeschooled graduates, but from their mothers, as well. Five research questions were developed to guide this study. Questionnaires and oral interviews were used to capture the unique personal experiences from both the students and their mothers. During the analysis phase, five recurring …

Zika Virus-Associated Seizures, Ali Akbar Asadi-Pooya

Department of Neurology Faculty Papers

No abstract provided.

Creating A Christ-Centered Climate For Educational Excellence: Philosophical, Instructional, Relational, Assessment And Counseling Dimensions, Elvin Gabriel, Carole Woolford-Hunt, Esther M. Hooley

Faculty Publications

Interest is peaking among educators in North America, and around the world, on issues relating to school climate. A primary reason for this strong interest is research confirmation that school climate may have a positive or negative effect on educational processes. A Christ-Centered school climate provides the best opportunities for stakeholders to work collaboratively to achieve four primary educational outcomes. These are: (1) creating and sustaining bias free learning environments where relationships are nurtured by love, respect, tolerance, and kindness; (2) establishing faith-based instructional and service learning programs which cater to the needs of students; and (3) utilizing quality assessment …

Stack And Bend, Ngoc “Knock” Ho

The Transdisciplinary STEAM+ Journal

An excerpt on body contortion.

Transforming Body, Angelina Prendergast

The Transdisciplinary STEAM+ Journal

This is a reflection about the use of balls for body therapy.

Peaceful Ninjas: Merging Mindfulness Education With Holistic Arts, Zachariah Z. Fisher, April Tucker

The Transdisciplinary STEAM+ Journal

Peaceful Ninjas is a Holistic Peace Education Movement Empowering Youth to Co Create World Peace by Merging Ancient and Modern Mindfulness Practices. This piece provides an overview of the activities and approach we use.

Gathering Steam In Health Care: A Student History, Michael J. Leach

The Transdisciplinary STEAM+ Journal

In this reflection, I demonstrate STEAM in health care by outlining my 15 years as a university student engaged in formal education, extracurricular learning, research, and employment.

Leaf Miner's Leaves, Susan Hoenig

The Transdisciplinary STEAM+ Journal

For many years I have been collecting leaves and discovered a phenomena that I find truly fascinating on specific leaves called "leaf miner's leaves". The leaves are the dwellings of animals, various insects' architectural habitat. Leaf miner's leaves are a phenomena in nature in the plant kingdom where the larvae of various insects tunnel their way through a leaf eating its living tissue. The leaf miners create distinctive patterns on each leaf. The snake-like serpentine tunnels protect them from predators and plant defenses.

From Stem To Steam: Students’ Beliefs About The Use Of Their Creativity, Ayse Tugba Oner, Sandra Bonorden Nite, Robert M. Capraro, Mary Margaret Capraro

The Transdisciplinary STEAM+ Journal

To be successful in a STEM career, not only STEM knowledge and skills but also creativity is required. Therefore, the arts have been integrated into STEM disciplines and subsequently designated as STEAM education (Sousa & Pilecki, 2013). One example of informal learning environments that STEAM education provided is a summer camp. In this study, middle and highs school students’ use of their creativity in the Project-based Learning (PBL) courses was examined to determine students’ belief about the use of the arts in STEM activities. The results showed that students believed that they used their creativity in eight of the nine …

Educating Clinician Scientists Once Again—A Societal Need, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The Faculty Editor advocates for the training of clinician scientists again, using the body of clinical research as the laboratory.

Pbis Teams Perceived Connections Between Culture And Pbis Implementation, Kathryn M. Mcphee, Kiarra Givhan

Georgia Association for Positive Behavior Support Conference

Currently in Georgia, there is a strategic plan to “improve the climate in Georgia’s school and community settings through the Positive Behavior Interventions and Supports framework.” (GaDOE, 2013, p.2). As the GaDOE’s strategic plan develops, schools are becoming more diverse with students representing a range of academic, behavioral and cultural experiences and backgrounds (Cohn & Caumont, 2016). Researchers have demonstrated that racial/ethnic disparities exist in academic achievement, discipline practices and mental health services provided in schools (e.g., Fallon et al., 2015). Thus, to improve educational experiences for all students through PBIS, considering how culture and context influence what is being …

We Are...Marshall, November 30, 2016, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Sport-Specific Risk And Protective Factors For Low Back Pain In Olympic Class Sailors: An Epidemiologic Analytic Cohort Study, Shawn E. Hunt

Open Access Dissertations

This dissertation determined the effect of known and theoretical risk factors for LBP in the Olympic class sailors utilizing a cohort design. A secondary goal was to determine if any factors related to sailors or sailing would provide a protective effect, lowering the risk of LBP. Sailors exposed to hiking (a sailing-specific activity) and non-hiking sailing classes were analyzed for the effect of hiking activity as a risk factor for LBP. Hiking exposure increases risk of LBP. Exposure to more than two hours of unloading the sailors’ boats and equipment prior to a regatta was a second unique risk factor …

From The Dean, Joseph Harroz Jr.

Sooner Lawyer Archive

No abstract provided.

Letcher County - Place Names, Robert M. Rennick

Robert M. Rennick Manuscript Collection

Place names of Letcher County, Kentucky.

Community Conversation-Center For Michigan Event, John M. Dunn

WMU President John Dunn

No abstract provided.