Digital Commons Network^™

Review: A Novel Multiple Sclerosis Model Utilizing Cuprizone And Rapamycin, Mara Bahri

University Honors Theses

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system leading to debilitating long-term neurologic damage, primarily due to the limited ability of remyelination in the adult human brain. This review summarizes the current knowledge regarding the combined administration of Cuprizone (CPZ) and rapamycin as a novel animal model for MS. Utilization of CPZ induces non-immune mediated demyelination, therefore bypassing complexities of the immune system and allowing analysis of de-/remyelination. Furthermore, remyelination occurs simultaneous with demyelination due to ongoing oligodendrocyte progenitor cells (OPCs) differentiation into mature oligodendrocytes (OLGs).

The immunosuppressive agent, rapamycin inhibits the regulatory pathway Akt/mTOR, …

Following The Flat Hat: What Leads People To National Park Service Interpretive Careers?, Avarie Fitzgerald

University Honors Theses

National Park Service interpreters around the United States are dedicated to connecting people to their parks and historical sites. While these interpretive rangers have an important mission of preserving the landscape and stories of our nation’s most treasured places, a gap in the research of significant life experiences and environmental education professions exists in understanding the motivations behind following a career in the park service. Through semi-structured phenomenological interviews, the significant life experiences of interpretive park rangers were investigated as to their degree of influence on their choice of career. The findings indicate that quality time spent outdoors, family involvement, …

Preliminary Characterization Of Rock Units To Determine Layer Divisions In A High-Pressure Metamorphic Rock Package Of The Goshen Dome, Western Massachusetts, Usa, Eleanor Lahart

University Honors Theses

In Western Massachusetts a package of rocks, known as the Damon Pond section, has been the focus of ongoing study due to characteristics signifying it may have formed under suspected ultra-high pressure (UHP) conditions. Currently there are no confirmed UHP terranes in North America causing research surrounding this package of rocks to be of particular significance. In order to better understand the Damon Pond section and a mechanism of emplacement for this potential UHP terrane, more must be known about its size and the surrounding strata. Field observations, structural measurements, and samples were collected from in-situ outcrops surrounding the Damon …

Embracing Mission: Profile Of A Jesuit Leader, Allan L. Service

Jesuit Higher Education: A Journal

This article provides a profile of the leadership of David M. Clarke, S.J. as president of Regis College/University. The persona of the leader is the driving force. Leadership strategies and tactics are filtered through the talents, motivations, and values of the leader. Embracing Jesuit and institutional mission is the foundation. Pursuit of visibility follows naturally. Listening and learning are constants. Fostering collaboration is a capstone. Jesuit leadership advances mission and makes an enduring impact upon the institution.

‘Subvert And Survive’: Soft Power And Popular Resistance At The Transcultural Edges Of Hegemony, Harry Browne

Doctoral

This thesis, in three parts, documents and conceptualises a range of political and cultural activities that either sustain or challenge existing structures of power. It seeks to answer the question: how can we conjoin a Gramscian theoretical framework and the insights of transculturalism to understand and investigate practices of dominance and resistance operating in close cultural and ideological proximity to those they oppose? Drawing upon an understanding that a successful hegemonic discourse, one that earns consent and minimises conflict, must in some sense contain, and thus control, its own opposite, Part 1 of the thesis – divided into three chapters, …

Arnold Michael Shankman Papers - Accession 98, Arnold Michael Shankman

Manuscript Collection

The Arnold Shankman Papers consist mainly of photocopies of manuscript collections which Dr. Shankman used for his research and writing. Included are pamphlets, biographical sketches, correspondence and newspaper accounts. Most of the collection relates to the American Civil War, particularly in Illinois, Georgia, and Pennsylvania, but there is material relating to Jewish history, African-Americans and United States foreign relations.

Nathaniel Gist Gee Papers - Accession 395, Nathaniel Gist Gee

Manuscript Collection

The Nathaniel Gist Gee Papers consist of various papers concerning Gee’s years in China including correspondence, reports, newspaper and magazine clippings, Chinese poetry, statistics, manifestos, statements, his professional papers concerned primarily with freshwater sponges, and professional papers and publications he collected that chronicle China’s growth. Many of the records are concerned with China’s political and social changes including China’s Nationalist and Student Movements during Gee’s stay in China.

Nathaniel Gist Gee (1876-1937), born in Union, SC, was a professor of Natural Science at Soochow University and Yenching University in China from 1901-1932.

Junior Woman's Club Of Rock Hill Records - Accession 94, Woman's Club Of Rock Hill, Junior

Manuscript Collection

The Junior Woman's Club of Rock Hill Records contain a historical file, minutes, correspondence, membership lists, financial records, project reports, newsletters, yearbook and thirty-seven scrapbooks relating to the growth, activities and community contributions of the Rock Hill Junior Woman’s Club from 1955 to 2003.

Tap Journal: A Community Magazine Of Education & The Arts - Accession 1068 - M483 (534), Tap Journal: A Community Magazine Of Education & The Arts

Manuscript Collection

This collection consists of two editions of Tap Journal: A Community Magazine of Education an the Arts edited by writer Ron Padgett of the “Writer in the Community” program at the South Carolina Arts Commission. Included in the 1977 edition is an oral history of Lando, South Carolina in Chester County; information on artist Ralph Waldrop; Lancaster County Historical markers; an article about John T.M. McAfee’s store account ledger; and other information and articles concerning Lancaster and Chester counties and Fort Mill Township. The 1978 edition consists of articles on; history of Richburg, SC; Chester Confederate Records; fiddler John Broughton; …

Shaw Land Surveying Inc. Records - Accession 988, Shaw Land Surveying Inc.

Manuscript Collection

The Shaw Land Surveying, Inc. Records consist of the survey plats and field books pertaining to David Shaw and to Shaw Land Surveying, Inc. Shaw earned his professional surveying license in 1994 and operated his surveying business from 1994 until his death on November 5, 1998. The surveys are arranged in alphabetical order by the client requesting survey, how originally organized by David Shaw, and not necessarily the property owner, however, property owners of individual plats are cross-referenced in Appendix/Index I. There are often several surveys per job and many were performed by other surveyors, which are cross-referenced by the …

Family Community Leaders Lancaster County, Sc Records - Accession 1133, Family Community Leaders, Lancaster County, Sc

Manuscript Collection

This collection consists of scrapbooks, record books, yearbooks, minutes, by-laws, memoranda, and treasurer records from and relating to the South Carolina Family and Community Leaders organization and its involvement in Lancaster County. Some items in particular are from and about the organization’s activities in the community of Douglas, SC.

Annie Davis Collection - Accession 1324, Annie Davis Epting

Manuscript Collection

Annie Davis Epting (1888-1974) was a 1909 graduate of Winthrop College. The collection contains personal items of Annie Davis including photographs, postcards, letters, Winthrop memorabilia, sewing items, and other miscellaneous artifacts, pertaining to her Winthrop career, teaching career, and passion for needlework.

Marguerite Dawson King Papers - Accession 1528, Marguerite Dawson King

Manuscript Collection

Mrs. Marguerite Dawson King (1901-1979) was a very active and civic minded woman and the collection of her papers attests to the valuable contributions which can be made by women and by senior citizens. The King Papers are a valuable source of information on women in politics and on the American Association of Retired Persons (AARP). This collection consists of letters, records, and newspapers which belonged to Marguerite Dawson King, concerning Mrs. King’s activities as chapter chairman and assistant state director of the AARP; as district chairman of the United Daughters of the Confederacy; as the first woman County Chairman …

Acceptance Of Uncertainty: Uncertainty As A Heuristic Tool Applied To The Issue Of Medical Errors, Angelika Potempa

Philosophy Faculty Publications

This is an exploration of uncertain certainties and certain uncertainties with reference to, mainly, systemic approaches to medical errors.

Be An Advocate For Others, Unless You Are A Man: Backlash Against Gender-Atypical Male Job Candidates, Janine Bosak, Clara Kulich, Laurie Rudman, Mary Kinahan

Conference Papers

Previous research shows that gender vanguards (individuals who demonstrate gender-atypical skills and behavior) suffer backlash in the form of social and economic penalties (Rudman & Phelan, 2008). This study examined backlash against female and male job applicants who were either gender-atypical or typical. Professionals (N = 149) evaluated female or male managerial applicants for internal promotion described in their performance review as showing either self-advocacy or advocacy on behalf of their team. Atypical, other-advocating men were judged to be low on agency and competence and penalized with job dismissal. Serial mediation analysis demonstrated that, compared with other-advocating women, other-advocating men …

The Many Lives Of Stephen Pan, Pam Windsor, Tim Obermiller

Illinois Wesleyan University Magazine, 2002-2017

Stephen S.T. Pan '55 survived years of war and many brushes with death before starting a new life at IWU. At age 93, he looks back on his journey with both gratitude and amazement.

A Novel Approach, Kim Hill

Illinois Wesleyan University Magazine, 2002-2017

Jac Jemc '05 developed her award-winning first novel as an IWU student. With a new book set for release by a major publisher, she reflects on setbacks and successes in a famously tough business.

Strategy/Enterprise Discourse Bounds In Business Talk., Brendan O'Rourke

Articles

Corporate strategy emerged as large non-owner managed firms became economically important (Knights and Morgan, 1991). Strategy became the substitute for the earlier enterprise discourse, which depended on the dominance, in entrepreneurial capitalism, of owner-managed firms. The discourses of strategy and enterprise developed as separate academic areas and as logics of two very different economic domains. From the late 1970s however, large organizations (Kanter, 1983:27) and governments have been urged to be more entrepreneurial (Klein et al., 2010; Osborne and Gaebler, 1993). Meanwhile, small firms were encouraged to be more strategic (Carr, 2000). This article looks at evidence from small …

An Integrated Completion And Reservoir Modeling Methodology For Horizontal Shale Wells: A Montney Formation Example, Rashid S. Kassim, Larry K. Britt, Shari Dunn-Norman, Bryan Lang

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

The Montney Formation is one of the largest unconventional resources in North America covering from southwestern Alberta to northeast British Columbia. The Montney Formation has natural gas, natural gas liquids (NGL) and oil from conventional and unconventional reservoirs. The first multiple fractured horizontal well (MFHW) was drilled in 2005. However, since the first MFHW, different methods were proposed to optimize completion designs in the Montney Formation. Some of the optimized completions utilized the "operational effectiveness" of high-rate slick-water fracture designs while other designs utilized energized fracturing fluids. What has been missing was an integrated methodology that utilizes all available data …

Laboratory Evaluation Of A Real-Time Coaxial Cable Casing Imager For Wellbore Integrity Monitoring, Yurong Li, Runar Nygaard, Baokai Cheng, Wenge Zhu, Hai Xiao

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Leakage is one of the major concerns in a geological carbon sequestration project due to the adverse environmental consequences. The main leakage risk of CO₂ through a thick, low permeable cap rock is identified to be along wells, especially in sedimentary basins that have a history of oil and gas exploration and production. To pursue a robust and cost-effective real-time monitoring technology for CO₂ leakage risk detection along the wellbore, a permanently downhole deployed coaxial cable casing imaging system is developed and tested for various deformation modes in laboratory in this paper. The casing imager consists of a …

Nitrogen Gas Flooding For Naturally Fractured Carbonate Reservoir: Visualisation Experiment And Numerical Simulation, Zhaojie Song, Jirui Hou, Zhongchun Liu, Fenglan Zhao, Shijun Huang, Yong Wang, Jieheng Wu, Baojun Bai

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Tahe Naturally Fractured Carbonate Reservoir has implemented nitrogen gas flooding since 2013, with daily oil production of 7580 bbls and oil recovery increment of 0.83% by the end of 2015. However, the presence of fractures significantly affects gas swept volume and production performance, so large amount of oil reserves is poorly flooded due to gas channeling through fractures. The fluid flow mechanisms in fractured models were discussed in order to improve field gas flooding efficiency. Based on the geological constrains of Tahe Oilfield, fractured models with different apertures were fabricated using acrylic glass to model carbonate matrix wettability and for …

Direct Experimental Evidence For Differing Reactivity Alterations Of Minerals Following Irradiation: The Case Of Calcite And Quartz, Isabella Pignatelli, Aditya Kumar, Kevin G. Field, Bu Wang, Yingtian Yu, Yann Le Pape, Mathieu Bauchy, Gaurav Sant

Materials Science and Engineering Faculty Research & Creative Works

Concrete, used in the construction of nuclear power plants (NPPs), may be exposed to radiation emanating from the reactor core. Until recently, concrete has been assumed immune to radiation exposure. Direct evidence acquired on Ar⁺-ion irradiated calcite and quartz indicates, on the contrary, that, such minerals, which constitute aggregates in concrete, may be significantly altered by irradiation. More specifically, while quartz undergoes disordering of its atomic structure resulting in a near complete lack of periodicity, calcite only experiences random rotations, and distortions of its carbonate groups. As a result, irradiated quartz shows a reduction in density of around …

A Clash Of Fictions: Geopolitics In Recent Russian And Ukrainian Literature, Yvonne Howell

Languages, Literatures, and Cultures Faculty Publications

When the vast, multinational Soviet empire collapsed in 1991, the geopolitical structure it had struggled to maintain for most of the 20111 century - often by means of brutal repression and forced remobilization of entire populations - proved itself in the eyes of many to be fatally out of sync with the epochal norm of the nation-state. By the end of the 18th century, people in many parts of the world had begun to "imagine themselves" as nations and to organize politically into states whose primary function would be to protect, nurture, and (in a kind of Romantic feedback loop) …

Experimental Investigation Of Fracture Width Limitations Of Granular Lost Circulation Treatments, Mortadha Al-Saba, Runar Nygaard, Arild Saasen, Olav Magnar Nes

Geosciences and Geological and Petroleum Engineering Faculty Research & Creative Works

Drilling fluid losses into fractured shales is a major challenge. Lost circulation treatments are widely applied to mitigate the losses; however, the effectiveness of these treatments is affected by different physical properties of the used lost circulation materials (LCM). This paper presents an experimental investigation to study the effect of LCM type, concentration, particle size distribution, temperature, and LCM shape on the formed seal integrity, with respect to differential pressure, at different fracture widths. The overall objective of this study is to address the effectiveness of LCM treatments in sealing fractured shales, with specific application to the over consolidated Barents …

Pumping Of Fresh Concrete: Insights And Challenges, Geert De Schutter, Dimitri Feys

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Pumping of Fresh Concrete is of Utmost Importance for Concrete Practice. Required Pumping Pressures Are Typically Estimated based on Design Charts. However, with the Increased Use of Chemical Admixtures and the Development of More Flowable Concrete Mixtures, the Accuracy of Traditional Design Charts is Questioned. in Recent Years, Significant Progress Has Been Obtained in Understanding the Flow of the Material in the Pumping Pipe, Including the Behavior of the Lubrication Layer Near the Pipe Surface. in Comparison with Traditional Design Charts, This Results in More Reliable Pressure Predictions When Considering Very Fluid Concrete Types Like Self-Consolidating Concrete. Some Remaining Challenges …

Gallium-Containing Mesoporous Bioactive Glass With Potent Hemostatic Activity And Antibacterial Efficacy, Sara Pourshahrestani, Ehsan Zeimaran, Nahrizul Adib Kadri, Nicola Gargiulo, Shani Samuel, Sangeetha Vasudevaraj Naveen, Tunku Kamarul, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Haemorrhage remains the leading cause of potentially survivable death in both military and civilian populations. Although a large variety of hemostatic agents have been developed, many of them have an inadequate capacity to induce hemostasis and are not effective in killing bacteria. In recent years, mesoporous bioactive glasses (MBGs) were found to be effective in inducing hemostasis. However, the materials may not be considered as ideal hemostats since they do not offer antimicrobial activity. The gallium ion (Ga⁺³) not only exhibits antibacterial properties but also accelerates the blood coagulation cascade. The aim of this study was to develop …

Antibacterial Properties Of Poly (Octanediol Citrate)/Gallium-Containing Bioglass Composite Scaffolds, Ehsan Zeimaran, Sara Pourshahrestani, Ivan Djordjevic, Belinda Pingguan-Murphy, Nahrizul Adib Kadri, Anthony W. Wren, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Bioactive glasses may function as antimicrobial delivery systems through the incorporation and subsequent release of therapeutic ions. The aim of this study was to evaluate the antimicrobial properties of a series of composite scaffolds composed of poly (octanediol citrate) with increased loads of a bioactive glass that releases zinc (Zn²⁺) and gallium (Ga³⁺) ions in a controlled manner. The antibacterial activity of these scaffolds was investigated against both Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. The ability of the scaffolds to release ions and the subsequent ingress of these ions into hard tissue was evaluated …

Relating Ion Release And Ph To In Vitro Cell Viability For Gallium-Inclusive Bioactive Glasses, Timothy J. Keenan, L. M. Placek, T. L. Mcginnity, Mark R. Towler, M. M. Hall, A. W. Wren

Chemical and Biochemical Engineering Faculty Research & Creative Works

A bioactive glass (BG) in which Ga was substituted for Zn was formulated to investigate whether the ionic form of Ga can elicit effects similar to gallium nitrate. The ion release and pH of BG extracts were evaluated, as well as the in vitro cytocompatibility of extracts in contact with mouse fibroblasts and human osteoblasts. After incubation times of 1 year, the glass (TGa-1) containing the smaller Ga-addition (8 mol%) released the most sodium (Na) (1420 mg/L), silicon (Si) (221 mg/L), and Ga (1295 mg/L), while the glass (TGa-2) containing the larger Ga-addition (16 mol%), exhibited release levels between TGa-1, …

Inorganic Hemostats: The State-Of-The-Art And Recent Advances, Sara Pourshahrestani, Ehsan Zeimaran, Ivan Djordjevic, Nahrizul Adib Kadri, Mark R. Towler

Chemical and Biochemical Engineering Faculty Research & Creative Works

Hemorrhage is the most common cause of death both in hospitals and on the battlefield. The need for an effective hemostatic agent remains, since all injuries are not amenable to tourniquet use. There are many topical hemostatic agents and dressings available to control severe bleeding. This article reviews the most commonly used inorganic hemostats, subcategorized as zeolite and clay-based hemostats. Their hemostatic functions as well as their structural properties that are believed to induce hemostasis are discussed. The most important findings from in vitro and in vivo experiments are also covered.

Analysis Of The Developing States In The Mena Region Seeking Civilian Nuclear Energy, With A Primary Focus On The Kingdom Of Saudi Arabia (Ksa) And The United Arab Emirates (Uae), Thaqal Alhuzaymi, Ayodeji Babatunde Alajo

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

The comprehensive analysis presented here attempts to ana­lyze “newcomer” states in the Middle East and North Africa (MENA), primarily the Kingdom of Saudi Arabia (KSA) and Unit­ed Arab Emirates (UAE), seeking to implement civilian nuclear energy according to their political and economic situations. By investigating their motivations and funding resources for fu­ture nuclear projects, this analysis provides guidance for these states in terms of their nuclear infrastructure and nonprolifera­tion. The overall approach of this analysis relies on the factors for the success of civilian nuclear energy programs identified in experiential studies conducted since the Atoms for Peace speech in 1953.This …