Digital Commons Network^™

Cofactor Binding Determinants In The Nadph-Dependent Nitrile-Oxidoreductase Quef, Spencer William Cohen

University Honors Theses

The NADPH-dependent nitrile-oxidioreductase, QueF is the only known enzyme capable of reducing a nitrile group to an amine. This ability makes it an attractive alternative to conventional industrial nitrile reduction. Understating how QueF binds NADPH may lead to the development of an enzyme capable of using the less expensive reductive cofactor NADH. A cofactor docking model indicates that key residues, Q60 and Y21, interact with the ribose phosphate moiety unique to NADPH. Mutants of these residues (Q60A, Q60N, Q60E, Y21A and Y21F) were developed for steady-state kinetic analysis. Modification to either residue resulted in a decrease in binding and catalytic …

Pre-Roosting Assemblages In Birds: An Observation Of American Crows In The Portland Park Blocks, Katherine Hendricks

University Honors Theses

The first objective of this study is to describe the seasonal patterns of variation in crow numbers and to assess the extent to which crow numbers vary with weather over the course of the winter in the Portland State University Park Blocks. The second objective of this study is to draw on current literature to help determine a possible explanation for the crow gatherings that occur at the Portland State University Park Blocks. I observed the population of crows from October 23^rd 2016 to March 31^st 2016 with a restricted survey area around Millar Library on the Portland …

A Low-Cost Apparatus For Laboratory Exercises And Classroom Demonstrations Of Geometric Optics, William Vincent Tex Hahn

University Honors Theses

Current trends in research towards the teaching of geometric suggest a constructivist approach. Student experimentation dealing directly with student misconceptions through repetition of examples in many contexts to confront conflicting reasoning allow students to construct definitions with their experiences and observations. Developing the scientific method of observation, prediction/experimental design, conducting experiments and repeating is reinforced with these techniques. Cataloguing student misconceptions and redesigning course material and laboratory experiments in their context has only recently begun. Use of technology has also been shown to increase student interest in course material and 3D printers have recently become common tools in schools. Additionally, …

Perceived Addiction To Pornography, Level Of Distress And Their Correlates, Paul Grimes

University Honors Theses

Negative psychological states such as distress, shame and depression have been linked to problematic porn use. This is a proposal for a study that seeks to identify if perceived addiction to pornography and stress are correlated. In addition to this perceived addiction to porn, other perceived addictions (food, sex, alcohol, marijuana and cigarettes) will be tested to determine the level of comorbidity of addictions in people. The hypothesis of this study is: People that perceive themselves as having pornography addiction will have higher rates of other perceived addictions than those who do perceive themselves to be addicted to pornography; in …

The Ethics And Evolution Of Library Information Sharing: Lessons From Interlibrary Loan Services For Library Open Access Publishing, Beth Posner

Publications and Research

One of the most essential missions of academic research libraries is to facilitate access to information. Librarians do this by sharing their print collections, as well as digital information, with members of their local communities. They also share this information, with each other, through interlibrary loan (ILL) services.

A fundamental belief in the mission of information access and the value of sharing information is why so many librarians also support the open access movement. In addition to this shared mission and value, there are also lessons the open access movement can learn by exploring how traditional ILL services – and …

Who’S Afraid Of Response Bias?, Megan A. K. Peters, Tony Ro, Hakwan Lau

Publications and Research

Response bias (or criterion) contamination is insidious in studies of consciousness: that observers report they do not see a stimulus may not mean they have absolutely no subjective experience; they may be giving such reports in relative terms in the context of other stimuli. Bias-free signal detection theoretic measures provide an excellent method for avoiding response bias confounds, and many researchers correctly adopt this approach. However, here we discuss how a fixation on avoiding criterion effects can also be misleading and detrimental to fruitful inquiry. In a recent paper, Balsdon and Azzopardi (Absolute and relative blindsight. Consciousness and Cognition 2015; …

Comparing Unmanned Aerial Systems (Uas) Structure-From-Motion Digital Surface Modeling To Laser Imaging Detection And Ranging (Lidar), Joshua D. Schane

Geography Masters Research Papers

UAS (unmanned-aerial systems) mapping is an emerging technology in spatial science. UAS, more informally referred to as “drones,” are small, radio-controlled or autonomous aerial platforms outfitted with camera sensor systems that can be deployed to fly missions for mapping terrain and structures. With the use of a photogrammetry technique called structure-from-motion, overlapping aerial images can be developed into high-resolution spatial data (< 5-cm). These data are georeferenced by GPS location information assigned to aerial targets which act as ground-control points (GCPs). This research explores the accuracy of the UAS-derived digital surface model (DSM) as it relates to a LIDAR DSM of the same study area in St. Helens, Oregon.

The site that was chosen to be mapped was a large wastewater treatment plant, with surrounding natural areas, residential, and industrial properties. The site was mapped using a small quadcopter-style UAS which was programmed autonomously; the overlapping aerial …

High-Resolution Ground-Penetrating Radar Profiles Of Perennial Lake Ice In The Mcmurdo Dry Valleys, Antarctica: Horizon Attributes, Unconformities, And Subbottom, Hilary A. Dugan, Steven A. Arcone, Maciej K. Obryk, Peter T. Doran

Geology Faculty Publications and Presentations

Ground-penetrating radar (GPR) is not commonly used to study lake ice, and in general, the ground-based use of radar frequencies greater than 500 MHz in cryosphere geophysics is rare, due to a general interest in deeper stratigraphy and the difficulty of extensive profiling over rough snow surfaces. Our goal was to find further information on the origin of the deposition and formation of intra-ice layers, bottom topography, and subbottom deposits using GPR with pulses centered near 850 MHz on two permanently ice-covered lakes in the Mc- Murdo Dry Valleys, Antarctica. The profiles were obtained using a one-person sled operation over …

The Risks Associated With Barley Production In North Dakota, Bernt Louis Nelson

Agribusiness and Applied Economics

The market for barley has shifted from a demand for exports and livestock feed, to a demand for human food and alcohol production. Due to the crop qualities required for malting in the alcohol industry, barley is perceived to be a more financially risky crop to grow in comparison to other crops. Monte Carlo simulation was used to estimate the distributions of net return to labor and management for barley, hard red spring wheat, corn, soybean, and canola in the primary, North Central, and transitional, Central, crop reporting districts of North Dakota. Stochastic efficiency with respect to a function was …

Hispanics Immigrants On The Fields: Is Discrimination A Barrier To Get Non-Agricultural Jobs?, Wilson Emiliano Lopez Barrera

Agribusiness and Applied Economics

This research presents evidence supporting the existence of differences in treatments received by Hispanics job-seekers on agricultural and non-agricultural labor markets found through an experimental labor market. Hispanics males’ productivity predicted by agricultural employers was higher than the predicted by non-agricultural employers, suggesting that Hispanics males are believed to fit better in agricultural activities. This may imply an invisible barrier preventing Hispanics to access non-agricultural jobs. Employers’ beliefs reactions to a more informative signal related to productivity sent to the labor market were tested. Hispanic job-seekers’ signals did not significantly reduce the gap between agricultural and non-agricultural employers’ beliefs; suggesting …

Effect Of Abnormal Loan Growth On U.S. Credit Union Performance, Dahye Han

Agribusiness and Applied Economics

This study examined the relationship between abnormally rapid loan growth and its impacts on U.S. credit union performance during 2007 – 2013. Three hypotheses were developed to test whether and how abnormal loan growth affects default risk, profitability, and solvency in credit unions. This study found that 1) rapidly loaning credit unions had larger average loan loss, smaller average profitability and solvency than normally loaning credit unions; 2) market concentration exhibited a negative and significant impact on default risk, profitability, and solvency; and 3) A size of credit union also exhibited a negative and significant impact on profitability and solvency. …

Perspectives On Transdermal Electroporation, Kevin B. Ita

Faculty Publications & Research of the TUC College of Pharmacy

Transdermal drug delivery offers several advantages, including avoidance of erratic absorption, absence of gastric irritation, painlessness, noninvasiveness, as well as improvement in patient compliance. With this mode of drug administration, there is no pre-systemic metabolism and it is possible to increase drug bioavailability and half-life. However, only a few molecules can be delivered across the skin in therapeutic quantities. This is because of the hindrance provided by the stratum corneum. Several techniques have been developed and used over the last few decades for transdermal drug delivery enhancement. These include sonophoresis, iontophoresis, microneedles, and electroporation. Electroporation, which refers to the temporary …

The Influence Of Solid Microneedles On The Transdermal Delivery Of Selected Antiepileptic Drugs, Julia Nguyen, Kevin B. Ita, Matthew J. Morra, Inna E. Popova

Faculty Publications & Research of the TUC College of Pharmacy

The aim of this project was to examine the effect of microneedle rollers on the percutaneous penetration of tiagabine hydrochloride and carbamazepine across porcine skin in vitro. Liquid chromatography-mass spectrometric analysis was carried out using an Agilent 1200 Series HPLC system coupled to an Agilent G1969A TOF-MS system. Transdermal flux values of the drugs were determined from the steady-state portion of the cumulative amount versus time curves. Following twelve hours of microneedle roller application, there was a 6.74-fold increase in the percutaneous penetration of tiagabine hydrochloride (86.42 ± 25.66 µg/cm²/h) compared to passive delivery (12.83 ± 6.30 µg/cm …

Absolute Pitch And Tone Identification, Gilead Bar-Elli

Contemporary Aesthetics (Journal Archive)

Absolute pitch (AP), besides the psychological and neurological interests it has, raises some conceptual difficulties that can teach us about the richness of our notion of musical tone and various aspects of its identification. It is argued that when AP is conceived under a slim notion of identifying the pitch of a crude sound, it is hardly meaningful and has no significance in music comprehension. The rich notion, which is the meaningful and important one, involves knowing the position of a tone in a tone-space and its relations. This is presented as experiential: hearing and identifying tones under concepts and …

Theoretical Estimates Of Spherical And Chromatic Aberration In Photoemission Electron Microscopy, Joseph P. S. Fitzgerald, Robert Campbell Word, Rolf Kӧnenkamp

Physics Faculty Publications and Presentations

We present theoretical estimates of the mean coefficients of spherical and chromatic aberration for low energy photoemission electron microscopy (PEEM). Using simple analytic models, we find that the aberration coefficients depend primarily on the difference between the photon energy and the photoemission threshold, as expected. However, the shape of the photoelectron spectral distribution impacts the coefficients by up to 30%. These estimates should allow more precise correction of aberration in PEEM in experimental situations where the aberration coefficients and precise electron energy distribution cannot be readily measured.

Regional Federal Administration, Dave Owen

Faculty Scholarship

No abstract provided.

Chinese Love Stories From Ch'ing-Shih, Hua-Yuan Li Mowry, Menglong Feng

Dartmouth Scholarship

About the Book

Ch'ing-shih is a lovingly made anthology of love stories, provided we push the limits of definition of "love story" just a little wider than they are usually set. The stories are classified into twenty-four major categories, each further divided into subsections and concluded with a paragraph of commentary. Professor Mowry provides a sampling of the contents of each category but not of each subsection, though the headings themselves are enough to pique our curiosity: shall we turn next to "incomplete resurrections," or "unusual degenerates"? The stories were collected in the early seventeenth century, just a decade or …

Assessing Differences Between Early And Later Adopters Of Accountable Care Organizations Using Taxonomic Analysis, Frances M. Wu, Stephen M. Shortell, Valerie A. Lewis, Carrie H. Colla, Elliott S. Fisher

Dartmouth Scholarship

Objective. To compare early and later adopters of the accountable care organization (ACO) model, using the taxonomy of larger, integrated system; smaller, physician-led; and hybrid ACOs. Data sources. The National Survey of ACOs, Waves 1 and 2.

Studydesign. Clusteranalysisusingthetwo-stepclusteringapproach,validatedusing discriminant analysis. Wave 2 data analyzed separately to assess differences from Wave 1 and then data pooled across waves. Findings. Compared to early ACOs, later adopter ACOs included a greater breadth of provider group types and a greater proportion self-reported as integrated delivery systems. When data from the two time periods were combined, a three-cluster solution similar to the original cluster …

Functional Mechanisms Underlying Pleiotropic Risk Alleles At The 19p13.1 Breast–Ovarian Cancer Susceptibility Locus, Kate Lawrenson, Siddhartha Kar, Karen Mccue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J. Ramus, Qiyuan Li, Melissa K. Delgado, Janet M. Lee, Kristiina Aittomäki, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Banu K. Arun, Brita Arver, Elisa V. Bandera, Monica Barile, Rosa B. Barkardottir, Daniel Barrowdale, Matthias W. Beckmann, Javier Benitez, Andrew Berchuck, Maria Bisogna, Line Bjorge, Carl Blomqvist, William Blot, Natalie Bogdanova, Anders Bojesen, Stig E. Bojesen, Manjeet K. Bolla, Bernardo Bonanni, Anne-Lise Børresen-Dale, Hiltrud Brauch, Paul Brennan, Hermann Brenner, Fionna Bruinsma, Joan Brunet, Shaik Ahmad Buhari, Barbara Burwinkel, Ralf Butzow, Sandra S. Buys, Qiuyin Cai, Trinidad Caldes, Ian Campbell, Rikki Canniotto, Jenny Chang-Claude, Jocelyne Chiquette, Ji-Yeob Choi, Kathleen B.M Claes, Gemo Study Collaborators, Linda S. Cook, Angela Cox, Daniel W. Cramer, Simon S. Cross, Cezary Cybulski, Kamila Czene, Mary B. Daly, Francesca Damiola, Agnieszka Dansonka-Mieszkowska, Hatef Darabi, Joe Dennis, Peter Devilee, Orland Diaz, Jennifer A. Doherty

Dartmouth Scholarship

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P = 9.2 X 10^-20), ER-negative BC (P = 1.1 X 10^-13), BRCA1 -associated BC (P = 7.7 X 10^-16) and triple negative BC (P-diff = 2 X 10^-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P = 2 X 10^{-3 …}

To Branch Out Or Stay Focused?: Affective Shifts Differentially Predict Organizational Citizenship Behavior And Task Performance, Liu-Qin Yang, Lauren S. Simon, Lei Wang, Xiaoming Zheng

Psychology Faculty Publications and Presentations

We draw from personality systems interaction theory (PSI; Kuhl, 2000) and regulatory focus theory (Higgins, 1997) to examine how dynamic positive and negative affective processes interact to predict both task and contextual performance. Using a twice-daily diary design over the course of a three-week period, results from multi-level regression analysis revealed that distinct patterns of change in positive and negative affect optimally predicted contextual and task performance among a sample of 71 individuals employed at a medium-sized technology company. Specifically, within persons, increases (upshifts) in positive affect over the course of a work day better predicted the subsequent day’s organizational …

Sweet Corn Production With Different Mulches, Varieties, And Planting Dates In North Dakota, Hannah Bye

Agribusiness and Biosystems Engineering

Sweetcorn is a high value crop that can grow almost anywhere given the right temperature conditions. In North Dakota those conditions are not always met. Using mulch increases the soil temperature. Early planting will have a higher soil temperature increase, but also creates risk from frost damage. In this study, three varieties of sweetcorn was planted with different maturity days, on four covers (black, clear, biodegradable and no mulch), with four different planting dates (from April 15 to June 1). Emergence, growth stage, plant height, leaf area index, soil and near surface air temperature, yield and sugar content was measured. …

Use Of Digital Imagery To Evaluate The Relationship Between Ndvi And Crop Production Field Data At Stutsman County, North Dakota, Rohit Pathak

Agribusiness and Biosystems Engineering

Remote sensing techniques using near infrared band and experimental field data has been already applied on experimental field conditions. However, actual field conditions can be different than experimental plots. This study aimed to test different regression model for precise mid-season corn yield prediction potential using digital imagery from Rapid Eye and actual field data and also to compare effective corn yield prediction potential of red and red edge band. In the research the concept of different management zones and effect of yield prediction potential was achieved through soil series data. Exponential and quadratic model was considerably better as compared to …

Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke

LSU Master's Theses

The medial geniculate body (MGB) is the target of excitatory and inhibitory inputs from several neural sources. Among these, the inferior colliculus (IC) is an important nucleus in the midbrain that acts as a nexus for many auditory pathways and projections, ascending and descending, throughout the rest of the central auditory system and provides both excitatory and inhibitory projections to the MGB. In addition, the thalamic reticular nucleus (TRN) is a major source of inhibition to the MGB, particularly in rodents. Finally, the auditory cortex (AC) is a major source of descending input to the MGB, providing direct excitation and …

Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements, Shona A. Mookerjee, David G. Nicholls, Martin D. Brand

Faculty Publications & Research of the TUC College of Pharmacy

Measurements of glycolytic rate and maximum glycolytic capacity using extracellular flux analysis can give crucial information about cell status and phenotype during normal operation, development of pathology, differentiation, and malignant transformation. They are also of great use when assessing the effects of chemical or drug treatments. Here, we experimentally define maximum glycolytic capacity, demonstrate how it differs from glycolytic rate, and provide a protocol for determining the basal glycolytic rate and maximum glycolytic capacity in cells using extracellular flux measurements. The results illustrate the power of extracellular flux analysis to describe the energetics of adherent cells in culture in a …

Measurement Of The Absolute Magnitude And Time Courses Of Mitochondrial Membrane Potential In Primary And Clonal Pancreatic Beta-Cells, Akos Gerencser, Shona A. Mookerjee, Martin Jastroch, Martin D. Brand

Faculty Publications & Research of the TUC College of Pharmacy

The aim of this study was to simplify, improve and validate quantitative measurement of the mitochondrial membrane potential (ΔψM) in pancreatic β-cells. This built on our previously introduced calculation of the absolute magnitude of ΔψM in intact cells, using time-lapse imaging of the non-quench mode fluorescence of tetramethylrhodamine methyl ester and a bis-oxonol plasma membrane potential (ΔψP) indicator. ΔψM is a central mediator of glucose-stimulated insulin secretion in pancreatic β-cells. ΔψM is at the crossroads of cellular energy production and demand, therefore precise assay of its magnitude is a valuable tool to study how these processes interplay in insulin secretion. …

Review Of The Tragedy Of The Commodity: Oceans, Fisheries, And Aquaculture, Julius Mcgee

Sociology Faculty Publications and Presentations

Book review of, The Tragedy of the Commodity: Oceans, Fisheries, and Aquaculture By Stefano B. Longo, Rebecca Clausen, and Brett Clark. Rutgers University Press (June 25, 2015).

Language Rich Early Childhood Classroom: Simple But Powerful Beginnings, Erin E. Flynn

School of Social Work Faculty Publications and Presentations

This article highlights research exploring the benefits of small group storytelling as a way to promote rich language in early childhood classrooms. Using the storytelling of children from a preschool classroom serving lower SES children, the collaborative affordances of story circles are explored. Results show that small group storytelling engages children in ways of using language associated with literacy learning. When storytelling, children use language in extended, multi-clause turns, relaying what happened in another context. Story requires children to communicate what happened as well as the interpersonal significance of events. Small group storytelling also gives children a chance to practice …

Creating An Inclusionary Bicycle Justice Movement, Aaron Golub, Melody L. Hoffman, Gerardo Francisco Sandoval, Adonia Lugo

Urban Studies and Planning Faculty Publications and Presentations

This is a chapter in: Bicycle Justice and Urban Transformation: Biking for All?

Halprin Sequence Reimagined, Andrea Villarroel, Nate Miller, Kris Decker, Foster Gough, Scott Robinson

Urban Design Workshop

The Halprin Sequence is a series of underutilized green spaces in the heart of Portland, Oregon. Once a booming attraction, as time has past and the city has grown, the Halprin Sequence has been forgotten amongst the towers. With a rich history in urban development and design, the Halprin Sequence could offer much more to the people of Portland than it is currently. The surrounding street of Fourth Avenue is also underutilized. The street is primarily used by automobiles, and the sidewalks are not pleasant to walk through.

For a green space network, the Halprin Sequence is in an ideal …

From Grapheme To Phonological Output: Performance Of Adults Who Stutter On A Word Jumble Task, Megann Mcgill, Harvey Sussman, Courtney T. Byrd

Speech and Hearing Sciences Faculty Publications and Presentations

Purpose

The purpose of the present study was to extend previous research by analyzing the ability of adults who stutter to use phonological working memory in conjunction with lexical access to perform a word jumble task.

Method

Forty English words consisting of 3-, 4-, 5-, and 6-letters (n = 10 per letter length category) were randomly jumbled using a web-based application. During the experimental task, 26 participants were asked to silently manipulate the scrambled letters to form a real word. Each vocal response was coded for accuracy and speech reaction time (SRT).

Results

Adults who stutter attempted to solve …