Digital Commons Network^™

Analyzing And Modeling The Dysfunction Of Inhibitory Neurons In Alzheimer’S Disease, Carlos Perez, Jokubas Ziburkus, Ghamim Ullah

Physics Faculty Publications

Alzheimer’s disease (AD) is characterized by the abnormal proteolytic processing of amyloid precursor protein, resulting in increased production of a self-aggregating form of beta amyloid (Aβ). Several lines of work on AD patients and transgenic mice with high Aβ levels exhibit altered rhythmicity, aberrant neuronal network activity and hyperexcitability reflected in clusters of hyperactive neurons, and spontaneous epileptic activity. Recent studies highlight that abnormal accumulation of Aβ changes intrinsic properties of inhibitory neurons, which is one of the main reasons underlying the impaired network activity. However, specific cellular mechanisms leading to interneuronal dysfunction are not completely …

Analysis Of Education Levels And Small Business Financial Worth In Uganda, Rogers Matama

Business Management Review

A common impression prevails that the higher the education of business owners the lower the business prosperity, that the highly educated individuals suffer from the ' paralysis of analysis ' and so their firms are alleged to financially starve due to excessive financial risk analyzes. This motivated investigations of the effect of educational levels of small business owners on small business financial worth. Financial worthiness in this study is defined by the financial value of the total assets of the firm while the educational levels constitute, secondary education, post-secondary and university degree. From a heterogeneous sample of 528 small firms …

Managers Or Corporates?: Curbing Non-Compliance Through Corporate Income Tax Penalty, Deogratias N. Mahangila

Business Management Review

Governments normally impose tax penalties for tax non-compliance. They can either impose financial corporate income tax penalties on corporates or tax managers in cases of corporate income tax non-compliance. However, the effectiveness of these corporate income tax penalty incidences remains largely unknown. This paper examines their effectiveness experimentally. In all, 100 Bachelor of Commerce second-year students at the University of Dar es Salaam participated in the laboratory experiment. The participants were randomly assigned into two groups: of managers and of owner-managers. Then the two groups were subdivided randomly into two groups based on corporate income tax penalty incidences: corporate income …

The Impact Of Owner's Identity On Corporate Capital Structure, Josephat Lotto

Business Management Review

This paper examines how the identity of corporate owners affects corporate leverage in the UK. Using data from a sample of 643 listed UK firms, the results show that family-controlled firms have higher debt ratios than companies controlled by financial institutions. The implication is that family-controlled companies prefer debt to equity in their capital structure due to either a control-enhancing mechanism and/or firm ' s protection from take-over threats. The paper, further confirms that corporate control contestability has also a positive impact on debt ratio. In essence, a smaller value of control contestability signifies more equal distribution of the voting …

State V. Wenzel Clerk's Record Dckt. 44649

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Single Molecule Mass Measurements And Mass Spectrometry, Kermit K. Murray

Faculty Publications

No abstract provided.

Stroke Outreach In The Lao Community, Noor A. Dythavon

Master's Projects and Capstones

CNL Abstract

A community health needs assessment for the service area prompted concern regarding access to quality healthcare for non-English speaking Southeast Asians (SEA) in the area. Goals of an initial investigation and subsequent implementation of sustainable stroke health fairs for non-English speaking communities were evaluated to assess primary healthcare concerns that the SEA community face and to suggest long-term solutions to these issues. Initial investigation required researching population-specific minority health statistics to quantify the prevalence of chronic diseases and conditions which were prioritized in terms of needs versus disparities. Research came from evidence base practice guidelines and personal concern …

Pengawasan Dpr-Ri Dalam Bisnis Militer Sebagai Bagian Dari Reformasi Tentara Nasional Indonesia (Tni), Yusa Djuyandi

Jurnal Wacana Politik

DPR-RI oversight in TNI (military) Business have very important role in forming of professional and reliable TNI, despitefully DPR-RI oversight also useful to link citizen priority and views in rule of policy and law in defence area. The purpose of this research is to analyze the oversight mechanism conducted by DPR-RI in the case of military business. Theory used by researcher in conducting this research is theory of parliamentary oversight, which is conducting through various mechanism which available in parliament, that is: passing debate mechanism; passing existence of commission; and through raised questions when in meeting. This research used qualitative …

Pengembangan Media Layanan Informasi Menghadapi Perubahan Masa Pubertas Bagi Siswa Sekolah Dasar, Fitri Firdayati, Ella Faridati Zen, Elia Flurentin

Jurnal Kajian Bimbingan dan Konseling

This research aims to produce a product in the form of information service media "dealing with changes in puberty" for elementary school students. The research method used is research and development adapted from the Borg and Gall development model with the following procedures: (1) planning; (2) product development; (3) product testing; (4) final product revision. Product trial data is analyzed quantitatively and qualitatively. Based on the results of the product trial assessment, it can be concluded that the product is very appropriate, very useful, very easy and very interesting theoretically and practically, so it can be used as a medium …

Keefektifan “Proses Guru” Sebagai Teknik Bimbingan Kelompok Untuk Meningkatkan Kemampuan Pengambilan Keputusan Karier Siswa Smk, Guruh Sukma Hanggara

Jurnal Kajian Bimbingan dan Konseling

Career decision-making abilities are an important part of a student's career development continuum. This research aims to determine the effectiveness of the GURU (Ground, Understand, Revise, Use) process as a group guidance technique to improve vocational school students' career decision-making abilities. The Pretest-Posttest Control Group Design experimental method was used in this research and the subjects were 12 students of SMKN 1 Trenggalek. Data analysis using the Two Independent Sample Test Mann Whitney U, obtained the Asymp value. Sig. (2-tailed) of 0.03 < real level ( /2 = 0.05) and it was concluded that the "GURU Process" as a group guidance technique was effective in improving the career decision making abilities of vocational school students. From these results, the researcher suggests that Counselors/BK Teachers can collaborate the TEACHER process with various other approaches, using it to develop various student potentials by paying attention to their development stages, psychological aspects and intervention content. Future researchers are advised to examine the GURU process with other research designs such as Single-Subject Designs or action research and pay attention to the use and feasibility of the instrument and its validity, as well as applying it to develop various other psychological aspects such as motivation, self-esteem, self-efficacy, critical thinking skills, the ability to think respectfully and so on.

Department Of Audit, 2016 Annual Report, Tennessee. Comptroller Of The Treasury.

Annual Reports

No abstract provided.

Kualitas Pembelajaran Ekonomi Di Sman Dan Man Malang Raya, Rahma Sandhi Prahara, Hari Wahyono, Sugeng Hadi Utomo

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Learning readiness of economy according to the needs of the students be a challenge for learners in formal education. The quality of a study can be seen if the purpose of learning itself achieved well. It is necessary for mapping the quality of learning to know how qualified learning is. Mapping quality using the input, process and output of education. The input aspect consists of teachers, students, and facilities and infrastructure. The process aspect consists of a syllabus, lesson plans, implementation, and assessment. The output aspect to be evaluated at the end of an activity to determine how far the …

Analisis Pengaruh Penerapan Sistem Informasi Akuntansi Terhadap Pengukuran Kinerja Umkm Di Wilayah Depok, Titis Wahyuni, Marsdenia Marsdenia, Istiadi Soenarto

Jurnal Vokasi Indonesia

The purpose of this study is to examine the effect of application accounting information system on SMEs performance measurement in Depok region. The number of samples taken were 30 SMEs using purposive sampling method with the critreria listed in the official city of Depok. The data was collected using questionnaires distributed to respondents and the analysis technique used in this research is logistic regression to determine whether there is any effect on the application of accounting information systems for the decrease or increase the performance of SMEs. The results of this study based on the analyses conducted found that the …

Evaluating Contradicting And Confirming Evidence: A Study On Beliefs And Motivated Reasoning, Zachary Alan Caddick

Master's Theses

The purpose of this study is to examine ideological, psychological, and demographic predictors of motivated reasoning. Three-hundred and seventy-seven participants from Amazon’s Mechanical Turk system completed written responses critically evaluating strengths and weaknesses in a vignette on the topic of anthropogenic climate change. The vignette has two fictional scientists present prototypical arguments for and against anthropogenic climate change that are constructed with equally flawed and conflicting reasoning from both view points. Written responses were coded by a team of trained and reliability assessed qualitative raters. Motivated reasoning is operationalized by providing supporting evidence for the congruent belief and counter evidence …

The Effects Of Repeated Global Self-Adapted Testing On Online Statistics Performance, Gita Sierra Hodell

Master's Theses

The purpose of this study was to evaluate the effectiveness of a computerized academic testing format. Centered on the motivating and stress-reducing aspects of personal control, a modified form of global self-adapted testing (GSAT) was explored to help students who are challenged by test anxiety or low academic motivation. Forty-two students completed multiple GSATs throughout one semester of college-level, online statistics. Of those students, 20 volunteered to complete an academic motivation questionnaire at the beginning of the semester. The relationships between scores on the motivation questionnaire, GSAT use characteristics, and statistics performance were analyzed. Students who used the GSATs correctly …

Sex-Specific Diet And Rockfish Consumption In California Sea Lions (Zalophus Californianus): Insights From Molecular Scatology, Keith Michael Hernandez

Master's Theses

Molecular diet analysis has the potential to overcome the limitations of traditional methods. I used prey hard parts and molecular methods to examine sex-specific diet trends and rockfish consumption of California sea lions (Zalophus californianus, CSL). Fresh scat samples (n=219) were collected from Año Nuevo Island, CA (ANI), during the summers of 2013 and 2014. Prey taxa were identified from fish otoliths and cephalopod beaks recovered from cleaned scats. Sex of the CSL depositing the scat was assigned via multiplex PCR of a CSL microsatellite and a carnivore Y chromosome marker. Prey species also were identified using multiple loci in …

Comparative Evaluation Of Malnutrition Screening In Oncology Patients In An Acute Care Hospital: A Pilot Study, Chandni Sen Sinha

Master's Theses

Malnutrition is associated with negative health consequences in the vulnerable cancer population, making it imperative for an efficient interdisciplinary approach to conduct nutritional screening using an appropriate scale. For the present study, a comparison between an existing malnutrition risk-screening questionnaire (EMR-SQ) and a comprehensive screening questionnaire (CMR-SQ) was performed on 37 cancer patients. The first stage of data collection required the nurses to electronically complete the EMR-SQ. In the second stage, the same patients’ data were assessed using the CMR-SQ, developed by the authors based on the guidelines of the PG-SGA and A.S.P.E.N. The CMR-SQ identified 32.4% at low, 37.8% …

The Moderating Role Of Perceived Organizational Support And Perceived Supervisor Support On The Relationship Between Teamwork Behaviors And Affective Commitment, Carlie Ann Stephens

Master's Theses

Researchers have identified employee affective commitment as a key indicator of variables that are of great interest to organizations (Mowday, Porter, & Steers, 1982). Teamwork behaviors have been identified as predictors of affective commitment (Meyer, Stanley, Herscovitch, & Topolnytsky, 2002). However, very few studies have examined the moderating effect organizational and supervisor support may have on these relationships. The purpose of this study was to examine the moderating effects of perceived organizational support and perceived supervisor support on the relationship between teamwork behaviors and affective commitment. Results of a survey administered to 3,926 employees in a medical device company revealed …

Zircon Geochemical And Isotopic Constraints On The Evolution Of The Mount Givens Pluton, Central Sierra Nevada Batholith, Callie Sendek

Master's Theses

The Late Cretaceous Mount Givens pluton, located in the central Sierra Nevada batholith, is noteworthy for its large size (~1400 km2) and relative compositional and textural homogeneity. The pluton is characterized by a 30 km wide, ellipse-shaped northern lobe (ca. 98-91 Ma) that connects with a long mass (ca. 95-91 Ma) about 15 km wide and extends 50 km SE. Zircon trace elements and d18O and eHf from a sample suite representative of the observable petrologic diversity of the pluton document significant heterogeneities. All zircons have high Ti-in-zircon model temperatures (850-1000 °C), pronounced negative Eu anomalies, and concave down MREE …

Sers Intensity Correlations To Lspr On Aggregated Au@Ag Systems, Caesar Alexander Munera

Master's Theses

The optimal surface enhanced Raman scattering (SERS) intensity was correlated to the localized surface plasmon resonance (LSPR) of individual and aggregated gold core/silver shell (Au@Ag) nanoparticles (NPs) in titrations involving the addition of both SERS label (e.g., rhodamine 6G, R6G) and the non-SERS active aggregant (chemical species that triggers the aggregation of NPs) potassium chloride (KCl). Titrating NP solutions with pure SERS label has often resulted in highly non-linear calibrations. In some cases, addition of non-SERS active aggregating agents such as KCl has also resulted in a large increase in SERS signals. An order of initial addition was followed in …

Minimization And Eulerian Formulation Of Differential Geometry Based Nonpolar Multiscale Solvation Models, Zhan Chen

Mathematical Sciences: Faculty Publications

In this work, the existence of a global minimizer for the previous Lagrangian formulation of nonpolar solvation model proposed in [1] has been proved. One of the proofs involves a construction of a phase field model that converges to the Lagrangian formulation. Moreover, an Eulerian formulation of nonpolar solvation model is proposed and implemented under a similar parameterization scheme to that in [1]. By doing so, the connection, similarity and difference between the Eulerian formulation and its Lagrangian counterpart can be analyzed. It turns out that both of them have a great potential in solvation prediction for nonpolar molecules, while …

Peran Penegakan Hukum Dalam Pembangunan Ekonomi, - Sukardi

Jurnal Hukum & Pembangunan

Economics is the backbone of the people's welfare, and science are the pillars supporting the nation's progress, but the law is the institution that ultimately determine how the public welfare can be enjoyed equitably, as well as how social justice can be realized in people's lives, and how progress of science and technology can bring progress for the people. In essence, the rule of law to support the transformation of SOEs (State-owned enterprises) as a locomotive driver of the national economy, especially in its role of guarding the whole process of public finance management and the area is clean and …

Adopsi Prinsip Permanent Sovereignty Over Natural Resources (Psnr) Migas, Cut Asmaul Husna Tr

Jurnal Hukum & Pembangunan

The specificity of the setting investment in upstream oil and gas consequences of role of the state that is large enough. This is because the upstream oil and gas sector requires capital investment costs are relatively large; high risk, the use of advanced technology and trained human resources. However, investment in upstream oil and gas sector also gives a great advantage. Therefore, oil and gas producing countries seek to maximize the full control over the affairs of operations, production, management, and marketing. It is supported by the United Nations General Assembly Resolution (UN) No. 2158 (XXI) of 25 November 1966 …

Generation Of Vector Partially Coherent Optical Sources Using Phase-Only Spatial Light Modulators, Milo W. Hyde Iv, Santasri Bose-Pillai, David G. Voelz, Xifeng Xiao

Faculty Publications

A simple and flexible optical system for generating electromagnetic or vector partially coherent sources or beams is presented. The alternative design controls field amplitude (beam shape), coherence, and polarization using only spatial light modulators. This improvement makes the apparatus simpler to construct and significantly increases the flexibility of vector partially coherent source generators by allowing many different types of sources to be produced without changing the physical setup. The system’s layout and theoretical foundations are thoroughly discussed. The utility and flexibility of the proposed system are demonstrated by producing a vector Schell-model and non-Schell-model source. The experimental results are compared …

Reporting Gleason Grade/Score In Synoptic Reports Of Radical Prostatectomies, Andrew Renshaw, Mercy Mena-Allauca, Edwin Gould

All Publications

No abstract provided.

Home Delinquency Rates Are Lower Among Aca Marketplace Households: Evidence From A Natural Experiment, Emily A. Gallagher, Radhakrishnan Gopalon, Michal Grinstein-Weiss, Stephen P. Roll, Genevieve Davison

Center for Social Development Research

This brief uses administrative income tax data coupled with survey responses from roughly 5,000 households living near the poverty line to estimate how access to the Affordable Care Act’s health insurance Marketplaces have affected households’ experiences of extreme illiquidity, which is measured by delinquencies on home payments. To estimate this relationship, we exploit a natural experiment underway in states that did not expand Medicaid and created by the eligibility rules for Marketplace subsidies. Results suggest that insured households living near the poverty line are better able to make timely rent and mortgage payments compared with similar, uninsured households. Given housing …

Pain Acceptance Potentially Mediates The Relationship Between Pain Catastrophizing And Post-Surgery Outcomes Among Compensated Lumbar Fusion Patients, Cassie Dance, M. Scott Deberard, Jessica Gundy Cuneo

Psychology Student Research

Purpose: Chronic low back pain is highly prevalent and often treatment recalcitrant condition, particularly among workers’ compensation patients. There is a need to identify psychological factors that may predispose such patients to pain chronicity. The primary aim of this study was to examine whether pain acceptance potentially mediated the relationship between pain catastrophizing and post-surgical outcomes in a sample of compensated lumbar fusion patients.
Patients and methods: Patients insured with the Workers Compensation Fund of Utah and who were at least 2 years post-lumbar fusion surgery completed an outcome survey. These data were obtained from a prior retrospective-cohort study that …

Elucidating The Role Of Mastermind-Like 1 In The Degradation Of Myocyte Enhancer Factor 2c, Azia S. Evans

Master's Theses

Mastermind-like 1 (MAML1) is well characterized for its involvement in the Notch signaling pathway where it functions as a transcriptional co-activator and facilitates the degradation of the Notch intracellular domain (NICD). MAML1 has recently been implicated as a multifunctional protein that interacts with a variety of other signaling pathways, including Wnt-β-catenin, NF-B, and MEF2C (myocyte enhancer factor 2C). MEF2C is a member of the family of transcription factors involved in muscle cell differentiation and proliferation. MAML1 has previously been shown to activate MEF2C transcription. Given that MAML1 is responsible for degradation of the NICD, we wanted to know if MAML1 …

Geochemical Modeling And Hydrothermal Experiments Used To Constrain The Conditions Of Illite Diagenesis In Sedimentary Basins, Michael Joseph Murphy

Master's Theses

Two hydrothermal experiments were performed using sandstone core material from

the Norwegian North Sea with synthetic brines reacted at approximately 150˚C and 450

bars, temperature and pressure calculated to simulate a depth of burial of approximately 4 km. The results of the experiments were analyzed with geochemical modeling and with

chemical and petrographic analyses. Geochemical modeling with several computer

programs indicated that the experimental fluid was undersaturated with respect to K-feldspar, kaolinite, and illite, but supersaturated with respect to muscovite. Chemical

analysis with inductively-coupled plasma mass spectrometry indicated that the fluid

reached saturation with respect to K-feldspar. Petrographic analysis with …

Winner's Curse Correction And Variable Thresholding Improve Performance Of Polygenic Risk Modeling Based On Genome-Wide Association Study Summary-Level Data, Jianxin Shi, Ju-Hyun Park, Jubao Duan, Sonja T. Berndt, Winton Moy, Kai Yu, Lei Song, William Wheeler, Xing Hua, Debra Silverman, Montserrat Garcia-Closas, Chao Agnes Hsiung, Jonine D. Figueroa, Victoria K. Cortessis, Nuria Malats, Margaret R. Karagas

Dartmouth Scholarship

Recent heritability analyses have indicated that genome-wide association studies (GWAS) have the potential to improve genetic risk prediction for complex diseases based on polygenic risk score (PRS), a simple modelling technique that can be implemented using summary-level data from the discovery samples. We herein propose modifications to improve the performance of PRS. We introduce threshold-dependent winner’s-curse adjustments for marginal association coefficients that are used to weight the single-nucleotide polymorphisms (SNPs) in PRS. Further, as a way to incorporate external functional/annotation knowledge that could identify subsets of SNPs highly enriched for associations, we propose variable thresholds for SNPs selection. We applied …