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The Effects Of Ketamine Exposure On Nmda Receptor Mediated Synaptic Transmission In The Developing Brain - A Mechanistic Study Of Ketamine-Induced Neuroapoptosis, Saurabh Kokane

Psychology Theses - Archive

Ketamine is a widely used pediatric anesthetic because of its high potency in pediatric patients. Side-effects produced by ketamine anesthesia in adults are also not seen in children after ketamine use. However, several preclinical studies have shown that prolonged or repeated exposure of neonates to ketamine resulted in widespread death of neurons (neuroapoptosis) in almost all areas of the neonatal brain (Brambrink et al, 2012; Hayashi et al, 2002; Ikonomidou et al, 1999; Scallet et al, 2004; Zou et al, 2009a, b). Increasing evidence shows that this neuroapoptosis affects prenatal and neonatal brain adversely, specifically in brain areas involved in …

Design And Evaluation Of Hmp Kinase Analogs As Thiamine Pathway Inhibitors, Diego A. Lopez

Chemistry & Biochemistry Dissertations - Archive

Current bacterial chemotherapy faces an overwhelming reduction in efficacy due to an increase in bacterial resistance; resulting in a higher clinical demand for novel therapeutics and the investigation for their respective targets. Vitamin pathways exogenous to the human body represent an attractive target for drug development since the enzymatic machinery is solely and ubiquitously to many infectious agents. HMP kinase [E.C 2.7.1.49] is a key enzyme in the thiamine metabolism. It catalyzes two subsequent phosphorylations of 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), making it indispensable for microbial survival. Our efforts aimed for a substrate-based approach, where over 50 HMP analogs were synthesized and assayed …

Derivatization Of Small Acids To Enhance Sensitivity In Gas Chromatography Mass Spectrometry And Gas Chromatography Vacuum Ultraviolet Spectroscopy, Chih-Hao Wang

Chemistry & Biochemistry Theses - Archive

Disinfection by-products (DBPs) are a significant concern in drinking water quality. Haloacetic acids, which are generated from disinfection processes, are one of the major groups in disinfection by-products. Because they induce potential harmful effects for human health, the US government has already established regulations to control the levels of haloacetic acids in drinking water. In order to control the presence of haloacetic acids in drinking water and monitor other potential harmful compounds, an appropriate analytical method is needed. In this study, a gas chromatography (GC) method was developed for detecting haloacetic acids in water. Three different derivatization reagents were compared …

Method Development For Qualification And Quantification Of Cannabinoids And Terpenes In Extracts By Gas Chromatography-Mass Spectrometry, Allegra Leghissa

Chemistry & Biochemistry Theses - Archive

Cannabinoids are a class of chemical compounds that act on cannabinoid receptors in cells. These receptors have different kinds of ligands, including endocannabinoids (produced in the body by humans and animals), phytocannabinoids (found mainly in Cannabis sativa), and synthetic cannabinoids. At least 85 different phytocannabinoids have been isolated; different cannabinoids are believed to have different effects and possible benefits in medical treatments, and it is therefore fundamental to classify cultivars prior to their medical use. The other class of compounds that characterize C.sativa are terpenes. They confer flavor and fragrance that are unique to each plant and further confer botanical …

Urban Ecology In North Texas: Native Plants And Nitrogen Deposition, Michelle Lynn Green

Biology Dissertations - Archive

Globally, the human population continues to grow and move into urban areas causing a range of effects on local ecosystems. Elevated temperatures, altered hydrology, and higher concentrations of atmospheric pollutants in urban environments create novel conditions for resident organisms. My research focused on one particular aspect of human alteration to urban environments – nitrogen (N) deposition – and its effects on native plants across an urban to rural gradient in the southern Great Plains, North Texas (NTX), USA. Nitrogen oxides (NOx) – the product of combustion and precursor to nitrate deposition in precipitation – were significantly positively correlated with impervious …

Exploring Engagement With Social Media Content, Holly Atwood Syrdal

Marketing Dissertations - Archive

Engagement in the realm of social media is thought to be related to a number of positive brand and organizational outcomes and has emerged as a hot topic among marketing academics and practitioners alike. However, there is currently no consensus on exactly what constitutes this type of engagement. This lack of agreement and, hence, lack of a “social media engagement” measure, have made it difficult for academics to advance theory in this area and for researchers to test hypotheses concerning positive brand and organizational outcomes that may be related to this form of engagement. This dissertation directly addresses this gap …

Around Campus

DePaul Magazine

The Compassionate Cosmopolitan: National Humanities Medal award-winner Kwame Anthony Appiah suggests a way to achieve peace; Beautiful sounds: School of Music supporters celebrate as new facilities take shape; Humanity Examined: India band Typhoon wrestles with life's fragility; Deja Vu All Over Again:Women's basketball returns to the NCAA tournament; Podkowa, January Earn Academic All-American Honors; Event Center Rising; Strong Career Finishes for Mitrea, Maize and Gorden; Blue Demons Reign at BIG EAST Indoor and Outdoor Track Meets; Must Islam Change?: Nathan Lean lectures on Islamophobia and the prejudices of liberalism; Alumni U Offers a "Touch of Class"

Class Notes

DePaul Magazine

Alumni announcements, engagements, marriages, births and deaths.

Type 2 Diabetes Mellitus (T2dm) Onset And "Remission"., Srikanth Tangelloju

Electronic Theses and Dissertations

Background: Type 2 diabetes mellitus (T2DM) is a progressive disease condition. As the disease progresses the function of beta (β) cells (cells which regulate insulin) decline, thereby increasing the circulating blood glucose levels. If left unmanaged the disease progresses from onset to development of T2DM related complications and eventually death. When managed, in certain individuals, T2DM onset can be prevented and/or slowed down and in certain T2DM individuals, remission is observed. There are some known modifiable risk factors such as diet and physical activities that are associated with the speed and direction of progression, but much is still unknown. In …

Air Pollution, Pulmonary Oxidative Stress, And The Endothelin System In The Development Of Cardiovascular Injury., Jordan B. Finch

Electronic Theses and Dissertations

The goal of this project was to examine the role of endothelin-1 (ET-1) as a mediator in the pathway between air pollution exposure and the development of vascular injury. A human cohort and male mice (C57BL/6 and ecSOD-Tg) were used to evaluate changes in the ET-1 system in response to exposures of fine particulate matter (PM2.5). Human ET-1 levels were significantly associated with environmental factors and markers of vascular change, but were decreased with increased PM2.5. No association was seen between ET-1 and endothelial progenitor cells (EPCs) except for EPC-4, possibly indicating a regulatory relationship with this specific population. In …

Vinyl Chloride-Diet Interactions In Liver Disease : Potential Roles Of Autophagy And Energy Management., Anna L. Lang

Electronic Theses and Dissertations

Vinyl chloride (VC) is a prevalent environmental toxicant that has been shown to cause liver injury at high, occupational exposures. However, most studies have not addressed interactions of low doses with risk-modifying factors. This study aims to explore low-level VC metabolite exposure interactions with other potential risk-modifying factors and their effect on underlying liver disease. We examined sub-hepatotoxic effects of a VC metabolite (chloroethanol, CE) in two murine models of liver injury using ethanol and lipopolysaccharide (LPS). In both, CE significantly enhanced liver injury when compared to either ethanol or LPS alone. Previous studies have shown an increase in mTOR …

Effects Of Attachment Style, Coping Strategy, Social Support And Spirituality On Parental Grief Among Older Chinese Parents : Structural Equation Modeling., Yongqiang Zheng

Electronic Theses and Dissertations

Most modern grief theories and clinical working models are constructed in the context of Western culture, and the effectiveness or explanatory power of those theories and models have not been fully tested in other cultures, especially through a more complex interactive model. The current study focuses on the role of attachment style, coping strategy, social support and spirituality on older bereaved parents’ grief. It also explores if differences in age, gender, causes of the child’s death, time since the death have a differential effect on parental grief. The purpose of this study was to test the main factors effectively mediating …

Polyandry In The Absence Of Fitness Benefits In A Species With Female-Biased Sexual Size Dimorphism, Marie Claire Chelini, Eileen A. Hebets

Eileen Hebets Publications

Most studies exploring the evolution of female mating systems focus on species in which females are either monandric (mate with a single male) or highly polyandric (mate with multiple males), but less is understood about variation in mating decisions within a species. How and why do females of a single species decide whether or not to copulate with additional mates? In this study we attempt to answer this question in the highly dimorphic crab spider, Mecaphesa celer, whose females may be either monandric or polyandric. We tested three hypotheses: (1) a female’s decision to remate is based on sequential mate …

Effects Of Invasive Shrub Honeysuckle (Lonicera Maackii) And Forest Composition On Bird Communities In Woodland Stands., Katie Rae Lynch

Electronic Theses and Dissertations

Invasive species pose a threat to aquatic and terrestrial ecosystems by decreasing biodiversity (Didham et al. 2005). Amur bush honeysuckle (Lonicera maackii) has typically reduced native plant diversity and altered animal communities by influencing animal abundance and activity (Collier and Vankat 2002). This study was intended to determine whether honeysuckle density or other characteristics of forested stands influence avian diversity, whether impacts are seasonally dependent, and whether correlations exist between attributes of forested stands and honeysuckle density. In order to test the hypotheses, thirteen forest stands within the Louisville Metropolitan Area were selected. They had similar tree composition …

Uab Researchers Discover Why Brain Neurons In Parkinson's Disease Stop Benefiting From Levodopa, Jeff Hansen

Browse All News

No abstract provided.

Mechanisms Responsible For The Development Of Causal Perception In Infancy., Nicholas A. Holt

Electronic Theses and Dissertations

The aim of the current dissertation was to investigate the mechanisms that contribute to the emergence of causal perception in infancy. Previous research suggests that the experience of self-produced causal action may be necessary to promote the development of causal perception (Rakison & Krogh, 2012). The goal of the current study was two-fold: (1) to further explore the roles of self-produced action, haptic, proprioceptive and visual information, and parental interaction on young infants’ understanding of causality. To assess the impact of these factors on infants’ causal learning, 4½-month-olds were randomly assigned to one four conditions. Three of the conditions (Active …

Carnosine, A Therapeutic Potential For Critical Limb Ischemic., Adjoa Agyemang Boakye

Electronic Theses and Dissertations

Critical Limb ischemia (CLI) is a serious manifestation of peripheral artery disease. Advanced CLI patients are poor candidates for vascular surgeries. Numerous studies have shown that hypoxia inducible factor 1α (HIF1-α) plays an important role in recovery from murine hindlimb ischemia (HLI). HIF1-α is regulated by oxygen dependent prolyl hydroxylases (PHDs). Previous studies have shown that inhibition of PHDs by metal quenchers and viral delivery of HIF1-α improves blood flow to the ischemic limb. However, clinical trials with these therapies are largely negative partly because they do not address the underlying chronic oxidative stress. Based on recent observations that endogenous …

Comparative Analyses Of Transcriptome Data From Beef Cattle Persistently Infected With Bovine Viral Diarrhea Virus, Sara Michelle Nilson

Department of Animal Science: Dissertations, Theses, and Student Research

Persistent infection (PI) with Bovine Viral Diarrhea Virus (BVDV) is a major source of economic loss for the livestock industry. Persistent infection occurs when a dam is exposed to the virus during 42 to 125 days of gestation and the virus is passed to the fetus without an adaptive immune response. These PI calves serve as continuous sources of infection to others. The identification of differences in expression of gene networks and/or genetic markers associated with infection could assist in the development of novel strategies to prevent, control, or treat BVDV. To examine the host response to PI, RNA-Seq data …

Genome-Wide Association Study For Feed Efficiency Traits Using Snp And Haplotype Models, Kashly Rene Schweer

Department of Animal Science: Dissertations, Theses, and Student Research

Feed efficiency has long been recognized for its economic importance in beef cattle production systems. Feed intake is not a routinely collected trait on-farm due to the expense of measuring individual feed intake. Identification of genomic regions associated with feed efficiency and its component traits would be advantageous for selection programs. The objective of this study was to uncover genomic regions associated with average daily gain (ADG) and average daily feed intake (ADFI) through genome-wide association studies (GWAS) with SNP and haplotype Bayesian models. Phenotypes of ADG and ADFI along with genotypes from the BovineSNP50v2 array from crossbred steers and …

Evaluation Of Hematological And Serum Biochemical Profiles Associated With The Supplementation Of Zilpaterol Hydrochloride To Feedlot Heifers, Sara Elizabeth Sieren

Department of Animal Science: Dissertations, Theses, and Student Research

Supplementation of zilpaterol hydrochloride (ZH; Zilmax^®) to cattle has been suggested to have a negative impact on well-being of cattle. The objective of this study was to evaluate the hematological and serum biochemical profiles in feedlot heifers supplemented with ZH in a minimal stress environment. Heifers were randomly assigned to one of two treatment groups: Control (CON no ZH), or ZH (supplemented with ZH at 8.33mg/kg of feed on a DM basis). The study was conducted over a period of 25 d (-2 to 23), with three serum collection periods [-2 to 4 d (ZH supplementation began on …

The Effects Of Zinc Supplementation From Two Sources On Egg Quality And Bone Health In Laying Hens, Kelli Marie Martin

Department of Animal Science: Dissertations, Theses, and Student Research

The objective of this study was to compare zinc sources and levels of supplementation on laying hen performance. Bovan White Leghorn hens were fed one of six dietary treatments in a 2x3 factorial arrangement consisting of two zinc sources (Availa®Zn or zinc sulfate) and three levels (40, 80, or 120 ppm). Treatments were randomly assigned to 48 cages with five hens/cage. Blocks provided eight replicates/treatment. Hens were housed in a tiered manure belt housing system providing 97.2 cm²/hen. Hens were given 110 g/hen/day of feed ad libitum. Feed intake, egg production, egg weights, egg components, eggshell strength, body …

Evaluation Of The Metabolic Response, Blood Chemistry Profile, And Cardiac Morphology Of Beef Heifers Supplemented With Zilpaterol Hydrochloride Followed By An Endocrine Induced Stress Challenge, Joe O. Buntyn

Department of Animal Science: Dissertations, Theses, and Student Research

The objective of this study was to determine the metabolic, stress, hematology, organ weights, histology and cardiac anatomical features of beef heifers supplemented with zilpaterol hydrochloride (ZH) when exposed to a corticotropin-releasing hormone (CRH) and arginine vasopressin (VP) challenge. Crossbred heifers (n = 20; 556 ± 7 kg BW) were randomized into two treatment groups: 1) Control (CON): no ZH, and 2) Zilpaterol (ZIL): supplemented with ZH at 8.33 mg / kg (DM basis). The ZIL group was supplemented ZH for 20 d, with a 3-d withdrawal period. On d 24, heifers received an intravenous bolus of CRH (0.3 µg …

Evaluating The Impacts Of The Internet Of Things To Reduce Runway Incursions: Understanding The Why, How, And When, Samuel Inanore Okate

Industrial, Manufacturing, and Systems Engineering Dissertations - Archive

The Federal Aviation Administration’s (FAA) mission is to maintain the safest and most efficient aerospace system in the world. The FAA has stated that runway safety is one of their top priorities, which encapsulates pilots, air traffic controllers, and airport vehicle drivers and workers (Federal Aviation Administration, June 2015). Federal Aviation Administration categorizes a runway incursion as a hazardous event that can occur in the Air Operations Area (AOA) that involves an incorrect presence of an aircraft, vehicle or person in the protected area of a surface designated for the landing and takeoff of an aircraft (Federal Aviation Administration, June …

Effects Of Salt And Nitrite Concentration On The Shelf Life Of Deli-Style Ham, Regan Elise Stanley

Department of Animal Science: Dissertations, Theses, and Student Research

Deli-style hams were manufactured to measure the effects of salt and nitrite concentration on shelf life and physicochemical characteristics. Three replications of deli-style ham treatments were manufactured in a 3 x 4 factorial arrangement of salt concentration (0.7%, 1.4%, or 2.1%, meat block basis) and nitrite concentration and source (0 ppm, 100 ppm or 200 ppm sodium nitrite, SN, or 100 ppm sodium nitrite equivalent from pre-converted celery juice powder, CP; Veg Stable 506, Florida Food Products). Salt concentration, water activity, cook yield, and texture profile analysis (TPA) were measured on w 0. Color, pH, residual nitrite, and aerobic and …

Development Of Terminal And Maternal Economic Selection Indices In Beefmaster Cattle, Kathleen Pearl Ochsner

Department of Animal Science: Dissertations, Theses, and Student Research

In the design of economic selection indices, the relative importance of traits in the breeding objective is reflected by their relative economic weighting. The objective of this study was to develop two economic selection indices for Beefmaster cattle: one for a terminal production system and one for a maternal production system. The terminal index was developed assuming bulls are mated to mature cows with all resulting progeny harvested. The maternal index was developed assuming bulls are mated to a combination of heifers and mature cows, with resulting progeny retained as replacements or sold at weaning.

National average prices from 2010 …

Impact Of Finishing Diets With De-Oiled Distillers Grains Or Antioxidant Containing Supplement On Beef Shelf Life, Katherine I. Domenech-Pérez

Department of Animal Science: Dissertations, Theses, and Student Research

In its entirety this dissertation intended to address the impact of feeding several forms of de-oiled corn distillers grains plus solubles and the effect of supplementing OmniGen-AF as a potential antioxidant source for extending beef shelf life. In study one we learned that despite the de-oiling process, greater inclusion levels (65%, DM basis) of de-oiled wet distillers grains plus solubles (WDGS) causes an increase in polyunsaturated fatty acids (PUFA) similar to the levels obtained with full-fat WDGS. Lower inclusion levels (35 and 50%, DM basis) of de-oiled WDGS have intermediate PUFA content in comparison to 65% de-oiled WDGS, full-fat WDGS …

Β1 Integrin- And Jnk-Dependent Tumor Growth Upon Hypofractionated Radiation., Aejaz Sayeed, Huimin Lu, Qin Liu, David Deming, Alexander Duffy, Peter Mccue, Adam P. Dicker, Roger J. Davis, Dmitry Gabrilovich, Ulrich Rodeck, Dario C. Altieri, Lucia R. Languino

Department of Cancer Biology Faculty Papers

Radiation therapy is an effective cancer treatment modality although tumors invariably become resistant. Using the transgenic adenocarcinoma of mouse prostate (TRAMP) model system, we report that a hypofractionated radiation schedule (10 Gy/day for 5 consecutive days) effectively blocks prostate tumor growth in wild type (β1wt /TRAMP) mice as well as in mice carrying a conditional ablation of β1 integrins in the prostatic epithelium (β1pc-/- /TRAMP). Since JNK is known to be suppressed by β1 integrins and mediates radiation-induced apoptosis, we tested the effect of SP600125, an inhibitor of c-Jun amino-terminal kinase (JNK) in the TRAMP model system. Our results show …

Forage News [2016-08], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Eden Shale Farm to Host KFGC Field Day Sept. 13th
• Forage News Quote of the Month: "Forages, particularly the Grasses, are the most important plants on the face of the earth"
• Sugarcane Aphid Found in Kentucky
• UK Breeder Develops New Tall Fescue Variety
• Featured Publication: Stockpiling for Fall and Winter Pasture (AGR-162)
• Planting Brassicas and Cereals for Fall Forage
• Choose Varieties Wisely

50th Anniversary Celebration: 1966 Best Sellers Display, Maggie Mason Smith

Presentations

Each of our fall semester book displays will coincide with Cooper Library’s 50th Anniversary celebrations.

The first of these displays features 1966 New York Times best sellers.

With subject matter varying from UFOs to Sammy Davis Jr. to romance to World War II, this display is sure to have something you’ll want to check out. Located on the bookshelf to the right of the Information Services desk, the display will be up all month.

General Catalog 2016-2017, Utah State University

University Catalogs

This catalog contains information on the Academic Departments and Programs as well as Course Descriptions for the above school year at Utah State University. To avoid large file downloads, the Academic Departments and Programs information is located in this file. The Course Description information is located in the secondary file.