Digital Commons Network^™

Immune- And Nonimmune-Compartment-Specific Interferon Responses Are Critical Determinants Of Herpes Simplex Virus-Induced Generalized Infections And Acute Liver Failure, Zachary M. Parker, Tracy Jo Pasieka, George A. Parker, David A. Leib

Dartmouth Scholarship

The interferon (IFN) response to viral pathogens is critical for host survival. In humans and mouse models, defects in IFN responses can result in lethal herpes simplex virus 1 (HSV-1) infections, usually from encephalitis. Although rare, HSV-1 can also cause fulminant hepatic failure, which is often fatal. Although herpes simplex encephalitis has been extensively studied, HSV-1 generalized infections and subsequent acute liver failure are less well understood. We previously demonstrated that IFN-αβγR-/- mice are exquisitely susceptible to liver infection following corneal infection with HSV-1. In this study, we used bone marrow chimeras of IFN-αβγR-/- (AG129) and wild-type (WT; 129SvEv) mice …

Abq Free Press, September 28, 2016, Abq Free Press

ABQ Free Press

No abstract provided.

Transitions In Morphologies, Fluid Regimes, And Feeding Mechanisms During Development Of The Medusa Lychnorhiza Lucerna, Renato M. Nagata, André C. Morandini, Sean Colin, Alvaro E. Migotto, John H. Costello

Arts & Sciences Faculty Publications

The early ontogeny of scyphomedusae involves morphological and functional transitions in body plans that affect the predators' propulsive and feeding strategies. We applied highspeed videography digital particle image velocimetry (DPIV), and dye visualization techniques to evaluate alterations in swimming and feeding mechanisms during ontogeny of the rhizostome medusa Lychnorhiza lucerna Haeckel, 1880 (Scyphozoa, Rhizostomeae). During early ontogeny the ephyral mouth lips develop into complex filtering structures along the oral arms. The viscous environments (Reynolds number < 100) experienced by ephyrae constrain the feeding mechanisms that transport fluid during ephyral bell pulsations. In contrast, adult medusan fluid flows are dominated by inertial forces, and bell pulsations effectively transport fluids and entrained prey toward the oral arms. The oral arm surfaces are covered by motile epidermal cilia that drive these entrained flows through filtering gaps in the oral arms where food particles are retained. In addition to this process within the oral arms, vortices generated during bell pulsation flow downstream along the outside of the medusae and continuously transport prey toward the exterior oral arm surfaces. Although calanoid copepods are capable of escape velocities that greatly exceed L. lucerna's feeding current speeds, copepods often fail to detect the predator's feeding currents or inadvertently jump into medusan capture surfaces during failed escape attempts. Consequently, the comparatively weak predator feeding currents successfully capture a portion of the copepods encountered by swimming medusae. These results clarify the processes that enable rhizostome medusae to play key roles as consumers in tropical and subtropical coastal environments.

Why Are There Developmental Stages In Language Learning? A Developmental Robotics Model Of Language Development, Af Morse, A Cangelosi

School of Engineering, Computing and Mathematics

Most theories of learning would predict a gradual acquisition and refinement of skills as learning progresses, and while some highlight exponential growth, this fails to explain why natural cognitive development typically progresses in stages. Models that do span multiple developmental stages typically have parameters to “switch” between stages. We argue that by taking an embodied view, the interaction between learning mechanisms, the resulting behavior of the agent, and the opportunities for learning that the environment provides can account for the stage-wise development of cognitive abilities. We summarize work relevant to this hypothesis and suggest two simple mechanisms that account for …

N-Acetylcysteine In Combination With Igf-1 Enhances Neuroprotection Against Proteasome Dysfunction-Induced Neurotoxicity In Sh-Sy5y Cells, Benxu Cheng, Pinki Anand, Anxiu Kuang, Feroz Akhtar, Virginia L. Scofield

School of Medicine Publications

Ubiquitin proteasome system (UPS) dysfunction has been implicated in the development of many neuronal disorders, including Parkinson’s disease (PD). Previous studies focused on individual neuroprotective agents and their respective abilities to prevent neurotoxicity following a variety of toxic insults. However, the effects of the antioxidant N-acetylcysteine (NAC) on proteasome impairment-induced apoptosis have not been well characterized in human neuronal cells. The aim of this study was to determine whether cotreatment of NAC and insulin-like growth factor-1 (IGF-1) efficiently protected against proteasome inhibitor-induced cytotoxicity in SH-SY5Y cells. Our results demonstrate that the proteasome inhibitor, MG132, initiates poly(ADP-ribose) polymerase (PARP) cleavage, caspase …

Resident Perspectives On Green Infrastructure In An Experimental Suburban Stormwater Management Program, V. Kelly Turner, Kimberly Jarden, Anne Jefferson

Cities and the Environment (CATE)

Municipalities are increasingly promoting green infrastructure in residential neighborhoods as a strategy to manage stormwater runoff, but the extent to which residents are willing to adopt these alternatives to conventional landscaping remains unclear. This study examines the West Creek Ecosystem Restoration Project in Parma, Ohio, a suburban green infrastructure demonstration site for a new regional stormwater management program in the Cleveland metropolitan region. Residents were offered free installation of green infrastructure (e.g., rain gardens, right-of-way bioretentions, and rain barrels) on their property. Through a mixed method case-study, we analyze the socio-cultural factors that influence participation including resident’s self-reported landscaping behaviors, …

Spartan Daily, September 27, 2016, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2016

Volume 147, Issue 12

Next Generation Sequencing Data Of A Defined Microbial Mock Community, Esther Singer, Bill Andreopoulos, Robert Bowers, Janey Lee, Shweta Deshpande, Jennifer Chiniquy, Doina Ciobanu, Hans-Peter Klenk, Matthew Zane, Christopher Daum, Alicia Clum, Jan-Fang Cheng, Alex Copeland, Tanja Woyke

Faculty Publications, Computer Science

Generating sequence data of a defined community composed of organisms with complete reference genomes is indispensable for the benchmarking of new genome sequence analysis methods, including assembly and binning tools. Moreover the validation of new sequencing library protocols and platforms to assess critical components such as sequencing errors and biases relies on such datasets. We here report the next generation metagenomic sequence data of a defined mock community (Mock Bacteria ARchaea Community; MBARC-26), composed of 23 bacterial and 3 archaeal strains with finished genomes. These strains span 10 phyla and 14 classes, a range of GC contents, genome sizes, repeat …

A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu, Tao Jin, Yingze Zhao, Jingdong Song, Yi Shi, Wei Ji, Hao Jia, Yongming Zhou, Honghua Wen, Honglan Zhao, Huaxing Liu, Hong Li, Qihui Wang, Ying Wu, Liang Wang, Di Liu, Guang Liu, Hongjie Yu, Edward C. Holmes, Lin Lu, George F. Gao

KIP Articles

No abstract provided.

Uab Introduces New Venue On Campus For Art Faculty To Showcase Visual Research And Interdisciplinary Work, Staff

Browse All News

No abstract provided.

Motor Experience Reprograms Development Of A Genetically-Altered Bilateral Corticospinal Motor Circuit, Najet Serradj, John H. Martin

Publications and Research

Evidence suggests that motor experience plays a role in shaping development of the corticospinal system and voluntary motor control, which is a key motor function of the system. Here we used a mouse model with conditional forebrain deletion of the gene for EphA4 (Emx1-Cre:EphA4tm2Kldr), which regulates development of the laterality of corticospinal tract (CST). We combined study of Emx1-Cre:EphA4tm2Kldr with unilateral forelimb constraint during development to expand our understanding of experience-dependent CST development from both basic and translational perspectives. This mouse develops dense ipsilateral CST projections, a bilateral motor cortex motor representation, and bilateral motor phenotypes. Together these phenotypes can …

A Bat-Derived Putative Cross-Family Recombinant Coronavirus With A Reovirus Gene, Canping Huang, William J. Liu, Wen Xu

KIP Articles

The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 has generated enormous interest in the biodiversity, genomics and cross-species transmission potential of coronaviruses, especially those from bats, the second most speciose order of mammals. Herein, we identified a novel coronavirus, provisionally designated Rousettus bat coronavirus GCCDC1 (Ro-BatCoV GCCDC1), in the rectal swab samples of Rousettus leschenaulti bats by using pan-coronavirus RT-PCR and next-generation sequencing. Although the virus is similar to Rousettus bat coronavirus HKU9 (Ro-BatCoV HKU9) in genome characteristics, it is sufficiently distinct to be classified as a new …

Executive Committee - Meeting Minutes, 9/27/2016, Academic Senate

Academic Senate Minutes

No abstract provided.

September 27, 2016 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Developing High-Content Screening To Assay Trans-Epithelial Transport Of Complex Proteins, Reid Allan Martin

Student Theses and Dissertations

Therapeutic proteins are becoming one of the fastest growing classes of drugs on the market. These large biologically-synthesized macromolecules are typically administered intravenously and are dependent upon cellular receptors and other active uptake mechanisms for delivery into tissues and cells. There is significant interest in developing cell-based assays to assess kinetics and mechanisms of endocytosis and transcytosis of large therapeutic proteins across various cell layers. The goal of this research was to develop a transwell “disease tissue on a chip” model to compare rates and efficiencies of different delivery systems for moving bioactive lysosomal enzymes across a human epithelial cell …

All Hands Bury The Dead, Summer Qabazard

Theses and Dissertations

All Hands Bury the Dead is a collection of poetry, salted with creative non-fiction, and images, exploring trauma, memory, time, nostalgia, mental health, and love in the backgrounds of the Gulf War in Kuwait (1990-1991), domestic violence, relationships, and academia. The dissertation includes a critical preface that theorizes how racist, sexist, and colonialist ideologies can be reproduced in and supported through the uncritical application of theory to practice. The dissertation also includes an exploration of the assumptions about the innateness of creative writing ability that utilizes psychological theories of creativity to build a pedagogy to support the creative potential of …

The Bg News September 27, 2016, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. September 27, 2016. Volume 96-Issue 12.

Characterization Of Chemical Profiles Produced By Opuntia Humifusa In Response To Herbivory And Exogenous Methyl Jasmonate In Comparison To Hairy Root Cultures, John Milton Kilmer

Student Theses and Dissertations

The South American Cactus Moth, Cactoblastis cactorum (Berg), an invasive insect herbivore, has similar feeding habits and life history as a native Florida cactus moth, Melitara prodenialis Walker; however, regional Opuntia species only defend against M. prodenialis. Extracts of C. cactorum host plants and M. prodenialis host plants were compared to methyl jasmonate (MeJA)-treated Opuntia humifusa and MeJA-treated O. humifusa hairy root cultures using high performance thin layer chromatography. MeJA and C. cactorum treatments led to a reduction in tissue concentrations of terpenoid or phenolic compounds; however, significant increases in seven putative terpenoid compounds were observed in hairy root culture …

Fall Concert Featuring Ksu Chorale, Men's Ensemble And Chamber Singers, Sherri N. Barrett, Huijeong Lee, Grace Johnston, Rachel Fishback, Michael Roberts, Marcel Benoit Iii, Kenan Mitchell, Brittany Griffith, Christina Vehar, Grace Breazeale, Xandrya Edwards, Sierra Manson, Forrest Starr, Savannah English, Selena Sanchez, Brooks Payne, Joe Donohue

Bailey School of Music Concert Programs

Kennesaw State University School of Music presents Fall Concert featuring University Chorale, Men's Ensemble and Chamber Singers under the direction of Leslie J. Blackwell.

Research Express News, Georgia Southern University

Research & Economic Development

• Polluter-funded research on the health of the Ogeechee River continues

University Honors Program News, Georgia Southern University

Honors College: News & Publications (2008-2020)

• Honors Students Cross the Equator
• Jenny Shaffer Engineers a Third Trip to Germany
• Of Dogs and Doctors: Presenting Research in Dublin
• Summer Research Update

Where's The Pair? A Spotting Book, Sydnee Burr

Children's Book and Media Review

In this book of discovery, children have a challenge on every page. Each page has a rhyme and a task, such as finding the two cats who match out of an entire page of cats. Great for learning and inquisitive minds, this spotting book will keep children and parents quietly entertained.

The Case Of The Vanishing Little Brown Bats: A Scientific Mystery, Aylea Stephens

Children's Book and Media Review

This book explores the mystery of why little brown bats are disappearing and the problems their disappearance could cause. Because bats eat insects that do damage to crops and transmit diseases, bats are important to the ecosystem. Researchers learned that these bats were dying in large numbers in 2007, and since then they have tried to find out why they keep dying and why the bats were flying during the winter when they should have been hibernating. The book explores what hibernating bats need to survive, what the killers could possibly be, the process it took to find the killer, …

If You Want To See A Whale, Liz Kazandzhy

Children's Book and Media Review

A boy and his dog go on an adventure to see a whale. Using his imagination, he and his canine friend go to the seaside, only to be distracted by a curious bird, sweet pink roses, possible pirates, a sitting pelican, a scooting caterpillar, and floating clouds. But they try to pay little attention to these fascinating things, and soon they row into the sea to wait, wait, and wait… until they finally see a whale!

Hedgehug's Halloween, Whitney Troxel

Children's Book and Media Review

Hedgehug completely forgot about Reginald's Halloween party and he has no costume. He goes to each of his friends for help, but the costumes either rip, pop, or fall apart. Discouraged, Hedgehug decides to go home. His friend's work together to come up with the perfect costume for Hedgehug. Hedgehug goes to the party as a cactus and everyone cheers.

Darkbeast, Tessa Mcmillan

Children's Book and Media Review

Like all the children in Keara’s world, she was blessed with an animal companion or darkbeast at her birth. The darkbeast has a magical connection to take upon themselves the faults and flaws of their human child. At the age of twelve, children sacrifice their darkbeasts to show they have left childhood and entered adulthood. But when Keara turns twelve, she cannot kill her darkbeast, Caw. Her failure causes her family to shun her and sets the religious order of the Inquisitors after her. She runs away with Caw and joins a caravan of actors called the Travelers. She keeps …

Creepy Creatures: Werewolves, Kiersten Carr

Children's Book and Media Review

This picture book is divided into short sections that cover the concept, history, and tradition of werewolves, both historically and in popular culture. The text is accompanied by short “Did You Know?” text boxes that provide additional facts and information, and features a weathered-looking layout and intriguing stock photography of animals, Hollywood monsters, and art. A short glossary in the back of the book contains definitions and pronunciations of words that young readers may not have encountered before.

Because Your Grandparents Love You, Liz Kazandzhy

Children's Book and Media Review

A little boy and girl have headed to the farm to visit their grandparents, but it doesn’t take long for them to get into mischief! As kids will be kids, these two end up stepping in manure by accident, trying to carry a huge bale of hay by themselves, spooking a hen while looking for eggs, peeling apples all wrong, and lighting a very smoky fire. At every turn and with every problem, Grandpa and Grandpa could react by reprimanding the kids or doing the job themselves, but they don’t—they patiently and kindly help their dear grandkids, and everyone works …

Bats At The Beach, Chelsie Troxel

Children's Book and Media Review

When the day ends all of the bats come out to play! On this particular night, the moon is just right for a night at the beach. The bats gather up their supplies and luggage and head from the sky down to the sandy shores. They have so many fun things to do in the sand and the water. They make new friends with other animals that join them for a beach night. They surf and sail, play games and snack. When the sun starts to rise the bats say good bye to their friends and fun then quickly fly …

After The Snow, Roger Layton

Children's Book and Media Review

Growing up is tough, but for Willo it gets a lot tougher. Living in a land where winters are getting longer and longer, one day his family is taken away and he must survive on his own. Facing the challenges of wild animals, hungry strangers, and the constant cold, Willo finds his way as best he can while facing decisions that force him to decide who he wants to be. Does he want to be more human or should he listen to the animal in his nature? Should he stay in the wild mountains or sneak into the city? Is …