Digital Commons Network^™

Death Vegas Valley, Eric M. Diehl

Theses and Dissertations

My work explores hallucinatory landscapes of the US American West by using a combination of painting styles outside of the Western painting canon. I cross-reference painting and cinema, interweaving video, acrylic paint and the panorama to create a satirical homage to the history and present state of the USA. However, through an earnest devotion to the medium - both painting and cinema - I find my criticisms also yearn to hold onto a belief in a myth I know to be false.

This is an American History conversation about artifice and consumerism through advertising. I use Las Vegas and the …

Truth And Doubt In Representation, Mathew Gasparek

Theses and Dissertations

My work deals with the connection between the act of representation and conceptions of truth in the contemporary image-mediated social environment. This thesis details elements of my paintings in exchange with methods and ideas from artists and writers in order to position my aesthetic and conceptual sensibilities within a historical and contemporary framework.

Novel Small Airway Model Using Electrospun Decellularized Lung Extracellular Matrix, Bethany M. Young

Theses and Dissertations

Chronic respiratory diseases affects many people worldwide with little known about the mechanisms diving the pathology, making it difficult to find a cure. Improving the understanding of smooth muscle and extracellular matrix (ECM) interaction is key to developing a remedy to this leading cause of death. With currently no relevant or controllable in vivo or in vitro model to investigate diseased and normal interactions of small airway components, the development of a physiologically relevant in vitro model with comparable cell attachment, signaling, and organization is necessary to develop new treatments for airway disease. The goal of this study is to …

Antithetical Commentaries On X, Y And The Disruption Of Being, Eva Rocha

Theses and Dissertations

Through discursive essays and poetic narrative, Antithetical Commentaries on X, Y and the Disruption of Being explores the tenuous relationship between modes of measurement and the struggle for human relevance in the post-contemporary digital age. In the introductory essay, “Not the Feather, but the Bird”, I give an overview of the inherent problems of object-oriented ontology, and how it relates to aesthetics and social issues of our times. In the Developmental Overview, I detail how I developed my installation approach and techniques, particularly with regard to the three-way dynamic of the artist:work:viewer relationship and how it can encourage …

Sensible Nonsense, Timothy J. Woodbrey

Theses and Dissertations

“Truth happens only by establishing itself in the strife and the free space opened up by truth itself. Because truth is the opposition of clearing and concealing, there belongs to it what is here called establishing.”[i]—Martin Heidegger

All things contain their own individual existence. When I look at objects I notice material, tradition, individual history. These are starting points for my imagination to seed and germinate. My ideas are fragmented, nonlinear and nonsensical to others but they hold honesty to me. Honesty is powerful and is worth sharing.

This document is an examination of my work during …

Quantitative Analysis Of 5-Chloro-2-Methoxy-N-[2-(4-Sulfamoylphenyl)Ethyl]Benzamide (Glyburide Analogue, Ga) In Mouse Plasma And Whole Blood Using A Micro-Extraction And Liquid Chromatography-Tandem Mass Spectrometry, Ankit Zalavadia

Theses and Dissertations

Pharmacokinetic evaluation of 5-chloro-2-methoxy-N-[2-(4- sulfamoylphenyl)ethyl]benzamide in mouse plasma demanded for a suitable bioanalytical method. No reported bioanalytical method exists to-date that can quantify concentration of this compound in any biological matrix. The purpose of this study was 1) to develop and validate a new bioanalytical method using a micro-extraction and LC-MS/MS to quantify the target analyte in mouse plasma and 2) to partially validate the method in whole blood. A bioanalytical method was developed and validated in both matrices for a linear concentration range of 2-1000 ng/ml. For both matrices, the reverse predicted concentration of calibration standards (-8.95% to 12.16% …

Conditional Cardiac-Specific Akap13 Knockout Induces Sex Dependent Biventricular Dilated Cardiomyopathy With Sarcomeric And Mitochondrial Defects, Kimberlyn M. Baig-Ward

Theses and Dissertations

Heart disease is a complex and heterogeneous disease. Notably, studies have demonstrated gender differences in the expression and types of cardiovascular disease, such as dilated cardiomyopathy (DCM), a major underlying cause of heart failure. Previously we showed that loss of A-Kinase Anchoring Protein 13 (Akap13), a unique proto-oncogene and estrogen receptor modulator, resulted in enlarged embryonic hearts, defective cardiac sarcomere formation, and embryonic lethality in mice. Data have also shown cAMP-dependent Protein Kinase A (PKA) to be involved in DCM pathophysiology. Given the established role of AKAP13 in cell signaling, its ability to bind and modulate ligand-activated nuclear hormone …

Exploring The Outcomes Of Rehabilitative Care For Veterans And Service Members Treated For A Disorder Of Consciousness In The Vha Emerging Conciousness Program, Janette A. Hamilton

Theses and Dissertations

Over the past several years, there has been an influx in patients being treated for polytraumatic injuries within the Veterans Health Administration (VHA), largely due to the wars in Afghanistan and Iraq, but also due to advances in life sustaining medical interventions. The polytrauma population includes veterans who have sustained a severe traumatic or non-traumatic brain injury, and a significant loss in cognitive and physical functioning, referred to as a disorder of consciousness. The purpose of the current study was to explore factors related to successful emergence from a disorder of consciousness, using a sample of veterans who were treated …

Capturing Memory, Morgan A. Molenda

Theses and Dissertations

In my work, I present the moments of true emotional clarity and impactful memories from my life. I strive to provide insight into my experiences and my understanding of others’ motivations. The creative process helps safely guide me through memories of the past and understanding of others.

In my abstracted mixed media paintings and crafts, I use bold jewel tones to express strong feelings and passionate emotions. I also incorporate found objects and paints to communicate the layers and varied depth of memories. With the use of these varied materials, I have developed a personal symbolic language that allows me …

Human Neural Progenitor Cells Are Productively Infected By R5-Tropic Hiv-1: Opiate Interactions On Infection And Function Involve Cdk5 Signaling, Joyce Magat Balinang

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) is known to cause a spectrum of neurological, behavioral and motor deficits collectively termed as HIV-1 associated neurocognitive impairments (HAND). Opiates augment HIV-related CNS complications through both direct and indirect mechanisms that disrupt glial and neuronal function. All CNS macroglia and neurons derive from neural progenitor cells (NPCs) during development, and NPCs in the adult brain contribute to repair processes. Since disruptions in NPC function are known to impact CNS populations and brain function in a number of disease/injury conditions, we determined whether HIV ± opiate exposure affected the maturation and fate of human …

Curcumin/Melatonin Hybrids As Neuroprotective Agents For Alzheimer's Disease, John Saathoff

Theses and Dissertations

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting ~5.2 million Americans. Current FDA approved medications provide mainly symptomatic relief and there are no agents available to delay or cure this disease. Multiple factors such as amyloid-β aggregates, dyshomeostasis of biometals, oxidative stress, and neuroinflammation have been implicated in the development of AD. Even though significant advances have been made in understanding the mechanisms leading to AD, the exact etiology still remains elusive. Given AD’s multifactorial nature, a multifunctional strategy of small molecule design would help to identify novel chemical templates. Recently our lab …

“‘It’S A Cu’Ous Thing Ter Me, Suh’: The Distinctive Narrative Innovation Of Literary Dialect In Late-Nineteenth Century American Literature”, Kym M. Goering

Theses and Dissertations

American literature and verse advanced in dialectal writing during the late-nineteenth century. Charles Chesnutt’s “The Goophered Grapevine” (1887), “Po’ Sandy” (1888), and “Hot-Foot Hannibal” (1899); Joel Chandler Harris’ Uncle Remus: His Songs and His Sayings (1881); Thomas Nelson Page’s “Marse Chan” (1884); and Mark Twain’s “Sociable Jimmy” (1874) and “A True Story, Repeated Word for Word as I Heard It” (1874) provided diverse dialect representations. Dialect expanded into poetry with

James Whitcomb Riley’s “She ‘Displains’ It” (1888), “When the Frost is on the Punkin” (1882), and “My Philosofy” (1882) and Paul Laurence Dunbar’s “The Spellin’ Bee” (1895), “An Ante-Bellum Sermon” …

The Implementation And Emulation Of Cult Movie Marketing, Rebekah W. Mckendry

Theses and Dissertations

Cult media is often an area of media studies that is difficult to define. Cult media branches through numerous time periods, genres, and fandom patterns. Cult trends are also constantly evolving over time, changing from word-of-mouth and point-of-sale advertising to social networks and Internet culture. But have the rudimentary basics of how media cults develop and spread their message changed along with the progressing marketing presentation? This dissertation explores the definition of media cults, their history, and marketing styles over time, ultimately exploring the tools utilized to market cult media and examine how these tools are now synthetically applied to …

Exploring The Concept Of Human Oct3 Inhibitors As A Novel Class Of Antidepressants, Kavita A. Iyer

Theses and Dissertations

The Dukat laboratory developed 2-amino-6-chloro-3,4-dihydroquinazoline (A6CDQ) as a 5-HT₃ receptor ligand. A6CDQ and one of its positional isomers, the 7-chloro analog A7CDQ, produced antidepressant-like effects in the mouse tail suspension test (TST). We investigated and systematically ruled out a solely 5-HT₃ receptor or hSERT mediated mechanism of antidepressant-like effect for both A6CDQ and A7CDQ.

The role of organic cation transporter 3 (OCT3) as an alternative mechanism in the regulation of neurotransmitters including serotonin (5-HT) and the therapeutic potential of targeting hOCT3 to achieve antidepressant effects has been established. By virtue of possessing protonatable nitrogen atoms, 2-aminodihyroquinazolines could potentially …

Role Of Vav2 In Podocyte Inflammasome Activation And Glomerular Injury During Hyperhomocysteinemia, Sabena Conley

Theses and Dissertations

Hyperhomocysteinemia (hHcys) is a widely known pathogenic factor in the progression of end-stage renal disease (ESRD) and it is also associated with an increased risk for injurious cardiovascular pathologies during ESRD. HHcys is linked to the formation and activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, characterized as a critical early mechanism initiating the inflammatory response. NADPH oxidase (NOX)-derived reactive oxygen species (ROS) mediate the activation of the NLRP3 inflammasome in podocytes in response to elevated levels of homocysteine (Hcys) in vitro and in vivo. However, it remains unknown how NLRP3 inflammasome activation is triggered by NOX. The …

Eeg Interictal Spike Detection Using Artificial Neural Networks, Howard J. Carey Iii

Theses and Dissertations

Epilepsy is a neurological disease causing seizures in its victims and affects approximately 50 million people worldwide. Successful treatment is dependent upon correct identification of the origin of the seizures within the brain. To achieve this, electroencephalograms (EEGs) are used to measure a patient’s brainwaves. This EEG data must be manually analyzed to identify interictal spikes that emanate from the afflicted region of the brain. This process can take a neurologist more than a week and a half per patient. This thesis presents a method to extract and process the interictal spikes in a patient, and use them to reduce …

The Role Of Matrix Metalloproteinase 9 And Osteopontin In Synaptogenesis And Reinnervation Of The Olfactory Bulb Following Brain Injury, Melissa A. Powell

Theses and Dissertations

Traumatic brain injury (TBI) is a serious health concern, causing cognitive, motor, and sensory deficits, including olfactory dysfunction. This dissertation explores the effects of TBI on synaptic plasticity within the olfactory system, seeking to define mechanisms guiding postinjury sensory reinnervation. Physical forces induced by TBI can axotomize olfactory receptor neurons (ORNs), which innervate olfactory bulb (OB). These axons regenerate OB projections after injury, a process involving growth through a complex extracellular matrix (ECM). As such, we investigated a potential molecular mechanism capable of modifying local OB ECM to support postinjury synaptogenesis. Since matrix metalloproteinases (MMPs) and their ECM substrates are …

The Role Of Enteric Glia In Opioid-Induced Constipation, Sukhada Bhave

Theses and Dissertations

Morphine is one of the most widely used drugs for the treatment of pain but its clinical efficacy is limited by adverse effects including persistent constipation and colonic inflammation. Morphine-induced colonic inflammation is facilitated by microbial dysbiosis and bacterial translocation. In this study, we demonstrate that secondary inflammation and persistent constipation are modulated by enteric glia. In chronic morphine treated mice (75 mg morphine pellet/5 days), ATP-induced currents were significantly enhanced in enteric glia isolated from the mouse colon myenteric plexus. Chronic morphine resulted in significant disruption of the colonic epithelium and increased Il-1β in the myenteric plexus. The increase …

Investigating The Role Of The Nucleosome Remodeling Factor Ino80 In Development And Nurf In Anti-Tumor Immunity, Zeinab Abdallah Elsayed Ms

Theses and Dissertations

Understanding how an epigenetic regulator such as ATP-dependent chromatin-remodeling complexes modulate processes such as development and/or immune response is essential for our comprehension of cell biology. Deletion of the ATP-dependent chromatin remodeling factor INO80 is known to be embryonically lethal, however, the mechanism is not known. To identify roles for INO80 in mouse early development we generated Ino80 KO mice. Ino80 KO ESCs (Embryonic stem cells) were viable when maintained at ground state pluripotency but fail to differentiate in vitro and in vivo. Gene expression analysis of Ino80 KO early embryos by in situ hybridization showed elevated Bmp4 expression …

Wreading, Performing, And Reflecting: The Application Of Narrative Hypertext And Virtual World Experiences To Social Work Education, Linda Ayscue Gupta Phd

Theses and Dissertations

In this dissertation I propose the use of a new media composition of narrative hypertext, performances in a virtual world, and a dialogic process of writing to provide a continuum of learning opportunities in social work education. I suggest that the structure of the hypertext narrative, embedded with hypermedia, mirrors the dissociative aspects of traumatic memory. I argue that work with the multivocality and multisequentiality of narrative hypertext emulates the process of discovery in the clinical interview. The immersive component of work in a virtual world deepens the realism and affective impact of simulations and creates opportunities to practice and …

Atm Phosphorylates Subunit A Of Pp2a Resulting In Its Nuclear Export And Spatiotemporal Regulation Of The Dna Damage Response, Amrita D. Sule

Theses and Dissertations

Ataxia telangiectasia mutated (ATM) is a serine-threonine protein kinase and major regulator of the DNA damage response (DDR). One critical ATM target is protein phosphatase 2A (PP2A) known to regulate diverse cellular processes such as mitosis and cell growth as well as dephosphorylation of many proteins during the recovery from the DDR while returning the cell to normalcy. Interestingly, ATM and PP2A are known to form an auto-regulatory yin-yang kinase-phosphatase relationship. Herein, we show that the phosphorylation of the PP2A-Aα structural subunit at S401 by ATM results in nuclear export, which regulates the DDR at multiple levels and affects genomic …

Comparative Study Of Ethics In Librarianship And The Bible, Japheth Abdulazeez Yaya

The Christian Librarian

This paper is a comparative study that discusses ethical issues in librarianship and the Bible. Such issues include: Laws in librarianship vs. laws in the Bible; censorship in librarianship vs. censorship in the Bible; Bible teachings on access to information and access to information in librarianship; purification (i.e., book binding), conservation and preservation practices in the library and in the Bible; weeding of library collections and weeding practices in the Bible; privacy and confidentiality in the library and in the Bible; orderliness of the library collections and the Bible; consortium building of library collections and in the Bible; and consequences …

Systemic Risk Regulation In Comparative Perspective, Cristie Ford

All Faculty Publications

This report succinctly compares, with tables and diagrams, the systemic risk regulatory regimes that have been put in place since 2008 in the US, the UK, the EU and Canada. It describes systemic risk as a problem of a different order from the kinds of investor protection and efficient market concerns that animate day-to-day securities and capital markets regulation. Because contemporary markets operate as systems, characterized by interconnectedness, unpredictability, and fast-moving, multiple-round contagion effects, responding to systemic risk demands a different regulatory structure and a separate set of tools. This report was prepared for the Department of Finance, Government of …

Masthead & Table Of Contents, Vol. 95, No. 2

Nebraska Law Review

No abstract provided.

Assessing The Match Performance Of Non-Ideal Operational Facial Images Using 3d Image Data., Rupindrani Aila

Graduate Theses, Dissertations, and Problem Reports (ETD)

Biometric attributes are unique characteristics specific to an individual, which can be used in automated identification schemes. There have been considerable advancements in the field of face recognition recently, but challenges still exist. One of these challenges is pose-variation, specifically, roll, pitch, and yaw variations away from a frontal image. The goal of this problem report is to assess the improvement of facial recognition performance obtainable by commercial pose-correction software. This was done using pose-corrected images obtained in two ways: 1) non-frontal images generated and corrected using 3D facial scans (pseudo-pose-correction) and 2) the same non-frontal images corrected using FaceVACs …

The Warrior Kings And Their Giants: A Comparative Study Of Beowulf And King David, Fred Mcfarland

EWU Masters Thesis Collection

No abstract provided.

Three For A Girl, Danielle K. Weeks

EWU Masters Thesis Collection

No abstract provided.

Research That Matters: Transforming Community Based Education Through Feminist Pedagogy And Public Scholarship, Amber J. Johnson

EWU Masters Thesis Collection

This is a qualitative analysis of focus groups conducted with "Community Partners" (mostly Directors of non-profit social service agencies who have previously partnered with Eastern Washington faculty in community-based education efforts) in the Greater Spokane Area. This research is designed to address shortcomings of current forms of community based education, identify strategies for strengthening the partnerships that exist between Eastern Washington University and the surrounding community, and to establish the need for community based research at the graduate level. By conducting focus groups, this study analyzed Community Partner perceptions of community based education and research before and after watching a …

Elk Summer-Autumn Habitat Selection In The Clearwater Basin Of North-Central Idaho, Calla R. Hetzner Hagle

EWU Masters Thesis Collection

"Since the 1960's, Rocky Mountain elk (Cervus elaphus nelsoni) populations have declined steadily in the Clearwater Basin in north-central Idaho. The Clearwater Basin Collaborative (CBC) was formed with the goal of restoring healthy elk populations to the Clearwater Basin. They initiated this study by collaring 53 cow elk from four distinct areas. I analyzed elk detection and GIS-based habitat data from June 15-September 15 2014 to address one of the CBC's objectives: identifying elk habitat use responses on summer-autumn range. Ground-truth surveys are necessary to verify satellite-derived data are analogous to actual vegetation components. I used a proportion analysis to …

Identifying Risk Factors For Metabolic Syndrome In Division I Fcs Football Players, Julie Woolf

EWU Masters Thesis Collection

"Metabolic syndrome (MetS) is a collection of symptoms or markers leading to a higher risk for health problems including diabetes and cardiovascular disease. These markers include high blood pressure (BP), increased waist circumference (WC), high triglycerides, low HDL-C and increase glucose. Football players may be more at risk for developing MetS and other health problems due to the need for their large size, especially linemen. The purpose of this study was to determine the relationship between the MetS markers as well as the relationship between WC and visceral fat depth and measured with an ultrasound. MetS markers and visceral fat …