Digital Commons Network^™

Understanding The Home Math Environment And Its Role In Predicting Parent Report Of Children's Math Skills, Sara Ann Hart, Colleen M. Ganley, David J. Purpura

Department of Human Development and Family Sciences Faculty Publications

There is a growing literature concerning the role of the home math environment in children's math development. In this study, we examined the relation between these constructs by specifically addressing three goals. The first goal was to identify the measurement structure of the home math environment through a series of confirmatory factor analyses. The second goal was to examine the role of the home math environment in predicting parent report of children's math skills. The third goal was to test a series of potential alternative explanations for the relation between the home math environment and parent report of children's skills, …

Expectation, Expectoration And Disgust: Information Manipulation Alters Spitting Efficiency, A Proxy For Salivary Flow, Cordelia Running, John E. Hayes

Department of Nutrition Science Faculty Publications

Saliva is becoming an increasingly useful research material across multiple fields of inquiry, including biomedical, dental, psychological, nutritional, and food choice research. However, both the flow rate and protein composition of stimulated saliva differ as a function of the collection method. We hypothesized that the context in which a salivary stimulus is presented to participants may alter salivation via behavioral (i.e., spitting efficiency) or top down cognitive effects. We presented participants with a constant stimulus (commercially available green tea) in two distinct contexts, once where the tea was described as a food item (“tea”) and once where it was described …

Critical Literacy: An Innovative Approach To Learning Among Students With Reading Disabilities, Karyn Marie Chiapella

Wayne State University Dissertations

ABSTRACT

CRITICAL LITERACY: AN INNOVATIVE APPROACH TO LEARNING AMONG STUDENTS WITH READING DISABILITIES

by

KARYN M. CHIAPELLA

DECEMBER 2015

Co-Advisors: Dr. Marshall Zumberg; Dr. Gerald Oglan

Major: Special Education

Degree: Doctor of Philosophy

Many students, particularly those with learning disabilities do not read and/ or write at levels sufficient for meeting the demands of the 21st century. Successfully reading to learn requires the ability to analyze, synthesize, and evaluate information from multiple texts. Critical literacy provides a framework for students to engage in dialogue with texts to become more aware of the relationships of power communicated within texts. This study …

Using Video Games To Increase Motivation Of Saudi Students Learning English, Wadeeah Alshawi

Wayne State University Dissertations

The use of games in various stages of education has become an accepted method among instructional designers who are interested in adding technology to their designs. This research would benefit game designers and instructional designers who want to see what motivates students to learn English. The research used Keller’s ARCS Model, which addresses attention, relevance, confidence, and satisfaction, to investigate what game designs or characteristics will motivate students to learn more English language. The method of this study was a quasi-experimental design supplemented with quantitative and qualitative methods. The results indicated that both games used motivated students to learn because …

Assessing Patient-Centered Communication In Medical Education: A Crystallized Approach To Understanding The Quality, Nature, And Form Of Feedback By Standardized Patients, Simone Kathe Brennan

Wayne State University Dissertations

Patient-centered Communication (PCC) is the gold standard in effective clinical communication. Feedback from Standardized Patients (SPs) provides one strategy to teach PCC. SP feedback is highly valued, but little is understood about its quality, nature, and the form in which it is actually delivered. Methods: Using the meta-method of crystallization (Ellingson, 2009), I conducted three unique studies, content analysis, iterative thematic analysis, and narrative analysis of SP feedback. These analyses were conducted using transcribed SP feedback from a multi-station, residency-based Objective Structured Clinical Exam (OSCE). SPs in this OSCE were trained using the adapted version of the Kalamazoo Essential Elements …

Ecology Of Coyotes (Canis Latrans) In The Greater Detroit Area Of Southeastern Michigan, William B. Dodge

Wayne State University Dissertations

Coyote distribution and habitat use, diet and foraging behavior and space use patterns were investigated in the greater Detroit area of southeastern Michigan. We found evidence of coyotes on 24 of 30 (80%) suburban and 7 of 11 (64%) urban plots. Overall fifty-eight percent of coyote evidence was found within edge habitats, with den sites and tracks the only types of evidence found strictly in interior habitats. Land cover around evidence points included more wooded land cover than expected in suburban areas, suggesting the importance of tree cover for coyote occupancy, and more open space and wooded land cover than …

Muscle Metaboreflex And Arterial Baroreflex: Action, Interaction And Altered Control In Heart Failure, Jasdeep Kaur

Wayne State University Dissertations

Stimulation of skeletal muscle afferents by metabolites that accumulate in the exercising muscle elicits a large pressor response, termed the muscle metaboreflex. Muscle metaboreflex activation during submaximal exercise induces large increases in arterial pressure, cardiac output, heart rate and ventricular contractility however, the vascular responses have varied in previous studies. We addressed three specific questions: 1) what are the mechanism(s) regulating the non-ischemic vasculature during muscle metaboreflex activation in normal subjects, 2) whether muscle metaboreflex activation vasoconstricts the ischemic active muscle from which this reflex originates and if this vasoconstriction is exaggerated in heart failure and 3) how do the …

Neural Circuitry Deficits Associated With Dysfunctional Myelin, Kathleen June Maheras

Wayne State University Dissertations

In the current study, we have generated mutant mice that lack Claudin 11 (Cldn11) tight junctions in CNS myelin sheaths. In myelin sheaths, Cldn11 forms tight junctions located along the outer and inner edges of the membrane spiral, preventing ions and small molecules from entering the intramyelinic space. The function of Cldn11 tight junctions is to improve the passive properties of the myelin membrane, by increasing membrane resistance and reducing capacitance, thereby improving the speed of saltatory conduction. In the absence of Cldn11, conduction velocity is slowed, most dramatically in small diameter myelinated fibers, somewhat analogous to reducing myelin thickness. …

Development Of Carbon Based Neural Interface For Neural Stimulation/Recording And Neurotransmitter Detection, Wenwen Yi

Wayne State University Dissertations

Electrical stimulation and recording of neural cells have been widely used in basic neuroscience studies, neural prostheses, and clinical therapies. Stable neural interfaces that effectively communicate with the nervous system via electrodes are of great significance. Recently, flexible neural interfaces that combine carbon nanotubes (CNTs) and soft polymer substrates have generated tremendous interests. CNT based microelectrode arrays (MEAs) have shown enhanced electrochemical properties compared to commonly used electrode materials such as tungsten, platinum or titanium nitride. On the other hand, the soft polymer substrate can overcome the mechanical mismatch between the traditional rigid electrodes (or silicon shank) and the soft …

Utilization Of A Large-Scale Wireless Sensor Network For Intrusion Detection And Border Surveillance, Mosad Helsan Alkhathami

Wayne State University Dissertations

To control the border more effectively, countries may deploy a detection system that enables real-time surveillance of border integrity. Events such as border crossings need to be monitored in real time so that any border entries can be noted by border security forces and destinations marked for apprehension. Wireless Sensor Networks (WSNs) are promising for border security surveillance because they enable enforcement teams to monitor events in the physical environment. In this work, probabilistic models have been presented to investigate senor development schemes while considering the environmental factors that affect the sensor performance. Simulation studies have been carried out using …

Investigation Of Mutations In Nuclear Genes That Affect The Atp Synthase, Russell Dsouza

Wayne State University Dissertations

The F1 domain is the catalytic subunit of the mitochondrial ATP synthase. Studies with respiratory-deficient yeast identified ATP1 and ATP2 as nuclear genes encoding the alpha and beta subunits, respectively, of the mitochondrial F1-ATPase. The mutations in the atp1 and atp2 genes were cloned and sequenced, and they appear to affect the ATP synthase. Most yeast strains with mutations in the or the subunit primarily show an F1 assembly defective phenotype. This feature is similar to the assembly-defective mutants missing the chaperones required for assembly of the F1 oligomer or either the alpha/beta subunits.

Some of the atp2 and atp1 …

Effective Drug Treatment Induces Drug Resistance Through Rapid Genome Alteration-Mediated Cancer Evolution, Steven Horne

Wayne State University Dissertations

The central paradox associated with current cancer therapeutic strategies is initially effective treatment, which eliminates a high tumor cell count, consistently results in successful drug resistance. Mathematical and evolutionary modeling have previously suggested that therapeutic intervention could provide selective pressure for the expansion of resistant variants. Drug-related stress has been associated with genome chaos, a common phenomenon in cancer characterized as rapid, stochastic genomic fragmentation and reorganization. Since cancer represents an evolutionary process, analysis within the context of genome-mediated cancer evolution can shed light on this key problem of therapeutics. We propose that genomic change is a general response to …

Genome Wide Analysis Identifies Sphingolipid Metabolism As A New Target Of Valproic Acid, Shyamalagauri Jadhav Jadhav

Wayne State University Dissertations

Bipolar disorder (BD), which is characterized by depression and mania, affects about 1% of the total world population. Current treatments are effective in only 40-60% of cases and cause severe side effects. Valproic acid (VPA), a branched short-chain fatty acid, is one of the most widely used drugs for the treatment of BD. Although many hypotheses have been postulated to explain the molecular mechanism of action of this drug in BD, the therapeutic mechanism is not understood. This knowledge gap has hampered the development of new drugs to treat this disorder. To identify candidate pathways affected by VPA, I performed …

An Analysis Of The Interaction Between Sin3 And Methionine Metabolism In Drosophila, Mengying Liu

Wayne State University Dissertations

Chromatin modification and cellular metabolism are tightly connected. The mechanism for this cross-talk, however, remains incompletely understood. SIN3 controls histone acetylation through association with the histone deacetylase RPD3. In this study, my major goal is to explore the mechanism of how SIN3 regulates cellular metabolism.

Methionine metabolism generates the major methyl donor S-adenosylmethionine (SAM) for histone methylation. In collaboration with others, I report that reduced levels of some enzymes involved in methionine metabolism and histone demethylases lead to lethality, as well as wing development and cell proliferation defects in Drosophila melanogaster. Additionally, disruption of methionine metabolism can directly affect histone …

Imaging Anti-Proliferative Compounds With Flt-Pet, Christopher Mchugh

Wayne State University Dissertations

Imaging is critical in the detection and management of malignancies, and positron emission tomography (PET) is an imaging approach that provides information regarding cancer physiology through the tracking of molecular pathways and receptors. 3’-fluoro-3’-deoxythymidine (FLT) is a PET tracer designed to image cellular proliferation, which is a hallmark of cancer. FLT has been used to study the response of cancer to a variety of treatments such as chemotherapy, targeted agents, and radiation.

Here we explored FLT retention as a biomarker to monitor the anti-proliferative effect of the synthetic glucocorticoid (GC) dexamethasone (Dex) on non-small cell lung cancer (NSCLC). The basis …

Modeling The Mechanism Underlying Environmental And Genetic Determinants Of Gene Expression And Complex Traits, Gregory Alan Moyerbrailean

Wayne State University Dissertations

Advances in next-generation sequencing technologies and functional genomics strategies have allowed researchers to identify both common and rare genetic variation, to deeply profile gene expression, and even to determine regions of active gene transcription.

While these technologies and strategies have contributed greatly to our understanding of complex traits and diseases, there are many biological questions and analytical issues to be addressed.

Genome-wide association studies (GWAS) have successfully identified large numbers of genetic variants associated with complex traits and diseases. However, in many cases the mechanistic link between the phenotype and associated variant remains unclear. This may be because most variants …

Politics And Pedagogy: Recuperating Rhetoric And Composition's Native Ethical Tradition, Derek Risse

Wayne State University Dissertations

Over the past decade, scholars in Rhetoric and Composition have shown renewed interest in the topic of ethics, prompting what some have described as an ethical turn in the discipline. Spurred by a deep-seated concern for the legacies of humanism, scholars have turned increasingly to extra-disciplinary referents in continental philosophy. This dissertation works to recuperate the discipline’s native ethical tradition via a critical rereading of the often-implicit treatment of ethics in Composition scholarship of the 1980s and 1990s. Returning to this “critical” moment and emphasizing the rich thinking around the question of ethics provides fuller and more disciplinary-specific resources for …

Mediating Discovery Disputes: When "Meet And Confer" Alone Is Not Enough, Marian Riedy, Nancy Greenwald

Cardozo Journal of Conflict Resolution

It is universally agreed that mediation can be a very effective tool for resolving a civil lawsuit. For this reason, to save the parties' time and expense, and to conserve judicial resources, a large majority of jurisdictions require the parties to participate in mediation or another ADR technique before proceeding to trial. Mediation is not commonly employed, however, as a method of resolving discovery disputes. This article proposes that mediation, properly adjusted to account for the differences between the "endgame" and the discovery phase, can and should be used more widely as an efficient and cost-effective alternative to court orders …

Saving Mr. Banks And Other Interest-Based Negotiations, Michael Rogers

Cardozo Journal of Conflict Resolution

The goal of this article is to encourage the use of interestbased negotiations. Some of the stories included will be familiar; others will be fresh. In Getting to Yes, Fisher and Ury identify four principles of negotiation ("principled negotiation") that can be employed effectively in almost any type of dispute resolution: (1) Separate the people from the problem; (2) Focus on interests rather than positions; (3) Invent options for mutual gain; and (4) Insist on using objective criteria. Because focusing on interests is the second step identified in Getting to Yes, and inventing options for mutual gain is the …

Land Use Consultations Advancing Therapeutic Jurisprudence: Ripe For Clinical Trials, Michael N. Widener

Cardozo Journal of Conflict Resolution

This paper proposes educating law students in the processes of therapeutic justice through service as a neutral in land use controversies, and in the process, improving law student dispute resolution skills and enabling them to promote therapeutic outcomes.

Classwide Arbitration: A Method Of Resolving The "Natural" Food Label Litigations, Angelina Dalia

Cardozo Journal of Conflict Resolution

This Note discusses how classwide arbitration in food labeling disputes can better serve as a resolution method for both parties. Part I will review the current legal landscape surrounding food labeling litigations and the limitations of the FDA's regulatory and enforcement power. It will analyze how the lack of regulation has led to the recent surge in food labeling class actions. Part II will introduce the general benefits and downfalls of mandatory arbitration in comparison to litigation as a means of legal remedy. Furthermore, it will describe the recent trend of incorporating mandatory arbitration clauses and class action waivers in …

Oldowan Hominin Behavior And Ecology At Kanjera South, Kenya, Thomas W. Plummer, Laura C. Bishop

Publications and Research

The Early Stone Age archaeological record does not become persistent and widespread until approximately 2.0-1.7 million years ago, when Oldowan sites spread across Africa and ultimately into Eurasia. However, good records of hominin behavior from this important time interval are uncommon. Here we describe recent findings from the two million year old Oldowan site of Kanjera South, on the Homa Peninsula of southwestern Kenya. Kanjera South is the oldest Oldowan site with large assemblages of stone artifacts and well-preserved archaeological fauna. Our research indicates that hominin activities were situated in an open habitat within a grassland dominated ecosystem, the first …

Overlapping Signatures Of Chronic Pain In The Dna Methylation Landscape Of Prefrontal Cortex And Peripheral T Cells, Renaud Massart, Sergiy Dymov, Magali Millecamps, Matthew Suderman, Stephanie Gregoire, Kevin Koenigs, Sebastian Alvarado, Maral Tajerian, Laura S. Stone, Moshe Szyf

Publications and Research

We tested the hypothesis that epigenetic mechanisms in the brain and the immune system are associated with chronic pain. Genome-wide DNA methylation assessed in 9 months post nerve-injury (SNI) and Sham rats, in the prefrontal cortex (PFC) as well as in T cells revealed a vast difference in the DNA methylation landscape in the brain between the groups and a remarkable overlap (72%) between differentially methylated probes in T cells and prefrontal cortex. DNA methylation states in the PFC showed robust correlation with pain score of animals in several genes involved in pain. Finally, only 11 differentially methylated probes in …

Addressing Stress And Well-Being Among Women Of Arab Descent Living In The United States: Development Of A Training Workshop For Mental Health Professionals, Hoda Abou-Ziab

Theses and Dissertations

Due to the increasing number of persons of Arab descent living in the United States, estimated at over 3.5 million in 2012, there has been a recognized need for a deeper understanding of acculturative, gender, and immigration-related stressors that Arab American women face. In response to this need, a one-day workshop for mental health professionals interested in or currently working with women of Arab descent living in the United States was developed. The workshop focuses on increasing knowledge of the various types of stress (e.g., acculturation, discrimination, gender role strain, parent-child relationships, care giver, familial, cultural expectations, work, school, etc.) …

Modification Of The "Gold Standard"? Leadership Selection From An Attachment Lens: A Critical Analysis., Rebecca Pearlstein

Theses and Dissertations

The demands of corporate America are placing increased pressures on supervisors and executives to create and manage optimal organizational cultures. Relational capabilities and emotional intelligence have come to the fore as an essential component of effective and successful business leadership. When leaders are unable to create positive relationships with their working teams and navigate the day-to-day stressors of the workplace, the costs can be significant. In addition to losses in productivity, absenteeism, stress, burnout, and demoralization all take a heavy toll. From the perspective of attachment theory, the ability to connect with others, cope with stress, and engage in productive …

A Qualitative Study Of General Education Teachers' Perceptions Of Special Education Students' Attendance At Post-Secondary Education Institutions, Abraham B. De Villiers

Theses and Dissertations

This qualitative, phenomenological study will cross-sectionally examine the perceptions of general education teachers through in-person interviews to analyze their personal beliefs for special education students’ attendance at post-secondary education institutions. Data was collected from general education teachers working at different urban high schools in a Southern California charter management organization. Each of the interviewed teachers are currently responsible, or have been responsible, for the instruction of special education students in their classroom. A total of 6 general education teachers participated in semi-structured interviews that consisted of 10 open-ended questions. Three conclusions were extracted from the findings related to the data …

Critical Considerations On Interpersonal Impact For Next Generation Professional Services Leaders: A Case Study, John L. Evans Jr.

Theses and Dissertations

With all the discussion surrounding the significance of culture within the realms of professional services organizations, this researcher was curious as to how to improve the quality of a culture. A higher quality culture, evidenced by a more positively energized work force, serves to improve competitive advantage for a concern, in a commoditized world. The following qualitative case study, a thirty-five day intervention in the months of May and June, 2016, with nine participants, that happened at Think Creative, Inc., of Orlando, Florida, intends on shedding light on how and why professional services organizational leaders should consider instituting a regimen …

Stem-Themed Schools: A Case Study Of Its Effect On Student Educational Pathways, Monika R. Mcknight

Theses and Dissertations

As the country looks to increase the STEM workforce it is important to examine the effect of the programs in place, specifically the effect on the students choices in education. The Mathematics & Science Academy (MSA), is a STEM-themed, public magnet school in Southern California whose mission is to increase the nation’s pool of graduates in mathematics and science. It is 1 of the many schools and programs in place to increase the United States (U.S.) Science, Technology, Engineering, and Mathematics (STEM) workforce. This study, designed as a qualitative case study investigated how MSA has influenced female, African American students …

The Neuroscience Of Fear And Anxiety: A Primer For Clinicians, Lionel Lee

Theses and Dissertations

Over the last few decades, research in affective neuroscience has led to considerable insights into the biology of fear and anxiety. For those in the practice of psychotherapy, these advances hold the potential for explaining the evolutionary utility of these emotions and targeting psychotherapeutic interventions to neurobiological correlates when these emotions go awry. The conversation of neuroscience, however, has yet to find a comfortable place in the therapy room. Translational and conceptual disparities owing to the historical split between psychology and neuroscience, continue to present challenges to their integration. The present study seeks to reframe clinicians’ understanding of the biological …

Preliminary Report: A Survey Of Aggressive Behaviors In The American Coot (Fulica Americana) At Ballona Wetlands, California, Victor D. Carmona-Galindo, Mariele Anne Courtois, Kiara Cerda

Biology Faculty Works

Understanding interspecific and intraspecific aggression is important for wildlife management and sustainability of populations. The objective of this study was to evaluate whether there is a difference in number of occurrences of interspecific aggression between American coots (Fulica americana) and mallard ducks (Anas platyrhynchos) and intraspecific aggression among American coots in the Ballona wetland habitat of Southern California. Trends in literature describe coots as highly aggressive toward other coots year-round and toward other bird species during the breeding season. Because we conducted observations outside the breeding season, we hypothesized that more instances of intraspecific aggression would …