Digital Commons Network^™

Hsp27 Alleviates Cardiac Aging In Mice Via A Mechanism Involving Antioxidation And Mitophagy Activation, Shenglan Lin, Yana Wang, Xiaojin Zhang, Qiuyue Kong, Chuanfu Li, Yuehua Li, Zhengnian Ding, Li Liu

ETSU Faculty Works

Aging-induced cardiac dysfunction is a prominent feature of cardiac aging. Heat shock protein 27 (HSP27) protects cardiac function against ischemia or chemical challenge. We hypothesized that HSP27 attenuates cardiac aging. Transgenic (Tg) mice with cardiac-specific expression of the HSP27 gene and wild-type (WT) littermates were employed in the experiments. Echocardiography revealed a significant decline in the cardiac function of old WT mice compared with young WT mice. In striking contrast, the aging-induced impairment of cardiac function was attenuated in old Tg mice compared with old WT mice. Levels of cardiac aging markers were lower in old Tg mouse hearts than …

The Effect Of Long-Term Exercise On The Production Of Osteoclastogenic And Antiosteoclastogenic Cytokines By Peripheral Blood Mononuclear Cells And On Serum Markers Of Bone Metabolism, John K. Smith, Rhesa Dykes, David S. Chi

ETSU Faculty Works

Although it is recognized that the mechanical stresses associated with physical activity augment bone mineral density and improve bone quality, our understanding of how exercise modulates bone homeostasis at the molecular level is lacking. In a before and after trial involving 43 healthy adults, we measured the effect of six months of supervised exercise training on the spontaneous and phytohemagglutinin-induced production of osteoclastogenic cytokines (interleukin-1α, tumor necrosis factor-α), antiosteoclastogenic cytokines (transforming growth factor-β1 and interleukins 4 and 10), pleiotropic cytokines with variable effects on osteoclastogenesis (interferon-γ, interleukin-6), and T cell growth and differentiation factors (interleukins 2 and 12) by peripheral …

Breathless At The Point Of A Sword, Pooja Sethi, Zia Ur Rahman, Terry Forest, Timir Paul

ETSU Faculty Works

Context: Scimitar syndrome is a congenital anomaly of pulmonary venous return where right pulmonary artery drains into right side other heart, instead of the left side, causing pulmonary hypertension resulting in shortness of breath, recurrent lower respiratory tract infections, chest pain, and fatigue. Early diagnosis and surgical intervention would correct this congenital anomaly reducing morbidity and complications in otherwise healthy young patients. Case Report: We present a case of an 18-year-old female who presented with exertional shortness of breath, fatigue, and recurrent lower respiratory tract infections. She had unremarkable physical examination but chest x-ray showed an abnormal opacity next to …

Bottom-Up Ecology: An Agent-Based Model On The Interactions Between Competition And Predation, Istvan Karsai, Emil Montano, Thomas Schmickl

ETSU Faculty Works

Published by Informa UK Limited, trading as Taylor & Francis Group. We developed an agent-based computer model of an ecosystem to predict interactions of competition and predation. In our simulations of the model, the effects of the ‘Gause law’ emerged as the results of population fluctuations and a large number of stochastic events. Small biases in life history parameters produced strong effects through the interactions of positive feedback with the population fluctuations. In a low-production environment, the smaller and faster consumer outcompetes the larger and slower one, but in a high production environment the larger and slower consumer survives. Predation …

Assessing The Evolution Of Soil Moisture And Vegetation Conditions During The 2012 United States Flash Drought, Jason A. Otkin, Martha C. Anderson, Christopher R. Hain, Mark D. Svoboda, David K. Johnson, Richard Mueller, Tsegaye Tadesse, Brian D. Wardlow, Jesslyn Brown

National Drought Mitigation Center: Faculty Publications

This study examines the evolution of several model-based and satellite-derived drought metrics sensitive to soil moisture and vegetation conditions during the extreme flash drought event that impacted major agricultural areas across the central U.S. during 2012. Standardized anomalies from the remote sensing based Evaporative Stress Index (ESI) and Vegetation Drought Response Index (VegDRI) and soil moisture anomalies from the North American Land Data Assimilation System (NLDAS) are compared to the United States Drought Monitor (USDM), surface meteorological conditions, and crop and soil moisture data compiled by the National Agricultural Statistics Service (NASS).

Overall, the results show that rapid decreases in …

The Implications Of Climate Change For Nebraska: Summary Report Of Sector-Based Roundtable Discussions, Donald A. Wilhite, Kimberly Morrow

National Drought Mitigation Center: Faculty Publications

This report is the result of the work of many individuals that contributed to the success of the series of eight sector-based roundtable events that were held in September and October of 2015. First and foremost, we would like to thank the organizers and the organizations they represent for their leadership in bringing together a diverse set of key stakeholders to discuss the implications of climate change on their sector. It was such a pleasure to work with such a dedicated group of individuals. Second, we would like to thank the more than 350 people who participated in these discussions …

New Tools For Assessing Drought Conditions For Rangeland Management, Cody Knutson, Brian Fuchs

National Drought Mitigation Center: Faculty Publications

Historical drought assessment and ongoingmonitoring is essential for understanding past drought occurrence, the relationships between past drought and its impacts, and for triggering action during current drought events. • A variety of new products have recently been developed to better monitor drought conditions and assess past occurrences at the local scale. • A growing number of resources are available to assist rangeland managers to develop a monitoring system and incorporate it into a drought management plan.

Ab 159: Can It Really Hurt “To Try”?, Randy W. Tong

University of the Pacific Law Review

No abstract provided.

Work And The Legal Person In Thomas More's Utopia, Andreea D. Boboc

University of the Pacific Law Review

No abstract provided.

Perspectives On The United States Environmental Protection Agency's Clean Air Scientific Advisory Committee: A Survey Of State Air Agencies, Cassandra Yannelli

MPA/MPP/MPFM Capstone Projects

The U.S. Environmental Protection Agency’s (EPA) Clean Air Scientific Advisory Committee (CASAC) was created in 1977 under section 109 of the Clean Air Act (CAA). The role of CASAC is to provide technical and scientific advice to the EPA Administrator on National Ambient Air Quality Standards (NAAQS), required under the CAA. The standards themselves and the science upon which the standards are established for the six “criteria” pollutants included in the NAAQS are reviewed periodically by CASAC. The committee also exists to bridge new research developments to current environmental requirements.

Section 109(d) of the CAA requires the chartered CASAC to …

In The Light Of Evolution: Human Nature, Political Behavior, And Making Sense Of Our Social Identity, Corby F. Burger 16

Honor Scholar Theses

No abstract provided.

Land-Use Change Reduces Habitat Suitability For Supporting Managed Honey Bee Colonies In The Northern Great Plains, Clint R. V. Otto, Cali L. Roth, Benjamin L. Carlson, Matthew D. Smart

Department of Entomology: Faculty Publications

Human reliance on insect pollination services continues to increase even as pollinator populations exhibit global declines. Increased commodity crop prices and federal subsidies for biofuel crops, such as corn and soybeans, have contributed to rapid land-use change in the US Northern Great Plains (NGP), changes that may jeopardize habitat for honey bees in a part of the country that supports >40% of the US colony stock. We investigated changes in biofuel crop production and grassland land covers surrounding ~18,000 registered commercial apiaries in North and South Dakota from 2006 to 2014. We then developed habitat selection models to identify remotely …

The Influence Of Photoperiod On Development Rates Of Three Species Of Forensically Important Blow Flies, M. L. Fisher, Leon G. Higley, John E. Foster

Department of Entomology: Faculty Publications

Environmental factors, such as temperature and photoperiod can play important roles in insect development. Numerous studies have researched insects and their responses to photoperiod, but there has been little research to show if the duration of light alters development rates in blow flies. A review of previous literature revealed differences in the light regime (L:D) reported for the study. This study examined the effects of photoperiod on development rates of Phormia regina Meigen, Cochliomyia macellaria F., and Calliphora vicina Robineau-Desvoidy using four light regimes of 0, 12, 16, and 24 h of light measured at both 20C and 26C. Environmental …

Book Review: Sacred Groves And Local Gods: Religion And Environmentalism In South India, James Ponniah

Journal of Hindu-Christian Studies

Book Review of Sacred Groves and Local Gods: Religion and Environmentalism in South India. Eliza F.Kent. Oxford University Press, 2013. 236 pages.

Hsp90 Inhibition Suppresses Nf-Κb Transcriptional Activation Via Sirt-2 In Human Lung Microvascular Endothelial Cells, Gagan S. Thangjam, Charalampos Birmpas, Nektarios Barabutis, Betsy W. Gregory, Mary Ann Clemens, Joseph R. Newton, David Fulton, John D. Catravas

Bioelectrics Publications

The ability of anti-heat shock protein 90 (Hsp90) drugs to attenuate NF-κB-mediated transcription is the major basis for their anti-inflammatory properties. While the molecular mechanisms underlying this effect are not clear, they appear to be distinct in human endothelial cells. We now show for the first time that type 2 sirtuin (Sirt-2) histone deacetylase binds human NF-κB target gene promoter and prevents the recruitment of NF-κB proteins and subsequent assembly of RNA polymerase II complex in human lung microvascular endothelial cells. Hsp90 inhibitors stabilize the Sirt-2/promoter interaction and impose a “transcriptional block,” which is reversed by either inhibition or downregulation …

Goddesses Of Color: Interfaith Altars, Aimee H. Miller

Scripps Senior Theses

This paper explores the intertwined history of certain goddesses of the Middle East and the Americas. This history informs the original invented contemporary deities that my project centers around. Using recycled materials and collected objects, my project displays two religious altars, one from my heritage and one from my experience living in Brazil. One altar is based on afro-Brazilian sea goddesses, and one is a contemporary imagined interpretation of a Judeo-Christian female figure. The two altars together compose an installation that seeks to unify a pagan practice and two distinct monotheistic traditions while still honoring their separate parts. These parts …

Out Of Site, But Not Out Of Mind: The Conservation And Display Of Ancient Roman Floor Mosaics In Situ And In Museums, Erin M. Hoey

Scripps Senior Theses

This thesis explores the display of Roman floor mosaics in museums and in situ. Taking the original mosaic to museums for display and protection, and replacing them on site with replicas, is best for the preservation of the original material and its context.

The Philosophy Of Ecology In John Steinbeck's The Grapes Of Wrath, Stephanie A. Steinbrecher

Scripps Senior Theses

This thesis explores the possibilities for ecocritical study in fiction through John Steinbeck’s 1939 novel The Grapes of Wrath. Major ecocritical interpretation has yet to gain much traction in novels; by focusing on human nature, this form’s “anthropocentric” posture seems itself to be antithetical to ecocritical efforts, which aim to unseat humans as the center of the moral universe. However, by analyzing The Grapes of Wrath’s formal, narratorial, and thematic valences, I argue that principles of social justice concurrently imply environmental justice in the philosophical currents of the text. Tenets of deep ecology and Aldo Leopold’s “land ethic” …

Guarded Optimism, Cynical Fatalism: An Intertextual Analysis Of Selected Victorian Novels And Their Modernist Reinterpretations, Michelle L. Strickland

Master of Liberal Studies Theses

The Victorian and modern eras are known for being a time of great change. Victorian authors focused their works on the social, political, and religious upheaval that the country was experiencing during the period. They felt a strong sense of pride in their country, and there was always a sense of hope in their writing. These views are what draw the modern author to retell Victorian novels; yet, the modern writer removes the Victorian sense of hope and replaces it with the sense of the disillusionment which engulfed their era. In this paper, I examine the concept of intertextuality, the …

Early Childhood Ipad Use And Effects On Visual Spatial Attention Span, Maya Espiritu

Scripps Senior Theses

Despite the rising prevalence of mobile media in young children’s lives, little research exists that examines the effects of mobile media use on early childhood cognitive development. This study will explore how mobile media use, specifically iPad use, in early childhood affects development of visual spatial attention span. Researchers will recruit 160 participants, ages 3 to 6, and categorize them into three groups: TV viewers only, interactive iPad users, and passive iPad users. Children will complete a computer task to measure the length of their visual spatial attention span. Parents will report on the average daily amount of media use, …

Dark Humor And Suicide: Exploring Viewer Suicidality In "The Long Way", Sarah M. Rosen

Scripps Senior Theses

Death, dying, and the actual loss of life are some of the broadest sweeping concepts that typically evoke a wide array of emotions from sadness and anger to fear and despondence. It is unlikely that the first words associated with death are comedy, humor, or laughter. However, that is precisely what creators and comedians of dark, death, and gallows humor seek to achieve. For my senior capstone project, I have created a short fictional narrative film encompassing the traits of a dark comedy. However, noticing that few dark comedies delve into topics surrounding suicide, I wondered if it was possible …

The Ceramic Body: Concepts Of Violence, Nature, And Gender, Chrysanna R. Daley

Scripps Senior Theses

This thesis is an exploration of the connection between women and nature, specifically the violence that has been inflicted upon them both and how it is interrelated. I positioned my research within the field of Ecofeminism, which critiques the language we (as a Western culture) use to associate women with nature and vice-versa. Traditionally, women are more often associated with nature than men are, and the environment is personified as “Mother Nature”. I argue that uncritically gendering nature as “female” is problematic because of the associations we typically make between the two, and the expectations and values we assign to …

Understanding Postcolonial South Asian Communities Through Bollywood, Noor A. Asif

Scripps Senior Theses

Inspired by my personal experience as a South Asian-American, I chose to create a series of paintings that seek to analyze the relationship between South Asians and a Western environment. I was further influenced by Bollywood painted posters, which I argue encapsulate postcolonial aesthetics in the form of fair skin, colored eyes, and exoticism. Moreover, I believe that Bollywood has continued to disseminate these aesthetics to the South Asian collective community. Bollywood and its implicit fascination with the West, in addition to its inherently South Asian identity, embody the struggle that many South Asians face. This struggle, which I as …

Analyzing The Safety And Efficacy Of Fecal Microbiota Transplantations For Inflammatory Bowel Disease Using Clostridium Difficile Infection As A Reference, Cassie Chan

Scripps Senior Theses

Fecal microbiota transplantation (FMT) is the process by which fecal suspension from a healthy individual is transferred into the gastrointestinal tract of another individual in an attempt to cure certain diseases. This transplantation process has been accredited as being a potential remedy for a growing number of diseases that have been associated with gut microbial imbalances. Interest in FMT has largely been driven by the science community’s increasing interest in the gut microbiome and its role in potentially regulating a multitude of different functions and processes within the human body. One disease that has been found to respond exceptionally well …

Women Surrealists: Muses Or Seekers?, Noor A. Asif

Scripps Senior Theses

Surrealism has often been labeled as a misogynistic movement that sought to provide man with an avenue into a higher reality at the expense of the humanity of women. By perceiving the opposite sex as their muses, Surrealist men rendered women as mysterious sources of the marvelous, the name given to the higher realm, which they desired to attain. I propose that Surrealist women were empowered by the fact that ‘woman’, as an abstract concept, and femininity were synonymous with the marvelous. This entailed that Surrealist women had the advantage of being “sources of revelation, as provokers of wonder, dreams, …

The Connection And We Learned It From The Birds, Alexandra T. Copp

Scripps Senior Theses

The Connection is a story about a detective hired to find her client's one true connection in the world.

We Learned It From The Birds, follows the workday of two men as the control the birds population at JFK.

William Morris And Diego Rivera: The Pursuit Of Art For The People, Heidi S. Shugg

Master of Liberal Studies Theses

The purpose of this thesis is to draw parallels between the art and philosophy of William Morris (1834-1896) and Diego Rivera (1886-1957). Morris drew on his interest in gothic art and architecture, his love of Romantic literature, and his commitment to social reform, to articulate the aesthetic and social vision of the Arts and Crafts Movement in England. Examples of Morris’s writings and his handicraft in the form of wallpapers, books, furniture, and the Red House will be examined. Diego Rivera was a Mexican painter and socialist activist perhaps best known for his murals depicting the working class. Several of …

La Identidad Ecuatoriana A Través Del Humor De Miguel Antonio Chávez, Luis Enrique Yanez

All Graduate Theses, Dissertations, and Other Capstone Projects

This thesis project provides a close reading of the literary work of Ecuadorian author Miguel Antonio Chávez. The analysis in this work discuses how the author use humor to criticize the discourses that have been produced in order to represent indigenous and Afro-descendants in the country, as well as the fragility of social and political institutions such as the church, the state, and the country's educational system in the pieces La puta madre patria, La kriptonita del Sinaí, and El electroshock nuestro de cada día. This thesis analyses humor as a narrative tool with its function to reproduce and criticize …

Where Should These Books Go?, Haruko Yamauchi

Publications and Research

Designed for pre-college and first-year students new to conducting independent research, this is a lesson plan for an activity that is part of a workshop to strengthen students’ skills in using books for research. The activity includes small groups coming to consensus about a hypothetical shelf order for a set of books, and a larger class discussion about the Library of Congress call number system as a useful-to-know but ultimately arbitrary system created within a particular historical context. Chapter within the Assocation of College and Research Association’sCritical Library Pedagogy Handbook, vol. 2.

Public Perceptions Of Genetically Engineered Nutraceuticals, Kofi Britwum, Amalia Yiannaka

Cornhusker Economics

The 2016 World Food Prize was awarded in October to four scientists for their pioneering work on bio-fortification — a process of enhancing traditional foods with micronutrients, particularly vitamins and minerals, through conventional selective breeding or genetic engineering. Three of the laureates who work in African countries bred and championed the orangefleshed sweet potatoes1. Although not native to the African continent, the orange-fleshed sweet potato is enhanced with beta-carotene to boost vitamin A content and combat vitamin A deficiency, a health challenge in many developing countries.