Digital Commons Network^™

“A Right Judgment”: Rape Trial Conventions Revisited In Joseph Andrews And Tom Jones, Melissa Bloom Bissonette

English Faculty/Staff Publications

This article argues that in both Joseph Andrews (1742) and Tom Jones (1749), Henry Fielding, who practiced law and wrote novels when both were undergoing significant transformations, takes what could have been archetypal scenes of rape and rescue and makes them illuminating explorations of how juries determine the truth. In presenting these attempted rape scenes within the implicit format of a contemporary rape trial, Fielding directs the reader to observe the missteps in the process of judicial decision-making, as well as the steps and missteps in his or her own determination of the trustworthiness of characters and their testimony.

Intranasal Oxytocin Enhances Connectivity In The Neural Circuitry Supporting Social Motivation And Social Perception In Children With Autism., Ilanit Gordon, Allison Jack, Charlotte M Pretzsch, Brent Vander Wyk, James F Leckman, Ruth Feldman, Kevin A. Pelphrey

Pharmacology and Physiology Faculty Publications

Oxytocin (OT) has become a focus in investigations of autism spectrum disorder (ASD). The social deficits that characterize ASD may relate to reduced connectivity between brain sites on the mesolimbic reward pathway (nucleus accumbens; amygdala) that receive OT projections and contribute to social motivation, and cortical sites involved in social perception. Using functional magnetic resonance imaging and a randomized, double blind, placebo-controlled crossover design, we show that OT administration in ASD increases activity in brain regions important for perceiving social-emotional information. Further, OT enhances connectivity between nodes of the brain's reward and socioemotional processing systems, and does so preferentially for …

V-Src Oncogene Induces Trop2 Proteolytic Activation Via Cyclin D1., Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C. Casimiro, Gabriele Disante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Andò, Alessandro Fatatis, Michael P. Lisanti, Leonard G. Gomella, Lucia R. Languino, Richard G. Pestell

Department of Cancer Biology Faculty Papers

Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment of Src tyrosine kinase activity in approximately 90% of patients. Src is known to induce cyclin D1, and a cyclin D1-regulated gene expression module predicts poor outcome in human prostate cancer. The tumor-associated calcium signal transducer 2 (TACSTD2/Trop2/M1S1) is enriched in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a γ-secretase cleavage complex (PS1, PS2) and TACE (ADAM17), which releases the Trop2 intracellular domain (Trop2 ICD). Herein, v-Src transformation of primary murine prostate epithelial cells increased the proportion of prostate cancer stem cells as characterized by gene expression, …

The Emergence Of Contemporary Bestiality Law: Applying The Integrative Conflict Model To The Enumclaw Case, Jason S. Ulsperger, Kristen L. Ulsperger, Cole Smith

Qualitative Criminology (QC)

"This article examines the social construction of bestiality law in the United States using the Integrative Conflict Model of law formation. With qualitative findings from a media content study including newspaper articles, a documentary transcript, and a variety of online data sources, it explores the dynamics behind the formation of bestiality law in the state of Washington. The research specifically uses the circumstances surrounding the death of Kenneth Pinyan, and the subsequent Enumclaw horse sex scandal that took place in the summer of 2005, to support the idea that bestiality law can emerge due to specific factors: structural foundations, perceptions …

Lois Presser And Sveinung Sandberg (Eds), Narrative Criminology: Understanding Stories Of Crime, Adam Veitch

Qualitative Criminology (QC)

"Over the last two decades there has been an epistemological push in the social sciences to bring narrative into the methodological fold. Narrative social science is steeped in theories of humans as story tellers. The foreword to Narrative Criminology argues that this theoretical line of thought originates in Jean-Paul Sartre’s belief that people are fundamentally storytelling creatures, or “homo narrativus.” The guiding thought here is that stories are central to understanding how and why we act in society. We are all storytellers, and we enjoy sharing tales with an audience. Furthermore, the way that we construct stories of our social …

Daily Eastern News: November 15, 2016, Eastern Illinois University

November

No abstract provided.

Quantitative Proteomic Profiling Reveals Hepatic Lipogenesis And Liver X Receptor Activation In The Pander Transgenic Model., Mark G. Athanason, Whitney A. Ratliff, Dale Chaput, Catherine B. Marelia, Melanie N. Kuehl, Stanley M. Stevens Jr., Brant R. Burkhardt

Molecular Biosciences Faculty Publications

PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. Our PANDER transgenic (PANTG) mouse displays a selective hepatic insulin resistant (SHIR) phenotype whereby insulin signaling is blunted yet lipogenesis is increased, a phenomena observed in type 2 diabetes. To examine the complex PANDER-induced mechanism of SHIR, we utilized quantitative mass spectrometry-based proteomic analysis using Stable Isotope Labeling by Amino Acids in Cell …

Learning And Memory Abnormalities In Mice Deficient In The Rna-Binding Protein Ksrp, Sarah L. Olguin

Biomedical Sciences ETDs

Post-transcriptional regulation plays a critical role in the function and development of the nervous system; especially in the control of specific subsets of mRNAs localized to dendrites and axons. One such regulatory mechanism is the stabilization or disruption of mRNA through association of RNA binding proteins (RBPs) such as the KH-type splicing regulatory protein (KSRP). We have previously shown that loss of KSRP results in dysregulation of GAP-43 and increased growth of hippocampal neurons in vitro. Therefore, KSRP-/- and KSRP+/- animals were subjected to a battery of behavioral tests including Novel Object Recognition and Trace Fear Conditioning to assess hippocampal …

Proteasome Inhibitors, Kyung Bo Kim, Venod Kasam, Wooin Lee, Dong-Eun Kim, Zachary Miller, Chang-Guo Zhan, Do-Min Lee

Pharmaceutical Sciences Faculty Patents

To see this patent's abstract, please download it.

The Molecular Systematics And Phylogeography Of The Widespread North American Meadow Vole (Microtus Pennsylvanicus), Donavan J. Jackson

Biology ETDs

The climatic and environmental fluctuations of the Quaternary played an integral role in geographic distribution and genetic structure within many organisms today. Understanding how these historical biogeographic events may have partitioned genetic variation throughout the landscape is critical to forecasting the implications of modern climate change and how animals will respond to projected climate shifts. Through geographic and taxonomically comprehensive sampling, we used multi-locus and species delimitation analyses along with niche modeling methods to investigate the evolutionary and biogeographic history of the meadow vole, Microtus pennsylvanicus. The findings of this study highlight the vulnerability and importance that special consideration …

Volume 90, Issue 6 (2016)

Obiter Dicta

No abstract provided.

Stressed Out And Vulnerable, Larry Clow

UNH Today Archive

No abstract provided.

White Slavery In The Northwoods: Early U.S. Anti–Sex Trafficking And Its Continuing Relevance To Trafficking Reform, Bonnie Shucha

William & Mary Journal of Race, Gender, and Social Justice

No abstract provided.

Performance Of Gender Social Status: Social Identity Through Clothes, Fanny M. Hamon

Foreign Languages & Literatures ETDs

I focus on the study of the role of the ball gowns in fairy tales, and I argue that Donkey Skin and Cinderella’s civilization process happens through their clothes. I demonstrate that the garments bear considerable historic values in the narratives. The performance they put in place is allowed by the wealth of their dresses.
I apply Butler’s performance theory to show that the performance of the two heroines is the inherent necessity to their social ascent and social recognition. For both heroines, the performance is a strategy to overcome the punitive aspects they underwent in their animal state. The …

The Sun Star Vol 70 No 12 ( November 15th, 2016), N/A N/A

Sun Star

No abstract provided.

Putting The Illegal Wildlife Trade In The Crosshairs: How The Global Conservation Crisis Demonstrates The Need For Lacey Act Enforcement Of Foreign Laws, Jonathan Gonzalez

William & Mary Environmental Law and Policy Review

No abstract provided.

Creative Capitalism And Human Trafficking: A Business Approach To Eliminate Forced Labor And Human Trafficking From Global Supply Chains, Dana Raigrodski

William & Mary Business Law Review

A great amount of revenue generated by businesses in the global economy can be linked to the trafficking and enslavement of human beings. Yet, the current discourse on human trafficking fails to recognize the magnitude of benefit consumers, businesses, and economies gain from the work of forced and trafficked labor. Moreover, the limited efforts that seek to address this situation have focused on ways to encourage businesses to voluntarily adopt more socially responsible practices. These measures have had only limited success, and are generally believed to be in tension with the for-profit purposes of businesses. Hence, the task of convincing …

Quantitative And Qualitative Nutritional Analysis Of Gvsu Managed Honey Bee Colonies, Emily Noordyke, Anne Marie Fauvel

Student Summer Scholars Manuscripts

Managed honeybee colonies are in significant decline worldwide. The interaction between poor nutrition, pests and diseases, and pesticide use are most cited as potential culprits for the precarious state of the beekeeping industry. By evaluating food coming into the hive, conclusions can be drawn about the quality of hive location and forage availability. Pollen from an apiary with historically low honey production and poor colony health was compared to pollen from an apiary with high honey production and good colony health. Pollen was collected weekly in a 24-hour period, hive weight was monitored, and colonies were assessed for overall growth …

The Zircon, November 15, 2016 [Spoof Issue], Dordt College

Dordt Diamond

No abstract provided.

Trans/Formations: A Photovoice Assessment Of Transgender People’S Wellness, E. Ricky Hill

Communication ETDs

The purpose of this study is to identify and understand ways transgender and gender non-conforming people living in Albuquerque, New Mexico are communicating about and understanding their health and wellness needs and the health and wellness needs of their community. Partnering with the Transgender Resource Center of New Mexico, I used a community-based participatory approach to work on a Photovoice project that identified health and wellness related needs as defined by the community. Emergent themes identified by the participants highlighted various challenges and strengths to health and wellness for transgender and gender non-conforming people. I identify five core cultural premises …

Computational Models Of Auditory Scene Analysis: A Review, Bt Szabó, Sl Denham, I Winkler

School of Psychology

Auditory scene analysis (ASA) refers to the process (es) of parsing the complex acoustic input into auditory perceptual objects representing either physical sources or temporal sound patterns, such as melodies, which contributed to the sound waves reaching the ears. A number of new computational models accounting for some of the perceptual phenomena of ASA have been published recently. Here we provide a theoretically motivated review of these computational models, aiming to relate their guiding principles to the central issues of the theoretical framework of ASA. Specifically, we ask how they achieve the grouping and separation of sound elements and whether …

The Use Of Hydroxyethyl Starch 200/0,5 As Plasma Subtitutes Is Safe In Hypovolemic Patients As Indicated In Changes Of N-Acetyl-ρ¢-Glucosaminidase And Creatinin Serum Parameters, Dewi Wara Shinta, Junaidi Khotib, Eddy Rahardjo, Mahardian Rahmadi, Budi Suprapti

Folia Medica Indonesiana

Hydroxyethyl Starch (HES) is a compound that improves intravascular volume effectively and rapidly without causing tissue edema. However, HES also has renal safety profile which is still being debated. Based on clinical experience in Dr. Soetomo Hospital, the frequency of acute renal failure following HES 200/0.5 administration at a dose of less than 20 ml/kg (maximum dose) is very rare. The purpose of this study was to evaluate the effect of HES 200/0.5 at a dose of less than 20 ml/kg in patients undergoing surgery. N-acetyl-b-D-Glucosaminidase (NAG) per urine creatinine ratio and creatinine serum were used as main parameter to …

Injected Citicoline Improves Impairment And Disability During Acute Phase Treatment In Ischemic Stroke Patients, Rino Wahyudi, Didik Hasmono, Ruhaya Fitrina, Khairil Armal

Folia Medica Indonesiana

Treatment strategy of ischemic stroke is to reduce the extent of the damage and rescue neurons from death in the early days of ischemic events. Recombinant Tissue-Plasminogen Activator (r-TPA) is the only recommended therapy, but their use is very limited. Citicoline is a neuroprotectant with a therapeutic effect on several stages of the ischemic cascade. However, its use is still being debated. The purpose of this study was to analyze the use of supplementation citicoline injection in patients with acute ischemic stroke in relations to differences in changes in the level of interference (impairment), rate limitation (disability) and the level …

Papaya Seed Extract Lowers Sperm Concentrations, Motility And Viability In Male Mice, Reryd Arindany Wiryawan, Reny I'Tishom, Sri Purwaningsih

Folia Medica Indonesiana

Indonesia is a developing country with a dense population, so the government carry on KB (Family Planning) program in which the targets are mostly women. Contraceptives are intended for women are birth control pills and IUD (Intra Uterine Device), whereas until now the contraceptive for men who are considered well-established are condom and vasectomy. Thus, the development of herbal medicine, which is cheap and affordable, makes it possible to be consumed in a long term with less meaningful side effects. Papaya seeds (Carica papaya) is one of the many plants used by communities to eradicate intestinal worms, menstrual laxative, and …

Toxic Effect Of Lead Chloride On Antioxidant Enzyme In The Liver And Kidney Of Fish, Bakhtawar Raza, Muhammad Javed, Faiza Ambreen, Fariha Latif

Journal of Bioresource Management

The contamination of aquatic habitats has become a serious problem for sustainability of the fisheries sector in Pakistan. Among different pollutants, heavy metals are very toxic. Their toxicity can be assessed by using antioxidant enzymes as biomarkers. These enzymes protect the living organisms from the oxidative stress caused by the heavy metals. Therefore, the effect of lead chloride (PbCl2) on the peroxidase enzyme activity in the tissues (liver and kidney) of Cirrhinamrigala was investigated. Four groups of Cirrhinamrigala were exposed, separately, to 96-hr LC50 concentration of PbCl2 along with its sub-lethal concentrations, viz.2/3rd, 1/4th and 1/5th for a period of …

Theory And Practice Of Computing With Excitable Dynamics, Alireza Goudarzi

Computer Science ETDs

Reservoir computing (RC) is a promising paradigm for time series processing. In this paradigm, the desired output is computed by combining measurements of an excitable system that responds to time-dependent exogenous stimuli. The excitable system is called a reservoir and measurements of its state are combined using a readout layer to produce a target output. The power of RC is attributed to an emergent short-term memory in dynamical systems and has been analyzed mathematically for both linear and nonlinear dynamical systems. The theory of RC treats only the macroscopic properties of the reservoir, without reference to the underlying medium it …

The Eastern Echo, November 15, 2016, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Investigation Of Self-Organizing Traffic Signal Control With Graphical Signal Performance Measures, Christopher M. Day, Darcy M. Bullock

Lyles School of Civil Engineering Faculty Publications

Adaptive signal control is the subject of an increasing amount of research, as well as development and implementation. Most existing adaptive control systems achieve coordination by applying system control as a constraining layer on top of local control. Some researchers have suggested that, with the right local-control logic, coordination might be achieved as an dynamically emergent phenomenon without the need for a management layer. This paper explores the potential of a self-organizing signal control algorithm using a variety of performance measures. First, the initially reported algorithm performance is reproduced in an idealized environment; next, the algorithm is applied in a …

South Sudan : A New History For A New Nation, Douglas H. Johnson

Ohio University Press Open Access Books

Africa’s newest nation has a long history. Often considered remote and isolated from the rest of Africa, and usually associated with the violence of slavery and civil war, South Sudan has been an arena for a complex mixing of peoples, languages, and beliefs. The nation’s diversity is both its strength and a challenge as its people attempt to overcome the legacy of decades of war to build a new economic, political, and national future.

Most recent studies of South Sudan’s history have a foreshortened sense of the past, focusing on current political issues, the recently ended civil war, or the …

The Prospector, November 15, 2016, Utep Student Publications

The Prospector

Headline: Bringing the World to the Border