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Requiems, Reports, Resurrections: Archives And The Alchemy Of Historical Inquiry, Tayana L. Hardin, Paul M. Farber, Grace L. Sanders-Johnson

Reconstruction: Studies in Contemporary Culture

[First paragraph]

Writing at the "limit of the unspeakable and the unknown" in her 2008 article "Venus in Two Acts," literary critic Saidiya Hartman demonstrates how the "scandal and excess" of literature productively disrupts and unfailingly reifies the status of the archive as the exemplar of historical knowledge. [1] For Hartman, the facts and fictions of history bear traces of power and violence that are evident in what can and cannot be said about historical subjects like Venus, "the emblematic figure of the enslaved woman in the Atlantic world." Despite her ubiquity in "the archive of Atlantic slavery," Venus nonetheless …

Worldwide Cutaneous Malignant Melanoma Incidences Analyzed By Sex, Age, And Skin Type Over Time (1955–2007): Is Hpv Infection Of Androgenic Hair Follicular Melanocytes A Risk Factor For Developing Melanoma Exclusively In People Of European-Ancestry?, Stephen Merrill, Madhan Subramanian, Dianne E. Godar

Mathematics, Statistics and Computer Science Faculty Research and Publications

The cutaneous malignant melanoma (CMM) incidence has been increasing in an exponential manner in certain populations around the world for over 7 decades. To help illuminate the etiology, we performed worldwide temporal (1955–2007) CMM incidence analysis by sex, age (0–14, 15–29, 30–49, 50–69, 70–85+), and skin type on 6 continents using data from the International Agency for Research on Cancer. We observe an exponential increase in the CMM incidence over time and an increase of about 2 orders of magnitude between age groups 0–14 and 15–29 exclusively in European-ancestry populations around the world independent of skin type (I–III or III–IV). …

The Relationship Of Chlamydia Antigen, Ad-Like Pathology, And Inflammation In The Brains Of Intranasally Infected Balb/C Mice, Brittany L. Kane

PCOM Biomedical Studies Student Scholarship

Alzheimer's' Disease (AD) is a progressive neurodegenerative disease that affects millions of elderly individuals in the western world. There are two forms of AD, sporadic late-onset AD and Familial AD. The neuropathy seen in both cases of AD is the same; neurofibrillary tangles (NFTs) that are composed of modified tau protein, and neuritic senile plaques (NSPs) composed of deposited beta amyloid peptide. The objective of this study is to continue to investigate the role of infection as a possible risk factor for sporadic AD. Previous mouse models using Chlamydia pneumoniae demonstrated that intranasal inoculation with this organism induced AD-like pathology …

Fatty Acid Profile In Ruminal Content And Blood Plasma Of Finishing Beef Cattle, Supplemented With Different Sources Of Fat, Amanda Pesqueira

Theses and Dissertations--Animal and Food Sciences

Eight steers were used in a replicated 4 x 4 Latin square design experiment to study the rumen metabolism of polyunsaturated fatty acids. The animals were fed a concentrate diet based on cracked corn grain, corn silage and hay fescue (K31). The dietary fat treatments were a negative control, tallow added at 60g/day, fish oil at 60g/day and heterotrophically grown microalgae high in DHA at 100g/day. Treatments were incorporated immediately prior to feeding each day and dosed through a ruminal fistula mixed with 0.45kg of the diet. Animals were fed at 1.75 x NEm once daily during adaptation then switched …

Towards Determination Of The Threonine Requirement Of Yearling Horses Fed Varying Dietary Compositions Using The Indicator Amino Acid Oxidation Method, Kelsey M. Smith

Theses and Dissertations--Animal and Food Sciences

The amino acid requirements of growing horses are currently unknown, and studies suggest that threonine is a limiting amino acid in common horse diets. Thus, the objective of this study was to determine the threonine requirement of growing horses fed two different forage to concentrate ratios using the indicator amino acid oxidation method. The study consisted of a high concentrate phase (HC; 60% concentrate and 40% forage) and a high forage phase (HF; 25% concentrate and 75% forage). Within each phase, 6 female yearling Thoroughbred horses were randomly assigned each of 6 dietary treatments in a 6 x 6 Latin …

Effects Of Dietary Amino Acid Supplementation On Measures Of Whole-Body And Muscle Protein Metabolism In Aged Horses, Christine M. Latham

Theses and Dissertations--Animal and Food Sciences

Sarcopenia is a condition that is most common in aged animals, and is characterized by the loss of skeletal muscle mass and integrity, and can lead to physical disability and poor quality of life. Since skeletal muscle protein synthesis can be limited by the availability of amino acids, supplementation of limiting amino acids to ameliorate the progression of sarcopenia has become a topic of interest in companion animal research. Although there is some data to support the idea that amino acid supplementation improves maintenance of muscle mass in aged horses, the cellular mechanisms behind that improvement have yet to be …

Relationships Between Behavioral Measures And Productivity In Finishing Beef Cattle, Jasmyn Mimiko

Theses and Dissertations--Animal and Food Sciences

The relationship between measures of temperament, growth performance, and social hierarchy in finishing beef cattle were explored in two experiments. In experiment 1, high OCS (objective chute score) steers had periods of significantly higher ADG (P < 0.01), but OCS had no relationship with dominance ranking (P > 0.47). Conversely, slow exit velocity (EV) correlated with higher ranking (P ≤ 0.06), but EV had no relationship with performance (P > 0.37) in a competitive environment. Rank showed no relationship with performance (P > .58). In experiment 2, steers with fast EV had periods of decreased growth (P ≤ .06), intake (P ≤ .06), and gain:feed (G:F; P = 0.02). There were no interactions between …

Specialty Poultry Production: Impact Of Genotype, Feed Strategies, Alternative Feedstuffs, And Dietary Enzymes On The Growth Performance And Carcass Characteristics Of Heritage Breed Chickens, Tatijana Fisher

Theses and Dissertations--Animal and Food Sciences

There is a growing market for specialty poultry production using alternative genotypes and management systems. However, producers interested in specialty poultry production face several challenges. One challenge is that little published data exists regarding the growth and production parameters for alternative genotypes like slow-growing meat strains and heritage breeds. To address this challenge, research at the University of Kentucky examined the effect of feed strategies, alternative feedstuffs, and dietary enzymes on the growth and performance of heritage breeds of chicken used for either egg- or meat-production. The first trial documented the growth and nutrient intake of pullets from three heritage …

Influence Of Shear Stress Magnitude And Direction On Atherosclerotic Plaque Composition, Ryan M. Pedrigi, Vikram V. Mehta, Sandra M. Bovens, Zahra Mohri, Christian Bo Poulsen, Willy Gsell, Jordi L. Tremoleda, Leila Towhidi, Ranil De Silva, Enrico Petretto, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

The precise flow characteristics that promote different atherosclerotic plaque types remain unclear. We previously developed a blood flow-modifying cuff for ApoE^−/− mice that induces the development of advanced plaques with vulnerable and stable features upstream and downstream of the cuff, respectively. Herein, we sought to test the hypothesis that changes in flow magnitude promote formation of the upstream (vulnerable) plaque, whereas altered flow direction is important for development of the downstream (stable) plaque. We instrumented ApoE^−/− mice (n=7) with a cuff around the left carotid artery and imaged them with micro-CT (39.6 μm resolution) eight to nine weeks …

Mathematics Anxiety In Society: A Real Phenomena And A Real Solution, Joseph M. Furner, Carol A. Marinas

Transformations

While math anxiety still remains a real issue affecting student performance and confidence, today it is even more critical with the greater emphasis on producing more students for careers in STEM fields. In an effort to understand ways to ease math anxiety and encourage adaptive achievement behaviors to deal with such anxiety, this paper will explore the topic and provide research-based practices in providing a solution to this existing problem in our schools. There are many studies that show using technology in the teaching of mathematics will help to alleviate math anxiety and encourage students to enjoy learning mathematics. GeoGebra, …

Winter 2016, Transformations

Transformations

No abstract provided.

The Ncaa 'Doth Protest Too Much, Methinks' About Dfs, Walter T. Champion

Cardozo Public Law, Policy & Ethics Journal

No abstract provided.

Reconsidering Virtue, John M. Duffy

The Journal of the Assembly for Expanded Perspectives on Learning

Re-appropriating the Aristotelian concept of virtue in composition classes could become the means of transforming the polarized state of public discourse in America.

Jaepl, Vol. 21, Winter 2015-2016, Joonna Smitherman Trapp, Brad Peters

The Journal of the Assembly for Expanded Perspectives on Learning

Essays

Fond Farewells: Judy Halden-Sullivan and Helen Walker

SPECIAL SECTION: RHETORIC AND ETHICS

John M. Duffy - Reconsidering Virtue

Lois Agnew - Why Rhetoric and Ethics? Revisiting History/Revising Pedagogy

Paula Mathieu - Being There: Mindfulness as Ethical Classroom Practice

Scott Wagar - Composition as a Spiritual Discipline

Erec Smith - Buddhism’s Pedagogical Contribution to Mindfulness

Peter H. Khost - “Alas, Not Yours to Have”: Problems with Audience in High-Stakes Writing Tests and the Promise of Felt Sense

TEACHING AND LEARNING

Sheri Rysdam & Lisa Johnson-Shull - Introducing Feedforward: Renaming and Reframing Our Repertoire for Written Response

Mark Noe - Autoethnography …

Buddhism’S Pedagogical Contribution To Mindfulness, Erec S. Smith

The Journal of the Assembly for Expanded Perspectives on Learning

Considering the rhetorical elements in the Buddhist text “The True Aspect of All Phenomena” opens the possibility of teaching students a more mindful approach to writing.

Composition As A Spiritual Discipline, Scott Wagar

The Journal of the Assembly for Expanded Perspectives on Learning

Analyzing a widely-read history of composition yields clear elements associated with the contemporary definition of spirituality.

Book Reviews, Julie Nichols, Peter Fields, Walter L. Reid, Jeffrey H. Taylor, Warren Hatch

The Journal of the Assembly for Expanded Perspectives on Learning

Julie Nichols - Reading Ethically

Peter Fields - Gregory Marshall. Shaped by Stories: The Ethical Power of Narratives. Notre Dame, IN: U of Notre Dame P., 2009

Walter L. Reed - Gregory, Marshall. Teaching Excellence in Higher Education, ed. Melissa Valiska Gregory. NY: Palgrave Macmillan, 2013

Jeffrey H. Taylor - Musgrove, Laurence. Local Bird. Beaumont, TX: Lamar U Press, 2015

Warren Hatch - Lynch, Tom, Cheryll Glotfelty, Karla Armbruster. The Bioregional Imagination—Literature, Ecology, and Place. Athens, GA: U of GA Press, 2012

Winter 2016 - Hips Newsletter, Department Of History And Political Science

Department of History and Political Science Newsletter

No abstract provided.

Winter 2016, Department Of Conflict Analysis And Resolution

DCRS on the Move

No abstract provided.

Impaired Social Behavior In Mice With Tyrosinemia Type 1 Is Associated With Hypermyelination Of The Cerebral Cortex, Marissa E. Moore

Summer Community of Scholars Posters (RCEU and HCR Combined Programs)

No abstract provided.

The Mare Model To Study The Effects Of Ovarian Dynamics On Preantral Follicle Features., Kele A Alves, Benner G Alves, Gustavo D A Gastal, Saulo G S De Tarso, Melba O Gastal, José R Figueiredo, Maria L Gambarini, Eduardo L Gastal

Peer-reviewed Articles

Ovarian tissue collected by biopsy procedures allows the performance of many studies with clinical applications in the field of female fertility preservation. The aim of the present study was to investigate the influence of reproductive phase (anestrous vs. diestrous) and ovarian structures (antral follicles and corpus luteum) on the quality, class distribution, number, and density of preantral follicles, and stromal cell density. Ovarian fragments were harvested by biopsy pick-up procedures from mares and submitted to histological analysis. The mean preantral follicle and ovarian stromal cell densities were greater in the diestrous phase and a positive correlation of stromal cell density …

Delayed Valuation: A Reanalysis Of Goal Features, “Upwards” Complementizer Agreement, And The Mechanics Of Case, Vicki Carstens

Articles

There are at least four opposing views on the directionality and configuration of Agree relations. In mainstream Minimalism, Agree is strictly downward “probing” (Chomsky 2000, 2001, Boskovic 2007, Epstein & Seely 2006), but some recent works argue instead that Agree always looks upwards (Zeijlstra 2012; Wurmbrand 2012). A third perspective takes agreement to follow from the Spec, head configuration (Koopman 2006; and see Chomsky’s 2013 labeling through shared prominent features), and under a fourth proposal, the directionality of Agree varies parametrically (Baker 2008). While each of these approaches has some empirical support, none achieves the strict conceptual necessity that is …

Accumulation Of Zinc, Copper, Or Cerium In Carrot (Daucus Carota) Exposed To Metal Oxide Nanoparticles And Metal Ions, Stephen Ebbs, Scott Jared Bradfield, Pawan Kumar, Jason White, Craig Musante, Xingmao Ma

Publications

The release of engineered nanoparticles (ENPs) into the environment has raised concerns about the potential risks to food safety and human health. There is a particular need to determine the extent of ENP uptake into plant foods. Belowground vegetables growing in direct contact with the growth substrate are likely accumulate the highest concentration of ENPs. Carrot (Daucus carota) was grown in sand amended with ZnO, CuO, or CeO₂ NPs or the same concentrations of Zn²⁺, Cu²⁺, or Ce⁴⁺. Treatment with ZnO or Zn²⁺ produced a concentration-dependent decrease in root and …

Whole Mount Dissection And Immunofluorescence Of The Adult Mouse Cochlea., Scott C Montgomery, Brandon C Cox

Articles

The organ of Corti, housed in the cochlea of the inner ear, contains mechanosensory hair cells and surrounding supporting cells which are organized in a spiral shape and have a tonotopic gradient for sound detection. The mouse cochlea is approximately 6 mm long and often divided into three turns (apex, middle, and base) for analysis. To investigate cell loss, cell division, or mosaic gene expression, the whole mount or surface preparation of the cochlea is useful. This dissection method allows visualization of all cells within the organ of Corti when combined with immunostaining and confocal microscopy to image cells at …

Structure And Function Relationships Of Proteins Based On Polar Profile: A Review, Carlos Polanco, Thomas Buhse, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Proteins in the post-genome era impose diverse research challenges, the main are the understanding of their structure-function mechanism, and the growing need for new pharmaceutical drugs, particularly antibiotics that help clinicians treat the ever- increasing number of Multidrug-Resistant Organisms (MDROs). Although, there is a wide range of mathematical-computational algorithms to satisfy the demand, among them the Quantitative Structure-Activity Relationship algorithms that have shown better performance using a characteristic training data of the property searched; their performance has stagnated regardless of the number of metrics they evaluate and their complexity. This article reviews the characteristics of these metrics, and the need …

Cross-Cultural Challenges, Consensus, And Opportunities For Advancing The Professional Ethical Integrity Of Legal System Actors, Rory K. Little

UC Law SF International Law Review

No abstract provided.

Detection Of Productively Rearranged Tcr-Α V–J Sequences In Tcga Exome Files: Implications For Tumor Immunoscoring And Recovery Of Antitumor T-Cells, Thomas R. Gill, Mohammad D. Samy, Shanitra N. Butler, James A. Mauro, Wade J. Sexton, George Blanck

Molecular Medicine Faculty Publications

Tumor immunoscoring is rapidly becoming a universal parameter of prognosis, and T-cells isolated from tumor masses are used for ex vivo amplification and readministration to patients to facilitate an antitumor immune response. We recently exploited the cancer genome atlas (TCGA) RNASeq data to assess T-cell receptor (TcR) expression and, in particular, discovered strong correlations between major histocompatibility class II (MHCII) and TcR-α constant region expression levels. In this article, we describe the results of searching TCGA exome files for TcR-α V-regions, followed by searching the V-region datasets for TcR-α-J regions. Both primary and metastatic breast cancer sample files contained recombined …

A Widely Employed Germ Cell Marker Is An Ancient Disordered Protein With Reproductive Functions In Diverse Eukaryotes, Michelle A. Carmell, Gregoriy A. Dokshin, Helen Skaletsky, Yueh-Chiang Hu, Josien C. Van Wolfswinkel, Kyomi J. Igarashi, Daniel W. Bellott, Michael Nefedov, Peter W. Reddien, George C. Enders, Vladimir N. Uversky, Craig C. Mello, David C. Page

Molecular Medicine Faculty Publications

The advent of sexual reproduction and the evolution of a dedicated germline in multicellular organisms are critical landmarks in eukaryotic evolution. We report an ancient family of GCNA (germ cell nuclear antigen) proteins that arose in the earliest eukaryotes, and feature a rapidly evolving intrinsically disordered region (IDR). Phylogenetic analysis reveals that GCNA proteins emerged before the major eukaryotic lineages diverged; GCNA predates the origin of a dedicated germline by a billion years. Gcna gene expression is enriched in reproductive cells across eukarya – either just prior to or during meiosis in single-celled eukaryotes, and in stem cells and germ …

Two Isoforms Of Yersinia Pestis Plasminogen Activator Pla: Intraspecies Distribution, Intrinsic Disorder Propensity, And Contribution To Virulence, Svetlana V. Dentovskaya, Mikhail E. Platonov, Tat’Yana E. Svetoch, Pavel Kh. Kopylov, Tat’Yana I. Kombarova, Sergey A. Ivanov, Rima Z. Shaikhutdinova, Lyubov’ V. Kolombet, Sadhana Chauhan, Vitaly G. Ablamunits, Vladimir L. Motin, Vladimir N. Uversky, Andrey P. Anisimov

Molecular Medicine Faculty Publications

It has been shown previously that several endemic Y. pestis isolates with limited virulence contained the I259 isoform of the outer membrane protease Pla, while the epidemic highly virulent strains possessed only the T259 Pla isoform. Our sequence analysis of the pla gene from 118 Y. pestis subsp. microtus strains revealed that the I259 isoform was present exclusively in the endemic strains providing a convictive evidence of more ancestral origin of this isoform. Analysis of the effects of the I259T polymorphism on the intrinsic disorder propensity of Pla revealed that the I259T mutation slightly increases the intrinsic disorder propensity of …

Structure And Stability Of Recombinant Bovine Odorant-Binding Protein: I. Design And Analysis Of Monomeric Mutants, Olga V. Stepanenko, Denis O. Roginskii, Olesya V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and for being able to form the domain-swapped dimers. To identify structural features responsible for the formation of the bOBP unique dimeric structure and to understand the role of the domain swapping on maintaining the native structure of the protein, structural properties of the recombinant wild type bOBP and its mutant that cannot dimerize via the domain swapping were analyzed. We also looked at the effect of the disulfide bond by designing a monomeric bOBPs with restored disulfide bond which is conserved in other lipocalins. Finally, …