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The Limits Of Regulation: A Case Study Of Virtual And Intangible Harm, Nachshon Goltz

PhD Dissertations

This dissertation deals with the limits of regulation through the analysis of virtual and intangible harm and the capacity of regulation to prevent or at least reduce such harm. The case study at hand is the potential harm to childrens imaginative development in virtual worlds. A comparison is drawn from the regulation of online advertising to children in Canada and the US. Based on a review of the literature in chapter 1, it is suggested that there are serious and long-term consequences to an underdeveloped imagination, including pathological phenomenon and lack of imaginative ability. As with other harms to children, …

The Intestinal Copper Exporter Cua-1 Is Required For Systemic Copper Homeostasis In Caenorhabditis Elegans, Haarin Chun, Anuj Kumar Sharma, Jaekwon Lee, Jefferson Chan, Shang Jia, Byung-Eun Kim

Department of Biochemistry: Faculty Publications

Copper plays key catalytic and regulatory roles in biochemical processes essential for normal growth, development, and health. Defects in copper metabolism cause Menkes and Wilson’s disease, myeloneuropathy, and cardiovascular disease and are associated with other pathophysiological states. Consequently, it is critical to understand the mechanisms by which organisms control the acquisition, distribution, and utilization of copper. The intestinal enterocyte is a key regulatory point for copper absorption into the body; however, the mechanisms by which intestinal cells transport copper to maintain organismal copper homeostasis are poorly understood. Here, we identify a mechanism by which organismal copper homeostasis is maintained by …

Groundwater Declines Are Linked To Changes In Great Plains Stream Fish Assemblages, Joshuah S. Perkin, Keith B. Gido, Jeffrey A. Falke, Kurt D. Fausch, Harry Crockett, Eric R. Johnson, John Sanderson

United States Geological Survey: Staff Publications

Groundwater pumping for agriculture is a major driver causing declines of global freshwater ecosystems, yet the ecological consequences for stream fish assemblages are rarely quantified. We combined retrospective (1950–2010) and prospective (2011–2060) modeling approaches within a multiscale framework to predict change in Great Plains stream fish assemblages associated with groundwater pumping from the United States High Plains Aquifer. We modeled the relationship between the length of stream receiving water from the High Plains Aquifer and the occurrence of fishes characteristic of small and large streams in the western Great Plains at a regional scale and for six subwatersheds nested within …

Photography-Based Taxonomy Is Inadequate, Unnecessary, And Potentially Harmful For Biological Sciences, Luis M. P. Ceríaco, Eliécer E. Gutiérrez, Alain Dubois, Rafael O. De Sá, Et Al.

Biology Faculty Publications

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per …

Importance Of Heat And Pressure For Solubilization Of Recombinant Spider Silk Proteins In Aqueous Solution, Justin A. Jones, Thomas I. Harris, Paula F. Oliveira, Brianne E. Bell, Abdulrahman Alhabib, Randolph V. Lewis

Biology Faculty Publications

The production of recombinant spider silk proteins continues to be a key area of interest for a number of research groups. Several key obstacles exist in their production as well as in their formulation into useable products. The original reported method to solubilize recombinant spider silk proteins (rSSp) in an aqueous solution involved using microwaves to quickly generate heat and pressure inside of a sealed vial containing rSSp and water. Fibers produced from this system are remarkable in their mechanical ability and demonstrate the ability to be stretched and recover 100 times. The microwave method dissolves the rSSPs with dissolution …

Circular Economy And System Thinking Framework In Design; Food System Design, Mehrafza Mirzazad Barijugh

Theses

The purpose of this thesis is to bring the circular economy framework and system thinking into the process of design thinking. The traditional design process is made up of five steps: 1) Discover a challenge. 2) Interpret the challenge. 3) Create opportunities and ideas. 4) Develop a solution and experiment with it. 5) Evolve the idea. This project is structured upon a methodology generated to apply a circular system framework in design that begins with taking a holistic view of topic. This methodology structured into five phases. The first phase is referring to this approach as moving from Macrocosm to …

Deposition Methods For Microstructured And Nanostructured Coatings On Metallic Bone Implants: A Review, Bailey Jordan Moore

Electronic Theses and Dissertations Archive

A review of current deposition processes is presented as they relate to osseointegration of metallic bone implants. The objective is to present a comprehensive review of different deposition processes used to apply microstructured and nanostructured osteoconductive coatings on metallic bone implants. Implant surface topography required for optimal osseointegration is presented. Five of the most widely used osteoconductive coating deposition processes are reviewed in terms of their microstructure and nanostructure, usable thickness and cost, all of which are summarized in tables and charts. Plasma spray techniques offer cost-effective coatings, but exhibits deficiencies with regard to osseointegration such as, high density, amorphous …

The Influence Of Plant- And Animal-Based Diets On Testosterone And Lean Body Mass Is Male Rats, Damien Christopher Moore

Electronic Theses and Dissertations Archive

Background: It is commonly believed but unproven that plant-based diets result in low circulating testosterone, with minimal gains in lean body mass (LBM). Methods: Long-Evans rats (N=28) were assigned to experimental diets with either plant (PD) or animal (AD) protein sources. Animals were further divided into two additional conditions without and with exercise. Animals were fed ad libitum for 3 months and at the end of month three blood was collected for measurement of testosterone and estradiol concentrations. Dual x-ray absorptiometry assessed body composition. Results: Neither blood testosterone concentrations nor LBM differed between rats fed the PD or AD. Conclusion: …

Speak, Mira, Bret Vincent Lebeau

Electronic Theses and Dissertations Archive

A full-length work of fiction in the novel form, the story begins with Caden Carlisle, 20, as he kidnaps his sister, Mira, 15, liberating her from the abusive household of their drug-addled parents. With hopes of finding an older half-brother, Rob, the two seek refuge in New Orleans. At first, Rob's whereabouts remain unknown to Caden, so he must struggle to care for Mira, ultimately finding work in a record store. As Caden eventually narrows in on where his brother has been living, he discovers an underground world of crime and violence reminiscent of the life he had escaped.

Tingkat Kecukupan Dan Bioavailabilitas Asupan Zat Besi Pada Ibu Hamil Di Kota Tangerang, Yuni Pradilla Fitri, Dodik Briawan, Ikeu Tanziha, Siti Madanijah

Media Kesehatan Masyarakat Indonesia

Anemia merupakan masalah kesehatan masyarakat yang masih umum dijumpai. Sebagian besar anemia pada ibu hamil disebabkan oleh defisiensi zat besi. Penelitian ini secara umum bertujuan menganalisis kecukupan dan bioavailabilitas asupan zat besi pada ibu hamil di Kota Tangerang. Penelitian ini menggunakan desain cross-sectional. Wawancara mengenai konsumsi pangan dilakukan kepada 91 orang ibu hamil pada bulan Februari sampai Juni 2015 menggunakan food frequency questionnaire semi-kuantitatif. Hasil penelitian menunjukkan bahwa 97,8% ibu hamil memiliki tingkat kecukupan zat besi yang berada dalam kategori kurang. Seluruh ibu hamil memiliki bioavailabilitas besi dalam kategori rendah. Terdapat hubungan signifikan antara frekuensi konsumsi nasi (p=0,000), kacang-kacangan (p=0,000), …

Mutagenic Analysis Of Sh3 Binding Site In The Avian Chb6 Alloantigen, Rohini Bhattacharya

College of Science and Health Theses and Dissertations

To effectively eliminate the variety of pathogens that an individual may encounter in their lifetime, the immune system has evolved to recognize many different antigens. Within adaptive immunity there are also safe guards where the self-reactive or defective cells are eliminated (1). The removal of such cells is by apoptosis, which is a form of cell suicide characterized by an orderly breakdown of the cell to limit the leakage of cytoplasmic components that could cause inflammation. Apoptosis can be initiated by signaling through specific cell surface molecules and is carried out by downstream mediators. While several model systems of apoptosis …

Harlan County - Place Names, Robert M. Rennick

Robert M. Rennick Manuscript Collection

Place names of Harlan County, Kentucky.

Methylphenidate And Memory And Attention Adaptation Training For Persistent Cognitive Symptoms After Traumatic Brain Injury: A Randomized, Placebo-Controlled Trial, Brenna C. Mcdonald, Laura A. Flashman, David B. Arciniegas, Robert J. Ferguson, Li Xing, Jaroslaw Harezlak, Gwen C. Sprehn, Flora M. Hammond, Arthur C. Maerlender, Carrie L. Kruck, Karen L. Gillock, Kim Frey, Rachel N. Wall, Andrew J. Saykin, Thomas W. Mcallister

Center for Brain, Biology, and Behavior: Faculty Publications

The purpose of this multicenter, prospective, randomized, placebo-controlled study was to evaluate and compare the efficacy of two cognitive rehabilitation interventions (Memory and Attention Adaptation Training (MAAT) and Attention Builders Training (ABT)), with and without pharmacologic enhancement (i.e., with methylphenidate (MPH) or placebo), for treating persistent cognitive problems after traumatic brain injury (TBI). Adults with a history of TBI at least four months prior to study enrollment with either objective cognitive deficits or subjective cognitive complaints were randomized to receive MPH or placebo and MAAT or ABT, yielding four treatment combinations: MAAT/MPH (N=17), ABT/MPH (N=19), MAAT/placebo (N=17), and ABT/placebo (N=18). …

Why The Supreme Court Should Use Ariosa V. Sequenom To Provide Further Guidance On U.S.C. § 101 Patent Eligibility, Naira Rezende Simmons

Chicago-Kent Journal of Intellectual Property

35 U.S.C. § 101 provides patent protection to “any new and useful process, machine, manufacture, or composition of matter, or any new and useful improvement thereof.” The Supreme Court previously concluded that Congress intended patentable subject matter to “include anything under the sun that is made by man.” Nevertheless, over the past five years the U.S. Supreme Court has made a series of decisions that narrowed the scope of subject matter eligible for patent protection.

In Mayo the court held that correlations between the concentrations of a metabolite in the blood and the concentration of a drug are not patent …

Neglected Diseases: How Intellectual Property Can Incentivize New Treatment, Vinita Banthia

Chicago-Kent Journal of Intellectual Property

No abstract provided.

Proceedings Of The Fourth Annual Deep Brain Stimulation Think Tank: A Review Of Emerging Issues And Technologies, Wissam Deeb, James J. Giordano, Peter J. Rossi, Alon Y. Mogilner, Aysegul Gunduz, Jack W. Judy, Bryan T. Klassen, Christopher R. Butson, Craig Van Horne, Damiaan Deny, Darin D. Dougherty, David Rowell, Greg A. Gerhardt, Gwenn S. Smith, Francisco A. Ponce, Harrison C. Walker, Helen M. Bronte-Stewart, Helen S. Mayberg, Howard J. Chizeck, Jean-Philippe Langevin, Jens Volkmann, Jill L. Ostrem, Jonathan B. Shute, Joohi Jimenez-Shahed, Kelly D. Foote, Aparna Wagle Shukla, Marvin A. Rossi, Michael Oh, Michael Pourfar, Paul B. Rosenberg

Neurosurgery Faculty Publications

This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging …

Bis-Quaternary Ammonium Salts As Pain Modulating Agents, Joseph R. Holtman, Peter A. Crooks, Linda Phyliss Dwoskin, J. Michael Mcintosh

Pharmaceutical Sciences Faculty Patents

Provided are methods for using his-quaternary ammonium compounds to treat inflammatory pain, neuropathic pain and nociceptive pain.

Bright V. Maznik Respondent's Brief Dckt. 44129

Idaho Supreme Court Records & Briefs, All

No abstract provided.

Design, Synthesis, And Evaluation Of Dasatinib-Amino Acid And Dasatinib-Fatty Acid Conjugates As Protein Tyrosine Kinase Inhibitors, Rakesh Tiwari, Alex Brown, Neda Sadeghiani, Amir Nasrolahi Shirazi, Jared Bolton, Amanda Tse, Gennady M. Verkhivker, Keykavous Parang, Gongqin Sun

Pharmacy Faculty Articles and Research

Derivatives of dasatinib were synthesized via esterification with 25 carboxylic acids including amino acids and fatty acids by extending the inhibitor to interact with more diverse sites and to improve specificity. Dasatinib-L-arginine derivative (Das-R, 7) was the most potent of the inhibitors tested with IC50 values of 4.4 nM, <0.25 nM, and <0.45 nM against Csk, Src, and Abl kinases, respectively. The highest selectivity ratio obtained in our study, 91.4 Csk/Src belonged to compound 18 (Das-C10) with an IC50 of 3.2 μM for Csk compared to 35 nM for Src. Furthermore, many compounds displayed increased selectivity toward Src, as compared with Abl. Compounds 15 (Das-E) and 13 (Das-C) demonstrated the largest gains (10.2 and 10.3 Abl/Src IC50 ratios). Das-R (IC50 = 2.06 μM) was significantly more potent than Das (IC50 = 26.3 μM) against Panc-1 cells while they both showed an IC50 < 51.2 pM against BV-173 and K562 cells. Molecular modeling and binding free energy simulations revealed a good agreement with the experimental results and rationalized differences in selectivity of the studied compounds. Integration of experimental and computational approaches in the design and biochemical screening of dasatinib derivatives facilitated rational engineering and diversification of dasatinib scaffold, providing useful insights into mechanisms of kinase selectivity.

Systems And Methods For Stable Haptic Feedback Over Packet-Switched Networks, Parikshit S. Kulkarni, Susana K. Lai-Yuen

USF Patents

Providing haptic feedback to a user over a packet-switched network includes sensing movement of a haptic device by a user, the haptic device being configured to control a first virtual object within a virtual environment, transmitting data associated with the movement of the haptic device from a client computer to a remote server via the packet-switched network, the server modeling movement of the first virtual object in the virtual environment and estimating an orientation and a position of the first virtual object within the virtual environment, the server determining a type of tactile feedback to be provided to the user, …

Post-Transplantation Cyclophosphamide And Ixazomib Combination Rescues Mice Subjected To Experimental Graft-Versus-Host Disease And Is Superior To Either Agent Alone, Ahmad Samer Al-Homsi, Austin Goodyke, Michael Mclane, Sarah Abdel-Mageed, Kelli Cole, Marlee Muilenburg, Benjamin Feng

Peer Reviewed Articles

Lapses in the prevention of graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT) warrant novel approaches. Such approaches include, among others, the use of post-transplantation cyclophosphamide (PTC) and proteasome inhibitors. Although PTC alone consistently produces low rates of chronic GVHD, the incidence of acute GVHD remains significant. Inversely, prolonged post-transplantation administration of proteasome inhibitors carries a risk of paradoxical aggravation of GVHD. We examined whether the combination of cyclophosphamide and ixazomib addresses the limitations of each of these agents when used alone to prevent GVHD in mice subjected to allogeneic HSCT across MHC barriers. We chose ixazomib, an …

Using Line Acceleration To Measure False Killer Whale (Pseudorca Crassidens) Click And Whistle Source Levels During Pelagic Longline Depredation, Lauren Wild, Janice M. Straley, Dustin Barnes, Ali Bayless, Victoria O'Connell, Erin Oleson, Jit Sarkar, Linda Behnken, Dan Falvey, Sean Martin, Aaron Thode

Faculty, Staff, and Students

False killer whales (Pseudorca crassidens) depredate pelagic longlines in offshore Hawaiian waters. On January 28, 2015 a depredation event was recorded 14m from an integrated GoPro camera, hydrophone, and accelerometer, revealing that false killer whales depredate bait and generate clicks and whistles under good visibility conditions. The act of plucking bait off a hook generated a distinctive 15 Hz line vibration. Two similar line vibrations detected at earlier times permitted the animal’s range and thus signal source levels to be estimated over a 25-min window. Peak power spectral density source levels for whistles (4–8 kHz) were estimated to be between …

The Sun Star Vol 70 No 13 (November 22nd, 2016), N/A N/A

Sun Star

No abstract provided.

November 22, 2016, The Dakota Student

The Dakota Student

No abstract provided.

Conditional Loss Of Pten In Myogenic Progenitors Leads To Postnatal Skeletal Muscle Hypertrophy But Age-Dependent Exhaustion Of Satellite Cells, Feng Yue, Pengpeng Bi, Chao Wang, Jie Li, Xiaoqi Liu, Shihuan Kuang

Department of Animal Sciences Faculty Publications

Skeletal muscle stem cells (satellite cells [SCs]) are normally maintained in a quiescent (G0) state. Muscle injury not only activates SCs locally, but also alerts SCs in distant uninjured muscles via circulating fac- tors. The resulting GAlert SCs are adapted to regener- ative cues and regenerate injured muscles more effi- ciently, but whether they provide any long-term benefits to SCs is unknown. Here, we report that em- bryonic myogenic progenitors lacking the phospha- tase and tensin homolog (Pten) exhibit enhanced proliferation and differentiation, resulting in muscle hypertrophy but fewer SCs in adult muscles. Interest- ingly, Pten null SCs are predominantly …

Introducing Allergenic Food Into Infants' Diets: Systematic Review, Katelin Larson, Jessica Mclaughlin, Mallory Stonehouse, Brittany Young, Kristin Haglund

College of Nursing Faculty Research and Publications

Purpose: The purpose of this systematic review was to explore the association between timing of introduction of potentially allergenic foods to infants and development of food allergies.

Methods: CINAHL, Medline, PubMed, Science Direct, and Web of Science were searched using the terms solid food, complementary food, or infant feeding combined with allergy or hypersensitivity for articles published in English in 2000 or later. Inclusion criteria were 1) primary research articles with 2) a focus on association between introduction of complementary foods including potentially allergenic foods into diets of infants less than 12 months of age and development of food allergies. …

Assessing Nurses' Knowledge About Autism Spectrum Disorders, Cynthia Queisser

DNP and Student Works

Background: Autism spectrum disorders (ASD) consist of a group of neurodevelopmental disorders with lifelong effects. Autism is rising at an alarming rate for unclear reasons. Increasing ASD rates create major concern for nurses in a variety of clinical surroundings and they need to be adequately prepared to interact with and provide care for these special individuals.

Method: The methodology included the use of a nonexperimental, quantitative research design using two different knowledge assessment tools, the Survey of Knowledge of Autism Spectrum Disorders among Professionals along with the Knowledge about Childhood Autism Among Health Workers (KCAHW), the implementation of an evidence-based …

Vocal Flexibility In Early Human Communication, Y Jhang

Electronic Theses and Dissertations Archive

The dissertation contains two papers on the theme of flexibility in infant communication using an infrastructural approach. An infrastructural approach considers infant communication in terms of properties of human language (i.e., spontaneous vocalization, functional flexibility, social interactivity, and etc.). Infants' vocal flexibility is explored in two ways in the dissertation: 1) How infants use sounds with varying emotional valences, a primary determiner of their communicative functions, and when this infrastrucutral property emerges (the first paper, in Chapter 2), and 2) what role the voice plays independently and jointly with the face in the transmission of affect and vocal type (the …

The Difference Between Conscious And Unconscious Brain Circuits, Ezequiel Morsella, Zaviera Reyes

Animal Sentience

Theoretical frameworks in which consciousness is an inherent property of the neuron must account for the contrast between conscious and unconscious processes in the brain and address how neural events can ever be unconscious if consciousness is a property of all neurons. Other approaches have sought answers regarding consciousness by contrasting conscious and unconscious processes and through investigating the complex interactions between the two kinds of processes, as occurs most notably in human voluntary action. In voluntary action, consciousness is associated most, not with motor control or low-level perceptual processing, but with the stage of processing known as action selection.

Animal Owners In Pennsylvania Are Not Afforded An Absolute Right To Kill Their Healthy Animal: Commonwealth V. Kneller, Erika Farkas

Duquesne Criminal Law Journal

Recent Decisions