Digital Commons Network^™

Enhancing Education Of Medication Side Effects To Improve Patient Outcomes, Kyle R. Woolley

Master's Projects and Capstones

Patient satisfaction scores regarding how effectively staff educates patients about possible side effects of new medications are not consistently above the national average at a large metropolitan hospital in California (MHC). The results of these patient satisfaction scores shed light on the need for evidence-based strategies to improve a patient’s perception of the medication education provided to them. The basis of the incentive to improve care is ultimately increased safety and better patient outcomes. From the Root Cause Analysis, it became apparent that a few common barriers need to be addressed, but the one most frequently reported by everyone that …

Utilizing Ecological Connectivity In California Desert Wilderness Preservation, Lauren Kahal

Master's Projects and Capstones

The Wilderness Act of 1964 gave the federal land management agencies—the National Park Service, United States Forest Service, U.S Fish and Wildlife Service, and Bureau of Land Management—the authority to identify, propose, and manage lands as wilderness. Wilderness, once approved by Congress for inclusion in the National Wilderness Preservation System, is offered the highest form of land preservation in the nation. However, the wilderness identification process used by the implementing agencies is based on a half-century old statute with an aging definition of wilderness. While designated wilderness can protect the plant and wildlife communities within its borders from direct anthropogenic …

Beyond Access To Education: Using Collaborative Learning To Promote Agency In Unauthorized Latinos Entering Community College, Amanda C. Price

Master's Projects and Capstones

The US is widely recognized as a nation of immigrants; however, when an estimated 70,000 unaccompanied child migrants arrived from Central America in 2014, unauthorized immigration became a full-blown humanitarian crisis. Unauthorized immigrants, 71% of whom come from Mexico and Central America, make up an increasingly significant portion of the population. This is particularly true in California, where 28% of unauthorized immigrants reside. However, despite the overwhelming consensus that command of English is paramount to a successful life in the US, an alarming 51% of unauthorized immigrants speak English “not well” or “not at all”.

Unauthorized immigrants face unique challenges …

The Rhetoric Of Law And The Epistle To The Hebrews, Theodore A. Holt Iv

Electronic Theses and Dissertations

The Epistle to the Hebrews demonstrates a complex of what scholars label technical legal terms. Enlisting a series of word studies, this thesis attempts to uncover where the author learned the terminology in order to understand more about the anonymous author and the theology of the Epistle to the Hebrews. This thesis examines terms in Heb 2:2-4; 6:13-18; 7:11-19; 8:13; 9:15-18; 10:9.

Examining Employee Knowledge Of The Jennie Edmundson Hospital Active Shooter Policy, Mallory W. Darais

Theses & Dissertations

Nationally, there has been a large increase in the number of active shooter events within healthcare facilities such as hospitals. Due to this increase, government organizations have recently released documents to guide healthcare facilities on implementing active shooter policies and updating emergency operation plans. Currently, recommendations from government entities such as the Federal Bureau of Investigation and the Department of Homeland Security suggest the “Run, Hide, Fight” approach during an active shooter incident. Jennie Edmundson Hospital, located in Council Bluffs, Iowa, and affiliated with the Methodist Health System, currently has an active shooter policy in place. Data was collected from …

Regulation Of The Transmembrane Mucin Muc4 By Wnt/Β-Catenin In Gastrointestinal Cancers, Priya Pai

Theses & Dissertations

The transmembrane mucin MUC4 is a high molecular weight glycoprotein that is expressed de novo in pancreatic ductal adenocarcinoma (PDAC). MUC4 has been shown to play a tumor-promoting role in malignancies such as PDAC, ovarian cancer and breast cancer. Unlike the normal pancreas, MUC4 is ordinarily expressed by goblet and absorptive cells in the normal colonic epithelium. However, its expression/role in colorectal cancer (CRC) is not well studied.

In this dissertation, the goal was to identify factor(s) that may differentially regulate MUC4 in these two disparate malignancies. Furthermore, in light of its pro-tumorigenic role in other malignancies, we analyzed the …

Control Of The Basal Recycling And Surface Expression Of Epidermal Growth Factor Receptor By The Endocytic Recycling Regulator Ehd1 Utilizing A Pathway Shared By Rusc2, Eric Tom

Theses & Dissertations

The epidermal growth factor receptor (EGFR) is a prototype receptor tyrosine kinase (RTK) and oncogene aberrantly expressed or mutated in solid tumors. Its surface expression is dynamically regulated. Display of an activation-competent pool is essential for response to ligands. Internalization and degradation of EGFR following stimulation has received the most attention, fewer studies have characterized the recycling arm of EGFR transit, basal traffic and surface display are poorly understood. Thus, we evaluated the endocytic recycling of EGFR for its therapeutic potential in EGFR driven cancers. The C-Terminal Eps15 homology (EH) domain-containing proteins have emerged as regulators of surface receptor recycling …

A Role For Ehd Family Endocytic Regulators In Endothelial Biology, Alexandra E. J. Moffitt

Theses & Dissertations

Endocytic trafficking is an essential process in eukaryotic cells, specifically for the transport of nutrients, membrane components, and receptors. Cargo destined for endocytic traffic is internalized at the cell surface via clathrin-dependent and clathrin-independent pathways, and brought to the early or sorting endosomes. From there, cargo is further trafficked to lysosomes for degradation, trafficked to other compartments in the cell, or recycled back to the cell surface (either directly or via the endocytic recycling compartment).

Mammalian C-terminal Eps15 homology domain-containing proteins, or EHD proteins (EHD1 to 4), are a family of highly conserved ATPases that function as key regulators of …

Epacs: Epigenetic Regulators That Affect Cell Survival In Cancer., Catherine Murari

Theses & Dissertations

Cyclic adenosine monophosphate (cAMP) is a second messenger responsive to many external stimuli, playing an important role in cellular gene expression, metabolism, migration, differentiation, hypertrophy, apoptosis and secretion. All of these cellular functions are important in many diseases including cancer. Most of its effects were initially attributed to the classical protein kinase A (PKA) protein, but cellular functions such as proliferation and migration were found to be PKA independent and dependent on the newly discovered exchange proteins directly activated by cAMP (EPACs). EPACs are single polypeptides that primarily function as guanine exchange factors (GEFs) for Rap proteins that allow the …

The Effects Of Severe Weather Warnings On Limited English Proficient (Lep) Hispanics/Latinos In Rural Nebraska, Joan E. Nelson

Theses & Dissertations

The language barrier may severely restrict how severe weather warnings are received and responded to by Hispanics/Latinos in rural Nebraska, a state well known for frequent, volatile weather patterns. Nearly 50% of Spanish speaking Nebraskans rated their English abilities as “less than very well” (US Census Bureau, 2013). The estimated number of Hispanics/Latinos with limited English proficiency (LEP) in Nebraska equates to approximately 57,000 people. This thesis attempted to assess English ability and how severe weather warnings were received and responded to by LEP Hispanics/Latinos in rural Nebraska. This was accomplished by analysis of data from completed optional Spanish or …

Postural Responses To Perturbations Of The Vestibular System During Walking In Healthy Young And Older Adults, Jung Hung Chien

Theses & Dissertations

It has been shown that approximate one-third of US adults aged 40 years and older (69 million US citizens) have some type of vestibular problems. These declining abilities of the vestibular system affect quality of life. Difficulties in performing daily activities (dressing, bathing, getting in and out of the bed and etc.) have been highly correlated to loss of balance due to vestibular disorders. The exact number of people affected by vestibular disorders is still difficult to quantify. This might be because symptoms are difficult to describe and differences exist in the qualifying criteria within and across studies. Thus, it …

The Battle Against Childhood Obesity, Allison Fox

Capstones

When 16-year-old Eric Foy came home from high school one weeknight in the fall of 2005, his life changed forever. His mother, Claudia, was resting on the tan couch in the living room, but she was slumped over to the left, towards the end table that held a dozen framed photos of his extended family. “Get me juice,” Claudia whispered to her son. Immediately, Eric knew what was happening –his mother’s blood sugar level was crashing. As he ran to the kitchen to pour a glass of orange juice, he started to panic.

The Effects Of Income Inequality On Service Sector Growth, Jeeten K. Giri

Research Papers

The objective of this paper is to investigate the effects of income inequality on the service sector growth of 45 countries from the period 1971 to 2010. The countries are divided into low, middle and high income groups, and the analysis is carried out in two sub-time periods, 1971 to 1990 and 1991 to 2010. The analysis reveals that during 1971-1990, the effect of income inequality on service sector growth is negative and significant for low and middle income countries, whereas it is insignificant for high income countries. During 1991-2010 the effect of income inequality on service sector growth is …

Atypical Protein Kinase C Dependent Polarized Cell Division Is Required For Myocardial Trabeculation, Derek L. Passer

Theses & Dissertations

A hallmark of cardiac development is the formation of myocardial trabeculations exclusively from the luminal surface of the primitive heart tube. Although a number of genetic defects in the endocardium (Grego-Bessa et al., 2007; Liu et al., 2010) and cardiac jelly (Camenisch et al., 2000) disrupt myocardial trabeculation, the role of cell polarity machinery in driving this process remains unclear. Herein, we demonstrate that atypical protein kinase C iota (Prkci) and its interacting partners of Par polarity complex are localized to the luminal side of luminal myocardial cells. Remarkably, a subset of these cells undergoes polarized cell division with the …

The Role Of Cxcr2 In Pancreatic Cancer Development And Progression, Abhilasha Purohit

Theses & Dissertations

This dissertation examines the role of CXCR2, a seven transmembrane G- protein coupled receptor, in mediating autocrine as well as paracrine mechanisms during pancreatic cancer progression. Data presented in the initial section demonstrates the aberrant expression of the CXCR2 biological axis in human pancreatic cancer tissue specimens. A study performed within the first section of this dissertation investigates the contribution of CXCR2 signaling in pancreatic cancer initiation. These studies have identified a novel role of CXCR2 in mediating KRAS^(G12D) -induced autocrine growth transformation of pancreatic cancer cells. The upregulation of the CXCR2 biological axis was found to be directly …

Antiviral Peptide Nanocomplexes As Potential Therapeutics For The Treatment Of Infectious Diseases, Jinjin Zhang

Theses & Dissertations

Hepatitis C Virus (HCV) is recognized as a major burden in global public health, which can be further exacerbated by several cofactors such as human immunodeficiency virus (HIV). Currently, there is no vaccine for HCV. The emergence of potent and highly specific direct-acting antivirals (DAA) has marked a new era in HCV therapy, however, the remaining issues like affordability, genotype dependency, and potential resistance still necessitate the development of additional therapeutic approaches to be used instead or in combination with DAA.

Recently, the antiviral peptide C5A (in our studies designated as p1) and its cationic derivative p41 have been identified …

The Role Of Genetic Alterations In Tumor Initiation, Progression And Transformation, Weiwei Zhang

Theses & Dissertations

Follicular lymphoma (FL) is the second most common lymphoma in the United States. Although it is generally an indolent lymphoma, FL is not curable, and, in about 30% of patients, the FL undergoes transformation into an aggressive lymphoma (tFL) with marked worsening of prognosis. To identify mutations preferentially present in tFL, we performed whole exome sequencing (WES) on paired FL and tFL arising in the same patients and developed a mutational analysis pipeline. After we identified potentially important genes that have been found to be mutated in our paired FL and tFL study, we constructed a custom capture platform including …

Regulatory Roles Of Mical-L1 And Ehd1 In Cell Signaling And Mitosis, James B. Reinecke

Theses & Dissertations

Membrane trafficking is a basic cell biological process that controls the distribution of proteins and lipids. Our lab is particularly interested in delineating the cellular functions as well as the molecular mechanisms that regulate the C-terminal Eps15 Homology Domain (EHD) protein family of adenosine-5’-triphosphatases in mammalian cells. EHD1-4 are ubiquitously expressed in mammalian tissues and serve partially overlapping but also distinct functions in regulating membrane shaping and fission along the endocytic pathway. Specifically, EHD1 is recruited to tubular recycling endosomes (TREs) by Molecule Interacting with CasL Like-1 (MICAL-L1) and facilitates TRE fission and release of cargo from the perinuclear endocytic …

Interaction Between Angiotensin Ii And Bdnf In Modulating Sympathetic Nerve Activity, Bryan K. Becker

Theses & Dissertations

Over activation of the sympathetic nervous system is prevalent in many forms of cardiovascular disease such as chronic heart failure (CHF) and hypertension. Although increased neuronal renin-angiotensin system activity in presympathetic neurons has been well implicated in mediating this sympatho-excitation, many of the neuronal effects of angiotensin II (Ang II) signaling remain poorly understood. One particular mechanism of Ang II-mediated increases in presympathetic neuronal activity is through reductions in voltage-gated K⁺ currents. Another pathway that has profound effects on neuronal K⁺ currents and that has been previously implicated in Ang II-signaling is brain-derived neurotrophic factor (BDNF) activity through …

The Role Of Tumor Suppressor Co-Chaperone Chip/Stub1 In Erbb2-Mediated Oncogenesis, Haitao Luan

Theses & Dissertations

The epidermal growth factor receptor (EGFR) family member ErbB2 (Her2) is overexpressed in 20 -30% of invasive breast cancers and this overexpression correlates with poor prognosis and shorter overall as well as disease-free survival. Aberrant expression of ErbB2 through gene amplification, transcriptional deregulation and/or altered endocytic trafficking results in overexpression of ErbB2 at the plasma membrane and biases ErbB2 from primarily ligand-driven hetero-dimerization under normal expression conditions to increased ligand-independent homo-dimer and hetero-dimer formation and consequent activation. C-terminus of HSC70-Inteeracting protein (CHIP)/STIP1-homologous U-Box containing protein 1 (STUB1) is an HSP90/HSC70 interacting negative co-chaperone known to promote ubiquitination and degradation of …

The Effects Of An Overnight Environmental Science Education Program On Students' Attendance Rate Change For Middle School Years, Jennifer Elizabeth Basham

Dissertations and Theses

Programs that engage middle students in participatory, real-world, and hands-on field based instruction can be a powerful asset to the educational experiences for students; motivating and inspiring some to appreciate and value school in a different way. Overnight environmental science programs have a unique opportunity to support students by creating experiences where students can participate in learning in vastly different ways from what they may engage with in the traditional 4-walled classroom, while concurrently developing a relationship with the natural world. Decreasing educational budgets and increased need to substantiate educational programs in terms of their impact on students has added …

The Tunisian Revolution: Empire And The Power Of The Multitude, Caroline A. Burns

Master's Theses

The self-immolation of Mohammed Bouazizi ignited the revolution that would oust Tunisian dictator Ben Ali in 2011. The momentum of the revolution in Tunisia spread ideas, tactics, and revolutionary chants across borders to various parts of the globe. The speed and intensity of the revolution dominated the attention of the unsuspecting global community. In order to understand the conditions under which this revolution transpired, I use Michael Hardt and Antonio Negri's theory of Empire to show how the contemporary global system functions. Through the historical development of Tunisia and concurrent rise of Empire emerges "the multitude," the heterogeneous manifestation of …

Dislocation And Adjustment Of International Student-Athletes, Thiago Brito Lopes

Master's Theses

One reason that attracts international student-athletes to American universities could be the interest in earning high quality education with the possibility of playing high performance sports. However, when compared to other international students, differences are seen: Other foreign students who look for a degree in the US desire not only an international education, but also potentially staying in the country. The University of San Francisco, where a cosmopolitan city meets education, fits it best. At USF, 82 countries are represented, reaching a number of 1708 students. Approximately ¼ of the whole student population is international. The ratio with student-athletes is …

Power, Subjectivity, And Life In Spain: A Continuation Of Elite Power, Matthew Mason

Master's Theses

On December 20, Spain will hold national elections to determine the new prime minister and national and local parliaments. These elections will be another crossroads in the long history of Spain. The elections come about in a political and social atmosphere of ‘change’ and ‘regeneration,’ marked by the rise of two new political parties, Podemos and Ciudanos. These parties are the new forces in the political scene in Spain. This atmosphere of change is the result of the 2008 economic crisis. The economic crisis of 2008 was not only an economic crisis in Spain, but it provoked a political and …

Photooxidation Reactions Of Small-Chain Methyl Esters, Aerosol Photoelectron Spectroscopy, And The Photodissociation Of Ethylenediamine, Giel Muller

Master's Theses

Research conducted at the University of San Francisco is presented within this masters thesis, including the Cl-initiated photooxidation reactions of methyl propanoate, methyl butanoate, and methyl valerate (pentanoate), the aerosol photoelectron spectroscopy of isoprene and gamma-valerolactone, and the TPEPICO investigation of ethylenediamine. Experiments were conducted at the Lawrence Berkeley National Lab Advanced Light Source (ALS), the National Synchrotron Radiation Research Center in Hsinchu City (NSRRC), and the University of Stockton in California, respectively.

The Multidimensionality Of Schoolgirl Dropouts In Rural Bangladesh, Tiffany Yancey

Master's Theses

This thesis outlines the underlying causes for girl dropouts in the secondary school system of rural Bangladesh and assesses the barriers that affect adolescent girls and their families. The complex dynamics of the historical context within the patriarchal-dominant structure of society creates a system that hinders girls’ education and forces them into marriage at an early age. Poverty and lack of parental involvement in schools, as well as societal traditions and lack of government infrastructure play an enormous role and are the main structural factors that are linked to schoolgirl dropouts in this study. This thesis also analyzes previous education …

Evolution Of A Nation After A Dictatorship: How Law, Politics And Society Of The 1973 Dictatorship In Uruguay And Of The Subsequent Return Of Democracy In 1985, Potentially Helped Evolve The Nation Of Today., Jonathan A. Fein Proaño

Master's Theses

In 1973, Uruguay’s president authored a coup d’état with the military and changed the history and fabric of Uruguay. Once democracy returned to Uruguay in 1985, it was a chance to see if an evolution of the law, politics and society would occur. This thesis aims to analyze and understand the patterns of change and de-evolution or evolution that happened during the dictatorship and then over the last 30 years. I break down the process of changes that happened legally and politically, how the dictatorship and its leaders used law to destroy rule of law, and how society changed.

This …

The German Army At A Crossroads Of Modernization, Sarah E. Liebig

Master's Theses

This thesis examines the German civil-military relationship and the challenges the country is facing amidst modernizing reforms to the German armed forces. Over the last quarter of a century, new international security threats have manifested and continue to transform requiring Germany to adapt its military and defense policies in order to effectively protect itself and serve as a capable ally to other member states of international organizations such as NATO and the EU. The adaptations and reforms required of Germany have led to concern that the cornerstone civil-military relationship concepts are at risk. In this thesis I identify the major …

Mechanisms Of Hepatitis C Viral Resistance To Direct Acting Antivirals, Asma Ahmed, Daniel J. Felmlee

Peninsula Medical School

No abstract provided.

Editorial: "Euscorpius" At 50, Victor Fet, Michael E. Soleglad

Euscorpius

Five years since its conception, “Euscorpius”, the online peer-reviewed research journal devoted to scorpion science, celebrates its 50th issue today with its 50th author, and shows no signs of aging or slowing down. We celebrate these achievements together with the colleagues and friends all around the world, since success of “Euscorpius” became possible only through collaboration, networking, and mutual support—aptly provided in the Internet environment. No other medium allows so much connectivity, rapid response, and coordination as this marvelous modern communication device. For us, “Euscorpius” in its five years became much more than a …