Digital Commons Network^™

Properties Of A Fluorescent Deoxycytidine Analog In I-Motif Dna, Sara E. Wingate

Honors Theses

Experiments to determine fluorescence lifetimes and fluorescence quenching constants were performed using oligonucleotides of DNA containing PdC, a fluorescent analog of cytidine, at five different locations in the i-motif. My experiments were chosen in order to better understand the structural characteristics of i-motif DNA, which are thought to have biological importance in cancer and drug delivery. Fluorescent lifetime experiments were carried out using an ISS K2 fluorescence instrument with a modulated LED light source in order to determine if the cytidine bases in DNA replaced by PdC were paired or unpaired in the i-motif structure. The resulting data allowed us …

The Fall Of Teotihuacan, Elizabeth P. Ale

UROP Posters

In this project I present a survey of multiple theories regarding the dissolution of the ancient Mesoamerican city of Teotihuacan. This complex city-state was established around 100 BCE and became one of the largest and most powerful sites in Mesoamerica. Located about 25 miles northeast of what is today known as Mexico City, Teotihuacan was home to many advanced technological and social structures, including a pyramid called The Pyramid of the Sun that boasted a base as large as the Great Pyramid of Giza’s. At some time between the 7^th and 8^th century CE, Teotihuacan went into decline. …

Decreased Pain Severity And Differential Gene Expression Following Calmare Therapy, Jeffrey Petraco, Angela R. Starkweather, Amy Heineman

UROP Posters

We present the results of a double-blinded randomized sham-controlled research study of a non-pharmacologic low back pain intervention. Calmare therapy is an neurocutanous electrical stimulation approach for pain management. The intervention group received Calmare therapy and the other received sham. Differences in pain severity and interference scores, pain sensitivity measures and gene expression profiles are reported. Patterns of downregulated gene expression suggest that Calmare may alter proteins involved in pain transduction may have implications for the treatment of other chronic pain conditions.

Physician Role In Enhancing Patient Communication, Tamanna Sahni

UROP Posters

Communication in the in-patient environment is crucial, and the relationship between a patient and physician enhances patient health and wellness. Patients should feel confident with their abilities to feel comfortable conversing with physicians, which would thus treat symptoms more effectively. This communication has decreased over time, hence patients are often are unable to obtain medical information from their healthcare providers. What is the relationship between psychological factors, such as self-esteem, and quality of patient-physician communication? And can physicians ensure increased patient comfort in the medical environment?

Various factors can affect the patients’ comfort with their physicians, and when addressed, these …

Asthma-Related Anxiety And Quick-Relief Medication Use In Urban Children With Asthma, Sarah E. Astrab, Robin Everhart

UROP Posters

Among children, asthma is the most common chronic illness. Although not curable, asthma is manageable with the use of both daily controller medication and quick relief or rescue medication. Anxiety has been found to increase asthma symptoms in children. Caregivers who are anxious about their child’s asthma symptoms may perceive their child’s asthma as more severe or doubt their ability to manage their child’s asthma, which can result in the misuse of asthma medication. This study focused on the association between asthma-related anxiety and the use of quick-relief asthma medications in a low-income, urban sample in Richmond, Virginia. Child participants …

Queer-Baiting On The Bbc’S Sherlock: Addressing The Invalidation Of Queer Experience Through Online Fan Fiction Communities, Cassidy Sheehan

UROP Posters

Fans of a particular media source often write fan fiction to build on, deviate from, and transform original source material. The BBC’s Sherlock is not exempt from this common practice; in fact, the homoerotic subtext which persistently endures within the show lends itself to the production of slash fan fiction. Many perceive this subtext as a method of queer-baiting, or an ultimately harmful tactic used by writers and producers to lure in queer viewers. In this paper, dialogue and scenes from the show itself are compared to excerpts from works of fan fiction in order to explore reactions to queer-baiting …

Effect Of Maternal Sensitivity On Language Acquisition Of Multiples, Madhuri Prayaga

UROP Posters

The purpose of this study was to examine language acquisition and development in multiple birth children compared to singleton children in order to examine how decreased maternal sensitivity amongst mothers of multiple compared to mothers of singletons affects language acquisition skills in children.. The first phase of research for this study started with research on maternal sensitivity, specifically differing levels of it amongst mothers of different types of children, either by singletons of multiples, and potential causes for these differing levels of maternal sensitivity. The second phase focused on language skills of multiple and singletons at a young age and …

The Increase On Nonconsensual Bride Kidnapping In Kyrgyzstan, Amna Nawaz

UROP Posters

Since the fall of the Soviet Union, the country of Kyrgyzstan has had an unprecedented jump in bride kidnapping. The number of occurrences has skyrocketed and with that so has the severity of the violence. In this time women are taken, with no prior indication of when or how, and forced to marry their kidnappers. This non-consensual practice has morphed for reasons unknown. To stop the increasingly abysmal state of women’s rights in Kyrgyzstan, and in countries all of over the world, we must discover why people turned towards violence and lack of consent in the 1990’s.

To determine the …

Modeling Atp-Binding Cassette G2 (Abcg2) Substrate Specificity, Raghav D. Acharya, Aurijit Sarkar, Glen E. Kellogg

UROP Posters

How well can we predict efflux by ATP-binding cassette G2?

It is estimated that there will be about 1.6 million new cases of cancer and half a million cancer deaths in the US during 2015.ATP-binding cassette (ABC) efflux transporters such as ABCG2 are overexpressed in chemotherapy-resistant cancer cells. Anticancer drugs are prone to efflux by these transporters. Being able to identify drugs that are effluxed is of great interest in drug discovery.The current arsenal of methods used to detect efflux are not easily adaptable to high throughput formats and are limited in scope, making experimental analysis an expensive prospect. Hence, …

Stand-Up Comedy And Self-Deprecating Humor, Amelia M. Bell

UROP Posters

Stand-up comedy has been around for centuries, making people laugh for generations. Through the years the forms and techniques stand-up comedians use have shifted back and forth. Self-deprecation humor is one of these forms of humor, where the comedian pokes fun at his or herself, and it has recently become more incredibly popular in today’s society. Stand-up comedians like Louis C.K. have risen to newfound popularity by using self-deprecating humor almost completely in their sets. This paper attempts to answer the question of why audiences respond so positively to stand-up comedians who use self-deprecating humor. It does so by arguing …

Narco Trafficking, Corruption, And Perpetuated Violence In Guatemala, Ima T. Haque

UROP Posters

ABSTRACT: Narco-trafficking and Perpetuated Violence in Guatemala

Over the years drug cartels have made their way into Guatemala through their borders. Drug trafficking is the main reason why the border between Guatemala and Honduras is one of the most violent locations in Central America. Due to lawlessness and corruption, wealthy drug traffickers assume an authoritative role in the region (Crisis Group, 2014). A 2010 report done by U.S. International Narcotics Control Strategy says that “Guatamala is the epicenter of the drug threat.” (Brice, CNN, 2011). However, the increase in drug related violence is due to Zetas, a Mexican drug cartel. …

Beyond The Horizon: The Limitless Potential Of 3d Technology In Archaeology, Rebecca Bowman

UROP Posters

My research started during the summer of 2014 with a joint internship at VCU’s Virtual Curation Lab and the Virginia Department of Historic Resources under the supervision of Dr. Bernard K. Means and Katherine Ridgway. The purpose of my research was to conduct a comparative study between the virtual and physical process of mending, or repairing, artifacts. I was granted access to three different vessel fragments which were improperly mended in the 1960s. It was my goal to remove the previous adhesive adhered to the sherds and replace it with a safer adhesive. Simultaneously, I brought the previously mended sherds …

Increasing Vaccination Rates In Children Of Vaccine-Hesitant Parents, Keegan G. Edgar

UROP Posters

In recent years, the number of parents who have declining vaccinations or instituting altered immunization schedules for their children has risen. This has caused an increased number of outbreaks of vaccine-preventable diseases. It has also threatened herd immunity, which provides a measure of protection for those who are susceptible to disease given enough people are vaccinated, as this hinders the spread of the disease. To combat this threat to herd immunity, it is becoming increasingly necessary to find a solution to the problem of increasing personal belief exemption.

I took a cause and effect approach in the way I researched …

Icp-Oes Analysis Of The Chemical Composition Of Hypergolic Mixtures, Monique Jones

UROP Posters

Hypergolic mixtures involve a chemical reaction between an oxidant and a fuel source. These reactions are self-igniting and can be performed using common household materials. The ease of access to the reactants, and delayed ignition have increased the occurrence of hypergolic mixtures in arson-related crimes and incendiary devices. Currently, few chemical signatures exist to link hypergolic residues to a perpetrator. This makes it difficult to obtain forensically relevant information from evidence during an investigation. A hypergolic reaction of interest to forensic laboratories involves combustion between a glycol-based fuel source and potassium permanganate. Past studies have determined that one can distinguish …

Don't Walk Alone, Sarah Hughes

UROP Posters

Dont walk alone: The effect of the widely accepted behavior of street harassment on women’s mobility

Sarah Hughes, School of Humanities and Life Sciences. Mentor: Bonnie Boaz

ABSTRACT

Women are continuously exposed to street harassment in their daily lives, however this issue lacks the recognition that it deserves as a societal problem. This paper explores to what extent men control public space and the effect that street harassment has on women both psychologically and physically. Data has been collected from scholarly articles as well as published studies. Unfortunately the research finds that society accepts the mistreatment of women through street …

How Breastfeeding Affects Postpartum Depression, Elisabeth Lamas

UROP Posters

According to the 2008 CDC report, nearly one out of every eight women are affected by postpartum depression at one point or another in their lives. The purpose of my research was to study the potential effects of breastfeeding on postpartum depression. The objective was to study how breastfeeding affects the occurrence of postpartum depression in mothers in the United States. To understand the relationship between postpartum depression and breastfeeding, I read science journal articles describing the biological background behind breastfeeding and postpartum depression. I read psychology and biology journal articles dealing with possible forms of treatment for postpartum depression …

Anxiety Reactivity In Monozygotic Twins Discordant For Major Depression, Sravya Uppalapati

UROP Posters

Transient anxiety is a healthy response to stress. However, constant anxiety elicits negative responses and threatens an individual’s day-to-day living. The onset of anxiety disorders excluding specific phobias is often childhood to late adolescence or early adulthood. Though depression is characterized as a low-energy state unlike anxiety, there is a high concordance between anxiety and depression. “Nearly one-half of those diagnosed with depression are also diagnosed with an anxiety disorder” (“Facts and Statistics”). There are two goals of the study:

1. To compare the individual response levels between monozygotic (MZ) twins discordant for major depressive disorder (MDD) during an anxiety-provoking …

Progression Of The Representation Of Female Protagonists In The Sci-Fi/Fantasy Genres, Dakota S. Becker

UROP Posters

Broadcast television has been plagued by the misrepresentation and absence of progressive female protagonists. Contemporary television programs have begun to address issues of diversity and empowerment, but it is questionable whether substantial strides in the representation of women have truly been made. The science fiction and fantasy genres in particular are infamous for perpetuating rampant sexism and the objectification of female characters. I analyze aspects of the television shows Orphan Black and Buffy the Vampire Slayer, two broadcast television series which aired over ten years apart, to broadly evaluate whether the science fiction and fantasy genres have progressed or …

Greek Involvement And Personality, Sara Lee, Nikita Amin, Sabbu Bajimaya, Brandon Love

UROP Posters

Many young college students participate in Greek life to involve themselves with a group of people similar to themselves and to engage in life on campus. The intent of this research is to measure the relationship between Greek membership and/or involvement and personality. Data from Spit for Science: the VCU Student Survey will be examined to analyze this relationship. The participants included freshman fall and sophomore spring survey participants from the 2012 Spit for Science cohort. The measures for the study were the Big Five Inventory (BFI) and the UPPS impulsive behavior scales.

The BFI includes the personality traits of …

Organophosphates In Chlorpyrifos Insecticide: Neurobehavioral Development Of Children In Agricultural Communities, Sravya Uppalapati

UROP Posters

The chemicals found in fertilizers and pesticides are known to adversely affect the human nervous system even at low levels of exposure. Neither the agricultural industry nor the EPA can deny scientific findings regarding the toxic qualities of organophosphates in the insecticide chlorpyrifos, but that does not deter pesticide manufacturers from selling harmful products. In fact, Dow AgroSciences, a pesticide company, states on its website that, “Insecticides, such as chlorpyrifos, provide important protection for our food supply and thus safeguard farm and consumer economy.” To understand the health risks associated with pesticide exposure, I studied the influence of organophosphates in …

Feasibility Of Integrating Tripterygium Wilfordii Into Modern Cancer Therapy For Increased Efficacy And Minimal Toxicity, Ngoc T. Vo

UROP Posters

Cancer is the second leading cause of death in the U.S. and millions of novel cancer cases are being diagnosed each year. While chemotherapy and ionizing radiation are effective treatments against these malignant tumors, the adverse effects that accompany such treatments are devastating. In order to find alternative treatment methods with less side effects, we turn to Eastern herbal medicine. Recent scientific research has found that Tripterygium wilfordii, an herbal medicine traditionally used to treat inflammation in China, contains compounds (triptolide and celastrol) that prevent the growth of solid tumors, induce apoptosis, and prevent metastasis of developed tumors. Investigations …

Queer Mysticism In The High Middle Ages: Pain, Love, Earth, And The Female Body In The Illustrations Of Hildegard Of Bingen’S Scivias, Becky Bushnell

UROP Posters

Many view Hildegard of Bingen as one of the most important female theologians of the 12th century, and her writing and sphere of influence is remarkable considering her gender. Many scholars, like Barbara Newman, Caroline Walker Bynum, and Carolyn Worman Sur, agree that Hildegard’s portrayals of God in Scivias are distinctly feminine. Scholars like Karma Lochrie, Sheryl Chen, and Flora Lewis have written on Christ’s wound as a metaphor for the womb or vulva. Yet what scholars don’t seem to focus on, as Lochrie writes in “Mystical Acts, Queer Tendencies,” is the ways that the work of many female mystics …

Ketamine, A Brighter Future For Those In Darkness, Matthew D. Gayhart

UROP Posters

Millions of people around the world suffer from Major Depressive Disorder, and many of these people are given drugs to help treat this potentially devastating disease. For many, the first treatment is successful, and if not, certainly the second treatment gives them the relief they so desperately need. Others, however, are not so lucky, people with treatment resistant depression undergo numerous treatments, some of which are more aggressive than others, but still nothing helps alleviate their depression. Recently an older anesthetic, the drug Ketamine, has been making some news as a new depression treatment. This paper will compare Ketamine to …

Smoking Patterns Among Vcu Students, Jasmine Saini

UROP Posters

For some individuals, college can be a high risk time for the development of problems associated with alcohol use and other substances. The purpose of this study is to examine these initiation and use patterns as they relate to nicotine use among college students 18 years of age and older enrolled in Spit for Science: The VCU Student Survey. The Spit for Science research project evaluates how genetic and environmental factors contribute to substance use and emotional health among college students at VCU. This study uses data from the Spit for Science 2011 cohort (n=2007) to investigate smoking patterns among …

Factors Involved In The Successful Transition To And Subsequent Use Of Electronic Health Records (Ehrs) Systems By Individual And Group-Practice Physicians, Naveen Chandra Kotha

UROP Posters

The use of Electronic Health Records (EHRs) by healthcare professionals has been recommended as a way of improving healthcare quality, patient safety, and workflow efficiency, and lowering costs in the long run. While large hospital systems integrate EHRs into their services, individual and group practice-owning physicians, especially those of specialties and subspecialties, are often left wondering whether they should follow the trend and whether the transition from traditional, paper-chart systems or older EHRs to newer, commercial ones will truly benefit their patients and their practice as a whole. These physicians also often wonder whether benefits such as electronic-prescribing, clinical decision …

Crime And Security In Brazil: Brazil's Pacification Efforts In The Favelas Of Rio De Janeiro, Susan C. Shea

Honors Theses

The purpose of this research is to study Brazil's current pacification efforts in the favelas of Rio de Janeiro. Brazil has long been linked to violent crime, corruption, and increasing social inequality. It features more homicides than any other country on earth: one in ten people killed around the world each year is a Brazilian (Carvalho, 2015). However, in 2008, Rio's state government began applying a new law enforcement program to rid favelas of gangs and crime before hosting the 2014 FIFA World Cup and 2016 Summer Olympics. Information on the current/future tactics and strategies that Rio will incorporate into …

Assessment Of The Neighborhood Environment And Its Association With Gestational Age At Birth, Brittaney A. Castro

UROP Posters

Preterm birth is one of the most persistent of health disparities and accounts for five times more African American versus European American infant death. The preterm birth rate in African American is nearly twice as high compared to European Americans. Recent studies have shown that a major contributor to this disparity is accounted for by the greater environmental heterogeneity seen in African American populations. The purpose of this study is to examine how the measured neighborhood environment influences race-specific preterm birth rates by: 1) assessing the degree of neighborhood heterogeneity that exists between self-identified race; 2) estimate the extent these …

Analysis Of Treatments Used For Individuals With Rett Syndrome Who Experience Seizures, Harshita Nangunuri

UROP Posters

Rett Syndrome (RTT) is a severe Autism Spectrum disorder affecting one in ten thousand females. Seizures are a common symptom associated with RTT, as up to eighty percent of individuals with RTT have seizures. Most of these individuals are treated for these seizures with antiepileptic drugs (AEDs). However, AEDs are not very effective for treating seizures in all cases, have many side effects such as increasing the risk of vitamin D deficiency for individuals with RTT and do not help with any other symptoms associated with RTT. Because of these problems associated with AEDs, two additional treatments to treat seizures …

Advisor And Student Experiences Of Summer Support For College-Intending, Low-Income High School Graduates, Karen D. Arnold, Alexandra Chewning, Benjamin Castleman, Lindsay Page

Journal of College Access

Summer melt occurs when students who have been accepted to college and intend to enroll fail to matriculate in college in the fall semester after high school. A high rate of summer melt contributes to the lower postsecondary attainment rates of low-income students, in particular. This article presents qualitative findings from two interventions intended to reduce summer melt among low-income, urban high school graduates who had been accepted to college and indicated their intention to enroll. Results from student and counselor surveys, interviews, and focus groups point to a web of personal and contextual factors that collectively influence students’ college …

Guest Perspective: Preparation Gaps, Mandy Savitz-Romer

Journal of College Access

No abstract provided.