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Articles 11011 - 11040 of 146916
Full-Text Articles in Entire DC Network
Michael Gorman, Jim Browne
Michael Gorman, Jim Browne
Interviews for WGLT
Jim Browne from WGLT speaks with Michael Gorman, treasurer for Bike BloNo, about a study the organization conducted regarding bike use and safety in Bloomington/Normal. Michael is the Senior Web Developer and Bike Committee Chair at Illinois Wesleyan University.
A transcript of this interview is available at the download link, above and to the right on this page.
Visit WGLT, for more information about the interview. For information on the study and the organization, visit Bike BloNo.
Getting It Wrong, Neal Deroo
Getting It Wrong, Neal Deroo
Faculty Work Comprehensive List
"We need to remember our sinfulness so we don't get too proud of our own accomplishments or too sure of our ability to save ourselves."
Posting about differing perceptions of history from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.
http://inallthings.org/getting-it-wrong/
The Impact Of Technology-Enhanced Learning Activities On Nursing Student Engagement In The Classroom, Alicia A. Stone
The Impact Of Technology-Enhanced Learning Activities On Nursing Student Engagement In The Classroom, Alicia A. Stone
Theses & Dissertations
Educating student nurses in the present environment requires professors to stay current with new methodologies as well as innovations in technology. The question is how to address both the impact of technology and the skills of clinical reasoning, and keep the students involved in the material. If there can be integration of each aspect through the use of technology-enhanced learning activities on the internet and preparation to approach the issue, then perhaps this can increase success. This is a quasi-experimental intervention study that explored the impact of a case study blogging assignment on the engagement of students enrolled in a …
Auditing Standards Board (Asb) Teleconference Meeting Highlights November 23, 2015, Auditing Standards Board
Auditing Standards Board (Asb) Teleconference Meeting Highlights November 23, 2015, Auditing Standards Board
Association Sections, Divisions, Boards, Teams
No abstract provided.
Auditing Standards Board (Asb), Conference Call, November 23, Meeting Agenda, American Institute Of Certified Public Accountants. Auditing Standards Board
Auditing Standards Board (Asb), Conference Call, November 23, Meeting Agenda, American Institute Of Certified Public Accountants. Auditing Standards Board
Association Sections, Divisions, Boards, Teams
No abstract provided.
Winthrop University President Schedules His Investiture At May Commencement, Winthrop University
Winthrop University President Schedules His Investiture At May Commencement, Winthrop University
Winthrop News 2015
- Mahony said he has given the inauguration a lot of thought, talked with a number of people and decided against doing a stand-alone event.
- In a campus-wide e-mail sent today to faculty and staff, he said he would rather spend the money elsewhere and prefer to have people spend their time focused on other, more critical activities.
The Dacus Digest Volume 2 Issue 1, Michaela Eileen Volkmar, Dacus Library
The Dacus Digest Volume 2 Issue 1, Michaela Eileen Volkmar, Dacus Library
Dacus Digest
Inside This Issue:
New Login Credentials
Interlibrary Loan Changes
Where's the Call Number?
Catalog Features and Tips
Electronic Access to the NYTimes
Donating Popular Fiction and DVDs
Book A Librarian
New SelectedWorks Features
Friend's Beach House Raffle
The Impact Of Pedagogical Agents' Conversational Formality On Learning And Learner Impressions, Haiying Li
The Impact Of Pedagogical Agents' Conversational Formality On Learning And Learner Impressions, Haiying Li
Electronic Theses and Dissertations Archive
The dissertation examined the impact of agents' conversational formality on the learning of summarization skills and learner impressions in an intelligent tutoring system (ITS) with trialogues (a teacher agent, a student agent, and a human learner). Formal language is in the informational genre (as opposed to narrative) and increases with word abstractness, syntactic complexity, referential cohesion, and deep cohesion. At the other end of the continuum, informal discourse tends to have concrete words, simple syntax, low cohesion (because knowledge-based inferences can fill the gaps), and high narrativity. There have been no experimental investigations that have maniputed teacher language because it …
Molecular Role Of Dab2ip Gtpase Activating Protein In Brain Development, Farimah Salami
Molecular Role Of Dab2ip Gtpase Activating Protein In Brain Development, Farimah Salami
Electronic Theses and Dissertations Archive
Dab2ip is the member of Ras GTPase activating protein family that interacts with Disabled-1/2 famlily proteins, which play a critical role in brain development. Dab2ip is mainly known as a tumor suppressor, however recent studies have shown that it has important functions in the mammalian brain. In this study, using bioinformatics and experimental techniques, I characterized the mouse Dab2ip gene structure. Unlike previous reports, I found that the mouse Dab2ip gene has 20 exons and 3 CpG islands. I identified three transcript variants of Dab2ip which starts from exon one. Alternative splicing at the 5' end of these transcripts result …
High Performance Liquid Chromatography Tandem Mass Spectrometry For Trace Analysis In Environmental Samples, Heather L. Fleming
High Performance Liquid Chromatography Tandem Mass Spectrometry For Trace Analysis In Environmental Samples, Heather L. Fleming
Electronic Theses and Dissertations Archive
1,3-Dimethylamylamine (1,3-DMAA) is a stimulant commercially sold in a variety of dietary supplements as a chemical species derived from geranium plants (Pelargonium graveolens). Whether 1,3-DMAA naturally occurs in geranium plants or other dietary ingredients, it has important regulatory and commercial ramifications. An extraction method combined with HPLC-MS/MS is used to determine 1,3-DMAA and 1,4-dimethylamylamine (1,4-DMAA) concentrations in geranium plants with both external calibration and standard addition methods. Samples from the Changzhou, Kunming, and Guiyang regions of China during both winter and summer were analyzed. Following the detection of DMAA in the Changzhou sample, an extraction and pre-column, chiral derivatization chemistry …
Recharge Pathways And Mechanisms To The Memphis Aquifer, John Michael Bursi
Recharge Pathways And Mechanisms To The Memphis Aquifer, John Michael Bursi
Electronic Theses and Dissertations Archive
As the primary source of water for Memphis, Tennessee and surrounding areas, the Memphis aquifer is an important natural resource. Recharge to the Memphis aquifer, which is thought to occur by infiltration of precipitation in the exposure belt, is impeded by Quaternary loess and paleosols on the upland surfaces. This study investigated whether incised stream gullies provide a faster rate of infiltration, and potential recharge, relative to the upland surfaces. Through a year of monitoring of physical hydrology and water chemistry within a watershed at the Pinecrest research site, located in Fayette County, Tennessee, along with the implementation of environmental …
Living Your Best Life: Identities Of Televangelist Joel Osteen And His Imagined Audience, Reginald Bell Jr.
Living Your Best Life: Identities Of Televangelist Joel Osteen And His Imagined Audience, Reginald Bell Jr.
Electronic Theses and Dissertations Archive
How does one analyze the impact of televangelist Joel Osteen? Attempts have been made to answer this question primarily from a theological perspective and occassionally from cultural and media perspectives. Though these analytical lenses have provided some limited insight into Osteen, his rise to prominence, and the growth of his ministry, none has sufficiently addressed or critcally analyzed Osteen's discursive artistry. Utilizing important analytical principles and research tools from the field of Communication, this dissertation provides three new critical lenses: first persona, second persona, and third persona. These lenses will help televangelist studies uncover the artistry and compliexity of how …
The Source Of Saline Groundwater In The Mississippi River Valley Alluvial Aquifer In Southeast Arkansas, Justin Michael Paul
The Source Of Saline Groundwater In The Mississippi River Valley Alluvial Aquifer In Southeast Arkansas, Justin Michael Paul
Electronic Theses and Dissertations Archive
In this study, the source of historical chloride anomalies in the Mississippi River Valley alluvial aquifer from southeast Arkansas is investigated using spatial statistical and geochemical techniques. The spatial statistical and geochemical techniques are employed to determine whether the source of the saline groundwater is due to evaporative processes in the soil column, injection of saline fluids from depth, or infiltration from rivers. Spatial statistical analyses show chloride anomalies in the alluvial aquifer are more closely related to tectonic features associated with the injection of saline fluids from depth than evaporative concentration of soil waters that may have recharged groundwater. …
Matched, Somewhat-Matched Or Mismatched? Predictors Of Degree-Job Match Among Stem Graduates, Taghreed Ahmed Alhaddab
Matched, Somewhat-Matched Or Mismatched? Predictors Of Degree-Job Match Among Stem Graduates, Taghreed Ahmed Alhaddab
Seton Hall University Dissertations and Theses (ETDs)
The current third-generation globalization caused structural, organizational and functional changes in the STEM workforce along with changes in human capital flow. The new globalization shift produced new world order causing the STEM workforce to adopt new frameworks, new skills, and new policy approaches to maintain economic strength and achieve growth and prosperity. Available data indicate that the U.S. secondary and postsecondary education system prepares and produce more than an adequate number of STEM graduates. The perceived crisis in the number of U.S. STEM graduates was not confirmed by any data or policy report. Thus, attention should not be caught simply …
Twin Pregnancy With A Complete Hydatidiform Mole And A Coexisting Live Fetus : Rare Entity, Shahila Sheik, Nihal Al-Riyami, Namitha R. Al-Sukaiti, Rashid, Asim Qureshi, Mariam Mathew
Twin Pregnancy With A Complete Hydatidiform Mole And A Coexisting Live Fetus : Rare Entity, Shahila Sheik, Nihal Al-Riyami, Namitha R. Al-Sukaiti, Rashid, Asim Qureshi, Mariam Mathew
Sultan Qaboos University Medical Journal
A hydatidiform mole with a coexisting live fetus is a rare occurrence and the optimal management for this condition is not yet known. We report the case of a 32-year-old woman (gravida 3, para 2) who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in March 2012 at 13 gestational weeks with abdominal pain and vaginal bleeding. An ultrasound examination revealed a hydatidiform mole pregnancy coexisting with a live fetus. After extensive counselling, the patient and her husband opted for a conservative management approach. Unfortunately, a hysterotomy had to be performed at 17 gestational weeks due to severe haemorrhage. …
Echocardiographic Evidence Of Early Diastolic Dysfunction In Asymptomatic Children With Osteogenesis Imperfecta, Khalfan S. Al-Senaidi, Irfan Ullah, Hashim Al-Khabori, Murtadha, Saif Al-Yaarubi
Echocardiographic Evidence Of Early Diastolic Dysfunction In Asymptomatic Children With Osteogenesis Imperfecta, Khalfan S. Al-Senaidi, Irfan Ullah, Hashim Al-Khabori, Murtadha, Saif Al-Yaarubi
Sultan Qaboos University Medical Journal
Objectives: Structural and functional cardiovascular abnormalities have been reported in adults with osteogenesis imperfecta (OI); however, there is a lack of paediatric literature on this topic. This study aimed to investigate cardiovascular abnormalities in children with OI in comparison to a control group. Methods: This case-control study was conducted at the Sultan Qaboos University Hospital in Muscat, Oman, between May 2013 and August 2014. Data from eight patients with OI and 24 healthy controls were compared using conventional and tissue Doppler echocardiography (TDE). Results:The OI group had significantly lower peak early mitral valve flow velocity (P = 0.027), peak a-wave …
Accuracy Of Platelet Counting By Optical And Impedance Methods In Patients With Thrombocytopaenia And Microcytosis, Mohamed-Rachid Boulassel, Raya Al-Farsi, Sulaiman Al-Riyami, Hamad, Hammad Khan, Salam Al-Kindi
Accuracy Of Platelet Counting By Optical And Impedance Methods In Patients With Thrombocytopaenia And Microcytosis, Mohamed-Rachid Boulassel, Raya Al-Farsi, Sulaiman Al-Riyami, Hamad, Hammad Khan, Salam Al-Kindi
Sultan Qaboos University Medical Journal
Objectives: Obtaining accurate platelet counts in microcytic blood samples is challenging, even with the most reliable automated haematology analysers. The CELL-DYN™ Sapphire (Abbott Laboratories, Chicago, Illinois, USA) analyser uses both optical density and electronic impedance methods for platelet counting. This study aimed to evaluate the accuracy of optical density and electrical impedance methods in determining true platelet counts in thrombocytopaenic samples with microcytosis as defined by low mean corpuscular volume (MCV) of red blood cells. Additionally, the impact of microcytosis on platelet count accuracy was evaluated. Methods: This study was carried out between February and December 2014 at the Haematology …
Association Of Angiotensin-Converting Enzyme And Glutathione S-Transferase Gene Polymorphisms With Body Mass Index Among Hypertensive North Indians, Saliha Rizvi, Syed T. Raza, Zeba Abbas, Shania, Farzana Mahdi
Association Of Angiotensin-Converting Enzyme And Glutathione S-Transferase Gene Polymorphisms With Body Mass Index Among Hypertensive North Indians, Saliha Rizvi, Syed T. Raza, Zeba Abbas, Shania, Farzana Mahdi
Sultan Qaboos University Medical Journal
Objectives: This study aimed to examine the association of angiotensin-converting enzyme (ACE) and glutathione S-transferase (GST) gene polymorphisms with body mass index (BMI) in hypertensive North Indians. Methods: This case-control study was carried out between May 2013 and November 2014 at the Era’s Lucknow Medical College & Hospital, Lucknow, India, and included 378 subjects divided into three groups. One group constituted 253 hypertensive individuals (sustained diastolic blood pressure of >90 mmHg and systolic blood pressure of >140 mmHg) who were subcategorised according to normal (<25 kg/m2) or high (≥25 kg/m2) BMI. The third group consisted of 125 age-, gender- and ethnically-matched normotensive controls with a normal BMI. Gene polymorphisms were evaluated by polymerase chain reaction. The genotypic and allelic frequency distribution among both groups were analysed. Results: A significant difference was found between GST theta 1-null and GST mu 1-positive genotype frequencies among the hypertensive overweight/obese individuals and controls (P = 0.014 and 0.033, respectively). However, no difference was observed in the frequency of ACE polymorphisms. ACE insertion/insertion genotype (P = 0.006), insertion and deletion alleles (P = 0.007 each) and GST theta 1-null and GST theta 1-positive genotypes (P = 0.006 each) were found to differ significantly between hypertensive cases and controls, regardless of BMI. Conclusion: ACE and GST gene polymorphisms were not associated with BMI but were significantly associated with hypertension among the studied group of North Indians.
Frequencies Of The Arg16gly, Gln27glu And Thr164ile Adrenoceptor Β2 Polymorphisms Among Omanis, Khalid Al-Balushi, Fahad Zadjali, Sawsan Al-Zadjali, Al-Muatasim, Riad Bayoumi
Frequencies Of The Arg16gly, Gln27glu And Thr164ile Adrenoceptor Β2 Polymorphisms Among Omanis, Khalid Al-Balushi, Fahad Zadjali, Sawsan Al-Zadjali, Al-Muatasim, Riad Bayoumi
Sultan Qaboos University Medical Journal
Objectives: This study aimed to assess the distribution of missense mutations in the adrenoceptor β2 (ADRB2) gene in an Omani cohort. Methods: This study was carried out between May 2014 and March 2015 at the Sultan Qaboos University, Muscat, Oman. Blood samples were taken from 316 unrelated Omani subjects. Genotyping for rs1042713 (c.46A>G, p.Arg16Gly), rs1042714 (c.79C>G, p.Gln27Glu) and rs1800888 (c.491C>T, p.Thr164Ile) polymorphisms was performed by real-time polymerase chain reaction using single nucleotide polymorphism (SNP) genotyping assays. The allelic frequencies of these polymorphisms were estimated on the basis of the observed numbers of specific alleles from the genotype …
Association Of Higher Defensin Β-4 Genomic Copy Numbers With Behçet’S Disease In Iraqi Patients, Ammar F. Hameed, Sameh Jaradat, Bassam M. Sharquie, Khalifa, Mazin J. Ibrahim, Raafa K. Hayani, Johannes Norgauer
Association Of Higher Defensin Β-4 Genomic Copy Numbers With Behçet’S Disease In Iraqi Patients, Ammar F. Hameed, Sameh Jaradat, Bassam M. Sharquie, Khalifa, Mazin J. Ibrahim, Raafa K. Hayani, Johannes Norgauer
Sultan Qaboos University Medical Journal
Objectives: Behçet’s disease (BD) is an immune-mediated small vessel systemic vasculitis. Human β-defensins are antimicrobial peptides associated with many inflammatory diseases and are encoded by the β-defensin family of multiple-copy genes. However, their role in BD necessitates further investigation. The aim of the present study was to investigate the possible association of BD in its various clinical forms with defensin β-4(DEFB4) genomic copy numbers. Methods: This case-control study was conducted from January to September 2011 and included 50 control subjects and 27 unrelated Iraqi BD patients registered at Baghdad Teaching Hospital, Bagdad, Iraq. Copy numbers of the DEFB4 gene were …
Safety And Complications Of Double-Lumen Tunnelled Cuffed Central Venous Dialysis Catheters : Clinical And Radiological Perspective From A Tertiary Centre In Oman, Rana S. Hamid, Anupam K. Kakaria, Saif A. Mohammed, Saja, Rashid Al-Sukaiti, Dawood Al-Riyami, Yasser W. Al-Mula Abed
Safety And Complications Of Double-Lumen Tunnelled Cuffed Central Venous Dialysis Catheters : Clinical And Radiological Perspective From A Tertiary Centre In Oman, Rana S. Hamid, Anupam K. Kakaria, Saif A. Mohammed, Saja, Rashid Al-Sukaiti, Dawood Al-Riyami, Yasser W. Al-Mula Abed
Sultan Qaboos University Medical Journal
Objectives: This study aimed to assess the technical success, safety and immediate and delayed complications of double-lumen tunnelled cuffed central venous catheters (TVCs) at the Sultan Qaboos University Hospital (SQUH), Muscat, Oman. Methods: This retrospective study took place between January 2012 and October 2013. The clinical records and radiological data of all patients who underwent ultrasound- and fluoroscopy-guided TVC placement at SQUH during the study period were reviewed. Demographic data and information regarding catheter placement, technical success and peri- and post-procedure complications (such as catheter-related infections or thrombosis) were collected. Results: A total of 204 TVCs were placed in 161 …
Evaluation Of Salivary Secretory Immunoglobulin A Levels In Diabetic Patients And Association With Oral And Dental Manifestations, Shahla Kakoei, Bahareh Hosseini, Ali-Akbar Sanjari, Mojgan, Ahmad Gholamhosseinian, Vahid Fn Afshar
Evaluation Of Salivary Secretory Immunoglobulin A Levels In Diabetic Patients And Association With Oral And Dental Manifestations, Shahla Kakoei, Bahareh Hosseini, Ali-Akbar Sanjari, Mojgan, Ahmad Gholamhosseinian, Vahid Fn Afshar
Sultan Qaboos University Medical Journal
Objectives: Oral and dental manifestations in diabetic patients can arise due to numerous factors, including elevated salivary secretory immunoglobulin A (s-IgA) levels. This study aimed to evaluate s-IgA concentrations in patients with type 2 diabetes mellitus (T2DM) and to investigate the association between s-IgA levels and oral and dental manifestations of T2DM. Methods: This cross-sectional descriptive study was carried out between October 2011 and September 2012 in Kerman, Iran, and included 260 subjects (128 patients with T2DM and 132 healthy controls). Unstimulated salivary samples were collected from all subjects and s-IgA levels were determined using the immunoturbidimetric method. The oral …
Serum Zinc Concentrations In Children With Acute Bloody And Watery Diarrhoea, Abolfazl Mahyar, Parviz Ayazi, Victoria Sahmani, Mehdi, Sonia Oveisi, Shiva Esmaeily
Serum Zinc Concentrations In Children With Acute Bloody And Watery Diarrhoea, Abolfazl Mahyar, Parviz Ayazi, Victoria Sahmani, Mehdi, Sonia Oveisi, Shiva Esmaeily
Sultan Qaboos University Medical Journal
Objectives: The role of zinc in the pathogenesis of diarrhoea is controversial. This study was conducted to compare serum zinc levels in children with acute diarrhoea to those found in healthy children. Methods: This case-control study was carried out at the Qazvin Children’s Hospital in Qazvin, Iran, between July 2012 and January 2013. A total of 60 children with acute diarrhoea (12 children with bloody diarrhoea and 48 children with watery diarrhoea) and 60 healthy children were included. Zinc levels for all subjects were measured using a flame atomic absorption spectrophotometer and data were analysed and compared between groups. Results: …
Eosinophilic Pneumonia In A Patient With Bronchial Myiasis : Case Report And Literature Review, Arindom Aich, Suad Al-Ismaili, Fatma A. Al-Wardi, Talal Hm, Quasem Al-Salmi, Hilal Al-Hashami
Eosinophilic Pneumonia In A Patient With Bronchial Myiasis : Case Report And Literature Review, Arindom Aich, Suad Al-Ismaili, Fatma A. Al-Wardi, Talal Hm, Quasem Al-Salmi, Hilal Al-Hashami
Sultan Qaboos University Medical Journal
Pulmonary myiasis is an unusual form of myiasis in humans and has been recently identified as a cause of eosinophilic pneumonia. We report the case of a 13-year-old Omani boy who presented to the Royal Hospital, Muscat, Oman, in October 2014 with respiratory distress. Bronchial aspirates revealed features of eosinophilic pneumonia. Possible larvae identified in the cytology report, a high immunoglobulin E level and the patient history all indicated bronchial myiasis. The patient was treated with steroids and ventilation and has since been diseasefree with no long-term side-effects. To the best of the authors’ knowledge, this is the first case …
Temporomandibular Joint Ankylosis As A Complication Of Neonatal Septic Arthritis : Report Of Two Cases, Noor J. Al-Saadi, Abdulaziz A. Bakathir, Ahmed K. Al-Ismaili, Mohammad I.
Temporomandibular Joint Ankylosis As A Complication Of Neonatal Septic Arthritis : Report Of Two Cases, Noor J. Al-Saadi, Abdulaziz A. Bakathir, Ahmed K. Al-Ismaili, Mohammad I.
Sultan Qaboos University Medical Journal
Temporomandibular joint (TMJ) ankylosis as a complication of neonatal septic arthritis is rarely reported in the literature. We report two clinical cases of unilateral TMJ ankylosis occurring in paediatric patients subsequent to neonatal septic arthritis. The first case was a 15-month-old male infant who presented to the Sultan Qaboos University Hospital, Muscat, Oman, in May 2010. According to the published English scientific literature, he is the youngest person yet to be diagnosed with this condition. The second case was a five-year-old female who presented to the Al-Nahda Hospital, Muscat, Oman, in October 2011. Both cases presented with facial asymmetry and …
Common Peroneal Nerve Mononeuropathy Due To An Amniotic Constriction Band, Susan Al-Nabhani, Hamdah Al-Abri, Instisar Venugopal, Prabhakaran, Roshan Koul
Common Peroneal Nerve Mononeuropathy Due To An Amniotic Constriction Band, Susan Al-Nabhani, Hamdah Al-Abri, Instisar Venugopal, Prabhakaran, Roshan Koul
Sultan Qaboos University Medical Journal
No abstract provided.
Appearance Of Renal Replacement Lipomatosis On Computed Tomography : Rare Pseudotumour, Kemal Kara, Ali K. Sivrioglu, Coskun Kafadar, Cahit
Appearance Of Renal Replacement Lipomatosis On Computed Tomography : Rare Pseudotumour, Kemal Kara, Ali K. Sivrioglu, Coskun Kafadar, Cahit
Sultan Qaboos University Medical Journal
No abstract provided.
Diagnosis And Genetic Analysis Of Glutaric Acidaemia Type I : Very Rarely Seen Inborn Error Of Metabolism, Madhavi Vasikarla, Aakash Pandita, Deepak Pratap, Oleti T., Srinivas Murki
Diagnosis And Genetic Analysis Of Glutaric Acidaemia Type I : Very Rarely Seen Inborn Error Of Metabolism, Madhavi Vasikarla, Aakash Pandita, Deepak Pratap, Oleti T., Srinivas Murki
Sultan Qaboos University Medical Journal
No abstract provided.
Presentations Of Sultan Qaboos University Clinico-Pathologic Conferences Sultan Qaboos University College Of Medicine & Health Sciences And Sultan Qaboos University Hospital, 2014–2015, Sultan Qaboos University
Presentations Of Sultan Qaboos University Clinico-Pathologic Conferences Sultan Qaboos University College Of Medicine & Health Sciences And Sultan Qaboos University Hospital, 2014–2015, Sultan Qaboos University
Sultan Qaboos University Medical Journal
No abstract provided.
Applications Of High Performance Affinity Chromatography With High Capacity Stationary Phases Made By Entrapment, John A. Vargas Badilla
Applications Of High Performance Affinity Chromatography With High Capacity Stationary Phases Made By Entrapment, John A. Vargas Badilla
Department of Chemistry: Dissertations, Theses, and Student Research
High performance affinity chromatography (HPAC) is a technique that uses a biologically-related agent such as a transport protein or an antibody as the stationary phase in an HPLC system. In recent years, HPAC has been shown to be a valuable bioanalytical tool for studying solute-protein interactions. Human serum albumin (HSA), the most abundant protein in blood (with concentrations of 35 to 50 mg/mL in serum), has been shown to interact with many drugs, affecting their transport, excretion and metabolism. A physical method for immobilizing proteins in HPAC supports has been optimized in this dissertation by using HSA as a model …