Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (9747)
- Medicine and Health Sciences (6748)
- Law (5753)
- Arts and Humanities (5718)
- Education (4955)
-
- Life Sciences (4271)
- Physical Sciences and Mathematics (4271)
- Engineering (2606)
- Business (2367)
- Communication (1626)
- Library and Information Science (1617)
- Psychology (1546)
- Medical Specialties (1445)
- History (1425)
- Sociology (1417)
- Higher Education (1299)
- Religion (1155)
- Public Affairs, Public Policy and Public Administration (1134)
- Public Health (1111)
- Computer Sciences (1040)
- Nursing (949)
- Economics (890)
- Biology (876)
- Medical Sciences (754)
- Political Science (721)
- Animal Sciences (709)
- Teacher Education and Professional Development (706)
- Chemistry (678)
- Curriculum and Instruction (649)
- International and Area Studies (649)
- Institution
-
- University of Nebraska - Lincoln (1614)
- TÜBİTAK (1279)
- Purdue University (1068)
- Brigham Young University (955)
- University of Kentucky (934)
-
- City University of New York (CUNY) (808)
- University of South Florida (799)
- Singapore Management University (707)
- Walden University (691)
- Utah State University (657)
- University of Central Florida (651)
- University of Mississippi (594)
- Louisiana State University (592)
- Georgia Southern University (564)
- University of Montana (521)
- University of Rhode Island (519)
- University of Plymouth (505)
- Portland State University (503)
- Technological University Dublin (487)
- Virginia Commonwealth University (471)
- San Jose State University (464)
- The University of Akron (452)
- University of Arkansas, Fayetteville (452)
- Missouri University of Science and Technology (442)
- Old Dominion University (436)
- Western Kentucky University (428)
- Western Michigan University (424)
- University of Malaya (419)
- Washington University School of Medicine (412)
- University of New Mexico (409)
- Keyword
-
- Education (487)
- Humans (334)
- Newspaper (248)
- History (242)
- Gender (218)
-
- Female (216)
- Higher education (209)
- 2015 (193)
- Male (193)
- United States (188)
- EIU (187)
- Women (181)
- Psychology (179)
- Concordia Journal (177)
- News Releases (176)
- Communication (175)
- Leadership (169)
- Technology (169)
- Race (168)
- Library science (164)
- Animals (146)
- College of Liberal Arts (146)
- Culture (144)
- Newsletter (140)
- Eastern Illinois University (139)
- Daily Eastern News (138)
- China (137)
- Research (137)
- Assessment (136)
- Faculty Senate (136)
- Publication
-
- Faculty Publications (965)
- Theses and Dissertations (961)
- Walden Dissertations and Doctoral Studies (642)
- Publications and Research (469)
- Faculty Scholarship (394)
-
- Electronic Theses and Dissertations (386)
- Open Access Publications (351)
- Articles (331)
- Honors Theses (328)
- Applied Mathematics & Information Sciences (311)
- Journal Articles (300)
- Akron Law Review (298)
- Research Publications (2011 to 2015) (289)
- Dissertations (278)
- Saudi Medical Journal (270)
- University of Mississippi News (258)
- Research Collection School Of Computing and Information Systems (227)
- Turkish Journal of Medical Sciences (225)
- Journal of Health Occupations Education (218)
- Open Access Dissertations (211)
- University of Montana Course Syllabi (211)
- Publications (208)
- Food and Machinery (206)
- Master's Theses (192)
- USF Tampa Graduate Theses and Dissertations (179)
- Concordia Journal (177)
- Journal of Extension (177)
- Theses (174)
- University of New Orleans Syllabi (173)
- Turkish Journal of Electrical Engineering and Computer Sciences (170)
- Publication Type
Articles 421 - 450 of 54405
Full-Text Articles in Entire DC Network
Chemical Analysis Of Urinary Tract Stones, Falah Mahdi Ali Al-Khafaji
Chemical Analysis Of Urinary Tract Stones, Falah Mahdi Ali Al-Khafaji
Muthanna Medical Journal
The aim of present study is to reveal the chemical composition of urinary tract stones in patients ministering in Al-Sadir medical city/Al-Najaf. The study conducted from March 2010 -December 2012. Convenience sampling technique was employed. The study included patients of either sex (470 cases, 342 were males 128 were females) and all ages (from 1 to 60 year) were diagnosed with urinary stones. All patients were treated conservatively or by intervention (ESWL, ureteroscopy, PNL, or open surgical therapy). Chemical analysis was performed. Out of 470 patients, 342(72.7%) were males and 128(27.2%) were females. Age of the patients ranging from 1- …
Percutanous Revascularization Of Chronic Total Occlusion Of Diabetic Patients At Iraqi Center For Heart Diseases, A Single Center Experience 2012, Hassan Abdul Amir Al-Daghir
Percutanous Revascularization Of Chronic Total Occlusion Of Diabetic Patients At Iraqi Center For Heart Diseases, A Single Center Experience 2012, Hassan Abdul Amir Al-Daghir
Muthanna Medical Journal
We aimed to evaluate the influence of DM on the results of PCI of patents with CTO and to compare that with the results in non-diabetic patients. Prospectively studied 150 consecutive cases of CTO with PCI at Iraqi center for heart diseases- Baghdad/Iraq for the period January– December 2012. Success of revascularization of chronic total occlusion by percutaneous coronary intervention was similar in both sexes (male 69.4%, female 72.4%). Intervention was successful in (40) out of (55) patients with diabetes mellitus (72.7%) which was identical to those without diabetes mellitus (66 patients out of 95 patients 69.47%). The success in …
Job Related Carpal Tunnel Syndrome, Zuhair Gheni Abd Ali
Job Related Carpal Tunnel Syndrome, Zuhair Gheni Abd Ali
Muthanna Medical Journal
This study include 60 patient had carpal tunnel syndrome signs and symptoms, treated by surgical release of the tunnel after the failure of the conservative measures from the period January 2010-October 2013 in Al Najaf city, 40 patients were female and 20 patients were male, mean age between 20-60 years, female occupation either farmer, cosmetic job mainly female hair clipper, computer worker, male occupation either farmer, industrials or driller peoples. The treatment program started by taking good history from the patients all those 60 patient included under this study feel their symptoms during performing their job or after that by …
Urinary Stone Distribution In Samawah: Current Status And Variation With Age And Sex A Cohort Study, Saad Hallawee Saad
Urinary Stone Distribution In Samawah: Current Status And Variation With Age And Sex A Cohort Study, Saad Hallawee Saad
Muthanna Medical Journal
The aim of the study was to describe the distribution of urinary stone. Age, sex, anatomical site and geographical correlations data were investigated. Cross-sectional and prospective data was made of three hundred and one (301) patients with stone were recorded in the consultation unit of Al-Hussien teaching hospital, Samawah city. The cohort study included 224 men (74%) and 77 women (26%) with a male to female ratio of 2.9:1 and a median age of 48 years (range 41-60 years). 181(60) patients have a single urinary stone and 120(40%) patients have multiple stone, 70(58%) live in rural area. The size of …
From The Editor, Romeo B. Lee
From The Editor, Romeo B. Lee
Asia-Pacific Social Science Review
No abstract provided.
Discourse, Identity And International Development Cooperation: China, Africa And Focac, Daniel Lemus Delgado
Discourse, Identity And International Development Cooperation: China, Africa And Focac, Daniel Lemus Delgado
Asia-Pacific Social Science Review
This article analyses the relationship between discourse and identity in the case of the People’s Republic of China in Africa. It assumes that the interests of the Chinese government in Africa can be understood from a theoretical constructivist approach. So, the activities of International Development Cooperation of China into Africa are a result of material and ideational aspirations. Thus, the ties of China in Africa have been boosted by the identity of the Chinese state in the international arena. To understand how identity and interest are linked, this article analyses the official discourse of China in Forum on China Africa …
Economic Determinants Of Communal Conflict: Evidence From Indonesia, Edgar Demetrio García, Indra Prasetya Adi Nugroho
Economic Determinants Of Communal Conflict: Evidence From Indonesia, Edgar Demetrio García, Indra Prasetya Adi Nugroho
Asia-Pacific Social Science Review
Religion, ethnicity, and politics are typical explanatory variables of violent conflicts. From an economic point of view, economic growth reduces the risk of civil war, yet the economic determinants of conflict have been little studied. In this article, we empirically study the impact of regional macroeconomic conditions on the number of violent conflicts in Indonesia, a country with potential risks of communal conflict because of the plurality of its society. We use panel data consisting of observations on 16 Indonesian regions from 2004 to 2013 to assess the impact of economic factors on conflict, reevaluating the religion effect using dynamic …
Culture, Structure, And Co-Ethnic Relations Of Indonesians Migrant Entrepreneurship In Taiwan, Paulus Rudolf Yuniarto
Culture, Structure, And Co-Ethnic Relations Of Indonesians Migrant Entrepreneurship In Taiwan, Paulus Rudolf Yuniarto
Asia-Pacific Social Science Review
Migrant entrepreneurship prompts a series of fascinating research questions on the nature, culture, and interconnectedness of migrant situations within host settlements. The rise of migrant entrepreneurship is the outcome of the integration of these cultural-structural elements in order to mobilize resources to fulfill the demands of entrepreneurship and to obtain competitive advantages in business. This paper describes how the symbiotic relations between migrants and their socio-cultural conditions shape the patterns of Indonesian entrepreneurship in Taiwan. In practice, Indonesian migrant entrepreneurship in Taiwan involves entrepreneurs applying local values or customs in the host society and then (re) produce them in their …
Experiences Of Coming Out In Japan: Negotiating “Perceived Homophobia”, Kotona Motoyama
Experiences Of Coming Out In Japan: Negotiating “Perceived Homophobia”, Kotona Motoyama
Asia-Pacific Social Science Review
Heteronormative society requires non-heterosexuals to come out in order to be recognized. Coming out is often the most challenging experience for non-heterosexuals and heteronormativity and homophobia are two powerful obstacles that they have to deal with. This paper considers how non-heterosexuals come out to themselves and to heterosexual others under the effect of Japanese cultural norms. Interviews with 24 non-heterosexuals and their experiences revealed that they have to deal with not only heteronormativity and homophobia like non-heterosexuals in the Western culture, but also “perceived homophobia,” which is created by the expectation of “respectable Japanese selves.” Thus, coming out in Japan …
Socioeconomic Disparities In Physical Activity Participation: An Exploratory Study Using Malay Sample, Yong Kang Cheah
Socioeconomic Disparities In Physical Activity Participation: An Exploratory Study Using Malay Sample, Yong Kang Cheah
Asia-Pacific Social Science Review
The objective of the present study is to examine the effects of socioeconomic factors on participation in physical activity among Malays in Malaysia. Drawing on a nationally representative sample that contains 17,515 respondents, a logit model is developed to estimate the likelihood of adopting a physically active lifestyle. The results of the present study show that income, age, sex, education, house locality, and employment status are significantly related to the levels of physical activity. In particular, there are negative relationships between higher-income earners, the elderly, females, the less-educated, urban dwellers, and the non-working adults, and the likelihood of being physically …
Ethics Of Thai Politicians, Wariya Chinwanno, Thitarree Sirisrisornchai
Ethics Of Thai Politicians, Wariya Chinwanno, Thitarree Sirisrisornchai
Asia-Pacific Social Science Review
No abstract provided.
All That Is Holy Profaned? The Disenchantment Of Romantic Love Under Global Capitalism, Yellowbelle Duaqui
All That Is Holy Profaned? The Disenchantment Of Romantic Love Under Global Capitalism, Yellowbelle Duaqui
Asia-Pacific Social Science Review
No abstract provided.
National Identity And Social Resilience In The Case Of South Korea, Pál Koudela
National Identity And Social Resilience In The Case Of South Korea, Pál Koudela
Asia-Pacific Social Science Review
No abstract provided.
Citizen Havel And The Construction Of Czech Presidentiality, Timothy Barney
Citizen Havel And The Construction Of Czech Presidentiality, Timothy Barney
Rhetoric and Communication Studies Faculty Publications
Václav Havel had two eventful terms as the first democratic president of the Czech Republic. The documentary Citizen Havel is one rhetorical artifact that captures the way a new democracy and its attendant executive power is constructed consciously in real time in a political culture where such a tradition has largely not existed. Culled from ten years of fly-on-the-wall-style footage, Citizen Havel captures the tensions between the constitutional expectations of the Czech presidency and Havel's own extraconstitutional interpretations of executive power. Ultimately, this essay argues that Citizen Havel is one influential representation of how Czech “presidentiality” during the post-communist transition …
Influence Of The Substrate Characteristics On The Bond Behavior Of Pbo Frcm-Concrete Joints, Tommaso D'Antino, Lesley H. Sneed, Christian Carloni, Carlo Pellegrino
Influence Of The Substrate Characteristics On The Bond Behavior Of Pbo Frcm-Concrete Joints, Tommaso D'Antino, Lesley H. Sneed, Christian Carloni, Carlo Pellegrino
Civil, Architectural and Environmental Engineering Faculty Research & Creative Works
Fiber Reinforced Cementitious Matrix (FRCM) composites can be employed as a valid alternative to Fiber Reinforced Polymers (FRP) composites for strengthening existing reinforced concrete (RC) structures. The weakness of FRCM-concrete joints has been reported to be at the matrix-fiber interface rather than within the concrete substrate, as is usually reported in the case of FRP-concrete joints. The experimental investigations regarding FRCM strengthening available in the literature have been performed by applying the FRCM composite onto a surface that was treated before the application, usually by grinding or sandblasting. However, the role of the substrate characteristics on the failure mechanism of …
Abq Free Press, December 30, 2015, Abq Free Press
Abq Free Press, December 30, 2015, Abq Free Press
ABQ Free Press
No abstract provided.
Minimising Risks In Research-Informed Teaching, Ka Gresty, T Heffernan, W Pan, A Edwards-Jones
Minimising Risks In Research-Informed Teaching, Ka Gresty, T Heffernan, W Pan, A Edwards-Jones
School of Law, Humanities and Social Sciences
Reported benefits of research-informed teaching include enhanced student engagement and graduates that are better prepared for employment in an uncertain world. However, there are a number of academic risks that can have both positive and negative impacts on staff and students when implementing research-informed teaching. Mitigating such risks could smooth the way for, or even encourage, wider exploration of innovative teaching methods with associated benefits. This paper presents findings of an empirical study that identifies what risks were encountered or perceived from both student and staff perspectives when adopting a research-informed teaching approach. Risks were identified through semi-structured interviews with …
What Does Recent Neuroscience Tell Us About Criminal Responsibility?, Uri Maoz, Gideon Yaffe
What Does Recent Neuroscience Tell Us About Criminal Responsibility?, Uri Maoz, Gideon Yaffe
Psychology Faculty Articles and Research
A defendant is criminally responsible for his action only if he is shown to have engaged in a guilty act—actus reus (eg for larceny, voluntarily taking someone else’s property without permission)—while possessing a guilty mind—mens rea (eg knowing that he had taken someone else’s property without permission, intending not to return it)—and lacking affirmative defenses (eg the insanity defense or self-defense). We therefore first review neuroscientific studies that bear on the nature of voluntary action, and so could, potentially, tell us something of importance about the actus reus of crimes.Then we look at studies of intention, perception of …
Concurrent Kleene Algebra With Tests And Branching Automata, Peter Jipsen, M. Andrew Moshier
Concurrent Kleene Algebra With Tests And Branching Automata, Peter Jipsen, M. Andrew Moshier
Mathematics, Physics, and Computer Science Faculty Articles and Research
We introduce concurrent Kleene algebra with tests (CKAT) as a combination of Kleene algebra with tests (KAT) of Kozen and Smith with concurrent Kleene algebras (CKA), introduced by Hoare, Möller, Struth and Wehrman. CKAT provides a relatively simple algebraic model for reasoning about semantics of concurrent programs. We generalize guarded strings to guarded series-parallel strings , or gsp-strings, to give a concrete language model for CKAT. Combining nondeterministic guarded automata of Kozen with branching automata of Lodaya and Weil one obtains a model for processing gsp-strings in parallel. To ensure that the model satisfies the weak exchange law (x‖y)(z‖w)≤(xz)‖(yw) of …
Tmsb4y Is A Candidate Tumor Suppressor On The Y Chromosome And Is Deleted In Male Breast Cancer., Hong Yuen Wong, Grace M Wang, Sarah Croessmann, Daniel J Zabransky, Anita Aggarwal, Min-Ling Liu, + 10 More
Tmsb4y Is A Candidate Tumor Suppressor On The Y Chromosome And Is Deleted In Male Breast Cancer., Hong Yuen Wong, Grace M Wang, Sarah Croessmann, Daniel J Zabransky, Anita Aggarwal, Min-Ling Liu, + 10 More
Pathology Faculty Publications
Male breast cancer comprises less than 1% of breast cancer diagnoses. Although estrogen exposure has been causally linked to the development of female breast cancers, the etiology of male breast cancer is unclear. Here, we show via fluorescence in situ hybridization (FISH) and droplet digital PCR (ddPCR) that the Y chromosome was clonally lost at a frequency of ~16% (5/31) in two independent cohorts of male breast cancer patients. We also show somatic loss of the Y chromosome gene TMSB4Y in a male breast tumor, confirming prior reports of loss at this locus in male breast cancers. To further understand …
Surface Display Of Glycosylated Tyrosinase Related Protein-2 (Trp-2) Tumour Antigen On Lactococcus Lactis, Jeevanathan Kalyanasundram, Suet Lin Chia, Adelene Ai Lian Song, Abdul Rahim Raha, Howard A. Young, Khatijah Yusoff
Surface Display Of Glycosylated Tyrosinase Related Protein-2 (Trp-2) Tumour Antigen On Lactococcus Lactis, Jeevanathan Kalyanasundram, Suet Lin Chia, Adelene Ai Lian Song, Abdul Rahim Raha, Howard A. Young, Khatijah Yusoff
United States Public Health Resources
Background: The exploitation of the surface display system of food and commensal lactic acid bacteria (LAB) for bacterial, viral, or protozoan antigen delivery has received strong interest recently. The Generally Regarded as Safe (GRAS) status of the Lactococcus lactis coupled with a non-recombinant strategy of in-trans surface display, provide a safe platform for therapeutic drug and vaccine development. However, production of therapeutic proteins fused with cell-wall anchoring motifs is predominantly limited to prokaryotic expression systems. This presents a major disadvantage in the surface display system particularly when glycosylation has been recently identified to significantly enhance epitope presentation. In this study, …
Questions Of Citizenship: Oregonian Reactions To Japanese Immigrants' Quest For Naturalization Rights In The United States, 1894-1952, Alison Leigh Jessie
Questions Of Citizenship: Oregonian Reactions To Japanese Immigrants' Quest For Naturalization Rights In The United States, 1894-1952, Alison Leigh Jessie
Dissertations and Theses
This study examines the discrimination against Japanese immigrants in U.S. naturalization law up to 1952 and how it was covered in the Oregonian newspaper, one of the oldest and most widely read newspapers on the West Coast. The anti-Japanese movement was much larger in California, but this paper focuses on the attitudes in Oregon, which at times echoed sentiments in California but at other times conveyed support for Japanese naturalization. Naturalization laws at the turn of the century were vague, leaving the task of defining who was white, and thus eligible for naturalization, to the courts. Japanese applicants were often …
‘Tell Your Own Story’: Manhood, Masculinity And Racial Socialization Among Black Fathers And Their Sons, Quaylan Allen
‘Tell Your Own Story’: Manhood, Masculinity And Racial Socialization Among Black Fathers And Their Sons, Quaylan Allen
Education Faculty Articles and Research
This study examines how black fathers and sons in the U.S. conceptualize manhood and masculinity and the racial socializing practices of black men. Drawing upon data from an ethnography on Black male schooling, this paper uses the interviews with fathers and sons to explore how race and gender intersect in how Black males make meaning of their gendered performances. Common notions of manhood are articulated including independence, responsibility and providership. However, race and gender intersect in particular ways for black men. The fathers engaged in particular racial socializing practices preparing their sons for encounters with racism. Both fathers and sons …
Vitamin E Conjugates, And Their Uses As Antioxidants And Prodrug Delivery Vehicles, Cristina M. Sabliov, Carlos E. Astete, David Spivak
Vitamin E Conjugates, And Their Uses As Antioxidants And Prodrug Delivery Vehicles, Cristina M. Sabliov, Carlos E. Astete, David Spivak
College of Engineering Patents
Tocopherol conjugates are disclosed that are useful as antioxidants or as pro-drug delivery vehicles. The conjugates are amphiphilic, and tend to localize at the interface between water domains and lipid domains. A prototype embodiment disclosed is an alpha tocopherol-linker-carnosine conjugate that has been designated VECAR.
Thermophilic Phosphatases And Methods For Processing Starch Using The Same, Matthew S. Gentry, Craig W. Vander Kooi
Thermophilic Phosphatases And Methods For Processing Starch Using The Same, Matthew S. Gentry, Craig W. Vander Kooi
Molecular and Cellular Biochemistry Faculty Patents
The presently-disclosed subject matter includes thermophilic glucan phosphatase polypeptides. In some embodiments the polypeptide includes non-native laforin polypeptides, or fragments and/or variants thereof, and in some instances the polypeptide can alter the biophysical properties of starch in vitro or in planta. The presently-disclosed subject matter also includes isolated polynucleotides encoding the present polypeptides, methods for processing starch by exposing starch to the present polypeptides, and methods for making the present polypeptides.
A Data Science Course For Undergraduates: Thinking With Data, Benjamin Baumer
A Data Science Course For Undergraduates: Thinking With Data, Benjamin Baumer
Mathematics Sciences: Faculty Publications
Data science is an emerging interdisciplinary field that combines elements of mathematics, statistics, computer science, and knowledge in a particular application domain for the purpose of extracting meaningful information from the increasingly sophisticated array of data available in many settings. These data tend to be nontraditional, in the sense that they are often live, large, complex, and/or messy. A first course in statistics at the undergraduate level typically introduces students to a variety of techniques to analyze small, neat, and clean datasets. However, whether they pursue more formal training in statistics or not, many of these students will end up …
The Association Of C-Reactive Protein In The Pathogenesis Of Meconium Stained Amniotic Fluid In Al- Najaf City, Basima Sh. Alghazali, Shameem R. Mohammed Hussien
The Association Of C-Reactive Protein In The Pathogenesis Of Meconium Stained Amniotic Fluid In Al- Najaf City, Basima Sh. Alghazali, Shameem R. Mohammed Hussien
Muthanna Medical Journal
The objectives of this study is to study the association of C-reactive protein in the pathogenesisof meconium stained amniotic fluid in women presented in labour. A case control study, 90women presented in labour 45 with meconium stained amniotic fluid (MSAF) and 45 clearamniotic fluid (CAF), from March 2013 to July 2013 in the labour room and operative theater.Data collected regarding their age, gestational age, mode of delivery, neonatal outcome, parityand maternal blood for C- reactive protein. Complete physical examination of the neonateregarding Apgar score, color of baby, response to a catheter in the nostril, muscle tone, heart rate and breathing …
Time Effects On Accuracy Of Homemade Urease Test In Diagnosis Of H. Pylori, Bashar Ali Saeed
Time Effects On Accuracy Of Homemade Urease Test In Diagnosis Of H. Pylori, Bashar Ali Saeed
Muthanna Medical Journal
o evaluate the effect of test duration on the sensitivity and specificity of positive urease test for the detection of Helicobacter pylori in patient with duodenal ulcer and gastropathy, and to evaluate the difference of the results of rapid urease test in patients with duodenal ulcer compared to patients with gastropathy. 117 patient "75 patient with duodenal ulcer group (A) and 42 patient with gastropathy group (B)" were included in the study, two sets of gastric biopsies "each contain one antral and one corpus biopsy" were obtained from each patient, one set used to obtain urease test which was read …
Risk Factors Of Perinatal Asphyxia: A Study At Al-Diwaniya Maternity And Children Teaching Hospital, Hulal Saleh Sahib
Risk Factors Of Perinatal Asphyxia: A Study At Al-Diwaniya Maternity And Children Teaching Hospital, Hulal Saleh Sahib
Muthanna Medical Journal
Perinatal asphyxia is a common neonatal problem that contribute significantly to neonatal morbidity and mortality. Total number of patient enrolled in our study was one-hundred seventy-one. Data collected from October 01, 2013 to the September 30, 2014. Many variables are included such as GA, BWT, gender, mode of delivery, maternal age, parity and their ANC. In addition, a number of risk factor were encountered; maternal anemia, maternal hypertension, maternal DM, PROM, prolong labor, meconium- stained amniotic fluid, maternal fever, fetal distress, multiple gestation and APH. As a result, there is no gender difference between patient and control. Among patients group, …
Atp-Site Binding Inhibitor Effectively Targets Mtorc1 And Mtorc2 Complexes In Glioblastoma, Jayson Neil, Craig Shannon, Avinash Mohan, Dimitri Laurent, Raj Murali, Meena Jhanwar-Uniyal
Atp-Site Binding Inhibitor Effectively Targets Mtorc1 And Mtorc2 Complexes In Glioblastoma, Jayson Neil, Craig Shannon, Avinash Mohan, Dimitri Laurent, Raj Murali, Meena Jhanwar-Uniyal
NYMC Faculty Publications
The PI3K-AKT-mTOR signaling axis is central to the transformed phenotype of glioblastoma (GBM) cells, due to frequent loss of tumor suppressor PTEN (phosphatase and tensin homolog deleted on chromosome 10). The mechanistic target of rapamycin (mTOR) kinase is present in two cellular multi-protein complexes, mTORC1 and mTORC2, which have distinct subunit composition, substrates and mechanisms of action. Targeting the mTOR protein is a promising strategy for GBM therapy. However, neither of these complexes is fully inhibited by the allosteric inhibitor of mTOR, rapamycin or its analogs. Herein, we provide evidence that the combined inhibition of mTORC1/2, using the ATP-competitive binding …