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Modeling Of Humoral Immune Response To Repeated Influenza A Virus Infections, Abbiana Arenas, Safiyah Muhammad, Ly Nguyen, Samita Andreansky, Evan Haskell

Mathematics Faculty Proceedings, Presentations, Speeches, Lectures

Seasonal infections by Influenza A virus (IAV) causes hundreds of thousands of deaths worldwide each year, with most individuals being infected multiple times throughout their lifetimes. The relative impact of the components of the host immune system in controlling the severity and duration of repeated challenges from an IAV infection remains unclear. In particular, the differential contribution of the humoral immune response in primary and secondary challenges from IAV are relatively little explored. We develop a parsimonious mathematical model of the humoral immune response to IAV infection with biologically meaningful and identifiable parameters. We show the relative sensitivity of the …

Fructose Mediated Non-Alcoholic Fatty Liver Is Attenuated By Ho-1-Sirt1 Module In Murine Hepatocytes And Mice Fed A High Fructose Diet, Komal Sodhi, Nitin Puri, Gaia Favero, Sarah Stevens, Charles Meadows, Nader G. Abraham, Rita Rezzani, Hayden A. Ansinelli, Edward Lebovics, Joseph I. Shapiro

Biochemistry and Microbiology

Background

Oxidative stress underlies the etiopathogenesis of nonalcoholic fatty liver disease (NAFLD), obesity and cardiovascular disease (CVD). Heme Oxygenase-1 (HO-1) is a potent endogenous antioxidant gene that plays a key role in decreasing oxidative stress. Sirtuin1 (SIRT1) belongs to the family of NAD-dependent de-acyetylases and is modulated by cellular redox.

Hypothesis

We hypothesize that fructose-induced obesity creates an inflammatory and oxidative environment conducive to the development of NAFLD and metabolic syndrome. The aim of this study is to determine whether HO-1 acts through SIRT1 to form a functional module within hepatocytes to attenuate steatohepatitis, hepatic fibrosis and cardiovascular dysfunction.

Methods …

College Of Arts And Sciences E-News Issue 26: June 2015, College Of Arts And Sciences

College of Arts and Sciences news

• Climate Change Studies Minor Available Fall 2015

• WMU receives one of six statewide college-access awards

• Coordinator named to oversee WMU's Lansing-area location

• Data Challenges • Student awarded prestigious Boren Scholarship for study abroad

• Student Given Creative Writing Fellowship

• Sociology Students Visit Prison Museum

Sibling Abuse: A Study Of School Counselors' Shared Attitudes And Beliefs, Diane Stutey

Publications

The impact of sibling abuse on children and adolescents is rarely contemplated. Counselors are in a position to advocate for all children and protect them from harm; yet one source of harm that counseling practitioners and educators might be unaware of stems from violence between siblings, which can become abusive. In this article, findings are presented from a phenomenological study examining eight practicing school counselors’ attitudes and beliefs about sibling abuse and the contexts or situations that have influenced them. Seven themes emerged supporting school counselors’ perceptions of their role in responding to sibling abuse and their beliefs about factors …

Effect Of Peer Assessment On Project Performance Of Students At Different Learning Levels, Lan Li, Fei Gao

Visual Communications and Technology Education Faculty Publications

Peer assessment has been increasingly integrated in educational settings as a strategy to foster student learning. Yet little has been studied about how students at different learning levels may benefit from peer assessment. This study examined how peer assessment and students’ learning levels influenced students’ project performance by using a two-way factorial design. One hundred and thirty teacher education students participated in this quasi-experimental study. When working on a technology-integrated lesson plan project, the experimental group completed an online peer assessment process while the control group followed the traditional discussion method. Students’ learning levels were measured and divided into low-, …

Mutations That Separate The Functions Of The Proofreading Subunit Of The Escherichia Coli Replicase, Zakiya Whatley, Kenneth N. Kreuzer

Biology Faculty Publications

The dnaQ gene of Escherichia coli encodes the Ɛ subunit of DNA polymerase III, which provides the 3' - 5' exonuclease proofreading activity of the replicative polymerase. Prior studies have shown that loss of Ɛ leads to high mutation frequency, partially constitutive SOS, and poor growth. In addition, a previous study from our laboratory identified dnaQ knockout mutants in a screen for mutants specifically defective in the SOS response after quinolone (nalidixic acid) treatment. To explain these results, we propose a model whereby, in addition to proofreading, Ɛ plays a distinct role in replisome disassembly and/or processing of stalled replication …

Retinoic Acid And The Development Of The Endoderm, Gregory M. Kelly, Thomas A. Drysdale

Paediatrics Publications

Retinoic acid (RA) is an important signaling molecule in the development of the endoderm and an important molecule in protocols used to generate endodermal cell types from stem cells. In this review, we describe the RA signaling pathway and its role in the patterning and specification of the extra embryonic endoderm and different endodermal organs. The formation of endoderm is an ancient evolutionary feature and RA signaling appears to have coevolved with the vertebrate lineage. Towards that end, we describe how RA participates in many regulatory networks required for the formation of extraembryonic structures as well as the organs of …

Molecular Dynamics Investigation Of The Arabinan-Cellulose Interface For Cellulose Nanocomposite Applications, Luke Thornley

Materials Engineering

Atom level computer simulations of the arabinan and cellulose interface were performed to better understand the mechanisms that give arabinan-cellulose composites (ArCCs) their strength with the goal to improve man-made ArCCs. The molecular dynamics (MD) software LAMMPS was used in conjunction with the ReaxFF/c force field to model the bond between cellulose and arabinan. A cellulose nanocrystal with dimensions 51 x 32 x 8 Å was minimized with various weight percent of water, 0%, 3%, 5%, 8%, 10%, and 12%. After the system was equilibrated for at least 100,000 femtoseconds, an arabinan molecule composed of 8 arabinose rings was added …

Sex Differences In Spatial Memory In Brown-Headed Cowbirds: Males Outperform Females On A Touchscreen Task, Mélanie F. Guigueno, Scott A. Macdougall-Shackleton, David F. Sherry

Biology Publications

Spatial cognition in females and males can differ in species in which there are sex-specific patterns in the use of space. Brown-headed cowbirds are brood parasites that show a reversal of sex-typical space use often seen in mammals. Female cowbirds, search for, revisit and parasitize hosts nests, have a larger hippocampus than males and have better memory than males for a rewarded location in an open spatial environment. In the current study, we tested female and male cowbirds in breeding and non-breeding conditions on a touchscreen delayed-match-to-sample task using both spatial and colour stimuli. Our goal was to determine whether …

Accurate Alternative Measurements For Female Lifetime Reproductive Success In Drosophila Melanogaster, Trinh T X Nguyen, Amanda Moehring

Biology Publications

Fitness is an individual's ability to survive and reproduce, and is an important concept in evolutionary biology. However, accurately measuring fitness is often difficult, and appropriate fitness surrogates need to be identified. Lifetime reproductive success, the total progeny an organism can produce in their lifetime, is thought to be a suitable proxy for fitness, but the measure of an organism's reproductive output across a lifetime can be difficult or impossible to obtain. Here we demonstrate that the short-term measure of reproductive success across five days provides a reasonable prediction of an individual's total lifetime reproductive success in Drosophila melanogaster. However, …

Insights Into The Origin Of Dna Methylation Differences Between Monozygotic Twins Discordant For Schizophrenia, Melkaye G. Melka, Christina A. Castellani, Richard O'Reilly, Shiva M. Singh

Biology Publications

BACKGROUND: DNA methylation differences between monozygotic twins discordant for schizophrenia have been previously reported. However, the origin of methylation differences between monozygotic twins discordant for schizophrenia is not clear. The findings here argue that all DNA methylation differences may not necessarily represent the cause of the disease; rather some may result from the effect of antipsychotics.

METHODS: Methylation differences in rat brain regions and also in two pairs of unrelated monozygotic twins discordant for schizophrenia have been studied using genome-wide DNA methylation arrays at Arraystar Inc. (Rockville, Maryland, USA). The identified gene promoters showing significant alterations to DNA methylation were …

Marx, Law, Ideology, Legal Positivism, Brian Leiter

Articles

No abstract provided.

Improved Measurement Of Blood Pressure By Extraction Of Characteristic Features From The Cuff Oscillometric Waveform, P.K. Lim, S.C. Ng, W.A. Jassim, S.J. Redmond, M. Zilany, A. Avolio, E. Lim, M.P. Tan, N.H. Lovell

Research Publications (2011 to 2015)

We present a novel approach to improve the estimation of systolic (SBP) and diastolic blood pressure (DBP) from oscillometric waveform data using variable characteristic ratios between SBP and DBP with mean arterial pressure (MAP). This was verified in 25 healthy subjects, aged 28 +/- 5 years. The multiple linear regression (MLR) and support vector regression (SVR) models were used to examine the relationship between the SBP and the DBP ratio with ten features extracted from the oscillometric waveform envelope (OWE). An automatic algorithm based on relative changes in the cuff pressure and neighbouring oscillometric pulses was proposed to remove outlier …

Graduate Internship Report - Linden High School, Christopher Charles Lemos

Agricultural Education: Graduate Internship Reports

This internship/project report includes validation documents required in meeting the quality criteria for secondary-level programs of instruction in agriculture. The documents are concurrently used for the Agriculture Incentive Grant review process at Linden High School conducted by representatives of the California Department of Education. The internship included updating the Agriculture Mechanics program at Linden High School in areas of safety and technology.

Nebline, June 2015

NEBLINE Newsletter Archive from Nebraska Extension in Lancaster County

Feature: After-Harvest Care Of Asparagus

Food & Health

Family Living

Farm & Acreage

Horticulture

Pests & Wildlife

4-H & Youth

Extension Calendar

and other extension news and events

Digitalcommons Report: 2015, Jean Bigger

DigitalCommons Documents

DigitalCommons has been fully operational for two and a half years:

• FY14: 464 works to date | 43,278 full-text downloads to date | 27,613 downloads in the past year
• FY15: 762 works to date | 88,466 full-text downloads to date | 44,033 downloads in the past year

Differential Effects Of Cold Atmospheric Plasma In The Treatment Of Malignant Glioma, Alan Siu, Olga Volotskova, Xiaoqian Cheng, Siri S. Khalsa, Ka Bian, Ferid Murad, Michael Keidar, Jonathan H. Sherman

Neurological Surgery Faculty Publications

Objective

Cold atmospheric plasma (CAP) has recently been shown to selectively target cancer cells with minimal effects on normal cells. We systematically assessed the effects of CAP in the treatment of glioblastoma.

Methods

Three glioma cell lines, normal astrocytes, and endothelial cell lines were treated with CAP. The effects of CAP were then characterized for viability, cytotoxicity/apoptosis, and cell cycle effects. Statistical significance was determined with student's t-test.

Results

CAP treatment decreases viability of glioma cells in a dose dependent manner, with the ID50 between 90-120 seconds for all glioma cell lines. Treatment with CAP for more than 120 seconds …

Genome-Wide Association Study And Admixture Mapping Reveal New Loci Associated With Total Ige Levels In Latinos, Maria Pino-Yanes, Christopher R. Gignoux, Joshua M. Galanter, Albert M. Levin, Catarina D. Campbell, Celeste Eng, Scott Huntsman, Katherine K. Nishimura, Pierre-Antoine Gourraud, Kiana Mohajeri, Brian O'Roak, Donglei Hu, Rasika A. Mathias, Elizabeth A. Nguyen, Lindsey A. Roth, Badri Padhukasahasram, Andres Moreno-Estrada, Karla Sandoval, Cheryl A. Winkler, Fred Lurmann, Adam Davis, Harold J. Farber, Kelley Meade, Pedro C. Avila, Denise Serebrisky, Rocio Chapela, Jean G. Ford, Michael A. Lenoir, Shannon M. Thyne, Emerita Brigino-Buenaventura, Luisa N. Borrell, William Rodriguez-Cintron, Saunak Sen, Rajesh Kumar, Jose R. Rodriguez-Santana, Carlos D. Bustamante, Fernando D. Martinez, Benjamin A. Raby, Scott T. Weiss, Dan L. Nicolae, Carole Ober, Deborah A. Meyers, Eugene R. Bleecker, Steven J. Mack, Ryan D. Hernandez, Evan E. Eichler, Kathleen C. Barnes, Keoki L. Williams, Dara G. Torgerson, Esteban G. Burchard

Center for Health Policy and Health Services Research Articles

BACKGROUND: IgE is a key mediator of allergic inflammation, and its levels are frequently increased in patients with allergic disorders.

OBJECTIVE: We sought to identify genetic variants associated with IgE levels in Latinos.

METHODS: We performed a genome-wide association study and admixture mapping of total IgE levels in 3334 Latinos from the Genes-environments & Admixture in Latino Americans (GALA II) study. Replication was evaluated in 454 Latinos, 1564 European Americans, and 3187 African Americans from independent studies.

RESULTS: We confirmed associations of 6 genes identified by means of previous genome-wide association studies and identified a novel genome-wide significant association of …

Why Fuzzy Cognitive Maps Are Efficient, Vladik Kreinovich, Chrysostomos Stylios

Departmental Technical Reports (CS)

In many practical situations, the relation between the experts' degrees of confidence in different related statements is well described by Fuzzy Cognitive Maps (FCM). This empirical success is somewhat puzzling, since from the mathematical viewpoint, each FCM relation corresponds to a simplified one-neuron neural network, and it is well known that to adequately describe relations, we need multiple neurons. In this paper, we show that the empirical success of FCM can be explained if we take into account that human's subjective opinions follow Miller's seven plus minus two law.

Mathematical Modeling Of Two-Dimensional Unsteady Flow In Growing Tumor, N. Gracia, D. N. Riahi, R. Roy

Applications and Applied Mathematics: An International Journal (AAM)

We investigate the problem of unsteady fluid flow in growing solid tumors. We develop a mathematical model for a growing tumor whose boundary is taken as a sphere, and the unsteady fluid flow within the tumor is assumed to be two dimensional with respect to the radial distance and the latitudinal angle in spherical coordinates. The expressions for the time, radial and latitudinal variations of the flow velocity, pressure, and the two investigated drug concentrations within the tumor were determined analytically. We calculated these quantities in the tumor as well as in a corresponding normal tissue. We find, in particular, …

A Stage-Structured Two Species Competition Mathematical Model Under The Effect Of Disease, Manju Agarwal, Vinay Verma

Applications and Applied Mathematics: An International Journal (AAM)

In this paper we study the dynamics of two competing species model; one of this competing species is stage structured and the disease spreads only in the other competing specie. In order to keep the model simple, we present it under the strong assumption that the disease can not cross the species barrier. Dynamical behaviors such as positivity, boundedness, stability, bifurcation and persistence of the model are studied analytically using the theory of differential equations. Computer simulations are carried out to substantiate the analytical findings. It is noted that c the loss rate of the population, T the maturation time …

Sex Differences In Morbidity And Care-Seeking During The Neonatal Period In Rural Southern Nepal, Summer Rosenstock, Joanne Katz, Luke C. Mullany, Subarna K. Khatry, Steven C. Leclerq, James M. Tielsch, Et Al.

Global Health Faculty Publications

Background

South Asian studies, including those from Nepal, have documented increased risk of neonatal mortality among girls, despite their early biologic survival advantage. We examined sex differences in neonatal morbidity and care-seeking behavior to determine whether such differences could help explain previously observed excess late neonatal mortality among girls in Nepal.

Methods

A secondary analysis of data from a trial of chlorhexidine use among neonates in rural Nepal was conducted. The objective was to examine sex differences in neonatal morbidity and care-seeking behavior for ill newborns. Girls were used as the reference group.

Results

Referral for care was higher during …

Graduate Internship Project & Report - Ron Sa, Ronald Sa

Agricultural Education: Graduate Internship Reports

This internship project includes validation documents that are required in meeting the quality criteria for Agriculture Programs in the secondary level programs for the California Department of Education for the Reedley Middle College High School program. The internship included the development and implementation of a comprehensive program plan RMCHS, which is a new program in its third year of existence. It outlines the goals and objectives of the FFA and school program to include a Program of Activities, and how the program is to follow criteria to meet the quality objectives for an Ag Program. It also contains the development …

Time-Frequency Analysis Reveals Pairwise Interactions In Insect Swarms, James G. Puckett, Rui Ni, Nicholas T. Ouellette

Physics and Astronomy Faculty Publications

The macroscopic emergent behavior of social animal groups is a classic example of dynamical self-organization, and is thought to arise from the local interactions between individuals. Determining these interactions from empirical data sets of real animal groups, however, is challenging. Using multicamera imaging and tracking, we studied the motion of individual flying midges in laboratory mating swarms. By performing a time-frequency analysis of the midge trajectories, we show that the midge behavior can be segmented into two distinct modes: one that is independent and composed of low-frequency maneuvers, and one that consists of higher-frequency nearly harmonic oscillations conducted in synchrony …

"We Didn't Cross The Border; The Border Crossed Us": Informal Social Adaptations To Formal Governance And Policies By Communities Across The Bering Sea Region In The Russian Far East And United States, Sarah Roop, Lilian Alessa, Andrew Kliskey, Maryann Fidel, Grace Beaujean

Washington Journal of Environmental Law & Policy

Territorially isolated villages along the shores of the U.S. and Russian Bering Sea live with stark political lines dividing a region that shares a common history, heritage, and contemporary existence. It is also a region whose environmental security is threatened by common changes occurring throughout the area but for whom possible responses to these changes are shaped by the policies and politics of the countries in which they reside. This paper is based on the experience from an international observing network, the Community Observing Network for Adaptation and Security (CONAS), which provides rare insights on how political context, across the …

"Lead In The Far North" By Acceding To The Law Of The Sea Convention, Craig H. Allen

Washington Journal of Environmental Law & Policy

This article is based on remarks given to the Arctic Encounter Symposium on Jan. 31, 2015.

Comments On Proposed Revisions To Subpart J Of The 1994 National Contingency Plan, Meghan Gavin

Washington Journal of Environmental Law & Policy

The National Oil and Hazardous Substances Pollution Contingency Plan (NCP) provides the organizational structure and procedures for preparing for and responding to discharges of oil and releases of hazardous substances. Subpart J of the NCP governs the use of chemical agents to control oil discharges, setting forth the criteria for listing an agent on the Product Schedule—a list of the dispersants and other spill-mitigating substances that responders may use in carrying out the NCP. Dispersants are chemical agents that emulsify and disperse oil into the water column. The Environmental Protection Agency (EPA) last amended Subpart J in September 1994. In …

"Lead In The Far North" By Acceding To The Law Of The Sea Convention, Craig H. Allen

Washington Journal of Environmental Law & Policy

This article is based on remarks given to the Arctic Encounter Symposium on Jan. 31, 2015.

Hyperhomocysteinemia - An Unidentified Risk Factor For Stroke In Our Population, Sabaa Asif, Bashir A Soomro, Kanwal Sartaj, Shafaq Alvi

Pakistan Journal of Neurological Sciences (PJNS)

Introduction:
Various studies show that moderate elevation of plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease.

Objective:
To observe the frequency of increased homocysteine level in ischemic stroke patients; and its association with other risk factors.

Methodology:
Observational pilot study was conducted on a sample of 75 ischemic stroke patients, enrolled regardless of their age, gender and comorbidities, at Ziauddin university hospital, Karachi. Fasting serum homocysteine, folate and vitamin B12 levels were measured. Results were interpreted using spss 20.0.

Results and Discussion:
Mean homocysteine level in our population was 19.51 (SD: 11.47)micromol/l. …

Stress Induced Hyperglycemia In Stroke Patients, Aziz U Rehman, Ajeet Kumar, Salma Razzaque, Ashok Kumar, M. Ishaq Ghauri

Pakistan Journal of Neurological Sciences (PJNS)

Background:
Stroke is the third most common cause of death in developed countries and second most common cause of death worldwide. High proportion of patients may develop hyperglycemia after an acute stress such as stroke or myocardial infarction even in the absence of preexisting diagnosis of diabetes mellitus. Prolonged stress hyperglycemia in ischemic stroke increases the risk of in-hospital 28- day mortality, especially in non-diabetic patients.

Aims and objectives:
To determine the frequency of stress-induced hyperglycemia in non-diabetic patients with ischemic or hemorrhagic stroke.

Subjects and methods:
A total of 255 patients admitted with acute stroke, fulfilling the inclusion …