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Changing Climates, Fading Cultures: A Study Of Place Annihilation As A Result Of Climate Change, Brooks A. Bolsinger

Honors Projects

Abstract

Research has established the phenomenon of cultural annihilation: the notion that the members of cultures can perceive a sense of loss when the geography upon which their culture is built undergoes a dramatic destructive change. This review examines prevailing literature to uncover existing and expected ways that climate change will impact cultures, specifically damaging the shared history that is infused into the geographic traits that make up a culture’s homeland. It examines three case studies - Native American tribes in Alaska, the island nation of the Maldives, and the country of the Netherlands – to highlight vulnerabilities that these …

The Bg News June 10, 2015, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. June 10, 2015. Volume 94-Issue 101.

Apoε2 And Education In Cognitively Normal Older Subjects With High Levels Of Ad Pathology At Autopsy: Findings From The Nun Study, Diego Iacono, Peter Zandi, Myron Gross, William R. Markesbery, Olga Pletnikova, Gay Rudow, Juan C. Troncoso

Sanders-Brown Center on Aging Faculty Publications

Asymptomatic Alzheimer's disease (ASYMAD) subjects are individuals characterized by preserved cognition before death despite substantial AD pathology at autopsy. ASYMAD subjects show comparable levels of AD pathology, i.e. β-amyloid neuritic plaques (Aβ-NP) and tau-neurofibrillary tangles (NFT), to those observed in mild cognitive impairment (MCI) and some definite AD cases. Previous clinicopathologic studies on ASYMAD subjects have shown specific phenomena of hypertrophy in the cell bodies, nuclei, and nucleoli of hippocampal pyramidal neurons and other cerebral areas. Since it is well established that the allele APOε4 is a major genetic risk factor for AD, we examined whether specific alleles of APOE …

Doxycycline Down-Regulates Dna-Pk And Radiosensitizes Tumor Initiating Cells: Implications For More Effective Radiation Therapy., Rebecca Lamb, Marco Fiorillo, Amy Chadwick, Bela Ozsvari, Kimberly J Reeves, Duncan L Smith, Robert B Clarke, Sacha J Howell, Anna Rita Cappello, Ubaldo E. Martinez-Outshoorn, Md, Maria Peiris-Pagès, Federica Sotgia, Michael P Lisanti

Kimmel Cancer Center Faculty Papers

DNA-PK is an enzyme that is required for proper DNA-repair and is thought to confer radio-resistance in cancer cells. As a consequence, it is a high-profile validated target for new pharmaceutical development. However, no FDA-approved DNA-PK inhibitors have emerged, despite many years of drug discovery and lead optimization. This is largely because existing DNA-PK inhibitors suffer from poor pharmacokinetics. They are not well absorbed and/or are unstable, with a short plasma half-life. Here, we identified the first FDA-approved DNA-PK inhibitor by "chemical proteomics". In an effort to understand how doxycycline targets cancer stem-like cells (CSCs), we serendipitously discovered that doxycycline …

Transcriptome Sequencing And Annotation Of The Polychaete Hermodice Carunculata (Annelida, Amphinomidae), Shaadi Mehr, Aida Verdes, Rob Desalle, John S. Sparks, Vincent A. Pieribone, David F. Gruber

Publications and Research

Background: The amphinomid polychaete Hermodice carunculata is a cosmopolitan and ecologically important omnivore in coral reef ecosystems, preying on a diverse suite of reef organisms and potentially acting as a vector for coral disease. While amphinomids are a key group for determining the root of the Annelida, their phylogenetic position has been difficult to resolve, and their publically available genomic data was scarce.

Results: We performed deep transcriptome sequencing (Illumina HiSeq) and profiling on Hermodice carunculata collected in the Western Atlantic Ocean. We focused this study on 58,454 predicted Open Reading Frames (ORFs) of genes longer than 200 amino acids …

Akt Inhibition Overcomes Rapamycin Resistance By Enhancing The Repressive Function Of Pras40 On Mtorc1/4e-Bp1 Axis, Wenting Mi, Qing Ye, Side Liu, Qing-Bai She

Markey Cancer Center Faculty Publications

The mTORC1 inhibitors, rapamycin and its analogs, are known to show only modest antitumor activity in clinic, but the underlying mechanisms remain largely elusive. Here, we found that activated AKT signaling is associated with rapamycin resistance in breast and colon cancers by sustained phosphorylation of the translational repressor 4E-BP1. Treatment of tumor cells with rapamycin or the AKT inhibitor MK2206 showed a limited activity in inhibiting 4E-BP1 phosphorylation, cap-dependent translation, cell growth and motility. However, treatment with both drugs resulted in profound effects in vitro and in vivo. Mechanistic investigation demonstrated that the combination treatment was required to effectively …

Behavioral Immunity Suppresses An Epizootic In Caribbean Spiny Lobsters, Mark J. Butler Iv, Donald C. Behringer Jr., Thomas W. Dolan Iii, Jessica Moss, Jeffrey D. Shields

Biological Sciences Faculty Publications

Sociality has evolved in a wide range of animal taxa but infectious diseases spread rapidly in populations of aggregated individuals, potentially negating the advantages of their social interactions. To disengage from the coevolutionary struggle with pathogens, some hosts have evolved various forms of "behavioral immunity"; yet, the effectiveness of such behaviors in controlling epizootics in the wild is untested. Here we show how one form of behavioral immunity (i.e., the aversion of diseased conspecifics) practiced by Caribbean spiny lobsters (Panulirus argus) when subject to the socially transmitted PaV1 virus, appears to have prevented an epizootic over a large seascape. We …

Age, Experience, And Nmda Antagonism: Dynamic Regulation Of Parvalbumin Expression In Normal And Chronically Ketamine-Treated Rats, Jennifer A. Corriveau

Doctoral Dissertations

A marked and selective decrease in the overall expression of the calcium-binding protein, parvalbumin (PV), has been a consistent postmortem finding in patients with schizophrenia. The documented reduction in calcium-binding protein immunoreactivity is specific to PV, and is observed exclusively within the prefrontal cortex and hippocampus (HPC) of patients. Models of schizophreniform cognitive dysfunction induced by chronic NMDA-receptor hypofunction utilizing non-competitive NMDA antagonist drugs such as ketamine (KET), have been shown to show comparable decreases in HPC and prefrontal cortical PV expression. Down-regulation of PV immunoreactivity within these key brain regions associated with cognition is often considered to be a …

The Energetic Value Of Land-Based Foods In Western Hudson Bayand Their Potential To Alleviate Energy Deficits Of Starving Adult Male Polar Bears, Linda J. Gormezano, Robert F. Rockwell

Publications and Research

Climate change is predicted to expand the ice-free season in western Hudson Bay and when it grows to 180 days, 28–48% of adult male polar bears are projected to starve unless nutritional deficits can be offset by foods consumed on land. We updated a dynamic energy budget model developed by Molnar et al. to allow influx of additional energy from novel terrestrial foods (lesser snow geese, eggs, caribou) that polar bears currently consume as part of a mixed diet while on land. We calculated the units of each prey, alone and in combination, needed to alleviate these lethal energy deficits …

The Nutritional Geometry Of Resource Scarcity: Effects Of Lean Seasons And Habitat Disturbance On Nutrient Intakes And Balancing In Wild Sifakas, Mitchell T. Irwin, Jean-Luc Raharison, David R. Raubenheimer, Colin A. Chapman, Jessica M. Rothman

Publications and Research

Animals experience spatial and temporal variation in food and nutrient supply, which may cause deviations from optimal nutrient intakes in both absolute amounts (meeting nutrient requirements) and proportions (nutrient balancing). Recent research has used the geometric framework for nutrition to obtain an improved understanding of how animals respond to these nutritional constraints, among them free-ranging primates including spider monkeys and gorillas. We used this framework to examine macronutrient intakes and nutrient balancing in sifakas (Propithecus diadema) at Tsinjoarivo, Madagascar, in order to quantify how these vary across seasons and across habitats with varying degrees of anthropogenic disturbance. Groups in intact …

Points Of Pride, Georgia Southern University

Points of Pride (2013-2023)

• Rankings
• Academics
• Athletics
• Facilities
• Outreach
• Research

Trop-2 Is Up-Regulated In Invasive Prostate Cancer And Displaces Fak From Focal Contacts., Marco Trerotola, Kirat K Ganguly, Ladan Fazli, Carmine Fedele, Huimin Lu, Anindita Dutta, Qin Liu, Tiziana De Angelis, Luke W Riddell, Natalia A Riobo, Martin E Gleave, Amina Zoubeidi, Richard Pestell, Dario C Altieri, Lucia R Languino

Department of Urology Faculty Papers

In this study, we show that the transmembrane glycoprotein Trop-2 is up-regulated in human prostate cancer (PCa) with extracapsular extension (stages pT3/pT4) as compared to organ-confined (stage pT2) PCa. Consistent with this evidence, Trop-2 expression is found to be increased in metastatic prostate tumors of Transgenic Adenocarcinoma of Mouse Prostate mice and to strongly correlate with α5β1 integrin levels. Using PCa cells, we show that Trop-2 specifically associates with the α5 integrin subunit, as binding to α3 is not observed, and that Trop-2 displaces focal adhesion kinase from focal contacts. In support of the role of Trop-2 as a promoter …

Volume 52, Number 43: June 10, 2015, University Of North Dakota

University Letter Archive

No abstract provided.

Characterization Of The Role That Alternative Ribonucleotide Reductases Play In Restoring Replication In The Presence Of Hydroxyurea In Escherichia Coli, Michael Sadek

PSU McNair Scholars Online Journal

DNA replication is essential for cells to grow and divide. Ribonucleotide reductase is an essential enzyme that is responsible for the formation of deoxyribonucleotides that are used in DNA synthesis during replication. Hydroxyurea is a chemotherapeutic agent that is thought to work by specifically inhibiting the ribonuceotide reductase to prevent replication. However, recent studies in E. coli have shown that following an initial period of inhibition, DNA synthesis then recovers in the presence of hydroxyurea, suggesting that the mode of death and cellular response to hydroxyurea is more complex than originally proposed. The E.coli genome encodes three ribonucleotide reductases that …

Role Of Metabolic Shifts In Protection From Mutation Damage: Characterizing Mitochondrial Membrane Potential In C. Elegans Gas-1 Mutants, Lauren S. Muñoz-Tremblay

PSU McNair Scholars Online Journal

Many terminal human diseases are caused by mutations affecting mitochondrial functioning. Mitochondria are essential organelles responsible for producing cellular energy, adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS) at mitochondrial electron transport chains (ETC). Proper ETC functioning relies on maintenance of the electrochemical gradient essential for energy production, known as mitochondrial membrane potential (ΔψM). The inner mitochondrial membrane is the site of the ETC and is most closely in contact with the enzymatic processes occurring within the mitochondrial matrix. Mutations affecting protein components of the ETC are especially troublesome for organelle health. ETC mutants commonly express altered ΔψM, as well as …

Women In Philosophy: A Qualitative Assessment Of Experiences At The Undergraduate Level, Crystal Nicole Lilith Aymelek

PSU McNair Scholars Online Journal

The underrepresentation of women in the field of philosophy has been a major concern for women in the discipline for at least the past ten years, and is increasingly gaining attention within academia. Current research at the undergraduate level suggests male and female enrollment occurs in relatively proportionate numbers in introductory philosophy courses but women’s enrollment dramatically decreases with the progression to upper division courses (Paxton, Figdor & Tiberius, 2012). To date, very little research has focused on the experiences of women philosophy majors at the undergraduate level. The present study conducted in-depth interviews with women who were either senior …

Challenging The View That Invasive Non-Native Plants Are Not A Significant Threat To The Floristic Diversity Of Great Britain, Philip E. Hulme, Aníbal Pauchard, Petr Pyšek, Montserrat Vilà, Christina Alba, Tim M. Blackburn, James M. Bullock, Milan Chytrý, Wayne Dawson, Alison M. Dunn, Franz Essl, Piero Genovesi, Lindsay C. Maskell, Laura A. Meyerson, Martin A. Nuñez, Jan Pergl, Oliver L. Prescott, Michael J.O. Pocock, David M. Richardson, Helen E. Roy, Simon M. Smart, Kateřina Štajerová, Thomas Stohlgren, Mark Van Kleunen, Marten Winter

Natural Resources Science Faculty Publications

No abstract provided.

Repeated, Long-Distance Migrations By A Philopatric Predator Targeting Highly Contrasting Ecosystems, James S.E. Lea, Bradley M. Wetherbee, Nuno Queiroz, Neil Burnie, Choy Aming, Laura L. Sousa, Gonzalo R. Mucientes, Nicolas E. Humphries, Guy M. Harvey, David W. Sims, Mahmood S. Shivji

Biological Sciences Faculty Publications

Long-distance movements of animals are an important driver of population spatial dynamics and determine the extent of overlap with area-focused human activities, such as fishing. Despite global concerns of declining shark populations, a major limitation in assessments of population trends or spatial management options is the lack of information on their long-term migratory behaviour. For a large marine predator, the tiger shark Galeocerdo cuvier, we show from individuals satellite-tracked for multiple years (up to 1101 days) that adult males undertake annually repeated, round-trip migrations of over 7,500 km in the northwest Atlantic. Notably, these migrations occurred between the highly …

Repeated, Long-Distance Migrations By A Philopatric Predator Targeting Highly Contrasting Ecosystems, James S. E. Lea, Bradley M. Wetherbee, Nuno Queiroz, Neil Burnie, Choy Aming, Lara L. Sousa, Gonzalo R. Mucientes, Nicolas E. Humphries, Guy Harvey, David W. Sims, Mahmood S. Shivji

Marine & Environmental Sciences Faculty Articles

Long-distance movements of animals are an important driver of population spatial dynamics and determine the extent of overlap with area-focused human activities, such as fishing. Despite global concerns of declining shark populations, a major limitation in assessments of population trends or spatial management options is the lack of information on their long-term migratory behaviour. For a large marine predator, the tiger shark Galeocerdo cuvier, we show from individuals satellitetracked for multiple years (up to 1101 days) that adult males undertake annually repeated, roundtrip migrations of over 7,500km in the northwest Atlantic. Notably, these migrations occurred between the highly disparate …

The Utah Statesman, June, 2015, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Do I Buy It? How Aidettm Training Changes Residents’ Values About Communication Skills In Doctor-Patient Interactions, Andrea Braverman, Phd, Austin Katona, B.Sc., Elisabeth Kunkel, Md, Leo Katz, Md, Matthew Keller, Md, Constantine Daskalakis, Sc.D, Jennifer Jasmine Arfaa, Phd, Mhsa

Department of Obstetrics and Gynecology Presentations and Grand Rounds

OBJECTIVES

Acquiring communication and interpersonal skills is an important part of providing patient-centered care and improving patient satisfaction. This study explores whether residents’ own values about patient communication change over time.

Development Of A Sustainable Engineering Masters Program: The Path Taken And Lessons Learned, Brian K. Thorn, Andres L. Carrano

Presentations and other scholarship

Beginning in 2002, the Kate Gleason College of Engineering (KGCOE) at the Rochester Institute of Technology (RIT) began implementing a series of sustainability themed curricular innovations. These innovations began in 2002 with the introduction of courses focused on sustainability, followed with the implementation of a programmatic minor in Sustainable Product Development in 2006, and culminated with the development and registration of the nation’s first Sustainable Engineering graduate programs in 2008. This article describes the genesis and maturation of KGCOE’s Sustainable Engineering graduate programs. The article reviews the early work that set the stage for the development of the new degree …

Evolutionary Dynamics Of Rhomboid Proteases In Streptomycetes, Peter A. Novick, Naydu M. Carmona, Monica Trujillo

Publications and Research

Background Proteolytic enzymes are ubiquitous and active in a myriad of biochemical pathways. One type, the rhomboids are intramembrane serine proteases that release their products extracellularly. These proteases are present in all forms of life and their function is not fully understood, although some evidence suggests they participate in cell signaling. Streptomycetes are prolific soil bacteria with diverse physiological and metabolic properties that respond to signals from other cells and from the environment. In the present study, we investigate the evolutionary dynamics of rhomboids in Streptomycetes, as this can shed light into the possible involvement of rhomboids in the complex …

College Within The College: Population Health, James Plumb, Md, Mph, Rickie Brawer, Phd, Mph, Mches, Abbie Santana, Msph, Robert Simmons, Drph, Mph, Mches, Cph, Nancy Chernett, Ma, Mph

Thomas Jefferson University Faculty Days

Rationale:

The current approach to educating health professionals has not kept pace with the needs of our growingly diverse population.

-Health Professional Education for the 21st Century-The Lancet

-Institute of Medicine

-APTR/CDC/AAMC-Patients and Populations. Public Health in Medical Education

JMC Leadership and Curriculum Committee-one year planning process-2009-2010

Method Of Treating Inflammation Using Human Immunosuppressive Protein, Paul R. Sanberg, Robert W. Engelman, William R. Gower

USF Patents

A method of treating inflammation by administering a therapeutically effective amount of a human immunosuppressant protein (HISP) to a subject is presented. The inventors have discovered a novel immunosuppressive protein purified from the supernatant of hNT cell culture. The immunosuppressant protein has a molecular weight of about 40-100 kDa, an isoelectric point of about 4.4, a net ionic charge and is capable of suppressing T-cell activation, T-cell proliferation and the production of IL-2. This protein can be used in treating inflammation, preventing graft rejection after transplantation, treating autoimmune diseases and suppressing allergic responses as well as other uses.

Spacetime Algebra As A Powerful Tool For Electromagnetism, Justin Dressel, Konstantin Y. Bliokh, Franco Nori

Mathematics, Physics, and Computer Science Faculty Articles and Research

We present a comprehensive introduction to spacetime algebra that emphasizes its practicality and power as a tool for the study of electromagnetism. We carefully develop this natural (Clifford) algebra of the Minkowski spacetime geometry, with a particular focus on its intrinsic (and often overlooked) complex structure. Notably, the scalar imaginary that appears throughout the electromagnetic theory properly corresponds to the unit 4-volume of spacetime itself, and thus has physical meaning. The electric and magnetic fields are combined into a single complex and frame-independent bivector field, which generalizes the Riemann-Silberstein complex vector that has recently resurfaced in studies of the single …

White Mountains Will Be Buzzing With First Unh Bee Bioblitz June 27-28, Lori Wright

Media Relations

No abstract provided.

The Effect Of Temperature, Relative Humidity, And Virus Infection Status On Off-Host Survival Of The Wheat Curl Mite (Acari: Eriophyidae), E. N. Wosula, A. J. Mcmechan, G. L. Hein

Department of Entomology: Faculty Publications

The wheat curl mite, Aceria tosichella Keifer, is an eriophyid pest of wheat, although its primary economic impact on wheat is due to the transmission of Wheat streak mosaic (WSMV), Wheat mosaic (also known as High Plains virus), and Triticum mosaic (TriMV) viruses. These viruses cause significant annual losses in winter wheat production throughout the western Great Plains. Temperature and humidity are factors that often influence arthropod survival, especially during dispersal from their hosts, yet the impact of these two factors on off-host survival has not been documented for wheat curl mite. Pathogen- infected host plants often influence the biology …

June 9, 2015, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

An Approach To An Agave Problem: The Bioremediation Of Agricultural Waste By Yeast Fermentations, Joshua Michael Jarodsky

Theses and Dissertations

The agricultural waste products created by industries, such as the Tequila manufacturing industry, create thousands of tons of waste material every year. This agricultural waste often becomes an environmental and ecological problem for fields and surrounding areas. The purpose of this study is to determine the potential of using the yeast Kluyveromyces marxianus 7-1 and Kluyveromyces marxianus 8-1 to ferment the leaf waste from the harvesting of the Agave tequilana as a form of bioremediation. Fermentations (anaerobic, under constant shaking, and at room temperature) were monitored for colony forming units, pH of fermentation broth, concentration of reducing sugars, and protein …