Digital Commons Network^™

Activation And Inhibition Of Pannexin 1 Channels, David George Jackson

Open Access Dissertations

Pannexin 1 is one of three pannexins, a vertebrate protein family related to the invertebrate innexins. Unlike its innexin relatives, Pannexin 1 does not form gap junctions in vivo, but it does form plasma membrane channels that act as ATP release channels. ATP release through Pannexin 1 serves multiple physiological roles throughout the body, including in the central nervous system, or CNS. Pannexin 1 also plays a pathophysiological role in CNS injury as part of the cell death-inducing P2X7-Pannexin 1 complex. During CNS injury, increased extracellular K+ activates Pannexin 1 by an unknown mechanism. Since Pannexin 1 block might ameliorate …

Drug Improves Cognition In Alzheimer's Disease-Mouse Model In Spite Of Diet, Jeff Hansen

Browse All News

No abstract provided.

Assessing The Carcinogenic Potential Of Low-Dose Exposures To Chemical Mixtures In The Environment: The Challenge Ahead, William H. Goodson, Leroy Lowe, David O. Carpenter, Michael Gilbertson, Abdul Manaf Ali, Adela Lopez De Cerain Salsamendi, Ahmed Lasfar, Amancio Carnero, Amaya Azqueta, Amedeo Amedei, Amelia K. Charles, Andrew R. Collins, Andrew Ward, Anna C. Salzberg, Annamaria Colacci, Ann-Karin Olsen, Arthur Berg, Barry J. Barclay, Binhua P. Zhou, Carmen Blanco-Aparicio, Debasish Roy

Publications and Research

Summary Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This risk may be overlooked by current regulatory practices and needs to be vigorously investigated.

Procollagen C-Endopeptidase Enhancer Protein 2 (Pcpe2) Reduces Atherosclerosis In Mice By Enhancing Scavenger Receptor Class B1 (Sr-Bi)-Mediated High-Density Lipoprotein (Hdl)-Cholesteryl Ester Uptake, Ricquita D. Pollard, Christopher N. Blesso, Manal Zabalawi, Brian Fulp, Mark Gerelus, Xuewei Zhu, Erica W. Lyons, Nebil Nuradin, Omar L. Francone, Xiang-An Li, Daisy Sahoo, Michael J. Thomas, Mary G. Sorci-Thomas

Pediatrics Faculty Publications

Studies in human populations have shown a significant correlation between procollagen C-endopeptidase enhancer protein 2 (PCPE2) single nucleotide polymorphisms and plasma HDL cholesterol concentrations. PCPE2, a 52-kDa glycoprotein located in the extracellular matrix, enhances the cleavage of C-terminal procollagen by bone morphogenetic protein 1 (BMP1). Our studies here focused on investigating the basis for the elevated concentration of enlarged plasma HDL in PCPE2-deficient mice to determine whether they protected against diet-induced atherosclerosis. PCPE2-deficient mice were crossed with LDL receptor-deficient mice to obtain LDLr^-/-, PCPE2^-/- mice, which had elevated HDL levels compared with LDLr^-/- mice with similar …

The Ocean Sampling Day Consortium, Anna Kopf, Mesude Bicak, Renzo Kottman, Julia Schnetzer, Ivaylo Kostadinov, Katja Lehmann, Antonio Fernandez-Guerra, Christian Jeanthon, Eyal Rahav, Matthias Ulrich, Antje Wichels, Gunnar Gerdts, Paraskevi Polymenakou, Giorgos Kotoulas, Rania Siam, Rehab Z. Abdallah, Eva C. Sonnenschein, Thierry Cariou, Fergal O'Gara, Stephen Jackson, Sandi Orlic, Michael Steinke, Julia Busch, Bernardo Duarte, Isabel Caçador, João Canning-Clode, Oleksandra Bobrova, Viggo Marteinsson, Eyjolfur Reynisson, Clara Magalhães Loureiro, Gian Marco Luna, Grazia Marina Quero, Carolin R. Löscher, Anke Kremp, Marie E. Delorenzo, Lise Øvreås, Jennifer Tolman, Julie Laroche, Antonella Penna, Marc Frischer, Timothy Davis, Barker Katherine, Christopher P. Meyer, Sandra Ramos, Catarina Magalhães, Florence Jude-Lemeilleur, Ma Leopoldina Aguirre-Macedo, Shiao Y. Wang, Nicole Poulton, Scott Jones, Rachel Collin, Jed A. Fuhrman, Pascal Conan, Cecilia Alonso, Noga Stambler, Kelly Goodwin, Michael M. Yakimov, Federico Baltar, Levente Bodrossy, Jodie Van De Kamp, Dion Mf Frampton, Martin Ostrowski, Paul Van Ruth, Paul Malthouse, Simon Claus, Klaas Deneudt, Jonas Mortelmans, Sophie Pitois, David Wallom, Ian Salter, Rodrigo Costa, Declan C. Schroeder, Mahrous M. Kandil, Valentina Amaral, Florencia Biancalana, Rafael Santana, Maria Luiza Pedrotti, Takashi Yoshida, Hiroyuki Ogata, Tim Ingleton, Kate Munnik, Naiara Rodriguez-Ezpeleta, Veronique Berteaux-Lecellier, Patricia Wecker, Ibon Cancio, Daniel Valout, Christina Bienhold, Hassan Ghazal, Bouchra Chaouni, Soumya Essayeh, Sara Ettamimi, El Houcine Zaid, Noureddine Boukhatem, Abderrahim Bouali, Rajaa Chahboune, Said Barrijal, Mohammed Timinouni, Fatima El Otmani, Mohamed Bennani, Marianna Mea, Nadezhda Todorova, Ventzislav Karamfilov, Petra Ten Hoopten, Guy Cochrane, Stephanie L'Haridon, Kemal Can Bizel, Alessandro Vezzi, Federico M. Lauro, Patrick Martin, Rachelle M. Jensen, Jamie Hinks, Susan Gebbels, Riccardo Rosselli, Fabio De Pascale, Riccardo Schiavon, Antonina Dos Santos, Emilie Villar, Stéphane Pesant, Bruno Cataletto, Francesca Malfatti, Ranjith Edirisinghe, Jorge A. Herrera Silveira, Michele Barbier, Valentina Turk, Tinkara Tinta, Wayne J. Fuller, Ilkay Salihoglu, Nedime Serakinci, Mahmut Cerkez Ergoren, Eileen Bresnan, Juan Iriberri, Paul Anders Fronth Nyhus, Edvardsen Bente, Hans Erik Karlsen, Peter N. Golyshin, Josep M. Gasol, Snejana Moncheva, Nina Dzhembekova, Zackary Johnson, Christopher Daivd Sinigalliano, Maribeth Louise Gidley, Adriana Zingone, Roberto Danovaro, George Tsiamis, Melody S. Clark, Ana Cristina Costa, Monia El Bour, Ana M. Martins, R. Eric Collins, Anne-Lise Ducluzeau, Jonathan Martinez, Mark J. Costello, Linda A. Amaral-Zettler, Jack A. Gilbert, Neil Davies, Dawn Field, Frank Oliver Glöckner

Faculty Publications

Ocean Sampling Day was initiated by the EU-funded Micro B3 (Marine Microbial Biodiversity, Bioinformatics, Biotechnology) project to obtain a snapshot of the marine microbial biodiversity and function of the world’s oceans. It is a simultaneous global mega-sequencing campaign aiming to generate the largest standardized microbial data set in a single day. This will be achievable only through the coordinated efforts of an Ocean Sampling Day Consortium, supportive partnerships and networks between sites. This commentary outlines the establishment, function and aims of the Consortium and describes our vision for a sustainable study of marine microbial communities and their embedded functional traits.

Temperature And Development Impacts On Housekeeping Gene Expression In Cowpea Aphid, Aphis Craccivora (Hemiptera: Aphidiae), Chunxiao Yang, Huipeng Pan, Yong Liu, Xuguo Zhou

Entomology Faculty Publications

Quantitative real-time PCR (qRT-PCR) is a powerful technique to quantify gene expression. To standardize gene expression studies and obtain more accurate qRT-PCR analysis, normalization relative to consistently expressed housekeeping genes (HKGs) is required. In this study, ten candidate HKGs including elongation factor 1 α (EF1A), ribosomal protein L11 (RPL11), ribosomal protein L14 (RPL14), ribosomal protein S8 (RPS8), ribosomal protein S23 (RPS23), NADH-ubiquinone oxidoreductase (NADH), vacuolar-type H+-ATPase (ATPase), heat shock protein 70 (HSP70), 18S ribosomal RNA (18S), and 12S ribosomal RNA (12S …

Samantha Reynolds Joins Faculty As Lecturer Of Chemistry, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Looking For Long-Term Outcomes: What Early Interventions Are Needed For Children And Young People At Risk Of Maltreatment In England?, Samantha Mcdermid, Georgia Hyde-Dryden, Harriet Ward

Irish Journal of Applied Social Studies

The Safeguarding Children Research Initiative (Davies & Ward, 2012) was a programme of fifteen studies commissioned by the Department of Health and what is now the Department for Education, each of which explored a different aspect of safeguarding children. This paper brings together the findings of these studies to explore the types of strategies that have been shown to promote positive long-term outcomes for children and young people at risk of maltreatment. The authors highlight the potential harm caused to children when they are exposed to maltreatment and demonstrate the range of interventions that have been developed to improve their …

Rewriting The Past: The Influence Of Written Emotional Expression On Psychosocial Outcomes, Physical Symptoms, Medication Adherence, Cd4 Cell Count, And Viral Load In Hiv., Courtney Biondi Kelsch

Open Access Dissertations

Psychosocial factors play a role in HIV progression. Expressive writing (EW) interventions have demonstrated positive effects on psychosocial and disease-related outcomes in HIV. Linguistic properties of written essays have been related to psychological outcomes, although such research is sparse in the HIV literature. This project examines the relationship of word usage to psychosocial and disease-related factors in HIV. As part of a larger randomized, controlled trial of EW, this project examined the subset of subjects (n = 121) randomized to write about trauma. Linguistic Inquiry and Word Count (LIWC) software was used to analyze word usage (pronouns, positive, negative, social, …

Numerical Modeling Of Onshore Plankton Transport, Atsushi Fujimura

Open Access Dissertations

Cross-shore exchange of plankton plays an important role in marine ecosystems and coastal communities. Larvae of many intertidal invertebrate species grow offshore and come back to the shore for settlement by crossing the energetic surf zone: however, shoreward transport mechanisms are not well understood. To test the possible onshore transport mechanisms, numerical simulations are performed based on the field campaigns conducted at Sand City beach (a mildly sloping rip-channeled beach) and Carmel River State Beach (CRSB, a steep pocket beach). The model consists of the 3D hydrodynamic model Delft3D and an individual based model for larval tracking. As weak swimmers, …

Increased Expression Of Simple Ganglioside Species Gm2 And Gm3 Detected By Maldi Imaging Mass Spectrometry In A Combined Rat Model Of A Beta Toxicity And Stroke, Sarah Caughlin, Jeffrey D. Hepburn, Dae Hee Park, Kristina Jurcic, Ken K. -C. Yeung, David F. Cechetto, Shawn N. Whitehead

Anatomy and Cell Biology Publications

The aging brain is often characterized by the presence of multiple comorbidities resulting in synergistic damaging effects in the brain as demonstrated through the interaction of Alzheimer's disease (AD) and stroke. Gangliosides, a family of membrane lipids enriched in the central nervous system, may have a mechanistic role in mediating the brain's response to injury as their expression is altered in a number of disease and injury states. Matrix-Assisted Laser Desorption Ionization (MALDI) Imaging Mass Spectrometry (IMS) was used to study the expression of A-series ganglioside species GD1a, GM1, GM2, and GM3 to determine alteration of their expression profiles in …

Uab Comprehensive Diabetes Center One Of Five Centers Selected To Be Part Of Hirn-Ctar, Tyler Greer

Browse All News

No abstract provided.

Uab Seeking Applicants For Pew, Searle Scholars Programs, Uab Heersink School Of Medicine News

Browse All News

No abstract provided.

Chromatin To Clinic: The Molecular Rationale For Parp1 Inhibitor Function., Felix Y. Feng, Johann S. De Bono, Mark A. Rubin, Karen E Knudsen

Department of Cancer Biology Faculty Papers

Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation. The molecular basis for PARP1 inhibitor function is complex, and appears to depend on the dual roles of PARP1 in DNA damage repair and transcriptional regulation. Here, the mechanisms by which PARP-1 inhibitors elicit clinical response are discussed, and strategies for translating the preclinical elucidation of PARP-1 function into advances in disease management are reviewed.

2015.06.18 - Board Of Trustees Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2015

Meeting materials for the NEIU Board of Trustees

A System Dynamics Approach To The Efficacy Of Oxime Therapy In Sub Lethal Exposure To Sarin Gas, Daniel J. Droste

Theses and Dissertations

The 2010 National Security Strategy states, The effective dissemination of a lethal agent would endanger the lives of thousands of people and have unprecedented economic, societal, and political consequences. We must continue to work at home with first responders and health officials to reduce the risk associated with high-consequence threats . Nerve agents, such as Sarin gas, are considered high consequence threats. The threat of use of agents such as Sarin is as much a threat today as any other time in our history. However, the suggested treatment protocol is not as precise as it could be. Debate exists over …

A New Species Of Burumoseria Csiki, 1939 From Taiwan, With Redescription Of The Genus And New Synonymy Of Licyllus Jacoby, 1885 With Thrasychroma Jacoby, 1885 (Coleoptera: Chrysomelidae: Galerucinae: Alticini), Chi-Feng Lee, Alexander Kostantinov

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

The Oriental genus Burumoseria Csiki, 1939 is redescribed. Burumoseria yuae Lee and Konstantinov, new species from Taiwan is described and illustrated. A key to Burumoseria species is provided. The Oriental and Australian genus Licyllus Jacoby, 1885 is synonymized with Thrasychroma Jacoby, 1885.

The Micronesia Challenge: Assessing The Relative Contribution Of Stressors On Coral Reefs To Facilitate Science-To-Management Feedback, Peter C. Houk, Rodney Camacho, Steven Johnson, Matthew Mclean, Selino Maxin, Jorg Anson, Eugene Joseph, Osamu Nedlic, Marsten Luckymis, Robert Van Woesik

Ocean Engineering and Marine Sciences Faculty Publications

Fishing and pollution are chronic stressors that can prolong recovery of coral reefs and contribute to ecosystem decline. While this premise is generally accepted, management interventions are complicated because the contributions from individual stressors are difficult to distinguish. The present study examined the extent to which fishing pressure and pollution predicted progress towards the Micronesia Challenge, an international conservation strategy initiated by the political leaders of 6 nations to conserve at least 30% of marine resources by 2020. The analyses were rooted in a defined measure of coral-reef-ecosystem condition, comprised of biological metrics that described functional processes on coral reefs. …

Induced Ankylosis Of A Primary Molar For Skeletal Anchorage In The Mandible As Alternative To Mini-Implants, Matina V. Angelopoulou, Despina Koletsi, George Vadiakas, Demetrios J. Halazonetis

School of Dentistry Faculty Research and Publications

Background

Mesial protraction of mandibular posterior teeth requires increased anchorage to avoid undesired tooth movements. Orthodontic mini-implants have become a popular and successful way to increase skeletal anchorage in such cases. However, mini-implants may cause injury to adjacent teeth or anatomical structures and may lead to tissue inflammation. Induced ankylosed primary teeth have been used in the past as abutments for the protraction of the maxilla in cases of maxillary retrognathism. However, this technique has not been described in the literature for the protraction of mandibular molars. The aim of this paper is to present, through a case report, an …

Quantitative Hermeneutics: Counting Forestructures On A Path From W.M. Davis To The Concept Of Multiple-Permeability Karst Aquifers, H. L. Vacher, Lee J. Florea

International Journal of Speleology

Hermeneutics is the theory of interpretation. One of its major components is recognizing prejudgments, or forestructures, that we bring to our objects of study. In this paper, we construct a historical narrative of the evolution of thinking about the role of caves in relation to groundwater flow in limestone, and we tabulate forestructures as they appear in the story. This account consists of three overlapping time periods: the before and after of an incident that repelled hydrogeologists and students of karst from each other in the middle of the 20^th century; a period, up to around the turn of …

Relationship Of Phenotypic Variation And Genetic Admixture In The Saltmarsh–Nelson's Sparrow Hybrid Zone, Jennifer Walsh, W. Gregory Shriver, Brian J. Olsen, Kathleen M. O'Brien, Adrienne I. Kovach

New Hampshire Agricultural Experiment Station Publications

Hybridization is influential in shaping species' dynamics and has many evolutionary and conservation implications. Identification of hybrid individuals typically relies on morphological data, but the assumption that hybrids express intermediate traits is not always valid, because of complex patterns of introgression and selection. We characterized phenotypic and genotypic variation across a hybrid zone between 2 tidal-marsh birds, the Saltmarsh Sparrow (Ammodramus caudacutus) and Nelson's Sparrow (A. nelsoni) (n = 290), and we sought to identify morphological traits that could be used to classify admixed individuals. Sparrows were sampled from a total of 34 marshes, including 23 sympatric and 11 putatively …

Structure-Based Redesign Of Lysostaphin Yields Potent Antistaphylococcal Enzymes That Evade Immune Cell Surveillance, Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi, Wen Li, Regina S. Salvat, Daniel C. Osipovitch, Jennifer Fields, Leonard Moise, Brett L. Berwin, Steven N. Fiering, Chris Bailey-Kellogg, Karl E. Griswold

Institute for Immunology and Informatics Faculty Publications

Staphylococcus aureus infections exert a tremendous burden on the health-care system, and the threat of drug-resistant strains continues to grow. The bacteriolytic enzyme lysostaphin is a potent antistaphylococcal agent with proven efficacy against both drug-sensitive and drug-resistant strains; however, the enzyme’s own bacterial origins cause undesirable immunogenicity and pose a barrier to clinical translation. Here, we deimmunized lysostaphin using a computationally guided process that optimizes sets of mutations to delete immunogenic T cell epitopes without disrupting protein function. In vitro analyses showed the methods to be both efficient and effective, producing seven different deimmunized designs exhibiting high function and reduced …

Investigating The Links Between Ozone And Organic Aerosol Chemistry In A Biomass Burning Plume From A Prescribed Fire In California Chaparral, M. J. Alvarado, C. R. Lonsdale, Robert Yokelson, Sheryl Kashi Akagi, H. Coe, J. S. Craven, E. V. Fischer, G. R. Mcmeeking, J. H. Seinfeld, T. Soni, J. W. Taylor, D. R. Weise, C. E. Wold

Chemistry and Biochemistry Faculty Publications

Within minutes after emission, complex photochemistry in biomass burning smoke plumes can cause large changes in the concentrations of ozone (O3) and organic aerosol (OA). Being able to understand and simulate this rapid chemical evolution under a wide variety of conditions is a critical part of forecasting the impact of these fires on air quality, atmospheric composition, and climate. Here we use version 2.1 of the Aerosol Simulation Program (ASP) to simulate the evolution of O₃ and secondary organic aerosol (SOA) within a young biomass burning smoke plume from the Williams prescribed fire in chaparral, which was sampled over …

Girls Build Candy Bridges Decode Dna At Tech Savvy, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Effective Factors For Increasing University Publication And Citation Rate, M. Shahbazi-Moghadam, H. Salehi, N. Ale Ebrahim, M. Mohammadjafari, H. Gholizadeh

Research Publications (2011 to 2015)

Despite the vital role of paper publication and citation in higher education institutions (HEIs), literature on publication exercises is relatively scarce. There are a number of factors which influence the rate of university publications and citations. Accordingly, with a focus on policy perspectives, this paper discusses publication exercises by addressing the factors that can increase or decrease the rate of publication and citation in HEIs. The investigated zones are divided into two macro and micro levels, in which macro level deals with global policy and micro level is related to local and university policies. The effective factors and their relevant …

2015-06-17-New Employees, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Emu Mcnair Scholars Program 2014-2015 Newsletter, Mcnair Scholars Program

EMU McNair Challenger

No abstract provided.

Study Shows Acute Pulmonary Fibrosis May Respond To Autoimmune Disease Therapy, Alicia Rohan

Browse All News

No abstract provided.

The Geographic Distribution Of A Tropical Montane Bird Is Limited By A Tree: Acorn Woodpeckers (Melanerpes Formicivorus) And Colombian Oaks (Quercus Humboldtii) In The Northern Andes, Benjamin G. Freeman, Nicholas A. Mason

Faculty Publications

© 2015 Freeman, Mason. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Species distributions are limited by a complex array of abiotic and biotic factors. In general, abiotic (climatic) factors are thought to explain species' broad geographic distributions, while biotic factors regulate species' abundance patterns at local scales. We used species distribution models to test the hypothesis that a biotic interaction with a tree, the Colombian oak (Quercus humboldtii), limits the broad-scale distribution of …

Structure-Based Redesign Of Lysostaphin Yields Potent Antistaphylococcal Enzymes That Evade Immune Cell Surveillance, Kristina Blazanovic, Hongliang Zhao, Yoonjoo Choi, Wen Li, Regina S. Salvat, Daniel C. Osipovitch, Jennifer Fields, Leonard Moise, Brent L. Berwin, Steven N. Fiering, Chris Bailey-Kellogg, Karl E. Griswold

Dartmouth Scholarship

Staphylococcus aureus infections exert a tremendous burden on the health-care system, and the threat of drug-resistant strains continues to grow. The bacteriolytic enzyme lysostaphin is a potent antistaphylococcal agent with proven efficacy against both drug-sensitive and drug-resistant strains; however, the enzyme's own bacterial origins cause undesirable immunogenicity and pose a barrier to clinical translation. Here, we deimmunized lysostaphin using a computationally guided process that optimizes sets of mutations to delete immunogenic T cell epitopes without disrupting protein function. In vitro analyses showed the methods to be both efficient and effective, producing seven different deimmunized designs exhibiting high function and …