Digital Commons Network^™

Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors, Bruno Ramos-Molina, Adam N. Lick, Amir Nasrolahi Shirazi, Donghoon Oh, Rakesh Tiwari, Naglaa Salem El-Sayed, Keykavous Parang, Iris Lindberg

Pharmacy Faculty Articles and Research

Cationic cell-penetrating peptides have been widely used to enhance the intracellular delivery of various types of cargoes, such as drugs and proteins. These reagents are chemically similar to the multi-basic peptides that are known to be potent proprotein convertase inhibitors. Here, we report that both HIV-1 TAT47-57 peptide and the Chariot reagent are micromolar inhibitors of furin activity in vitro. In agreement, HIV-1 TAT47-57 reduced HT1080 cell migration, thought to be mediated by proprotein convertases, by 25%. In addition, cyclic polyarginine peptides containing hydrophobic moieties which have been previously used as transfection reagents also exhibited potent furin inhibition in vitro …

Degradation Of Bunker C Fuel Oil By White-Rot Fungi In Sawdust Cultures Suggests Potential Applications In Bioremediation, Darcy Young, James Rice, Rachael Martin, Erika Lindquist, Anna Lipzen, Igor Grigoriev, David Hibbett

Biology

Fungal lignocellulolytic enzymes are promising agents for oxidizing pollutants. This study investigated degradation of Number 6 "Bunker C" fuel oil compounds by the white-rot fungi Irpex lacteus, Trichaptum biforme, Phlebia radiata, Trametes versicolor, and Pleurotus ostreatus (Basidiomycota, Agaricomycetes). Averaging across all studied species, 98.1%, 48.6%, and 76.4% of the initial Bunker C C10 alkane, C14 alkane, and phenanthrene, respectively were degraded after 180 days of fungal growth on pine media. This study also investigated whether Bunker C oil induces changes in gene expression in the white-rot fungus Punctularia strigosozonata, for which a complete reference genome is available. After 20 days …

Approche Intégrée Pour Une Conception Et Une Manipulation Sécuritaires Des Nanomatériaux : Un Programme Basé Sur Une Concertation Entre L’Industrie Et Des Évaluateurs Des Risques Sanitaires, Claude Emond, Serge Kouassi, Frédéric Schuster

Rapports de recherche scientifique

Les nanotechnologies de synthèse se développent à un rythme presque exponentiel. Les estimations anticipées des retombées de cette technologie font miroiter un potentiel économique énorme à la grandeur de la planète. Par conséquent, plusieurs pays investissent massivement dans ce domaine de nouvelles technologies. Cependant, les responsables industriels des nanomatériaux et les spécialistes en évaluation des risques sanitaires ont une compréhension différente des programmes de sécurité devant baliser l’utilisation de cette nouvelle technologie dont on connaît peu les dangers pour la santé et la sécurité des travailleurs.

Plusieurs études montrent l’existence d’une réactivité biologique particulière des nanoparticules en raison de leur …

Les Emplois Verts Au Québec : Définition Et Appréciation De Leurs Risques Chimiques Ou Biologiques Potentiels Pour La Santé Des Travailleurs, Erwan Cheneval, Marc-Antoine Busque, Claude Ostiguy, Jacques Lavoie, Robert Bourbonnais, France Labrèche, Joseph Zayed

Rapports de recherche scientifique

Les emplois générés par les efforts d’écologisation de l’économie sont en pleine croissance. Ces emplois, couramment appelés « emplois verts », étaient estimés en 2010 à plus de 155 000 au Québec et à 682 000 au Canada. Ces chiffres dépendent bien entendu des définitions données aux termes « écologie » et « environnement », mais donnent une idée de l’importance de ce secteur en croissance. Plusieurs nouvelles technologies se développent et il est impératif d’en apprécier les risques potentiels pour la santé des travailleurs.

L’objectif de cette recherche est de tracer le portrait québécois des emplois verts et d’apprécier …

Cell Type Specificity Of Tissue Plasminogen Activator In The Mouse Barrel Cortex, Philip Chu, Eric Chen, Adesh Bajnath, Joshua C. Brumberg

Publications and Research

It has been suggested that tissue-type plasminogen activator (tPA), a serine protease, plays a key role in regulating the extracellular matrix core proteins, thereby impacting the structural plasticity in the cerebral cortex. Much is known about its role in regulating plasticity in the visual cortex. However, its permissive role has not been demonstrated to generalize to other cerebral cortical areas. By utilizing a combination of immunofluorescent histochemistry and confocal microscopy, we demonstrate that endogenous tPA is indeed present in the somatosensory cortex, and its expression is experience-dependent. Chronic sensory deprivation induced by whisker trimming from birth for one month leads …

Discovery And Confirmation Of Novel Serum Biomarkers Diagnosing Alzheimer’S Disease, Tyler Mower, Dr. John Kauwe

Journal of Undergraduate Research

Background: Alzheimer’s disease (AD) remains challenging to diagnose, especially early disease. Useful serum AD biomarkers would be of great utility in clinical settings and in drug development efforts. We used a novel serum proteomic approach to interrogate the lowmolecular- weight proteome for AD biomarkers.

Experimental design: A discovery study used sera from 58 any-stage AD cases and 55 controls analyzed by capillary liquid chromatography-tandem mass spectrometry. Promising biomarkers were retested in a second, blinded confirmatory study (AD cases=68, controls=57). Several biomarkers replicated and multi-marker sets were modeled.

Results: The initial study found 59 potential AD biomarkers. Thirteen recurred in more …

Students Find, Name Bacteriophages In Massive Team Project, University Communications, Illinois Wesleyan University

News and Events (Discontinued Series)

No abstract provided.

The Parthenon, June 25, 2015, Jocelyn Gibson

The Parthenon

The Parthenon, Marshall University’s student newspaper, is published by students Monday through Friday during the regular semester and weekly Thursday during the summer. The editorial staff is responsible for the news and the editorial content.

The Murray Ledger And Times, June 25, 2015, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

Reformed Approach To The Interactions Of Science And Religion, Tony N. Jelsma

Faculty Work Comprehensive List

"Sometimes, despite our best theological and scientific study, religion and science still seem to be in conflict."

Posting about the interactions between religion and science from In All Things - an online hub committed to the claim that the life, death, and resurrection of Jesus Christ has implications for the entire world.

http://inallthings.org/a-reformed-approach-to-the-interactions-of-science-and-religion

Neural Tuning Functions Underlie Both Generalization And Interference, Ian S. Howard, David W. Franklin

School of Engineering, Computing and Mathematics

No abstract provided.

The Increasing Privatization Of Environmental Permitting, Jessica Owley

Akron Law Review

This article examines the increasing privatization of environmental law by taking a close look at mitigation measures in permitting programs. As mitigation has become an increasingly important element of permitting programs, permitting agencies have looked for outside organizations to help design, monitor, and enforce the mitigation projects. Thus, compensatory mitigation projects provide a good lens for examining the role of private organizations in environmental law. There are good reasons for drawing on the power of private organizations. They can provide flexibility and expertise as well as increased capacity. However, concerns regarding democracy and accountability arise when government agencies hand off …

Toward Regional Governance In Environmental Law, Douglas R. Williams

Akron Law Review

This article will proceed in three parts. Part I provides a brief introduction to the structured institutional arrangements under the CAA and the CWA. I discuss how these programs have evolved in ways that depart from what may have been originally anticipated and how their structure poses impediments to effective environmental management. Part II provides a short summary of current thinking about the institutional architecture of our environmental programs, focusing primarily on the “environmental federalism” scholarship of recent years. I offer reasons for abandoning federalism as an appropriate institutional framework. Part III presents a conceptual, rather than tightly engineered, argument …

Aligning Regulation With The Informational Need: Ecosystem Services And The Next Generation Of Environmental Law, Keith H. Hirokawa, Elizabeth J. Porter

Akron Law Review

This article explores the Clinch Coalition decision to understand why the court would perpetuate a process that systematically rejects the relevance and value of ecosystem processes in the information gathering exercise entailed in these environmental regulations. The discussion begins with an introduction to ecosystem services as a study of human dependency on the services provided by functioning ecosystems. In the second section, the article turns to the Clinch Coalition decision to outline the arguments relied upon by the court to legitimize the Forest Service’s decision to avoid an ecosystem services analysis. The article then presents the Clinch Coalition decision as …

Adaptive Management And The Future Of Environmental Law, Eric Biber

Akron Law Review

Adaptive management is the new paradigm in environmental law. It is omnipresent in scholarship and management documents and is even starting to appear in court opinions. There have been many calls for environmental law to adapt itself to adaptive management by becoming more flexible and dynamic. But does adaptive management really warrant a revolution in environmental law? Or is it adaptive management that might need to adapt to the world of environmental law? There has been an abundance of scholarship on the strengths of adaptive management, making the case for changing environmental law to embrace adaptive management. But answering the …

Recovering From The Recovery Narrative: On Globalism, Green Jobs And Cyborg Civilization, Michael Burger

Akron Law Review

In this Essay, I make a preliminary foray into this new narrative terrain, identifying several emerging legal storylines that have arisen in the wake of climate change disruptions and that I predict will prove influential in the coming years. In Part I, I discuss the ways in which new perceptions of scale are re-defining human beings’ attachments to a sense of “place” or “dwelling” and are shaping new attitudes about what constitutes the local, posing potential problems for existing federalism schemes. In Part II, I discuss the ways in which America’s long history of nationalizing nature manifests in the discourse …

Environmental Law And The Collapse Of New Deal Constitutionalism, Arthur F. Mcevoy

Akron Law Review

This Article, which is a précis for a book in progress about the history of late twentieth-century U.S. environmental law, argues that our modern environmental law is peculiarly a creature of the New Deal. Despite its obvious legacy from common-law nuisance and Progressive regulation, what makes modern environmental law different from anything that came before is the way in which reformers built it out of parts copied from New Deal reform projects: cooperative federalism, the tax-and-spend power, representation-reinforcing, rights trumps, and so on. Environmental law’s history, its character, its accomplishments, and its shortcomings thus entwined with those of the New …

Replacing Sustainability, Robin Kundis Craig, Melinda Harm Benson

Akron Law Review

This Article argues that, from a policy perspective, we must face the impossibility of even defining—let alone pursuing—a goal of “sustainability” in a world characterized by such extreme complexity, radical uncertainty, and discomfiting loss of stationarity. Instead, we need new policy directions and orientations that provide the necessary capacity to deal with these “wicked problems” in a meaningful and equitable way. The realities of current and emerging SES dynamics warrant a new set of tools and approaches to governance of those systems. Part II of this Article provides a brief history of sustainability and sustainable development, including corollary emphases on …

Splitting The Baby: Immigration, Family Law, And The Problem Of The Single Deportable Parent, Timothy E. Yahner

Akron Law Review

The purpose of this article is not to suggest that the Fifth Circuit was wrong in upholding the dismissal of Monica’s case. Indeed, the court was faced with a dilemma that would give King Solomon pause: what to do when two parents claim one child. This article’s purpose is to show that a regulatory solution is preferable to forcing the courts to make impossible choices between parents. Part II discusses the factual and procedural history of Castro. Part III details the policies and rules of law of immigration and custody at play in the case. Part IV explains why the …

2014 Georgia Scholarship Of Stem Teaching & Learning Conference Program, Georgia Scholarship Of Stem Teaching & Learning Conference

Interdisciplinary STEM Teaching & Learning Conference (2012-2019) (Archived)

N/A

2012 Georgia Scholarship Of Stem Teaching And Learning Conference Program, Georgia Scholarship Of Stem Teaching And Learning Conference

Interdisciplinary STEM Teaching & Learning Conference (2012-2019) (Archived)

Conference Program

Listen, Then Speak: Foregrounding Womens Spaces, Stories, And Relationships In Dramatic Writing, Irene Loy

Theatre & Dance ETDs

In this essay, I provide documentation for my theory and practice during this MFA degree. I begin with a short personal essay on my auto-biography leading up to and including this program. Then I follow with an overview of the theoretical underpinnings to my writing practice. Of particular importance here is the framing of listening and spaciousness as feminine and of speaking and activity as masculine, as a means of underscoring the inherent value of that which has traditionally been undervalued in the history of dramatic literature. This characterizes a move toward women's bodies, rather than away from them, including …

2015 June 24 -- Agenda And Attachments

Agendas and Minutes

No abstract provided.

Ucc Minutes September 24, 2015, Kutztown University Curriculum Committee

UCC Minutes

No abstract provided.

We Are...Marshall, June 24, 2015, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Prospectus, June 24, 2015, Parkland College, Zach Trueblood, Sarah Powers, Adam Vilmin

Prospectus 2015

Parkland campus to go smoke free, AMP reaching past Parkland campus, 'Triple Play' plan provides free tech services, 6 killed in California balcony collapse during a party(AP), An Interview with Lisa Costello, Giertz Gallery Director, Urbana’s Market at the Square working to increase fresh food access(City of Urbana), Donald Trump says he’s running for president in 2016(AP), Choosing your own: Definition of race becoming fluid(AP), Confidently Humble, or the time I started beating on the ground with a stick, Smashmouth to headline at Champaign Music Festival(Champaign Park District), Kosovo art installation of dresses supports war rape victims(AP), Obama says US …

Jimmy Tong Four Decades Of Wise Guidance, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Shifting Facilitator Roles: The Challenges And Experiences Of Tutors Within Aalborg And Maastricht Pbl Settings, Lilian Furquim, Elizabeth Pluskwik, Sally Wiggins

Integrated Engineering Department Publications

Problem-based learning (PBL) has become a widespread method of teaching and learning around the world since the early 1970s. While several varieties of PBL are in use in many educational institutions, two primary models have taken root: the Aalborg model originating in Aalborg University, Denmark and the Maastricht model, originating in Maastricht University in The Netherlands. The two models both guide self-directed student learning under PBL principles, but they also have distinct differences. As developing PBL facilitators ourselves, we were particularly interested in understanding the role of the facilitator as it differs across the two models. Our goal for this …

Aadr Clark Fellowship Awarded To Abou-Arraj, Tyler Greer

Browse All News

No abstract provided.

Deregulation Of Mir-34b/Sox2 Predicts Prostate Cancer Progression., Irene Forno, Stefano Ferrero, Maria Veronica Russo, Giacomo Gazzano, Sara Giangiobbe, Emanuele Montanari, Alberto Del Nero, Bernardo Rocco, Giancarlo Albo, Lucia R Languino, Dario C Altieri, Valentina Vaira, Silvano Bosari

Department of Cancer Biology Faculty Papers

Most men diagnosed with prostate cancer will have an indolent and curable disease, whereas approximately 15% of these patients will rapidly progress to a castrate-resistant and metastatic stage with high morbidity and mortality. Therefore, the identification of molecular signature(s) that detect men at risk of progressing disease remains a pressing and still unmet need for these patients. Here, we used an integrated discovery platform combining prostate cancer cell lines, a Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) model and clinically-annotated human tissue samples to identify loss of expression of microRNA-34b as consistently associated with prostate cancer relapse. Mechanistically, this was …