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2015

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Comparisons Of Lygus Lineolaris Populations From The Mississippi Delta And Hills Agricultural Regions, Daniel Edward Fleming Aug 2015

Comparisons Of Lygus Lineolaris Populations From The Mississippi Delta And Hills Agricultural Regions, Daniel Edward Fleming

Theses and Dissertations

Lygus lineolaris (Palisot de Beauvois) is a pest of cotton (Gossypium hirsutum L.) in Mississippi, particularly in the Delta region of the state. It is estimated that 3.1old more insecticide applications are needed to control this pest and it costs producers 3.6old more in the Delta region than in the Hills region. These differences have been attributed to increased insecticide resistance in the Delta and the possibility of a biotype of L. lineolaris in the Delta that is better adapted to cotton than the population in the Hills. A series of experiments were undertaken to evaluate these differences. The first …

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Ecology Of Yellow Rail (Coturnicops Noveboracensis) Overwintering In Coastal Pine Savannas Of The Northern Gulf Of Mexico, Kelly Marie Morris Aug 2015

Ecology Of Yellow Rail (Coturnicops Noveboracensis) Overwintering In Coastal Pine Savannas Of The Northern Gulf Of Mexico, Kelly Marie Morris

Theses and Dissertations

The Yellow Rail (Coturnicops noveboracensis) is a migratory nongame bird of high conservation priority throughout its entire range. The objectives of this study were: (1) assess Yellow Rail occupancy in the context of prescribed fire regime in pine savanna habitats of Mississippi and Alabama and (2) assess Yellow Rail habitat use in pine savanna habitats of coastal Mississippi. Yellow Rail occupancy decreased significantly with time since fire and increased with grassland patch size. Throughout the study area Yellow Rail maintained small (mean = 3.37 ha) home ranges aggregated within study areas, indicating suitable habitat may be limited. Yellow Rail used …

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Effect Of Omega-3 Fatty Acid Supplementation To Gestating And Lactating Mares On Milk Igg And Fatty Acid Composition, Mare And Foal Blood Concentrations Of Igg, Fatty Acid Composition, Insulin And Glucose, And Placental Efficiency, Lauren B. Hodge Aug 2015

Effect Of Omega-3 Fatty Acid Supplementation To Gestating And Lactating Mares On Milk Igg And Fatty Acid Composition, Mare And Foal Blood Concentrations Of Igg, Fatty Acid Composition, Insulin And Glucose, And Placental Efficiency, Lauren B. Hodge

Theses and Dissertations

There are conflicting results from previous research evaluating the effects of dietary omega-3 fatty acid supplementation on IgG concentration of colostrum, milk and foal blood. No research has been done on the effect of omega-3 fat supplementation on the placental efficiency of horses or the nitrite concentrations of the placenta as an indicator of vascularization. This study examined the effect of dietary omega-3 supplementation on composition of milk, mare and foal serum and if it will result in transfer of fatty acid in utero as well as providing the foal with adequate IgG concentrations in the milk and colostrum. Omega-3 …

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Effects Of Intercropping Switchgrass In Managed Pine Stands On Plant Communities And White-Tailed Deer Forage Production, Bradley Robert Wheat Aug 2015

Effects Of Intercropping Switchgrass In Managed Pine Stands On Plant Communities And White-Tailed Deer Forage Production, Bradley Robert Wheat

Theses and Dissertations

Interest in renewable energy and governmental mandates has motivated land managers to consider cellulosic feedstocks for bioenergy. I investigated plant community response to a system including switchgrass (Panicum virgatum) as a feedstock intercropped with loblolly pine (Pinus taeda). I estimated plant species evenness, richness, and diversity and biomass production, with emphasis on white-tailed deer (Odocoileus virginianus) forages. I detected 225 species in 2,220 1-m2 quadrats, and 7,495 biomass samples (96.4 kg dry weight) from 960 quadrats. Intercropping reduced plant species diversity, total non-pine tree biomass, and biomass of deer forages during switchgrass establishment. These effects were no longer apparent at …

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Effects Of Supplementing Ponies With Dietary Fat On Nutrient Digestibility And Blood Insulin, Glucose, And Fatty Acid Concentrations, Toree Lee Bova Aug 2015

Effects Of Supplementing Ponies With Dietary Fat On Nutrient Digestibility And Blood Insulin, Glucose, And Fatty Acid Concentrations, Toree Lee Bova

Theses and Dissertations

Fat supplementation is a common practice to increase caloric intake in the performance horse. The effects of fat on fiber digestibility is unknown. Understanding of digestibility in the equine digestive tract is limited by sampling technique. While cecal and ileal cannulations have previously been utilized to determine equine nutrient digestibility and gastrointestinal physiology, the current research has been limited to singular portions of the equine digestive tract. The objectives of this dissertation were to determine the effects of dietary fat supplementation on nutrient digestibility and blood insulin, glucose, and fatty acid concentrations using dual cannulated ponies. The first step to …

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Effects Of The In Ovo Injection Of Inovocox Em1 Vaccine On The Embryogenesis, Posthatch Performance, And Gut Pathology Of Ross Ross 708 Broilers, Adebayo Oluwaseun Sokale Aug 2015

Effects Of The In Ovo Injection Of Inovocox Em1 Vaccine On The Embryogenesis, Posthatch Performance, And Gut Pathology Of Ross Ross 708 Broilers, Adebayo Oluwaseun Sokale

Theses and Dissertations

Effects of the in ovo injection of Inovocox EM1 vaccine (EM1 vaccine) suspended in commercial diluent on developing broiler embryos were investigated in 3 trials. Effects of the EM1vaccine administered by in ovo injection on broiler embryogenesis and posthatch performance was determined by evaluating site of injection (SOI), embryo staging (ES), hatchability, and chick quality parameters. Oocyst output, microscopic lesion scores, and grow-out performance were further examined through day 35 posthatch. In these studies, it was shown that oocyst output began at day 3 posthatch (6 days post-injection), and peaked at day 7 posthatch (10 days post-injection). The EM1 vaccine …

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Evaluating Productivity Of Southern Agroforestry For Fiber, Biofuels, And Wildlife Habitat, Henry Gill Gordon Aug 2015

Evaluating Productivity Of Southern Agroforestry For Fiber, Biofuels, And Wildlife Habitat, Henry Gill Gordon

Theses and Dissertations

Wildlife habitat values associated with agroforestry systems in Mississippi are not fully understood. Landscape matrix changes resulting in close location of various agricultural and tree crops can provide habitat more suitable for use by game wildlife. This study examined the feasibility of improving habitat value by adopting agroforestry alley cropping practices. A completely randomized block design was utilized to ascertain production values for two different even-aged crop trees, shortleaf pine (Pinus echinata Mill.) and loblolly pine (Pinus taeda L.), and four different agricultural crops, corn (Zea mays L.), switchgrass (Panicum virgatum L.), grain sorghum (Sorghum bicolor L.), and soybeans (Glycine …

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Evaluating The Pest Status Of Threecornered Alfalfa Hopper In Mississippi Agricultural Crops, Jeffery Tyler Ramsey Aug 2015

Evaluating The Pest Status Of Threecornered Alfalfa Hopper In Mississippi Agricultural Crops, Jeffery Tyler Ramsey

Theses and Dissertations

Field experiments were conducted to determine the impact of threecornered alfalfa hopper, Spissistilus festinus, (Say), in reproductive growth stage soybeans. High densities of threecornered alfalfa hoppers were examined in field cages to understand feeding on soybean. No significant yield losses were observed from threecornered alfalfa hopper feeding during reproductive growth stages. Sweep net efficiency studies were conducted in order to convert the densities used in field cages to a sweep net threshold. Field experiments were also conducted to determine the impact of threecornered alfalfa hopper injury to seedling cotton. Threecornered alfalfa hopper injury to seedling cotton plants impacts individual plant …

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Antagonism Of Barnyardgrass (Echinochloa Crus-Galli) Control With Graminicides By Glufosinate In Libertylink Soybeans (Glycine Max), Amber Nicole Eytcheson Aug 2015

Antagonism Of Barnyardgrass (Echinochloa Crus-Galli) Control With Graminicides By Glufosinate In Libertylink Soybeans (Glycine Max), Amber Nicole Eytcheson

Theses and Dissertations

Field and greenhouse experiments were conducted to determine barnyardgrass control as affected by glufosinate and graminicide tank-mixtures, application timing of tank-mixtures of graminicides plus glufosinate and application time of day of tank-mixtures of glufosinate and clethodim. When increased rates of graminicide were tank-mixed with glufosinate, barnyardgrass control was unaffected by quizalofop-P plus glufosinate; however, clethodim plus glufosinate control in the field indicated the potential for reduced barnyardgrass control. When evaluating increasing glufosinate rates tank-mixed with graminicides, barnyardgrass control was not negatively affected by the combination of glufosinate and graminicides. The difference in soybean yield among the graminicides may indicate that …

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Spatial Ecology And Population Estimation Of The American Alligator (Alligator Mississippiensis) In Inland Systems Of Mississippi, Bradley Austin Strickland Aug 2015

Spatial Ecology And Population Estimation Of The American Alligator (Alligator Mississippiensis) In Inland Systems Of Mississippi, Bradley Austin Strickland

Theses and Dissertations

Wildlife management and conservation frequently rely on understanding mechanisms that influence distribution and abundance of animals. I quantified space use for a population of inland riverine adult male alligators in Mississippi. Results indicated habitat selection is a scale-dependent process and aquatic vegetation, water depth, and water temperature may be important factors influencing alligator foraging and thermoregulation. Apparent habitat suitability and low alligator density did not manifest in an observed body size-based dominance hierarchy. I also analyzed long-term Mississippi alligator spotlight survey data for trends and effects of environmental covariates on counts. Model results indicated alligator counts have increased over time. …

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The Development Of Next Generation, Unsymmetrical -Nhc Pincer Ligand Architectures And Metalation To Form Unsymmetrical -Nhc Pincer Ta Complexes, Hannah Killian Box Aug 2015

The Development Of Next Generation, Unsymmetrical -Nhc Pincer Ligand Architectures And Metalation To Form Unsymmetrical -Nhc Pincer Ta Complexes, Hannah Killian Box

Theses and Dissertations

The impact of N-heterocyclic carbenes (NHC) as ligands for transition metal catalysis has been rigorously investigated since their isolation by Arduengo in 1991. NHCs have become abundant in late-transition metal chemistry. This is attributed to NHCs being stronger sigma-donors than even the strongest phosphine analogues, thus constructing a transition metal-NHC complex with improved stability, catalytic reactivity, and selectivity. Additionally, pincer ligands have become recognized as an important class of ligands for transition metal complexes. The unique steric and electronic tunability of pincer ligands has resulted in pincer-transition metal complexes being exploited as catalysts for a multitude of transformations. Both ligand …

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Improvements To Broiler Production Through Amino Acid Digestibility And Feed Additives, Cameron Mario Cardenas Aug 2015

Improvements To Broiler Production Through Amino Acid Digestibility And Feed Additives, Cameron Mario Cardenas

Theses and Dissertations

Improvements to broiler production can be made through the means of nutrition and preventative health care. Formulating diets based on a digestible amino acid (AA) basis decreases feed cost and improves bird performance by providing a more accurate diet based on the bird’s specific production or age nutrient requirements. The apparent ileal amino acid digestibility (AIAAD) assay utilized in Experiment 1 demonstrated inconsistent results for age effects on AIAAD of an animal by-product blends for specific AA or age. Increasing pathogenic resistance and consumer’s push on the market, has caused integrators to incorporate alternative medications or inclusion strategies to coccidiosis …

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Influence Of Landscape- And Stand-Scale Factors On Avian Communities In Open Pine Ecosystems, Taylor Idora Hannah Aug 2015

Influence Of Landscape- And Stand-Scale Factors On Avian Communities In Open Pine Ecosystems, Taylor Idora Hannah

Theses and Dissertations

Identifying species occurrence in ecosystems of high conservation concern is especially important in the context of modern landscapes. This study investigated how stand-scale and landscape-scale factors affect priority birds associated with longleaf pine (Pinus palutris) ecosystems. Herein, I compared priority bird occupancy among 12 stand types throughout the historic range of longleaf pine. I found open pine stands positively influenced red-cockaded woodpecker (Picoides borealis) and Bachman’s sparrow (Peucaea aestivalis) occupancy, but were not significantly linked to northern bobwhite (Colinus virginianus) and brown-headed nuthatch (Sitta pusilla) occurrence. Landscape- and stand-scale factors affected red-cockaded woodpecker, Bachman’s sparrow, and brown-headed nuthatch occupancy. Northern …

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Integration Of Cereal Cover Crops And Synthetic Auxin Herbicides Into Rowcrop Production And Weed Management, Ryan James Edwards Aug 2015

Integration Of Cereal Cover Crops And Synthetic Auxin Herbicides Into Rowcrop Production And Weed Management, Ryan James Edwards

Theses and Dissertations

The occurrence of herbicide resistance weeds across the southern United States has been increasing. Research is needed to develop alternative control measures, while supporting sound agronomic practices. Greenhouse and field studies were conducted to evaluate cereal cover cropping techniques along with novel herbicides to determine their value for Mississippi growers. Field studies were performed to determine which combination of cereal cover crops (cereal rye, wheat and oats) and residual herbicides (S-metolachlor + metribuzin, S-metolachlor + fomesafen, pendimethalin, flumioxazin, sulfentrazone + metribuzin and pyroxasulfone + flumioxazin) would maximize soybean yield in the presence of weeds. Cereal cover crop termination methods were …

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Investigation Of Microbial Aspects Related To Salmonella As A Food Pathogen Bioluminescent Reporting System And Mechanisms For Host Invasion, Kevin Howe Aug 2015

Investigation Of Microbial Aspects Related To Salmonella As A Food Pathogen Bioluminescent Reporting System And Mechanisms For Host Invasion, Kevin Howe

Theses and Dissertations

Salmonella can reside in healthy animals without the manifestation of any adverse effects on the carrier. If raw products of animal origin are not handled properly during processing or cooked to a proper temperature during preparation, salmonellosis can occur. In this research, microbial aspects related to Salmonella as a food pathogen are investigated. A bioluminescent reporting system was developed for Salmonella to monitor the attachment and growth of the pathogen on food products. Twelve and eleven Salmonella strains from the broiler production continuum were tagged with bioluminescence by plasmid and integration of the lux operon into the chromosome, respectively. To …

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Modeling Tree Species Distribution And Dynamics Under A Changing Climate, Natural Disturbances, And Harvest Alternatives In The Southern United States, Zhen Sui Aug 2015

Modeling Tree Species Distribution And Dynamics Under A Changing Climate, Natural Disturbances, And Harvest Alternatives In The Southern United States, Zhen Sui

Theses and Dissertations

Forests in the southern United States with diverse forest ownership entities are facing threats associated with climate change and natural disturbances. This study represented the relationship between climate and species dominance, predicted future species distribution probability under a changing climate, and projected forest dynamics under ownership-based management regimes. Correlative statistics and mechanistic modeling approaches are implemented. Temporal scale includes the recent past 40 years and the future 60 years; spatial scale downscaled from southern United States to the coastal region of the northern Gulf of Mexico. In the southern United States, dominance of four major pine species experienced shifts from …

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Genetic Structure Of Rhizobia Associated With Chamaecrista Fasciulata, Hanna Elizabeth Dorman Aug 2015

Genetic Structure Of Rhizobia Associated With Chamaecrista Fasciulata, Hanna Elizabeth Dorman

Theses and Dissertations

The legume-rhizobia relationship is an important symbiosis. Studies have found variation in specificity and the functionality of symbiotic specificity can vary among plants of the same species and among rhizobia, as well as in concert with geographical variation. Here, we examined the diversity and geographic structure of rhizobia nodulating Chamaecrista fasciculata, which grows throughout the east-central U.S. and is symbiotic with Bradyrhizobium species. We investigated the association of geography and soil variables on rhizobial diversity by sampling plant nodules and soil across Mississippi and evaluated variation in rhizobia housed in different nodules of individual plants. Using nifH and truA, we …

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Human Carbonic Anhydrase Ii; Preparation, Metal-Substitution, Activity, And Inhibition, David L. Wilson Aug 2015

Human Carbonic Anhydrase Ii; Preparation, Metal-Substitution, Activity, And Inhibition, David L. Wilson

Theses and Dissertations

This report details the activities and inhibition of metal-substituted human carbonic anhydrase II (M-HCA-II). The traditional activities (hydrolysis of CO2 and para-nitrophenol acetate) in addition to new activities (oxidation of 2-aminophenol, disproportionation of H2O2, and disproportionation of superoxide) were investigated. Values reported for the relative hydrolytic activities of M-HCA-IIs are reported here for the first time, ranging from 47.5 % (plus or minus 0.6) to 86 % (plus or minus 4) for the hydrolysis of CO2 and from 0.299 % (plus or minus 0.012) to 4.72 % (plus or minus 0.015) for the hydrolysis of para-nitrophenol acetate. With respect to …

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Hybrid Functions In Fractional Calculus, Somayeh Mashayekhi Aug 2015

Hybrid Functions In Fractional Calculus, Somayeh Mashayekhi

Theses and Dissertations

In this dissertation, a new numerical method for solving the fractional dynamical systems, is presented. We first introduce Riemann-Liouville fractional integral operator for hybrid functions. Then we will show the spectral accuracy of the present method for solving fractional-order differential equations, and we will extend the present method for solving nonlinear fractional integro-differential equations, fractional Bagley-Torvik equation, distributed order fractional differential equations, two-dimensional fractional partial differential equations, and fractional optimal control problems. In all cases, we will show the rate of convergence is more than some existing numerical methods which were used to solve these kind of problems in the …

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I Can't Accept Your "Lifestyle" Because I Love You Mississippi Christians' Beliefs And Attitudes Toward Homosexuality And Gay And Lesbian Civil Rights, Ashley A. Baker Aug 2015

I Can't Accept Your "Lifestyle" Because I Love You Mississippi Christians' Beliefs And Attitudes Toward Homosexuality And Gay And Lesbian Civil Rights, Ashley A. Baker

Theses and Dissertations

Using surveys and interviews with Mississippi Christians, this study provides a more complete understanding of Christians’ beliefs and attitudes toward homosexuality and gay and lesbian civil rights. I analyze how Mississippi Christians make sense of their relationships with gay and lesbian friends and family members and how this differs based on their religious identity. I then consider how these beliefs and attitudes are influenced by social contact with gays and lesbians. I find Mississippi Christians’ views toward homosexuality and gay and lesbian civil rights vary widely from rejection to acceptance. The most conservative views are held by evangelical Protestants who …

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Impact Of Environmental And Cellular Factors On The Bioactivity Of A Novel Antifungal, Occidiofungin, Chase Alexander Robinson Aug 2015

Impact Of Environmental And Cellular Factors On The Bioactivity Of A Novel Antifungal, Occidiofungin, Chase Alexander Robinson

Theses and Dissertations

Occidiofungin is a novel glycolipopeptide, synthesized and secreted by Burkholderia contaminans MS14, demonstrating broad-spectrum antifungal activity and potential for successful clinical applications. Its mechanism of action has not yet been determined but is known to exhibit fungicidal activity via the induction of apoptosis in a manner unique from that of currently approved antifungals. As an early investigation into occidiofungin’s mechanism of action, we aimed to identify environmental and cellular factors that significantly alter the susceptibility of the model organism, Saccharomyces cerevisiae. To that end, we have demonstrated that occidiofungin’s bioactivity requires active cellular growth, that new protein synthesis is necessary …

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Evaluation Of Ultradwarf Bermudagrass Cultural Management Practices And Identification, Characterization, And Pathogenicity Of Ectotrophic Root-Infecting Fungi Associated With Summer Decline Of Ultradwarf Bermudagrass Putting Greens, Phillip Lavelle Vines Aug 2015

Evaluation Of Ultradwarf Bermudagrass Cultural Management Practices And Identification, Characterization, And Pathogenicity Of Ectotrophic Root-Infecting Fungi Associated With Summer Decline Of Ultradwarf Bermudagrass Putting Greens, Phillip Lavelle Vines

Theses and Dissertations

This research addressed the effects of cultural management practices, cultivar selection, and applications of seasonal fungicides on ultradwarf bermudagrass health and playability and occurrence of foliar diseases. Additionally, novel ectotrophic root-infecting fungi were isolated from ultradwarf bermudagrass roots exhibiting symptoms of summer decline, identified via multilocus phylogenetic analyses, and characterized by morphological assessments and pathogenicity evaluations.

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Evolutionary And Ecological Causes And Consequences Of Trophic Niche Variation In Ursids, Diana Jean Raper Lafferty Aug 2015

Evolutionary And Ecological Causes And Consequences Of Trophic Niche Variation In Ursids, Diana Jean Raper Lafferty

Theses and Dissertations

Individual variation and fitness are the cornerstones of evolution by natural selection. The trophic niche represents an important source of phenotypic variation on which natural selection can act. Although individual variation is fundamental to species-level ecological and evolutionary change, individual variation is often ignored in population-level approaches to wildlife ecology, conservation and management. Failing to link individual resource use to fitness or to biological outcomes related to fitness limits us to managing for the average resource needs of a population, which may be insufficient for protecting the diversity of resource use within populations and the underlying eco-evolutionary processes that generate …

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Examining The Relationship Between Avifauna And Green Roofs In Mississippi's Humid-Subtropical Climate, Sara Katherine Lamb Aug 2015

Examining The Relationship Between Avifauna And Green Roofs In Mississippi's Humid-Subtropical Climate, Sara Katherine Lamb

Theses and Dissertations

Human settlement displaces and fragments natural habitats. Design choices in the landscape directly affect both local diversity and extinction rates. This study seeks to understand how avifauna are responding to this new technology in Mississippi.

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Exploring The Role Of Dopamine In Stress Response And Aging In Drosophila Melanogaster - Implications For Neurodegenerative Diseases, Marley Elyse Hanna Aug 2015

Exploring The Role Of Dopamine In Stress Response And Aging In Drosophila Melanogaster - Implications For Neurodegenerative Diseases, Marley Elyse Hanna

Theses and Dissertations

Dopamine (DA) is a catecholamine that is involved in several neural functions such as modulation of locomotor behaviors, arousal states to appetitive aversive learning and memory. The relationships between DA, stress response and aging are unclear. This thesis examines numerous physiological, behavioral and biochemical parameters following perturbations in DA synthesis and transport in the Drosophila melanogaster model system. Intriguingly, elevated DA pools appear to confer protection, while depleted DA levels or transport increase susceptibility to oxidative insult. Resistance to oxidative stress in mutants with elevated DA levels was attributed to a significant up-regulation of glutathione S-transferase Omega-1. A sexually dimorphic …

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Familial Religious Practices, Religiosity, Family Connectedness, Parent Conflict, And Their Relation To Depressive Symptoms In An Adolescent Sample, Alice Cathryne Long Aug 2015

Familial Religious Practices, Religiosity, Family Connectedness, Parent Conflict, And Their Relation To Depressive Symptoms In An Adolescent Sample, Alice Cathryne Long

Theses and Dissertations

In recent decades, research on family life and religion has been conducted. Much of the research done on religion and well-being has shown beneficial effects of religion or religious practices on well-being (Bonner, Koven, & Patrick, 2003; Loser, Klein, Hill, & Dollahite, 2008). Using data from the Flourishing Families Project (N = 359 adolescents), the relationship between religious variables (family religious practices, family religious importance and religiosity), family climate measures (family connectedness and parent conflict) and adolescent depressive symptoms was examined. Results indicate no significant relationship between religious variables and adolescent depressive symptoms, but a positive relationship between parent conflict …

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A Functional Genomics Analysis Of Glycine Max Vesicle Membrane Fusion Genes In Relation To Infection By Heterodera Glycine, Keshav Sharma Aug 2015

A Functional Genomics Analysis Of Glycine Max Vesicle Membrane Fusion Genes In Relation To Infection By Heterodera Glycine, Keshav Sharma

Theses and Dissertations

Soybean cyst nematode (SCN), a major pathogen of soybean worldwide, causes huge losses in soybean production. Various approaches including cloning of genes to combat this devastating disease help to better understand the cellular function and immune responses of plants. Membrane fusion genes are the important regulatory parts of vesicular transport system, which works through packaging of intracellular compounds and delivering them to apoplast or nematode feeding sites to induce an incompatible reaction. The incompatible nature of membrane fusion proteins such as SNAP25, Munc18, Syntaxin, Synaptobrevin, NSF, Synaptotagmin and alpha-SNAP are conserved in eukaryotes and regulate the intracellular function to combat …

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A Study Of Abscisic Acid Regulated Enzymes And Histone Binding Proteins In Plants, Udhghatri Kolli Aug 2015

A Study Of Abscisic Acid Regulated Enzymes And Histone Binding Proteins In Plants, Udhghatri Kolli

Theses and Dissertations

Plant hormone abscisic acid (ABA) plays a main role in coordinating various stress signals in plants. ABA regulates the expression of genes and activities of enzymes in response to various stress conditions. In the following studies we were able to study the ABA mediated regulation of enzymes in plants. Using in-gel activity analysis we identified that ABA regulates the activity of aspartate aminotransferase (AAT), an enzyme involved in nitrogen assimilation and carbohydrate metabolism. Our results indicate that phosphorylation of AAT by SnRK2.2 and 2.3 kinases results in down regulation of AAT2 and AAT3 isozyme activities in Arabidopsis. AAT was identified …

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Carbonic Anhydrase Ix Induction Defines A Heterogeneous Cancer Cell Response To Hypoxia And Mediates Stem Cell-Like Properties And Sensitivity To Hdac Inhibition, I Ledaki, A Mcintyre, S Wigfield, F Buffa, Et Al Aug 2015

Carbonic Anhydrase Ix Induction Defines A Heterogeneous Cancer Cell Response To Hypoxia And Mediates Stem Cell-Like Properties And Sensitivity To Hdac Inhibition, I Ledaki, A Mcintyre, S Wigfield, F Buffa, Et Al

School of Biomedical Sciences

Carbonic anhydrase IX (CAIX) is strongly induced by hypoxia and its overexpression is associated with poor therapeutic outcome in cancer. Here, we report that hypoxia promotes tumour heterogeneity through the epigenetic regulation of CAIX. Based on hypoxic CAIX expression we identify and characterize two distinct populations of tumour cells, one that has inducible expression of CAIX and one that does not. The CAIX+ve population is enriched with cells expressing cancer stem cell markers and which have high self-renewal capacity. We show that differential CAIX expression is due to differences in chromatin structure. To further investigate the relationship between chromatin organization …

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Volume 45, Issue 1: Full Issue, Manuscripts Staff Aug 2015

Volume 45, Issue 1: Full Issue, Manuscripts Staff

Manuscripts

No abstract provided.

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