Digital Commons Network^™

Census Overview: Basics, Acs, And Estimates, Jerry Deichert

CPAR Presents: A Data and Research Series for Community Impact

No abstract provided.

2015 Fall Faculty Conference: Cultivating Curiosity: Teaching As A Vocation, Academic Affairs

Fall Faculty Conference

The 2015 Fall Faculty Conference featured teaching showcases by Sarah Bouchard (Biology and Earth Science), Jeff Demas (Communication), John Kengla (Arts & Sciences), Gayle Walker (Music), and Paul Wendel (Education).

There were also breakout sessions hosted by Colin Saunders with Kay Ball and Clare Kilbane and Jackie Haverkamp and Paul Longenecker and T. G. Gerckens and Eric Lloyd, Anna Young, Joan Esson, Paul Wendel Kathryn Plank, Jean Kelly, Carrie Scheckelhoff, Jeff Smith, Erica Womack, Rares Piloiu, Amy Parsons, Jessica Crossfield McIntosh, Beth Daugherty, Andrew Mills, Dee Knoblauch, Kristin Bourdage, Patti Wilson, Kristy Drobney, Nate Parsell, and Deanna Heerman.

Statistical Estimation Of T1 Relaxation Time Using Conventional Magnetic Resonance Imaging, Amanda Mejia, Elizabeth M. Sweeney, Blake Dewey, Govind Nair, Pascal Sati, Colin Shea, Daniel S. Reich, Russell T. Shinohara

UPenn Biostatistics Working Papers

Quantitative T₁ maps estimate T₁ relaxation times and can be used to assess diffuse tissue abnormalities within normal-appearing tissue. T₁ maps are popular for studying the progression and treatment of multiple sclerosis (MS). However, their inclusion in standard imaging protocols remains limited due to the additional scanning time and expert calibration required and susceptibility to bias and noise. Here, we propose a new method of estimating T₁ maps using four conventional MR images, which are intensity- normalized using cerebellar gray matter as a reference tissue and related to T₁ using a smooth regression model. Using …

Intracranial Glioblastomas: New Hope For An Effective Treatment, Arthur J L Cooper

NYMC Faculty Publications

Comment on Successful Treatment of Intracranial Glioblastoma Xenografts With a Monoamine Oxidase B-Activated Pro-Drug. [EBioMedicine. 2015]

Acidic And Basic Destruction Of Tissues, Cydney Eaton

University Honors Program

A coroner’s case I had learned about involved a man attempting to dispose of a body with acid. Shortly after exposure, the man was apprehended and the body was located. Upon investigation, police force determined the acid used to be hydrochloric acid, however, exact concentration remains unknown (Kohr, 2010). This led to the question of which easily accessible acid works best to degrade tissue. To answer this, an experiment was conducted involving pig feet and various concentrations of common acids and a single strong base. The feet were submerged in the solutions overnight and mass percent lost or gained was …

We Are...Marshall, August 19, 2015, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Outcome Prediction In Mathematical Models Of Immune Response To Infection, Manuel Mai, Kun Wang, Greg Huber, Michael Kirby, Mark D. Shattuck, Corey S. O’Hern

Publications and Research

Clinicians need to predict patient outcomes with high accuracy as early as possible after disease inception. In this manuscript, we show that patient-to-patient variability sets a fundamental limit on outcome prediction accuracy for a general class of mathematical models for the immune response to infection. However, accuracy can be increased at the expense of delayed prognosis. We investigate several systems of ordinary differential equations (ODEs) that model the host immune response to a pathogen load. Advantages of systems of ODEs for investigating the immune response to infection include the ability to collect data on large numbers of ‘virtual patients’, each …

Annual And Seasonal Price Patterns For Cattle, Kathleen Brooks

Cornhusker Economics

Annual average prices over the last 35 years for feeder steers (500-600 lb and 700-800 lb) and fed steers for Nebraska are shown in Figure 1. The U.S. cattle history has well documented 10 to 12 year cycles of rising and falling production with inverse price cycles. Historical prices within the cattle industry cycles for Nebraska can be seen from the figure with similar low prices during the bottom of the cycles in 1986 and 1996. In 1996, higher than average feed grain prices resulted in the narrowing of the spread between lighter weight and heavier weight steers. Cattle prices …

Targeted Salivary Biomarkers For Discrimination Of Periodontal Health And Disease(S), Jeffrey L. Ebersole, Radhakrishnan Nagarajan, David Akers, Craig S. Miller

Center for Oral Health Research Faculty Publications

Generally, clinical parameters are used in dental practice for periodontal disease, yet several drawbacks exist with the clinical standards for addressing the needs of the public at large in determining the current status/progression of the disease, and requiring a significant amount of damage before these parameters can document disease. Therefore, a quick, easy and reliable method of assessing and monitoring periodontal disease should provide important diagnostic information that improves and speeds treatment decisions and moves the field closer to individualized point-of-care diagnostics.

OBJECTIVE: This report provides results for a saliva-based diagnostic approach for periodontal health and disease based upon …

Application Of Ichip To Grow “Uncultivable” Microorganisms And Its Impact On Antibiotic Discovery, Rinzhin T. Sherpa, Caretta J. Reese, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Purpose. Antibiotics have revolutionized modern medicine, allowing significant progress in healthcare and improvement in life expectancy. Development of antibiotic resistance by pathogenic bacteria is a natural phenomenon; however, the rate of antibiotic resistance emergence is increasing at an alarming rate, due to indiscriminate use of antibiotics in healthcare, agriculture and even everyday products. Traditionally, antibiotic discovery has been conducted by screening extracts of microorganisms for antimicrobial activity. However, this conventional source has been over-used to such an extent that it poses the risk of “running out” of new antibiotics. Aiming to increase access to a greater diversity of microorganisms, …

Dichotomy In The Epigenetic Mark Lysine Acetylation Is Critical For The Proliferation Of Prostate Cancer Cells, Ravi Pathak, Marc Philizaire, Shiraz Mujtaba

Publications and Research

The dynamics of lysine cetylation serve as a major epigenetic mark, which regulates cellular response to inflammation, DNA damage and hormonal changes. Microarray assays reveal changes in gene expression, but cannot predict regulation of a protein function by epigenetic modifications. The present study employs computational tools to inclusively analyze microarray data to understand the potential role of acetylation during development of androgen-independent PCa. The data revealed that the androgen receptor interacts with 333 proteins, out of which at least 92 proteins were acetylated. Notably, the number of cellular proteins undergoing acetylation in the androgen-dependent PCa was more as compared to …

Development Of A Clickable Bimodal Fluorescent/Pet Probe For In Vivo Imaging, Andreas Paulus, Pooja Desai, Brandon Carney, Giuseppe Carlucci, Thomas Reiner, Christian Brand, Wolfgang A. Weber

Publications and Research

Background Fluorescent imaging agents are becoming evermore important in preclinical and clinical research. They do, however, suffer from poor tissue penetration, which makes optical fluorescence imaging incompatible with whole-body imaging techniques. The design of novel bimodal PET active and fluorescent tracers could therefore combine the benefits of optical imaging with radioactively labeled imaging probes. Herein, we report the synthesis and evaluation of a clickable 18F-labeled fluorescent dye. Methods An azide-modified BODIPY-Fl dye could be successfully radio-labeled with 18F using an 18F/19F exchange reaction of the boron-fluoride core of the BODIPY dye to yield a clickable bimodal PET/fluorescent imaging tool. In …

Influence Of Dietary Experience On The Induction Of Preference Of Adult Moths And Larvae For A New Olfactory Cue, Christophe Petit, Bruno Le Ru, Stéphane Dupas, Brigitte Frérot, Peter Ahuya, Laure Kaiser-Arnauld, Myriam Harry, Paul André Calatayud

All Peer-Reviewed Publications

In Lepidoptera, host plant selection is first conditioned by oviposition site preference of adult females followed by feeding site preference of larvae. Dietary experience to plant volatile cues can induce larval and adult host plant preference. We investigated how the parent's and self-experience induce host preference in adult females and larvae of three lepidopteran stem borer species with different host plant ranges, namely the polyphagous Sesamia nonagrioides, the oligophagous Busseola fusca and the monophagous Busseola nairobica, and whether this induction can be linked to a neurophysiological phenotypic plasticity. The three species were conditioned to artificial diet enriched with vanillin from …

Acidic And Basic Destruction Of Tissues, Cydney Eaton

University Honors College

A coroner’s case I had learned about involved a man attempting to dispose of a body with acid. Shortly after exposure, the man was apprehended and the body was located. Upon investigation, police force determined the acid used to be hydrochloric acid, however, exact concentration remains unknown (Kohr, 2010). This led to the question of which easily accessible acid works best to degrade tissue. To answer this, an experiment was conducted involving pig feet and various concentrations of common acids and a single strong base. The feet were submerged in the solutions overnight and mass percent lost or gained was …

Nutrient Dynamics Of Floating Seagrass Wracks In Greater Florida Bay, Rachel A. Perry

Master's Theses

Floating aggregations of seagrass wrack (i.e., leaves shed from seagrass beds) can serve as an ecological “hot spot” contributing to the survival of many species in the form of habitat and food source. Considerable research has been done on assessing trophic transfer of nutrients from seagrass wrack that is washed ashore, but little is known about nutrient dynamics in floating seagrass wrack. Here, drifters were deployed to track the location of floating wracks created in Greater Florida Bay and mesocosm experiments were conducted on two different of floating macrophytes (Syringodium filiforme, Thalassia testudinum, and Sargassum sp.) to estimate …

Secondary Messengers Involvement In Plant Signal Transduction, Hsuan Chou

Doctoral Dissertations

Archival abstract submitted

Papio Cranium From The Hominin-Bearing Site Of Malapa: Implications For The Evolution Of Modern Baboon Cranial Morphology And South African Plio-Pleistocene Biochronology, Christopher C. Gilbert, Christine M. Steininger, Job M. Kibii, Lee R. Berger

Publications and Research

A new partial cranium (UW 88-886) of the Plio-Pleistocene baboon Papio angusticeps from Malapa is identified, described and discussed. UW 88-886 represents the only non-hominin primate yet recovered from Malapa and is important both in the context of baboon evolution as well as South African hominin site biochronology. The new specimen may represent the first appearance of modern baboon anatomy and coincides almost perfectly with molecular divergence date estimates for the origin of the modern P. hamadryas radiation. The fact that the Malapa specimen is dated between ~2.026–2.36 million years ago (Ma) also has implications for the biochronology of other …

Identification Of Inhibitors That Target Dual-Specificity Phosphatase 5 Provide New Insights Into The Binding Requirements For The Two Phosphate Pockets, Terrence S. Neumann, Elise A. Span, Kelsey S. Kalous, Robert D. Bongard, Adam Gastonguay, Michael A. Lepley, Raman G. Kutty, Jaladhi Nayak, Chris Bohl, Rachel G. Lange, Majher I. Sarker, Marat R. Talipov, Rajendra Rathore, Ramani Ramchandran, Daniel S. Sem

Chemistry Faculty Research and Publications

Background: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5.

Methods: pNPP is a mimic of the phosphorylated tyrosine on the ERK2 substrate (pERK2) and binds the DUSP5 phosphatase domain with a Km of 7.6 ± 0.4 mM. Docking followed by inhibitor verification using the pNPP assay identified a series of polysulfonated aromatic inhibitors that occupy the DUSP5 active site in the region that is likely occupied by the dual-phosphorylated ERK2 substrate tripeptide (pThr-Glu-pTyr). Secondary assays …

Hepatocyte Growth Factor And Met Support Mouse Enteric Nervous System Development, The Peristaltic Response, And Intestinal Epithelial Proliferation In Response To Injury, Marina Avetisyan, Hongtao Wang, Ellen Merrick Schill, Saya Bery, John R. Grider, John A. Hassell, Thaddeus Stappenbeck, Robert O. Heuckeroth

Open Access Publications

UNLABELLED: Factors providing trophic support to diverse enteric neuron subtypes remain poorly understood. We tested the hypothesis that hepatocyte growth factor (HGF) and the HGF receptor MET might support some types of enteric neurons. HGF and MET are expressed in fetal and adult enteric nervous system. In vitro, HGF increased enteric neuron differentiation and neurite length, but only if vanishingly small amounts (1 pg/ml) of glial cell line-derived neurotrophic factor were included in culture media. HGF effects were blocked by phosphatidylinositol-3 kinase inhibitor and by MET-blocking antibody. Both of these inhibitors and MEK inhibition reduced neurite length. In adult mice, …

Gene Expression Of Bovine Embryonic Development And Nuclear Reprogramming In The Mouse, Zongliang Jiang

Doctoral Dissertations

Understanding of transcriptional machinery of early embryo development and epigenetic mechanisms of reprogramming is essential for embryogenesis and the success of animal biotechnology. This dissertation presents (1) transcriptional profiles of bovine in vivo pre-implantation development (Chapter Two); (2) bovine imprinted gene expression patterns across mammalian species (Chapter Three); (3) effects of High Hydrostatic Pressure (HHP) on expression profiles of in vitro produced embryos (Chapter Four); (4) roles of BAF complex in reprogramming (Chapter Five).

In the first section, we reported comprehensive transcriptome dynamics of single matured bovine oocytes and pre-implantation embryos developed in vivo using the RNA-seq technologies. Subsequently, using …

Geoheritage, A National Inventory In France, P De Wever, Kn Page, I Alterio, G Egoroff, Et Al

School of Geography, Earth and Environmental Sciences

Good protection measures for geological heritage should begin with an inventory of geosites. In France, for example, a law enacted in 2002 grants formal recognition to the notion of geological heritage. An inventory and evaluation were then established on a region-by-region basis. By April 2007, the French Ministry of Environment launched the inventory programme for the nation’s geological heritage and the data are now being collected at a regional scale. The data are being gathered and homogenised, and then transferred to the French National Museum of Natural History for examination. The ratified site data are stored and available for public …

The Johnsonian August 19, 2015, Winthrop University

The Johnsonian 2010-2019

The Johnsonian is the weekly student newspaper of Winthrop University. It is published during fall and spring semesters with the exception of university holidays and exam periods. We have proudly served the Winthrop and Rock Hill community since 1923.

Principal Component Gene Set Enrichment (Pcgse), H. Robert Frost, Zhigang Li, Jason H. Moore

Dartmouth Scholarship

Background:

Although principal component analysis (PCA) is widely used for the dimensional reduction of biomedical data, interpretation of PCA results remains daunting. Most existing interpretation methods attempt to explain each principal component (PC) in terms of a small number of variables by generating approximate PCs with mainly zero loadings. Although useful when just a few variables dominate the population PCs, these methods can perform poorly on genomic data, where interesting biological features are frequently represented by the combined signal of functionally related sets of genes. While gene set testing methods have been widely used in supervised settings to quantify the …

Considerations Of Potential Tort Liability With Respect To Natural Draft Cooling Towers Associated With Steam-Electric Power Plants, Thomas D. Corkran

Akron Law Review

To prevent thermal pollution and to conserve our water supply, it appears that we must learn to live with natural draft cooling towers, at least for the next several decades. Proponents of natural draft cooling towers maintain that the possibility of localized fogging and icing is negligible, but the potential hazards of artificial salt fallout are very real. Also, there appears to be a trend developing in the law which could lead to an action against the operator of a natural draft cooling tower for aesthetic annoyances. There are several theories of action which might lie in such cases, but …

Reflections Of The Holy Quran And The Mediterranean Diet: A Culturally Congruent Approach To Obesity?, Basil H. Aboul-Enein

Health & Wellness Department Faculty Publications and Research

BACKGROUND:

The Holy Quran is considered to be the authoritative spiritual and behavioral guide for practicing Muslims all around the world. With obesity becoming a growing public health problem in the predominantly Muslim Arab countries, culturally competent dietary and health-promoting strategies and interventions are warranted. The traditional Mediterranean-style diet (MD), which is considered among the healthiest diets, holds both a cultural and historical context within the dietary traditions of North Africa and the Middle East.

OBJECTIVE:

To conduct a narrative study of relevant passages mentioned in the Holy Quran which supports the characteristic features associated with the MD.

METHODS:

A …

2015 August 18 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

General Education Subcommittee Minutes, August 18, 2015, Utah State University

Educational Policies Committee

Course/Designation Removals

Business

• Water Cluster
• Connections Update
• What is an Educated Person?

Biological Engineering Faculty Awarded For Cutting-Edge Eye Health Research | Biological Engineering, Usu College Of Engineering

College of Engineering News

8/18/2015 - More than six million Americans are affected by age-related macular degeneration and other retinal diseases, and despite the prevalence of these disorders, few methods of prevention and treatment exist today.

Reach For The Stars: Improving Upper Extremity Function After Spinal Cord Injury, Carlisle Bland, Ots, Molly Bucciero, Ots, Shelby Hankins, Ots, Blair Krevitz, Ots, Nicole Matyas, Ots

Collaborative Research and Evidence shared Among Therapists and Educators (CREATE Day)

Objectives of Presentation:

1.) Describe how cervical spinal cord injury affects UE functioning necessary for activities of daily living.

2.) Describe occupational therapy interventions used to increase UE functioning in cervical SCI.

3.) Discuss how current evidence supports implementing occupational therapy interventions into clinical practice for individuals with cervical SCI, in order to maximize independence in activities of daily living.

PICO: What is the evidence supporting occupational therapy interventions to increase upper extremity function in order to improve ADL performance following Cervical Spinal Cord Injury?

Presentation: 42 minutes

Estimating Patient-Centered And Community-Centered Treatment Effects: Examples From Medical Care And Public Health, Glen P. Mays

Health Management and Policy Presentations

Health services researchers face growing clinical and policy imperatives for estimating how the effectiveness of medical and public health interventions vary across patients, population groups, and community settings. Recent advances in local instrumental variables estimation techniques allow for the estimation of person-specific and community-specific treatment effects in the presence of unobserved heterogeneity. This presentation explores examples from both medicine and public health following the local IV methods developed by Basu et al. (2013).