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Full-Text Articles in Entire DC Network
Put A Taste Of The South In Your Mouth: Carnal Appetites And Intersextionality, Jaime Cantrell
Put A Taste Of The South In Your Mouth: Carnal Appetites And Intersextionality, Jaime Cantrell
Study the South
Despite all the attention paid to the pleasure of food, and food’s usefulness as a critical node for analyzing southern sociality, sexuality is largely neglected in those discussions. Nevertheless, food and sex are intimately linked.
The Tiger Vol. 109 Issue 32 2015-09-10, Clemson University
The Tiger Vol. 109 Issue 32 2015-09-10, Clemson University
Tiger Newspapers 2015
No abstract provided.
Underserved Adoptive Families: Disparities In Postadoption Access To Information, Resources, And Services, Robin M. Hartinger-Saunders Ph.D., Alex R. Trouteaud Ph.D.
Underserved Adoptive Families: Disparities In Postadoption Access To Information, Resources, And Services, Robin M. Hartinger-Saunders Ph.D., Alex R. Trouteaud Ph.D.
Journal of Family Strengths
Parents who adopt children from the U.S. foster care system typically do so with assurances from the state that postadoption services will be accessible by the family, if needed, after the adoption is finalized. From the state’s perspective, the foremost purpose of these services is to ensure that the family remains intact, thereby avoiding adoption dissolution—a traumatic and costly outcome whereby the child is returned to state custody. This study looks specifically at underserved adoptive families—those who report needing specific services after adoption finalization, yet who are then unable to access these needed services through the state because of various …
Identifying The Tautomeric Form Of A Deoxyguanosine-Estrogen Quinone Intermediate, Douglas E. Stack
Identifying The Tautomeric Form Of A Deoxyguanosine-Estrogen Quinone Intermediate, Douglas E. Stack
Chemistry Faculty Publications
Mechanistic insights into the reaction of an estrogen o-quinone with deoxyguanosine has been further investigated using high level density functional calculations in addition to the use of 4-hyroxycatecholestrone (4-OHE1) regioselectivity labeled with deuterium at the C1-position. Calculations using the M06-2X functional with large basis sets indicate the tautomeric form of an estrogen-DNA adduct present when glycosidic bonds cleavage occurs is comprised of an aromatic A ring structure. This tautomeric form was further verified by use of deuterium labelling of the catechol precursor use to form the estrogen o-quinone. Regioselective deuterium labelling at the C1-position of the estrogen A ring allows …
Building On Strengths: Uab School Of Health Professions Is Shaping The Future Of Health Care, Alicia Rohan
Building On Strengths: Uab School Of Health Professions Is Shaping The Future Of Health Care, Alicia Rohan
Browse All News
No abstract provided.
Virologist Wolfe To Speak About Pandemic Dangers, Lindenwood University
Virologist Wolfe To Speak About Pandemic Dangers, Lindenwood University
Archived Lindenwood Press Releases
No abstract provided.
Persistence, Motivation, And Resilience: Older Youth Aging Out Of Foster Care Attending Historically Black Colleges And Universities (Hbcus), Belinda Davis Smith Ph.D., Lcsw, Dana Burdnell Wilson Msw, Ph.D., Lcsw, Tiffany Y. Lane Ph.D., Msw, Sonja V. Harry Ph.D., Msw, Isiah Marshall Jr., Ph.D., Msw
Persistence, Motivation, And Resilience: Older Youth Aging Out Of Foster Care Attending Historically Black Colleges And Universities (Hbcus), Belinda Davis Smith Ph.D., Lcsw, Dana Burdnell Wilson Msw, Ph.D., Lcsw, Tiffany Y. Lane Ph.D., Msw, Sonja V. Harry Ph.D., Msw, Isiah Marshall Jr., Ph.D., Msw
Journal of Family Strengths
Persistence, Motivation and Resilience: Older Youth Aging Out of Foster Care
Attending Historically Black Colleges and Universities
ABSTRACT
Many young adults involved with the child welfare system have a unique set of circumstances and needs. As they come of age, separated from their families of origin, additional services and supports are warranted to achieve their goals in life. This qualitative study explores the experiences of youth who have been impacted by the foster care system and are enrolled at a Historically Black College and University (HBCU) in the Mid-Atlantic region. Using a phenomenological approach, participants were interviewed regarding their motivation …
"Then You Fall Off": Youth Experiences And Responses To Transitioning To Homelessness, Diane M. Santa Maria, Sarah C. Narendorf, Noel Bezette-Flores, Yoonsook Ha
"Then You Fall Off": Youth Experiences And Responses To Transitioning To Homelessness, Diane M. Santa Maria, Sarah C. Narendorf, Noel Bezette-Flores, Yoonsook Ha
Journal of Family Strengths
Introduction: This study aims to broaden our understanding of the experience of homelessness and unstable housing in youth. While quantitative research highlights risk factors associated with experiencing homelessness as a youth, little qualitative research has been conducted to explore the lived experience of this transition to homelessness or unstable housing and how youth respond to becoming homeless. This study utilizes data from youth descriptions of their experiences to understand the context of the transition to homelessness and how youth manage this transition.
Methods: A qualitative study with a quantitative component was conducted with a nonprobability sample of homeless youth aged …
Underserved Populations In The United States: Research, Response And Resilience, Robert Sanborn, Angelo P. Giardino, William V. Flores, E. Christopher Lloyd
Underserved Populations In The United States: Research, Response And Resilience, Robert Sanborn, Angelo P. Giardino, William V. Flores, E. Christopher Lloyd
Journal of Family Strengths
Angelo P. Giardino, Robert Sanborn, William V. Flores and E. Christopher Lloyd discuss the latest issue of the Journal of Family Strengths.
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee R. Berger, John Hawks, Darryl J. De Ruiter, Steven E. Churchill, Peter Schmid, Lucas K. Delezene, Tracy L. Kivell, Heather M. Garvin, Scott A. Williams, Jeremy M. Desilva, Matthew M. Skinner, Charles M. Musiba, Noel Cameron, Trenton W. Holliday, William Harcourt-Smith, Rebecca R. Ackermann, Markus Bastir, Barry Bogin, Debra Bolter, Juliet Brophy, Zachary D. Cofran, Kimberly A. Congdon, Andrew S. Deane, Mana Dembo, Michelle Drapeau, Marina C. Elliott, Elen M. Feuerriegel, Daniel Garcia-Martinez, David J. Green, Alia Gurtov, Joel D. Irish, Ashley Kruger, Myra F. Laird, Damiano Marchi, Marc R. Meyer, Shahed Nalla, Enquye W. Negash, Caley M. Orr, Davorka Radovcic, Lauren Schroeder, Jill E. Scott, Zachary Throckmorton, Matthew W. Tocheri, Caroline Vansickle, Christopher S. Walker, Pianpian Wei, Bernhard Zipfel
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee R. Berger, John Hawks, Darryl J. De Ruiter, Steven E. Churchill, Peter Schmid, Lucas K. Delezene, Tracy L. Kivell, Heather M. Garvin, Scott A. Williams, Jeremy M. Desilva, Matthew M. Skinner, Charles M. Musiba, Noel Cameron, Trenton W. Holliday, William Harcourt-Smith, Rebecca R. Ackermann, Markus Bastir, Barry Bogin, Debra Bolter, Juliet Brophy, Zachary D. Cofran, Kimberly A. Congdon, Andrew S. Deane, Mana Dembo, Michelle Drapeau, Marina C. Elliott, Elen M. Feuerriegel, Daniel Garcia-Martinez, David J. Green, Alia Gurtov, Joel D. Irish, Ashley Kruger, Myra F. Laird, Damiano Marchi, Marc R. Meyer, Shahed Nalla, Enquye W. Negash, Caley M. Orr, Davorka Radovcic, Lauren Schroeder, Jill E. Scott, Zachary Throckmorton, Matthew W. Tocheri, Caroline Vansickle, Christopher S. Walker, Pianpian Wei, Bernhard Zipfel
Neuroscience Faculty Publications
Homo naledi is a previously-unknown species of extinct hominin discovered within the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind, South Africa. This species is characterized by body mass and stature similar to small-bodied human populations but a small endocranial volume similar to australopiths. Cranial morphology of H. naledi is unique, but most similar to early Homo species including Homo erectus, Homo habilis or Homo rudolfensis. While primitive, the dentition is generally small and simple in occlusal morphology. H. naledi has humanlike manipulatory adaptations of the hand and wrist. It also exhibits a humanlike foot …
Pili-Induced Clustering Of N. Gonorrhoeae Bacteria, Johannes Taktikos, Yen Ting Lin, Holger Stark, Nicolas Biais, Vasily Zaburdaev
Pili-Induced Clustering Of N. Gonorrhoeae Bacteria, Johannes Taktikos, Yen Ting Lin, Holger Stark, Nicolas Biais, Vasily Zaburdaev
Publications and Research
Type IV pili (Tfp) are prokaryotic retractable appendages known to mediate surface attachment, motility, and subsequent clustering of cells. Tfp are the main means of motility for Neisseria gonorrhoeae, the causative agent of gonorrhea. Tfp are also involved in formation of the microcolonies, which play a crucial role in the progression of the disease. While motility of individual cells is relatively well understood, little is known about the dynamics of N. gonorrhoeae aggregation. We investigate how individual N. gonorrhoeae cells, initially uniformly dispersed on flat plastic or glass surfaces, agglomerate into spherical microcolonies within hours. We quantify the clustering process …
Daily Eastern News: September 10, 2015, Eastern Illinois University
Daily Eastern News: September 10, 2015, Eastern Illinois University
September
No abstract provided.
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee Berger, John Hawks, Darryl J. De Ruiter, Steve E. Churchill, Peter Schmid, Lucas Delezene, Tracy Kivell, Heather Garvin, Scott Williams, Jeremy Desilva
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee Berger, John Hawks, Darryl J. De Ruiter, Steve E. Churchill, Peter Schmid, Lucas Delezene, Tracy Kivell, Heather Garvin, Scott Williams, Jeremy Desilva
Dartmouth Scholarship
Homo naledi is a previously-unknown species of extinct hominin discovered within the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind, South Africa. This species is characterized by body mass and stature similar to small-bodied human populations but a small endocranial volume similar to australopiths. Cranial morphology of H. naledi is unique, but most similar to early Homo species including Homo erectus, Homo habilis or Homo rudolfensis. While primitive, the dentition is generally small and simple in occlusal morphology. H. naledi has humanlike manipulatory adaptations of the hand and wrist. It also exhibits a humanlike foot and lower …
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee R. Berger, John Hawks, Darryl J. De Ruiter, Steven E. Churchill, Peter Schmid, Lucas K. Delezene, Tracy L. Kivell, Heather M. Garvin, Scott A. Williams, Jeremy M. Desilva, Matthew M. Skinner, Charles M. Musiba, Noel Cameron, Trenton W. Holliday, William Harcourt-Smith, Et Al.
Homo Naledi, A New Species Of The Genus Homo From The Dinaledi Chamber, South Africa, Lee R. Berger, John Hawks, Darryl J. De Ruiter, Steven E. Churchill, Peter Schmid, Lucas K. Delezene, Tracy L. Kivell, Heather M. Garvin, Scott A. Williams, Jeremy M. Desilva, Matthew M. Skinner, Charles M. Musiba, Noel Cameron, Trenton W. Holliday, William Harcourt-Smith, Et Al.
Publications and Research
Homo naledi is a previously-unknown species of extinct hominin discovered within the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind, South Africa. This species is characterized by body mass and stature similar to small-bodied human populations but a small endocranial volume similar to australopiths. Cranial morphology of H. naledi is unique, but most similar to early Homo species including Homo erectus, Homo habilis or Homo rudolfensis. While primitive, the dentition is generally small and simple in occlusal morphology. H. naledi has humanlike manipulatory adaptations of the hand and wrist. It also exhibits a humanlike foot and lower …
Gender Advantage? A Case Study Of Male Nursing Students At A New Jersey Community College, Kathleen Michell
Gender Advantage? A Case Study Of Male Nursing Students At A New Jersey Community College, Kathleen Michell
Theses and Dissertations
Nurses face many challenges in the health care arena. However, male nursing students face a unique set of challenges in a female dominated profession. Limited research looks to understand the male student perspective and success. This qualitative, case study explored the success of male nursing students at a Community College in Northern New Jersey. Focus groups and semi-structured interviews took place with the male nursing students in their second year of the program. Three main themes were identified including gender advantage, male students find that their gender provides an advantage in the classroom and clinical settings; encouragement and support, the …
Geological And Taphonomic Context For The New Hominin Species Homo Naledi From The Dinaledi Chamber, South Africa, Paul Hgm Dirks, Lee R. Berger, Eric M. Roberts, Jan D. Kramers, John Hawks, Patrick S. Randolph-Quinney, Marina Elliott, Charles M. Musiba, Steven E. Churchill, Darryl J. De Ruiter, Peter Schmid, Lucinda R. Backwell, Georgy A. Belyanin, Pedro Boshoff, K Lindsay Hunter, Elen M. Feuerriegel, Alia Gurtov, James Du G Harrison, Rick Hunter, Ashley Kruger, Hannah Morris, Tebogo V. Makhubela, Becca Peixotto, Steven Tucker
Geological And Taphonomic Context For The New Hominin Species Homo Naledi From The Dinaledi Chamber, South Africa, Paul Hgm Dirks, Lee R. Berger, Eric M. Roberts, Jan D. Kramers, John Hawks, Patrick S. Randolph-Quinney, Marina Elliott, Charles M. Musiba, Steven E. Churchill, Darryl J. De Ruiter, Peter Schmid, Lucinda R. Backwell, Georgy A. Belyanin, Pedro Boshoff, K Lindsay Hunter, Elen M. Feuerriegel, Alia Gurtov, James Du G Harrison, Rick Hunter, Ashley Kruger, Hannah Morris, Tebogo V. Makhubela, Becca Peixotto, Steven Tucker
KIP Articles
We describe the physical context of the Dinaledi Chamber within the Rising Star cave, South Africa, which contains the fossils of Homo naledi. Approximately 1550 specimens of hominin remains have been recovered from at least 15 individuals, representing a small portion of the total fossil content. Macro-vertebrate fossils are exclusively H. naledi, and occur within clay-rich sediments derived from in situ weathering, and exogenous clay and silt, which entered the chamber through fractures that prevented passage of coarser-grained material. The chamber was always in the dark zone, and not accessible to non-hominins. Bone taphonomy indicates that hominin individuals reached the …
A Prospective Highlight On Exosomal Nanoshuttles And Cancer Immunotherapy And Vaccination., Mohammad Rafi, Yadollah Omidi
A Prospective Highlight On Exosomal Nanoshuttles And Cancer Immunotherapy And Vaccination., Mohammad Rafi, Yadollah Omidi
Department of Neurology Faculty Papers
INTRODUCTION: Exosomes (EXOs) and ectosomes (ECTOs) are nanoscale membranous extracellular vesicles (EVs) derived from different cells mediating various cellular communications. EXOs are liberated based on the exocytosis of multivesicular bodies, while ECTOs are ubiquitously released from the plasma membranes.
METHODS: Here, in this paper, we go over the extracellular vesicular machineries and concisely highlight their clinical importance in solid tumors and their possible applications in cancer immunotherapy/vaccination.
RESULTS: In various types of cancers, these vesicles play central roles delivering cancer cell messages to the target cells, as a result both of them seem to provide a novel useful means for …
Prediction Of Relevant Biomedical Documents: A Human Microbiome Case Study, Paul Thompson, Juliette C. Madan, Jason H. Moore
Prediction Of Relevant Biomedical Documents: A Human Microbiome Case Study, Paul Thompson, Juliette C. Madan, Jason H. Moore
Dartmouth Scholarship
Background:
Retrieving relevant biomedical literature has become increasingly difficult due to the large volume and rapid growth of biomedical publication. A query to a biomedical retrieval system often retrieves hundreds of results. Since the searcher will not likely consider all of these documents, ranking the documents is important. Ranking by recency, as PubMed does, takes into account only one factor indicating potential relevance. This study explores the use of the searcher’s relevance feedback judgments to support relevance ranking based on features more general than recency.
Results:
It was found that the researcher’s relevance judgments could be used to accurately predict …
The Daily Gamecock, Thursday, September 10, 2015, The University Of South Carolina, Office Of Student Media
The Daily Gamecock, Thursday, September 10, 2015, The University Of South Carolina, Office Of Student Media
September
No abstract provided.
Soundings 2015-09-10, N/A N/A
Alcohol Use And Gamma-Glutamyltransferase Using A Mendelianrandomization Design In The Guangzhou Biobank Cohort Study, Lin Xu, Chao Qiang Jiang, Kar Keung Cheng, Shiu Lun Ryan Au Yeung, Wei Sen Zhang, Tai Hing Lam, Mary Schooling
Alcohol Use And Gamma-Glutamyltransferase Using A Mendelianrandomization Design In The Guangzhou Biobank Cohort Study, Lin Xu, Chao Qiang Jiang, Kar Keung Cheng, Shiu Lun Ryan Au Yeung, Wei Sen Zhang, Tai Hing Lam, Mary Schooling
Publications and Research
Background
Observational studies and small intervention studies suggest alcohol raises gamma-glutamyltransferase (GGT). We used Mendelian randomization to assess the causal effect of alcohol use on GGT in older Chinese people.
Methods
An instrumental variable (IV) analysis in 2,321 men and 2,757 women aged 50+ years from phase 3 of the Guangzhou Biobank Cohort Study with ALDH2 (rs671) genotyped, alcohol use and GGT available was used to assess the causal effect of alcohol use on GGT. Rs671 was used as an IV and F-statistics was used to test for weak instrument hypothesis. An F- statisticof ≥10 indicates the IV is not …
Utilization Of Antibody-Conjugated Gold Nanoparticles, Dynamic Light Scattering And Sers In Influenza Virus Detection, Yen Hoang Lai
Utilization Of Antibody-Conjugated Gold Nanoparticles, Dynamic Light Scattering And Sers In Influenza Virus Detection, Yen Hoang Lai
Theses and Dissertations
Influenza A H3N2, H1N1, and influenza B viruses primarily cause winter illness in humans, leading to significant morbidity and mortality in the population of the very young, the elderly, and people with chronic disease. In addition to the regular seasonal epidemics of influenza, influenza pandemics associated with the emergence of new influenza A strains are threatening due to high levels of mortality, social disruption, and economic losses. These novel strains are not affected by the human immunity developed to older strains of influenza, therefore can spread readily and infect a vast number of people. The most recent flu pandemic outbreak …
Designing A State-Of-The-Science, Accredited, Commercially-Successful Biorepository Utilizing Iso:9001(2008) Quality Management System Requirements To Construct The Framework, Kimberly S. Gonzalez
Designing A State-Of-The-Science, Accredited, Commercially-Successful Biorepository Utilizing Iso:9001(2008) Quality Management System Requirements To Construct The Framework, Kimberly S. Gonzalez
Master's Theses and Doctoral Dissertations
The research community relies upon biorepositories’ ability to prepare for the scientific advancement that can precipitate the discoveries of the future. Furthermore, as the complexities, financial pressure, and quality issues biorepositories face continue to unfold, it is imperative to explore unmet needs researchers may have for biorepository services as well as evaluate the commercial potential, funding, and competitiveness of a new biorepository. With the goal of contributing to medical and scientific research and the biorepository field, this paper utilizes principles from ISO 9001:2008 “Quality management systems- Requirements” to outline and explore the challenges in establishing a state-of-the-science, accredited, commercial BSL-2 …
Minutes From The September 10, 2015 Meeting Of The University Of Montana Faculty, University Of Montana--Missoula. Faculty
Minutes From The September 10, 2015 Meeting Of The University Of Montana Faculty, University Of Montana--Missoula. Faculty
University of Montana Faculty Senate Meeting Minutes
Meeting minutes from the September 10, 2015 meeting of the University of Montana faculty.
Zebrafish As A Model For Developmental Neurotoxicity Assessment: The Application Of The Zebrafish In Defining The Effects Of Arsenic, Methylmercury, Or Lead On Early Neurodevelopment, Jinyoung Lee, Jennifer L. Freeman
Zebrafish As A Model For Developmental Neurotoxicity Assessment: The Application Of The Zebrafish In Defining The Effects Of Arsenic, Methylmercury, Or Lead On Early Neurodevelopment, Jinyoung Lee, Jennifer L. Freeman
School of Health Sciences Faculty Publications
Developmental exposure to neurotoxic chemicals presents significant health concerns because of the vulnerability of the developing central nervous system (CNS) and the immature brain barrier. To date, a short list of chemicals including some metals have been identified as known developmental neurotoxicants; however, there are still numerous chemicals that remain to be evaluated for their potential developmental neurotoxicity (DNT). To facilitate evaluation of chemicals for DNT, the zebrafish vertebrate model system has emerged as a promising tool. The zebrafish possesses a number of strengths as a test species in DNT studies including an abundance of embryos developing ex utero presenting …
The Montclarion, September 10, 2015, The Montclarion
The Montclarion, September 10, 2015, The Montclarion
The Montclarion
Student Newspaper of Montclair State University
Skilled Linguistic Action In English As A Second Language Learners’ Play Of World Of Warcraft (Wow): A Distributed View, Kristi J. Newgarden
Skilled Linguistic Action In English As A Second Language Learners’ Play Of World Of Warcraft (Wow): A Distributed View, Kristi J. Newgarden
Doctoral Dissertations
This research provokes an action-oriented understanding of second language (L2) learning, as illustrated in the dynamics of World of Warcraft (WoW) gameplay. L2 learners picked up affordances for learning to take skilled linguistic actions in authentic interactions with meaningful outcomes. Agency, orientation to sociocultural norms and pragmatic competence were distributed in real-time languaging as learners coordinated actions using embodied, material and linguistic resources. Two studies examined data from a course in which English as a Second Language learners and native English speaking (NES) college students played WoW and explored its culture. Frames of ecological psychology and distributed language were applied …
Reduction Of Obesity-Associated Chronic Inflammation By Low-Fat Yogurt, Ruisong Pei
Reduction Of Obesity-Associated Chronic Inflammation By Low-Fat Yogurt, Ruisong Pei
Doctoral Dissertations
The objective of this study was to conduct an intervention study to test how low-fat yogurt consumption affects postprandial metabolism, chronic inflammation, and intestinal barrier function. Apparently healthy premenopausal women with body mass index (BMI) of 18.5 to 27 (lean) or 30 to 40 kg/m2 (obese) participated in a 9-week controlled intervention study. Participants in each BMI range were randomly assigned to either a low-fat yogurt-supplemented group (Y, yogurt lean; YO, yogurt obese) or a soy pudding-supplemented control group (C, control lean; CO, control obese), with n = 30/group. Participants consumed 12 oz. of yogurt or the control food …
Synthesis, Crystal Structures, And Dft Calculations Of Three New Cyano(Phenylsulfonyl)Indoles And A Key Synthetic Precursor Compound, William Montgomery, Justin Lopchuk, Gordon Gribble, Jerry Jasinski
Synthesis, Crystal Structures, And Dft Calculations Of Three New Cyano(Phenylsulfonyl)Indoles And A Key Synthetic Precursor Compound, William Montgomery, Justin Lopchuk, Gordon Gribble, Jerry Jasinski
Dartmouth Scholarship
Three cyano-1-(phenylsulfonyl)indole derivatives, 3-cyano-1-(phenylsulfonyl) indole, (I), 2-cyano-1-(phenylsulfonyl)indole, (II), and 2,3-dicyano-1-(phenylsulfonyl) indole, (III), and a key synthetic precursor 1-(phenylsulfonyl)-1-(1,1-dimethylethyl) indole-3-carboxamide, (IV), have been synthesized and their structures determined by single crystal X-ray crystallography. (I), C15H10N2O2S, is orthorhombic with space group P 212121 and cell constants: a = 4.9459(3) Å, b = 10.5401(7) Å, c = 25.0813(14) Å, V = 1307.50(14) Å3 and Z = 4. (II), C15H10N2O2S, …
Targeting Ezh2 Regulates Tumor Growth And Apoptosis Through Modulating Mitochondria Dependent Cell-Death Pathway In Hnscc, Xuan Zhou, Yu Ren, Lingping Kong, Guoshuai Cai, Shanshan Sun, Wangzhao Song, Yu Wang, Rui Jin, Lisha Qi, Mei Mei
Targeting Ezh2 Regulates Tumor Growth And Apoptosis Through Modulating Mitochondria Dependent Cell-Death Pathway In Hnscc, Xuan Zhou, Yu Ren, Lingping Kong, Guoshuai Cai, Shanshan Sun, Wangzhao Song, Yu Wang, Rui Jin, Lisha Qi, Mei Mei
Dartmouth Scholarship
EZH2 is a negative prognostic factor and is overexpressed or activated in most human cancers including head and neck squamous cell carcinoma (HNSCC). Analysis of The Cancer Genome Atlas (TCGA) HNSCC data indicated that EZH2 over-expression was associated with high tumor grade and conferred poor prognosis. EZH2 inhibition triggered cell apoptosis, cell cycle arrest and decreased cell growth in vitro. MICU1 (mitochondrial calcium uptake1) was shown to be down regulated when EZH2 expression was inhibited in HNSCC. When the EZH2 and MICU1 were inhibited, HNSCC cells became susceptible to cell cycle arrest and apoptosis. Mitochondrial membrane potential and cytosolic Ca2+ …