Digital Commons Network^™

Chelating Compounds And Immobilized Tethered Chelators, Robert A. Yokel, Christopher D. Spilling, Robert Kuhn, Wesley R. Harris, Surendra Dawadi

UMSL Patents

Novel compounds useful as chelators, intermediates for their production and methods for removing trivalent and tetravalent metal ions from solution are presented.

Independent - Sep. 22, 2015, Rut Ortiz

The Independent (1988-present)

No abstract provided.

Reproductive And Sexual Healthcare Needs Among Adults With Disabilities As Perceived By Social Workers, Kristen Faye Linton, Heidi Adams Rueda, Lela Rankin Williams, Alex Sandoval, Sharon J. Bolin

Social Work Faculty Publications

People with disabilities often experience unique gynecological and reproductive healthcare needs, which may be exacerbated by their experience of sexual victimization. Previous research on adolescents with disabilities found that social workers held beneficial roles in supporting their clients to make empowered decisions concerning sexual healthcare, pregnancy, and parenting. This study aimed to assess the reproductive and sexual health needs of adults with various disabilities from the perspectives of their social workers. Eleven social workers working primarily with adults with various disabilities were interviewed using a phenomenological study design to offer their perspectives of the sexual and reproductive health needs of …

Comparative Population Genomics Of African Montane Forest Mammals Support Population Persistence Across A Climatic Gradient And Quaternary Climatic Cycles, Terrence C. Demos, Julian C. Kerbis Peterhans, Tyler A. Joseph, John D. Robinson, Bernard Agwanda, Michael J. Hickerson

Publications and Research

The Eastern Afromontane biodiversity hotspot (EABH) has the highest concentration of biodiversity in tropical Africa, yet few studies have investigated recent historical diversification processes in EABH lineages. Herein, we analyze restriction-site associated DNA-sequences (RAD-Seq) to study recent historical processes in co-distributed mouse (Hylomyscus) and shrew (Sylvisorex) species complexes, with an aim to better determine how historical paleoenvironmental processes might have contributed to the EABH’s high diversity. We analyzed complete SNP matrices of > 50,000 RAD loci to delineate populations, reconstruct the history of isolation and admixture, and discover geographic patterns of genetic partitioning. These analyses demonstrate that persistently unsuitable habitat may …

Uni Scholarworks Quarterly Report, September 2015, Ellen E. Neuhaus

Library Documents & Reports (entire collection)

No abstract provided.

Possible Contributor To The Virulence Of The 1918 Flu Pandemic Discovered, Jeff Hansen

Browse All News

No abstract provided.

Off-Target V(D)J Recombination Drives Lymphomagenesis And Is Escalated By Loss Of The Rag2 C Terminus., Martina Mijušković, Yi-Fan Chou, Vered Gigi, Cory R Lindsay, Olga Shestova, Susanna M Lewis, David B Roth

Cardeza Foundation for Hematologic Research

Genome-wide analysis of thymic lymphomas from Tp53(-/-) mice with wild-type or C-terminally truncated Rag2 revealed numerous off-target, RAG-mediated DNA rearrangements. A significantly higher fraction of these errors mutated known and suspected oncogenes/tumor suppressor genes than did sporadic rearrangements (p < 0.0001). This tractable mouse model recapitulates recent findings in human pre-B ALL and allows comparison of wild-type and mutant RAG2. Recurrent, RAG-mediated deletions affected Notch1, Pten, Ikzf1, Jak1, Phlda1, Trat1, and Agpat9. Rag2 truncation substantially increased the frequency of off-target V(D)J recombination. The data suggest that interactions between Rag2 and a specific chromatin modification, H3K4me3, support V(D)J recombination fidelity. Oncogenic effects of off-target rearrangements created by this highly regulated recombinase may need to be considered in design of site-specific nucleases engineered for genome modification.

The Current Volume 26 : Issue 5, Nova Southeastern University

Student Newspapers

No abstract provided.

Influence Of Solvent On Poly(2-(Dimethylamino)Ethyl Methacrylate) Dynamics In Polymer-Concentrated Mixtures: A Combined Neutron Scattering, Dielectric Spectroscopy, And Calorimetric Study, Guido Goracci, Arantxa Arbe, Angel Alegría, Victoria García Sakai, Svemir Rudić, Gerald J. Schneider, Wiebke Lohstroh, Fanni Juranyi, Juan Colmenero

Faculty Publications

© 2015 American Chemical Society. We have investigated the dynamical processes-α-relaxation, local motions of the side-groups, and methyl group rotations-in poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) in the dry state and in mixtures (at 70 wt% polymer concentration) with tetrahydrofuran (THF) and water, to address the question as to how these polymer motions are affected by plasticizers interacting in different ways with the polymer. Differential scanning calorimetry, dielectric spectroscopy, and neutron scattering techniques on labeled samples (with deuterated solvents to isolate the signal of the polymer component) have been combined. The α-relaxation is drastically affected, with similar shifts of the glass-transition temperature for …

Injury-In-Fact In Chilling Effect Challenges To Public University Speech Codes, Jennifer L. Bruneau

Catholic University Law Review

Campus speech codes began to spring up on university campuses during the 1980s and continue to operate today. The codes regulate various forms of arguably offensive speech, including speech regarding race, gender, sexual orientation, ideology, views, and political affiliation. Numerous litigants have challenged the chilling effect these policies have on student and faculty speech, but in cases where the challenged code has not yet been enforced, some courts find that the plaintiff has not met the “injury-in-fact” requirement for Article III standing. The Supreme Court has not ruled on standing requirements in speech code challenges and lower courts are divided. …

A Multi-Institutional Study Of The Impact Of Open Textbook Adoption On The Learning Outcomes Of Post-Secondary Students, Lane Fischer, John Hilton Iii, T. Jared Robinson, David Wiley

Faculty Publications

In some educational settings, the cost of textbooks approaches or even exceeds the cost of tuition. Given limited resources, it is important to better understand the impacts of free open educational resources (OER) on student outcomes. Utilizing digital resources such as OER can substantially reduce costs for students. The purpose of this study was to analyze whether the adoption of no-cost open digital textbooks significantly predicted students’ completion of courses, class achievement, and enrollment intensity during and after semesters in which OER were used. This study utilized a quantitative quasi-experimental design with propensity-score matched groups to examine differences in outcomes …

2015-September-22-Kingsport Acl Fall Classes Begin October 12, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

On The Estimation Of Time Dependent Lift Of A European Starling (Sturnus Vulgaris) During Flapping Flight, Oksana Stalnov, Hadar Ben-Gida, Adam J. Kirchhefer, Christopher G. Guglielmo, Gregory A. Kopp, Alexander Liberzon, Roi Gurka

Physics and Engineering Science

We study the role of unsteady lift in the context of flapping wing bird flight. Both aerodynamicists and biologists have attempted to address this subject, yet it seems that the contribution of unsteady lift still holds many open questions. The current study deals with the estimation of unsteady aerodynamic forces on a freely flying bird through analysis of wingbeat kinematics and near wake flow measurements using time resolved particle image velocimetry. The aerodynamic forces are obtained through two approaches, the unsteady thin airfoil theory and using the momentum equation for viscous flows. The unsteady lift is comprised of circulatory and …

Ummc Fellowship Opens Door To Prestigious Mayo Clinic Opportunity, Rachel Gholson

University of Mississippi News

Public policy leadership major took new perspectives to summer program

2015-September-22-Kingsport Acl Fall Classes Begin October 12, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Religious Sex Status And The Implications For Transgender And Gender Nonconforming People, Shawn Markus Crincoli

FIU Law Review

No abstract provided.

Executive Committee - Agenda, 9/22/2015, Academic Senate

Academic Senate Agendas

No abstract provided.

Volume 113, Number 4 – Tuesday, September 22, 2015, Saint Mary's College Of California

The Collegian

No abstract provided.

International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci And Targetable Pathogenic Pathways, Heather J. Cordell, Younghun Han, George F. Mells, Yafang Li, Gideon M. Hirschfield, Casey S. Greene, Gang Xie, Brian D. Juran, Dakai Zhu, David C. Qian, James A.B Floyd, Katherine I. Morley, Daniele Prati, Ana Lleo, Daniele Cusi, Canadian–Us Pbc Consortium, Italian Pbc Genetics Study Group, Uk-Pbc Consortium, M. Eric Gershwin, Carl A. Anderson, Konstantinos N. Lazaridis, Pietro Invernizzi, Michael F. Seldin, Richard N. Sandford, Christopher I. Amos, Katherine A. Siminovitch

Dartmouth Scholarship

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (P_combined<5 × 10⁻⁸) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.

Isoflurane Inhibits Synaptic Vesicle Exocytosis Through Reduced Ca2+ Influx, Not Ca2+-Exocytosis Coupling, Joel Baumgart, Zhen-Yu Zhou, Masato Hara, Daniel Cook, Michael Hoppa

Dartmouth Scholarship

Identifying presynaptic mechanisms of general anesthetics is critical to understanding their effects on synaptic transmission. We show that the volatile anesthetic isoflurane inhibits synaptic vesicle (SV) exocytosis at nerve terminals in dissociated rat hippocampal neurons through inhibition of presynaptic Ca2+ influx without significantly altering the Ca2+ sensitivity of SV exocytosis. A clinically relevant concentration of isoflurane (0.7 mM) inhibited changes in [Ca2+]i driven by single action potentials (APs) by 25 ± 3%, which in turn led to 62 ± 3% inhibition of single AP-triggered exocytosis at 4 mM extracellular Ca2+ ([Ca2+]e). Lowering external Ca2+ to match the isoflurane-induced reduction in …

A Multilevel Analysis Of Neighborhood Socioeconomic Effect On Preterm Births In Georgia, Usa, Wei Tu, Jun Tu, Stuart H. Tedders

Earth, Environment & Sustainability: Faculty Publications

This study estimates the neighborhood socioeconomic status (SES) effect on the risk of preterm birth (PTB) using multilevel regression (MLR) models. Birth data retrieved from year 2000 and 2010 Georgia Vital Records were linked to their respective census tracts. Principle component analysis (PCA) was performed on nine selected census variables and the first two principal components (Fac1 and Fac2) were used to represent the neighborhood-level SES in the MLR models. Two-level random intercept MLR models were specified using 122,744 and 112,578 live and singleton births at the individual level and 1613 and 1952 census tracts at the neighborhood level, for …

Mir-497 Decreases Cisplatin Resistance In Ovarian Cancer Cells By Targeting Mtor/P70s6k1., Shaohua Xu, Guang-Bo Fu, Zhen Tao, Jun Ouyang, Fanfei Kong, Bing-Hua Jiang, Xiaoping Wan, Ke Chen

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The mechanism of cisplatin resistance in ovarian cancer is not clearly understood. In the present investigation, we found that the expression levels of miR-497 were reduced in chemotherapy-resistant ovarian cancer cells and tumor tissues due to hypermethylation of miR-497 promoter. Low miR-497 expression levels were associated with chemo-resistant phonotype of ovarian cancer. By analyzing the expression levels of miR-497, mTOR and p70S6K1 in a clinical gene-expression array dataset, we found that mTOR and p70S6K1, two proteins correlated to chemotherapy-resistance in multiple types of human cancers, were inversely correlated with miR-497 levels in ovarian cancer tissues. By using an orthotopic ovarian …

Ucc Minutes, September 22, 2015, University Curriculum Council

UCC Agendas/Minutes

No abstract provided.

The George-Anne, Georgia Southern University

The George-Anne

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Genome Reconstructions Indicate The Partitioning Of Ecological Functions Inside A Phytoplankton Bloom In The Amundsen Sea, Antarctica, Tom O. Delmont, A. M. Eren, Joseph H. Vineis, Anton F. Post

Graduate School of Oceanography Faculty Publications

Antarctica polynyas support intense phytoplankton blooms, impacting their environment by a substantial depletion of inorganic carbon and nutrients. These blooms are dominated by the colony-forming haptophyte Phaeocystis antarctica and they are accompanied by a distinct bacterial population. Yet, the ecological role these bacteria may play in P. antarctica blooms awaits elucidation of their functional gene pool and of the geochemical activities they support. Here, we report on a metagenome (῀160 million reads) analysis of the microbial community associated with a P. antarctica bloom event in the Amundsen Sea polynya (West Antarctica). Genomes of the most abundant Bacteroidetes and Proteobacteria populations …

International Genome-Wide Meta-Analysis Identifies New Primary Biliary Cirrhosis Risk Loci And Targetable Pathogenic Pathways, Heather J. Cordell, Younghun Han, George F. Mells, Y Li, Gideon M. Hirschfield, Casey S. Greene, Gang Xie, Brian D. Juran, Dakai Zhu, David C. Qian, James A.B. Floyd, Katherine I. Morley, Daniele Prati, Ana Lleo, Daniele Cusi, Erik M. Schlicht, Craig Lammert, Elizabeth J. Atkinson, Ll Chan, Andrade M De, Tobias Balschun, Andrew L. Mason, Robert P. Myers, Jinyi Zhang, Piotr Milkiewicz, Jia Qu, Joseph A. Odin, Velimir A. Luketic, Bruce R. Bacon, Henry C. Bodenheimer

Peninsula Medical School

AbstractPrimary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10−8) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.

Taking The Plunge: Online Data Collection Using Mturk, L. Jean Harrison-Walker

Atlantic Marketing Association Proceedings

Mechanical Turk, an online crowdsourcing service created in 2005 by Amazon.com, is gaining in popularity among academics as a source of subjects for survey research. The initial attraction is based on access to a very large pool of participants who can be accessed online producing rapid response at low cost with minimal effort on the part of the researcher. For the uninitiated, however, the task of designing and running a research project on MTurk is rather daunting.

This paper begins with an introduction to MTurk. We review the language of MTurk and explain how a researcher goes about setting up …

Announcing The 3rd Annual Winthrop Conference On Teaching And Learning—And A Plea For Teaching Critical Reading, John Bird, Teaching And Learning Center

The Weekly Reader

No abstract provided.

Curricular Affairs Committee Minutes September 21, 2015, University Of Rhode Island Faculty Senate

Faculty Senate Committee Reports and Appendices

No abstract provided.

Background Literature On Violence Against Children In South Africa: Foundation For A Phased Communications For Development (C4d) Strategy, Mark Edberg, Hina Shaikh, Shaneka Thurman, Rajiv N. Rimal

Center for Social Well-Being and Development

No abstract provided.