Digital Commons Network^™

Evaluating Faciltated Migration As A Climate Change Adaptation Approach In Southern Ontario's Sugar Maple Ecosystems, Kaitlyn Mcglade

Geography and Environmental Studies Major Research Papers

This research seeks to provide an explanation and evaluation of facilitated migration as an adaptation approach for improving the long-term resilience and sustainability of Acer saccharum (sugar maple) ecosystems and sugarbush production. The research concludes that faciliated migration is supported by producers and other industry stakeholders as a feasable adaptation approach for improving resilience and sustainability.

Global Patterns, Trends, And Drivers Of Water Use Efficiency From 2000 To 2013, Bao-Lin Xue, Qinghua Guo, Alvarez Otto, Jingfeng Xiao, Shengli Tao, Le Li

All Materials

Water use efficiency (WUE; gross primary production [GPP]/evapotranspiration [ET]) estimates the tradeoff between carbon gain and water loss during photosynthesis and is an important link of the carbon and water cycles. Understanding the spatiotemporal patterns and drivers of WUE is helpful for projecting the responses of ecosystems to climate change. Here we examine the spatiotemporal patterns, trends, and drivers of WUE at the global scale from 2000 to 2013 using the gridded GPP and ET data derived from the Moderate Resolution Imaging Spectroradiometer (MODIS). Our results show that the global WUE has an average value of 1.70 g C/kg H2O …

The Concept Of The State In American History, William J. Novak

Book Chapters

Debates about the state rage in contemporary America. On the right, libertarian and tea party rhetoric fulminates about shrinking the state or shutting down the government, frequently in hyperbolic terms like the Americans for Tax Reform notion of" drowning it in a bathtub." On the left, concern about the fate of the welfare state and an ever-expanding warfare and penal state produces equally impassioned retorts. Discussion of the American state-its nature, its size, and its uncertain future-dominates the political landscape as perhaps never before.

Comparing Species Tree Estimation With Large Anchored Phylogenomic And Small Sanger-Sequenced Molecular Datasets: An Empirical Study On Malagasy Pseudoxyrhophiine Snakes, Sara Ruane, Christopher J. Raxworthy, Alan R. Lemmon, Emily Moriarty Lemmon, Frank T. Burbrink

Publications and Research

Background Using molecular data generated by high throughput next generation sequencing (NGS) platforms to infer phylogeny is becoming common as costs go down and the ability to capture loci from across the genome goes up. While there is a general consensus that greater numbers of independent loci should result in more robust phylogenetic estimates, few studies have compared phylogenies resulting from smaller datasets for commonly used genetic markers with the large datasets captured using NGS. Here, we determine how a 5-locus Sanger dataset compares with a 377-locus anchored genomics dataset for understanding the evolutionary history of the pseudoxyrhophiine snake radiation …

Daily Eastern News: October 12, 2015, Eastern Illinois University

October

No abstract provided.

Dual Mode Of Action Of Bt Proteins: Protoxin Efficacy Against Resistant Insects, Bruce E. Tabashnik, Min Zhang, Jeffrey A. Fabrick, Yidong Wu, Meijing Gao, Fangneng Huang, Jizhen Wei, Jie Zhang, Alexander Yelich, Gopalan C. Unnithan, Alejandra Bravo, Mario Soberón, Yves Carrière, Xianchun Li

Faculty Publications

Transgenic crops that produce Bacillus thuringiensis (Bt) proteins for pest control are grown extensively, but insect adaptation can reduce their effectiveness. Established mode of action models assert that Bt proteins Cry1Ab and Cry1Ac are produced as inactive protoxins that require conversion to a smaller activated form to exert toxicity. However, contrary to this widely accepted paradigm, we report evidence from seven resistant strains of three major crop pests showing that Cry1Ab and Cry1Ac protoxins were generally more potent than the corresponding activated toxins. Moreover, resistance was higher to activated toxins than protoxins in eight of nine cases evaluated in this …

The Spinnaker The Current Vol. 1 No. 35, University Of North Florida

Spinnaker

Student newspaper for the UNF community.

2015-16 Faculty Senate Xx - October 12, 2015 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Crow's Nest, October 12, 2015, Crow's Nest Staff

Crow's Nest

The October 12, 2015, issue of the Crow's Nest.

Whalesong 2015-10-12, N/A N/A

Whalesong

No abstract provided.

Tryptophan 207 Is Crucial To The Unique Properties Of The Human Voltage-Gated Proton Channel, Hhv1, Vladimir V. Cherny, Deri Morgan, Boris Musset, Susan M. E. Smith

Faculty Articles

Part of the “signature sequence” that defines the voltage-gated proton channel (HV1) is a tryptophan residue adjacent to the second Arg in the S4 transmembrane helix: RxWRxxR, which is perfectly conserved in all high confidence HV1 genes. Replacing Trp207 in human HV1 (hHV1) with Ala, Ser, or Phe facilitated gating, accelerating channel opening by 100-fold, and closing by 30-fold. Mutant channels opened at more negative voltages than wild-type (WT) channels, indicating that in WT channels, Trp favors a closed state. The Arrhenius activation energy, Ea, for channel opening decreased to 22 kcal/mol from 30–38 kcal/mol for WT, confirming that Trp207 …

The New Hampshire, Vol. 105 [106], No. 11 (Oct. 12, 2015), The New Hampshire

The New Hampshire Print Edition

An independent student produced newspaper from the University of New Hampshire. This volume was printed as 105, but it is the 106th volume in the series.

Digital Game-Based Learning: Still Restless, After All These Years, Richard Van Eck

Teaching, Leadership & Professional Practice Faculty Publications

We have the evidence and the design tools to demonstrate that digital games are powerful learning tools. Whether we choose to take advantage of the opportunity before us is a completely different question.

Role Of The Slingshot-Cofilin And Ranbp9 Pathways In Alzheimer's Disease Pathogenesis, Jung A Woo

USF Tampa Graduate Theses and Dissertations

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by two major pathological hallmarks, amyloid plaques and neurofibrillary tangles. The accumulation of amyloid-β protein (Aβ) is an early event associated with synaptic and mitochondrial damage in AD. Therefore, molecular pathways underlying the neurotoxicity and generation of Aβ represent promising therapeutic targets for AD. Recent studies have shown that actin severing protein, Cofilin plays an important role in synaptic remodeling, mitochondrial dysfunction, and AD pathogenesis. However, whether Cofilin is an essential component of AD pathogenesis and how Aβ induced neurotoxicity impinges its signals to Cofilin are unclear.

In my dissertation studies, we …

Characterization And Diurnal Measurement Of Oral Inflammation In Association With Glycemic Control, Periodontal Status, & Glucose Stimulation, Melanie N. Kuehl

USF Tampa Graduate Theses and Dissertations

Diabetes has afflicted 8.3%, approximately 25.8 million, of the United States population and is the seventh leading cause of death [1]. Type I diabetes (T1D) accounts for 5 to 10% of all diagnosed cases of diabetes in the United States [2]. If present trends continue, the rate of T1D incidence among children under the age of 14 will increase by 3% globally [3]. T1D is an autoimmune disorder in which the β-cells of the pancreatic islets are destroyed, leading to high blood sugar. Hyperglycemia and loss of immunological tolerance to self-antigens are common associations of T1D [4]. Periodontal disease impacts …

Action Cameras: Bringing Aquatic And Fisheries Research Into View, Daniel P. Struthers, Andy J. Danylchuk, Alexander D.M. Wilson, Steven J. Cooke

School of Biological and Marine Sciences

Digital action cameras (ACs) are increasingly being utilized for aquatic research purposes due to their cost effectiveness, versatility, high-resolution imagery, and durability. Here we review the advantages of AC technology in research, with particular emphases on (a) research videography (both in the field and the laboratory), (b) animal-borne studies, and (c) outreach and education purposes. We also review some of the limitations of this technology as represented by environmental factors (e.g., depth, turbidity) and deployment considerations (e.g., lens choices, imaging settings, battery life). As AC technologies evolve in response to growing public interest in their application versatility, researchers are indirectly …

The Ecological Spirituality Of Elizabeth Ann Seton, Sung-Hae Kim S.C.

Vincentian Studies

Some ecologists believe that the global environmental crisis has been caused by placing humanity at the top of the ecosystem. They have asked religious traditions to help develop new ethics that restore equilibrium to the relationship between humanity and nature. One way to do this is to examine traditional texts from an ecological perspective. With extensive quotations, Sung-Hae Kim demonstrates how Elizabeth Seton saw the link between humanity and nature and how she experienced God in nature. Kim writes that Elizabeth learned to see suffering and death as transformative and part of an “ecological balance,” which led to trust in …

The Broad-Spectrum Antiviral Favipiravir Protects Guinea Pigs From Lethal Lassa Virus Infection Post-Disease Onset, David Safronetz, Kyle Rosenke, Cynthia Martellaro, Heinz Feldmann, Jonna B. Westover, Brian B. Gowen, Atsushi Okumura, Yousuke Furuta, Takashi Komeno, Greg Saturday, Joan Geisbert, Thomas W. Geisbert

Animal, Dairy, and Veterinary Science Faculty Publications

With up to 500,000 infections annually, Lassa virus (LASV), the cause of Lassa fever, is one of the most prevalent etiological agents of viral hemorrhagic fever (VHF) in humans. LASV is endemic in several West African countries with sporadic cases and prolonged outbreaks observed most commonly in Sierra Leone, Liberia, Guinea and Nigeria. Additionally several cases of Lassa fever have been imported into North America, Europe and Asia making LASV a global threat to public health. Despite this, currently no approved therapeutic or vaccine exists to treat or prevent LASV infections. Here, using a passaged strain of LASV that is …

West Chester University Emerald Ash Borer Plan, West Chester, Pa, Kendra Mcmillin, Gerard D. Hertel

WCU Tree Campus USA Documents

No abstract provided.

Traces Of Past Land Use In Stroud's Run Ohio Sense Of Place Field Trip Oct. 11, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Emerging Novel Therapies For Heart Failure., Anthony M Szema, Sophia Dang, Jonathan C Li

Department of Medicine Faculty Papers

Heart function fails when the organ is unable to pump blood at a rate proportional to the body's need for oxygen or when this function leads to elevated cardiac chamber filling pressures (cardiogenic pulmonary edema). Despite our sophisticated knowledge of heart failure, even so-called ejection fraction-preserved heart failure has high rates of mortality and morbidity. So, novel therapies are sorely needed. This review discusses current standard therapies for heart failure and launches an exploration into emerging novel treatments on the heels of recently-approved sacubitril and ivbradine. For example, Vasoactive Intestinal Peptide (VIP) is protective of the heart, so in the …

Breach Avoidance Or Treaty Avoidance?: The Problem Of Over-Compliance And U.S. Ratification Of The Basel Convention On Hazardous Wastes, Tseming Yang, C. Scott Fulton

Faculty Publications

Over the past two decades, the failure of the United States to ratify a string of global multilateral environmental agreements has become a significant source of frustration for environmentalists and diplomats. The common perception is that Washington politics is to blame. The problem has even led to scholarly suggestions that any new climate agreement coming out of the Paris negotiations later this year could be entered into by the U.S. as an Executive Agreement rather than a Senate-approved treaty.

Delay has been uniquely serious, however, with respect to the 1989 Basel Convention on Hazardous Wastes. Signed under the elder President …

Assessing Multiple-Herbicide Resistance In A 2,4-D Resistant Waterhemp (Amaranthus Tuberculatus) Biotype From Nebraska: Student Research, Roberto Crespo

Department of Agronomy and Horticulture: Dissertations, Theses, and Student Research

A waterhemp biotype was recently reported resistant to 2,4-D in Nebraska. In addition to the repeated use of 2,4-D, atrazine and imazathapyr were reported to be frequently used to control broadleaf weeds. Greenhouse experiments were conducted to confirm 2,4-D resistance and test for resistance to growth regulator herbicides and other herbicide modes-of-action (MoA). A single dose-response experiment showed reduced sensitivity in all three waterhemp biotypes to atrazine, imazethapyr and lactofen; therefore, they were generally considered resistant to those three herbicide MoA. None of the biotypes contained the Ser264 target-site mutation. Since the ametryn dose-response experiment resulted in all susceptible biotypes, …

Traversing Swanton Road, 21st Ed., James A. West

Academic, Government & Associated Organizational Research Resources

Situated at the northwest end of Santa Cruz County and occupying circa 30 square miles of sharply contrasted terrain, the Scott Creek Watershed concentrates within its geomorphological boundaries, at least 10-12% of California's flora, both native and introduced. Paradoxically, the use/abuse that the watershed has sustained over the past 140+ years, has not necessarily diminished the biodiversity and perhaps parallels the naturally disruptive but biologically energizing processes (fire, flooding, landslides and erosion), which have also been historically documented for the area for +60 years. This is an early edition of an extensive document by James A. West. Please visit the …

Cladribine Analogues Via O6-(Benzotriazolyl) Derivatives Of Guanine Nucleosides, Sakilam Satishkumar, Prasanna K. Vuram, Siva Subrahmanyam Relangi, Venkateshwarlu Gurram, Hong Zhou, Robert J. Kreitman, Michelle M. Martínez Montemayor, Lijia Yang, Muralidharan Kaliyaperumal, Somesh Sharma, Narender Pottabathini, Mahesh K. Lakshman

Publications and Research

Cladribine, 2-chloro-2′-deoxyadenosine, is a highly efficacious, clinically used nucleoside for the treatment of hairy cell leukemia. It is also being evaluated against other lymphoid malignancies and has been a molecule of interest for well over half a century. In continuation of our interest in the amide bond-activation in purine nucleosides via the use of (benzotriazol-1yl-oxy)tris(dimethylamino)phosphonium hexafluorophosphate, we have evaluated the use of O6-(benzotriazol-1-yl)-2′-deoxyguanosine as a potential precursor to cladribine and its analogues. These compounds, after appropriate deprotection, were assessed for their biological activities, and the data are presented herein. Against hairy cell leukemia (HCL), T-cell lymphoma (TCL) and chronic lymphocytic …

Cross-Sectional Associations Between Exposure To Persistent Organic Pollutants And Leukocyte Telomere Length Among U.S. Adults In Nhanes, 2001-2002., Susanna D. Mitro, Linda S. Birnbaum, Belinda L. Needham, Ami R. Zota

Environmental and Occupational Health Faculty Publications

Background: Exposure to persistent organic pollutants (POPs) such as dioxins, furans, and polychlorinated biphenyls (PCBs) may influence leukocyte telomere length (LTL), a biomarker associated with chronic disease. In vitro research suggests dioxins may bind to the aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL. However, few epidemiologic studies have investigated associations between POPs and LTL.

Objectives: We examined the association between 18 PCBs, 7 dioxins, and 9 furans and LTL among 1,330 U.S. adults from NHANES 2001-2002. Methods: We created three summed POP metrics based on toxic equivalency factor (TEF), a potency measure including affinity for the …

A Tail Of Two Phages: Genomic And Functional Analysis Of Listeria Monocytogenes Phages Vb_Lmos_188 And Vb_Lmos_293 Reveal The Receptor-Binding Proteins Involved In Host Specificity, Aidan Casey, Kieran Jordan, Horst Neve, Aidan Coffey, Olivia Mcauliffe

Department of Biological Sciences Publications

The physical characteristics of bacteriophages establish them as viable candidates for downstream development of pathogen detection assays and biocontrol measures. To utilize phages for such purposes, a detailed knowledge of their host interaction mechanisms is a prerequisite. There is currently a wealth of knowledge available concerning Gram-negative phage-host interaction, but little by comparison for Gram-positive phages and Listeria phages in particular. In this research, the lytic spectrum of two recently isolated Listeria monocytogenes phages (vB_LmoS_188 and vB_LmoS_293) was determined, and the genomic basis for their observed serotype 4b/4e host-specificity was investigated using comparative genomics. The late tail genes of these …

Ucc Minutes Oct 9, 2015, Undergraduate Curriculum Council

Undergraduate Currirculum Committee Minutes

No abstract provided.

Uab-Hudsonalpha Center For Genomic Medicine Awards First Pilot Grants, Alicia Rohan

Browse All News

No abstract provided.

Developing A Dissociative Nanocontainer For Peptide Drug Delivery, Patrick Kelly, Prachi Anand, Alexander Uvaydov, Srinivas Chakravartula, Chhime Sherpa, Elena Pires, Alison O’Neil, Trevor Douglas, Mandë Holford

Publications and Research

The potency, selectivity, and decreased side effects of bioactive peptides have propelled these agents to the forefront of pharmacological research. Peptides are especially promising for the treatment of neurological disorders and pain. However, delivery of peptide therapeutics often requires invasive techniques, which is a major obstacle to their widespread application. We have developed a tailored peptide drug delivery system in which the viral capsid of P22 bacteriophage is modified to serve as a tunable nanocontainer for the packaging and controlled release of bioactive peptides. Recent efforts have demonstrated that P22 nanocontainers can effectively encapsulate analgesic peptides and translocate them across …