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Hirsutella Sinensis Mycelium Attenuates Bleomycin-Induced Pulmonary Inflammation And Fibrosis In Vivo, Tsung-Teng Huang, Hsin-Chih Lai, Yun-Fei Ko, David M. Ojcius, Ying-Wei Lan, Jan Martel, John Ding-E. Young, Kowit-Yu Chong

All Dugoni School of Dentistry Faculty Articles

Hirsutella sinensis mycelium (HSM), the anamorph of Cordyceps sinensis, is a traditional Chinese medicine that has been shown to possess various pharmacological properties. We previously reported that this fungus suppresses interleukin-1β and IL-18 secretion by inhibiting both canonical and non-canonical inflammasomes in human macrophages. However, whether HSM may be used to prevent lung fibrosis and the mechanism underlying this activity remain unclear. Our results show that pretreatment with HSM inhibits TGF-β1–induced expression of fibronectin and α-SMA in lung fibroblasts. HSM also restores superoxide dismutase expression in TGF-β1–treated lung fibroblasts and inhibits reactive oxygen species production in lung epithelial cells. Furthermore, …

Feasibility Project To Determine Strategies For Self-Administration Of A Subcutaneous Orphan Drug For Treatment Of Short Bowel Syndrome: Impact On Adherence, Virginia A. Strootman

DNP and Student Works

Several strategies have been suggested to improve the nurse education provided to the nurses who educate the patients. The assumption is by providing evidence-based strategies to promote adherence to the nurses, prior to educating the patients, an increase in adherence rates can be demonstrated. Strategies discussed involve a feasibility project whereby an improved nurse educational model demonstrates improvement in medication adherence rates for adults with a rare and chronic disease states that self-administer an orphan drug for short bowel syndrome.

Meta-Gsa: Combining Findings From Gene-Set Analyses Across Several Genome-Wide Association Studies, Albert Rosenberger, Stefanie Friedrichs, Christopher I. Amos, Paul Brennan, Gordon Fehringer, Joachim Heinrich, Rayjean J. Hung, Thomas Muley, Martina Müller-Nurasyid, Angela Risch, Heike Bickeböller

Dartmouth Scholarship

Gene-set analysis (GSA) methods are used as complementary approaches to genome-wide association studies (GWASs). The single marker association estimates of a predefined set of genes are either contrasted with those of all remaining genes or with a null non-associated background. To pool the p-values from several GSAs, it is important to take into account the concordance of the observed patterns resulting from single marker association point estimates across any given gene set. Here we propose an enhanced version of Fisher’s inverse χ²-method META-GSA, however weighting each study to account for imperfect correlation between association patterns.

Reproductive Notes On Shrews (Family Soricidae) In Louisiana, Leann Lucas, Justin D. Hoffman

Western North American Naturalist

Little information is known about reproduction in the 3 species of shrews in Louisiana. We examined reproductive notes from specimen records for the southern short-tailed shrew (Blarina carolinensis), least shrew (Cryptotis parva), and southeastern shrew (Sorex longirostris). Most breeding activity occurred from March to December for B. carolinensis and C. parva. Average number of embryos was 3.75 for B. carolinensis and 5.5 for C. parva. The average length of testes was 5.2 mm for B. carolinensis and 3.8 mm for C. parva. One male S. longirostris possessed a testis length of 3 …

Survival And Plant Vigor Of Sclerocactus Parviflorus (Clover And Jotter) Following Different Transplanting Techniques, Richard Ballard, Rick Ott, Tim Novotny, Anna Lincoln, Eric Rechel

Western North American Naturalist

Cacti are transplanted when their occurrence conflicts with road and pipeline construction and mitigation requires relocation, or they are transplanted for personal use. Methods used in transplanting have credence by virtue of common practice; however, there are few scientific studies comparing different methods. Our objective was to determine if different transplanting techniques, time of year of transplanting, and association with a nurse plant upon transplanting affected the long-term survival (8 years) and vigor of Sclerocactus parviflorus (Clover and Jotter). The 3 transplanting procedures were as follows: (1) cacti excavated, soil removed from roots, roots trimmed, plants placed in shaded open …

Stream Macroinvertebrates And Habitat Below And Above Two Wilderness Fords Used By Mules, Horses, And Hikers In Yosemite National Park, Jeffrey G. Holmquist, Jutta Schmidt-Gengenbach, James W. Roche

Western North American Naturalist

Wilderness stream crossings used by mules, horses, and hikers are localized disturbances that may affect habitat immediately downstream, but the potential influence of fords on streams has received little investigation, particularly in terms of possible effects on fauna. Our overall null hypothesis was absence of below-above differences for either benthic macroinvertebrate assemblages or habitat characteristics at such fords. We further sought to determine (1) whether any such differences were present prior to annual use, suggesting longer-term effects, and (2) whether differences were present in late season, after annual use. We examined macroinvertebrates and habitat immediately below and above 2 fords …

Week Of October 26, 2015, New York Medical College

InTouch

• William Campbell, Ph.D., Longtime, Celebrated NYMC Adjunct Professor, Wins Nobel
• Steven A. Wartman, M.D., Ph.D., M.A.C.P., Announced as 2016 NYMC Commencement Speaker
• Dean Miller Reports on LCME Mock Site Visit
• School of Medicine Launches Personal Accolades and Incidents Reporting (PAIR)
• Medical Student Brian Yum Selected Semi-Finalist in Essay Program
• D.P.T. Students Host Successful Race for Rehab
• NYMC Welcomes BOCES New Visions Health Students
• NYMC Sends Support to Liberia
• SHSP Welcomes New Cohort of Dr.P.H. Candidates

Genetic Evidence For Recent Spread Of Springsnails (Hydrobiidae: Pyrgulopsis) Across The Wasatch Divide, Hsiu-Ping Liu, Peter Hovingh, Robert Hershler

Western North American Naturalist

The biogeographic history of aquatic organisms in relation to the Wasatch Mountains divide (which separates the eastern Great Basin and upper Colorado River basin in Utah) has been little studied aside from a large body of work on fishes. Pyrgulopsis kolobensis is a small springsnail that is distributed (in the eastern portion of its range) along the western flanks of the Wasatch Mountains, with a single population occurring just across the Wasatch divide in Strawberry Valley. Here we analyze the genetic structure of this species across the Wasatch divide (using the mtCOI gene) to discriminate between alternative hypotheses that explain …

Pine Bark Beetle And Dwarf Mistletoe Infestation In A Remnant Old-Growth Stand, Nicholas Aflitto, Tom Degomez, Richard Hofstetter, John Anhold, Joel Mcmillin, Mike Wagner, Eryn Schneider

Western North American Naturalist

We examined the incidence of bark beetle (Coleoptera: Curculionidae: Scolytinae) colonization and subsequent mortality, and the presence of dwarf mistletoe (Arceuthobium vaginatum subsp. crytopodum) within a rare remnant old-growth stand of ponderosa pine. In 2011, 96% of the old growth trees were remaining with additional dense ingrowth of ponderosa pine (Pinus ponderosa Douglas ex. Lawson) within the understory of the oldest trees. We compared the old-growth stand to abutting stands of ponderosa pine: a low-density seed-tree cut and a high-density post-1900 second growth. The old-growth stand had levels of bark beetle colonization similar to the seed-tree stand, …

Lichen Inventory Of White Rocks Open Space (City Of Boulder, Colorado), Erin A. Tripp

Western North American Naturalist

A lichen inventory of White Rocks Open Space (City of Boulder, CO), a unique outcropping of exposed unstable sandstones, is presented. White Rocks is an ecologically important, ~40.5-ha (100-acre) protected area whose biological significance is in part attributable to geological and climatological history as well as degree of preservation, but also because it represents a biodiversity reservoir in a sea of agriculture and urban development. This inventory resulted in documentation of 56 species, including 1 new record to the United States, 1 new record to Colorado, 2 species new to science, and 2 additional species potentially new to science pending …

A Note On The Observable Bark Coloration Of Quaking Aspen (Populus Tremuloides), Oren Rabinowitz, Erin A. Tripp

Western North American Naturalist

The bark of quaking aspen (Populus tremuloides), a clonal hardwood that is dominant in many Rocky Mountain forests, varies from white to orange to green among both ramets and populations. The proximate causes of this color variation remain controversial. We collected 72 samples of aspen bark from 11 locations in Boulder County, Colorado, and used microscopy, dissection, and thin layer chromatography to assess the structural and biochemical basis for the color gradient. Our study shows that the cork cells closest to the cork cambium of the aspen were consistently orange and conglutinated. Outward from this layer, the cork …

Phenotypic Assays For Reactive Gliosis: Towards Multicellular Polypharmacology For Spinal Cord Injury, Samuel Robert Beckerman

Open Access Dissertations

Following traumatic central nervous system (CNS) injury, most severed axons fail to regenerate beyond the glial scar. This results in persistent deficits, including paralysis. Regenerative failure is due to neuron-intrinsic and extrinsic factors (i.e. CNS glial cells). Astrocytes are interesting extrinsic factors because they are a major constituent of the glial scar. After injury, astrocyte phenotypes change in a process called reactive gliosis. Reactive astrocytes are characterized by expansion of their glial fibrillary acid protein (GFAP) cytoskeleton and increased expression of axon-growth inhibitory chondroitin sulfate proteoglycans (CSPGs). As there are no FDA-approved drugs that enhance regeneration or functional recovery, there …

Catalyzing Change: Identifying Action To Accelerate Collective Impact Progress In San Bernardino County, Stephanie Houston

Dissertations

The purpose of this study was to identify the most important actions for the implementation of the San Bernardino County Vison using a Collective Impact approach. Collective Impact is a structured approach to problem solving that includes the five core conditions of, common agenda, continuous improvement, shared measurement system, mutually reinforcing activities, and backbone functions. The Delphi technique was used to gather data, perceptions, and opinions from 16 cross-sector leaders identified as experts responsible for the implementation of the San Bernardino County Vision. Survey participants were identified as experts based upon their responsibility as cross-sector leaders engaged in the San …

Lack Of Resistance Of Plasmodium Falciparum To Dihydroartemisinin In Uganda Based On Parasitogolgical And Molecular Assays, Roland A. Cooper, Melissa D. Conrad, Quentin D. Watson, Stephanie J. Huezo, Harriet Ninsiima, Patrick Tumwebaze, Samuel L. Nsobya, Philip J. Rosenthal

Collected Faculty Scholarship

• Artemisinin-­‐based combination therapy is now standard treatment for falciparum malaria. However, this regimen is threatened by resistance to artemisinins, manifest as delayed clearance of parasitemia after therapy, in southeast Asia.

• Artemisinin resistance in southeast Asia is associated with increased parasitemias in culture, compared to those in sensi0ve parasites, 72 hours a=er a 6 hour pulse with 700 nM dihydroartemisinin (DHA), and with propeller domain polymorphisms in the Plasmodium falciparum kelch (K13; PF3D7_1343700) gene

• Given that artemether/lumefantrine has been adopted as standard therapy for malaria within the last decade in Uganda, we characterized artemisinin sensiBvity in fresh P. falciparum isolates from …

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Phytochemicals In Cancer Prevention And Therapy, Poyil Pratheeshkumar, Young-Ok Son, Preethi Korangath, Kanjoormana Aryan Manu, Kodappully Sivaraman Siveen

Toxicology and Cancer Biology Faculty Publications

Despite advances in modern medicine, cancer is still the major cause of mortality in both developing and developed countries. Search for safer and more effective chemoprevention and treatment strategy is a need for the improvement of patient care in the field. Prevention may be more effective and less costly because cancer is largely a preventable disease which could be attributed to a greater extent to lifestyle. Dietary phytochemicals have been used for the treatment of cancer throughout history due to their safety, low toxicity, and general availability. Population based studies suggest that a reduced risk of cancer is associated with …

A Polyglot Approach To Bioinformatics Data Integration: A Phylogenetic Analysis Of Hiv-1, Steven Reisman, Thomas Hatzopoulos, Konstantin Laufer, George K. Thiruvathukal, Catherine Putonti

Bioinformatics Faculty Publications

As sequencing technologies continue to drop in price and increase in throughput, new challenges emerge for the management and accessibility of genomic sequence data. We have developed a pipeline for facilitating the storage, retrieval, and subsequent analysis of molecular data, integrating both sequence and metadata. Taking a polyglot approach involving multiple languages, libraries, and persistence mechanisms, sequence data can be aggregated from publicly available and local repositories. Data are exposed in the form of a RESTful web service, formatted for easy querying, and retrieved for downstream analyses. As a proof of concept, we have developed a resource for annotated HIV-1 …

Creativity And Dissidence In Jordanian Women’S Literature, Omnia Amin

All Works

The journal provides a platform for different theoretical and thematic approaches to the following humanitarian research fields: linguistic researches, issues of literary narratives and contexts, influence of advertising discourse, theory and practice of translation, audiovisual research.

Microrna Circulating In The Early Aftermath Of Motor Vehicle Collision Predict Persistent Pain Development And Suggest A Role For Microrna In Sex-Specific Pain Differences., Sarah D. Linnstaedt, Margaret G. Walker, Joel S. Parker, Eunice Yeh, Robert L. Sons, Erin Zimny, Christopher A. Lewandowski, Phyllis L. Hendry, Kathia Damiron, Claire Pearson, Marc-Anthony Velilla, Brian J. O'Neil, Jeffrey Jones, Robert Swor, Robert Domeier, Scott Hammond, Samuel A. Mclean

Emergency Medicine Articles

BACKGROUND: Molecular mediators influencing the transition from acute to persistent musculoskeletal pain following common stress exposures such as motor vehicle collision (MVC) remain poorly understood. In this exploratory, proof of concept study, we compared circulating microRNA (miRNA) expression profiles in the early aftermath of MVC among individuals who did and did not subsequently develop persistent pain. Blood RNA samples were obtained from African American individuals (n = 53) who presented to the emergency department after MVC and were discharged to home after evaluation. The presence or absence of severe pain in the axial region, the most common and morbid region …

Differentiated Effects Of The Multimodal Antidepressant Vortioxetine On Sleep Architecture: Part 2, Pharmacological Interactions In Rodents Suggest A Role Of Serotonin-3 Receptor Antagonism, Steven C. Leiser, Deborah Iglesias-Bregna, Ligia Westrich, Alan Pehrson, Connie Sanchez

Department of Psychology Faculty Scholarship and Creative Works

Antidepressants often disrupt sleep. Vortioxetine, a multimodal antidepressant acting through serotonin (5-HT) transporter (SERT) inhibition, 5-HT 5-HTand 5-HTreceptor antagonism, 5-HTreceptor partial agonism, and 5-HTreceptor agonism, had fewer incidences of sleep-related adverse events reported in depressed patients. In the accompanying paper a polysomnographic electroencephalography (sleep-EEG) study of vortioxetine and paroxetine in healthy subjects indicated that at low/intermediate levels of SERT occupancy, vortioxetine affected rapid eye movement (REM) sleep differently than paroxetine. Here we investigated clinically meaningful doses (80-90% SERT occupancy) of vortioxetine and paroxetine on sleep-EEG in rats to further elucidate the serotoninergic receptor mechanisms mediating this difference. Cortical EEG, electromyography …

Sleep As An Occupation In College Students, Michelle Del Rosario, Lisa Mrsny, Amanda Cervantes, Carl Fitzgerald

Student Research Posters

The purpose of this study was to measure the quality of sleep in undergraduate college students and explore the relationship between academic self-efficacy and performance in student-related occupations. A quantitative, exploratory, descriptive and correlational research design was used to explore the relationship among sleep quality, perceived self-efficacy, and selected student characteristics. This study included undergraduate students, as well as self-identified student athletes, first generation students, and students with disabilities. To collect data, the researchers conducted an online survey, which consisted of the Pittsburgh Sleep Quality Index (PSQI), a demographic and self-efficacy questionnaire. The PSQI was used to evaluate the sleep …

The Abcs Of Stress Responding: Examining The Time Course Of Affective, Biological, And Cognitive Responses To Induced Stress As Prospective Predictors Of Depressive Symptoms, Marissa Erin Rudolph

Clinical Psychology Dissertations

Vulnerability-stress models of depression posit risk for depression is characterized by the presence of underlying affective, biological, and cognitive vulnerabilities that become activated during life stress exposure. Extant research has shown heightened reactivity to stress across these vulnerability domains predicts depression; however, little is known whether the persistence of and failure to down-regulate these maladaptive stress responses conveys greater risk of depression than initial reactivity alone. The current study examined associations between the time course of responses to a laboratory stress induction and depressive symptoms. I hypothesized that prolonged maladaptive responses to the stressor across affective (state negative affect; NA), …

Cognitive Innovation And The Cognitive Turn, M Punt

School of Art, Design and Architecture

For nearly half a century Leonardo has surveyed, reflected and shaped the intellectual project of ISAST. As part of this mission it has, in the best possible sense, been alert to ‘the next big thing’; what in the sciences is called a ‘breakthrough’, a ‘movement’ in the arts, and in technology an ‘opportunity’. In recent years in the humanities the ‘next big thing’ has been relentlessly labelled as a ‘turn’ to the extent that the term itself now resonates with self-irony. Nonetheless by tracking the bibliographies of various ‘breakthroughs’, ‘movements’, ‘opportunities’ and ‘turns’, it is possible to see the recurring …

Quarterly Meeting Agenda & Packet, Wku Board Of Regents

Board of Regents Documents

Meeting regarding Department of Physical Therapy, faculty emeriti, named rooms and areas, student retention, personnel actions and bonds.

Homecoming 2015 Booklet, Taylor University

Homecoming & Family Weekend

No abstract provided.

Steroid Receptor Isoform Expression In Drosophila Nociceptor Neurons Is Required For Normal Dendritic Arbor And Sensitivity, Aidan L. Mcparland, Taylor L. Follansbee, Gwendolyn D. Vesenka, Alexandra E. Panaitiu, Geoffrey K. Ganter

Biology Student Publications

Steroid hormones organize many aspects of development, including that of the nervous system. Steroids also play neuromodulatory and other activational roles, including regulation of sensitivity to painful stimuli in mammals. In Drosophila, ecdysteroids are the only steroid hormones, and therefore the fly represents a simplified model system in which to explore mechanisms of steroid neuromodulation of nociception. In this report, we present evidence that ecdysteroids, acting through two isoforms of their nuclear ecdysone receptor (EcR), modulate sensitivity to noxious thermal and mechanical stimuli in the fly larva. We show that EcRA and EcRB1 are expressed by third instar larvae in …

The Echo: October 23, 2015, Taylor University

2015-2016 (Volume 103)

Lacrosse at a crossroads – Upland update – Top five news events of the week – Late night for Taylor – In The Loop – Around The World – Democratic candidates unveiled – Road to Ohio – Stylish Staff – Grandma Gracie – O-Group heartbreak – Echograms #TaylorU -- #TaylorU’s Top Tweets – Journeying from Taylor to L.A. – Quartet returns – Hotel for spies – Marriage isn’t for everyone – Does anyone really care? – My real self – Trojans subdue Saints – Weekly Preview – Cross country moves up – Trojans’ big guns fizzle in shootout – Athlete …

Structural Characterization Of Cals8, A Tdp-Α-D-Glucose Dehydrogenase Involved In Calicheamicin Aminodideoxypentose Biosynthesis, Shanteri Singh, Karolina Michalska, Lance Bigelow, Michael Endres, Madan K. Kharel, Gyorgy Babnigg, Ragothaman M. Yennamalli, Craig A. Bingman, Andrzej Joachimiak, Jon S. Thorson, George N. Phillips Jr.

Center for Pharmaceutical Research and Innovation Faculty Publications

Classical UDP-glucose 6-dehydrogenases (UGDHs; EC 1.1.1.22) catalyze the conversion of UDP-α-d-glucose (UDP-Glc) to the key metabolic precursor UDP-α-d-glucuronic acid (UDP-GlcA) and display specificity for UDP-Glc. The fundamental biochemical and structural study of the UGDH homolog CalS8 encoded by the calicheamicin biosynthetic gene is reported and represents one of the first studies of a UGDH homolog involved in secondary metabolism. The corresponding biochemical characterization of CalS8 reveals CalS8 as one of the first characterized base-permissive UGDH homologs with a >15-fold preference for TDP-Glc over UDP-Glc. The corresponding structure elucidations of apo-CalS8 and the CalS8·substrate·cofactor ternary complex (at 2.47 and 1.95 Å …

Theaflavin-3, 3'-Digallate Decreases Human Ovarian Carcinoma Ovcar-3 Cell-Induced Angiogenesis Via Akt And Notch-1 Pathways, Not Via Mapk Pathways, Ying Gao, Gary O. Rankin, Youying Tu, Yi Charlie Chen

Biochemistry and Microbiology

Theaflavin-3, 3'-digallate (TF3) is a black tea polyphenol produced from polymerization and oxidization of the green tea ployphenols epicatechin gallate and (-)-epigallocatechin-3-gallate (EGCG) during fermentation of fresh tea leaves. TF3 has been reported to have anticancer properties. However, the effect of TF3 on tumor angiogenesis and the underlying mechanisms are not clear. In the present study, TF3 was verified to inhibit tumor angiogenesis. Compared with EGCG, TF3 was more potent. TF3 inhibited human ovarian carcinoma OVCAR-3 cell-induced angiogenesis in human umbilical vein endothelial cell model and in chick chorioallantoic membrane model. TF3 reduced tumor angiogenesis by downregulating HIF-1α and VEGF. …

Biodiversity And Ecological Dynamics Of Sciophilous Benthic Communities On Artificial Plates: Emphasis On Reef Sponges, Caidra Elizabeth Hassanzada

HCNSO Student Theses and Dissertations

Low light intensity habitats harbor unique sciophilous benthic communities and are a source of novel and unique sponge fauna. However, the community structure of these habitats is poorly studied to date. Thus, this study attempts to understand the composition and structure of sciophilous sponge populations in southeast Florida. Fifty limestone plates were placed on a shallow reef in Fort Lauderdale for two years (2010-2012). To identify the sponge community and their patterns over time, all plates were photographed at the end of each year. Then, samples were taken from each of the live sponge specimens observed on the plates and …

Interdisciplinary Approaches To Financial Stability, University Of Michigan Law School

Event Materials

Program for a conference on interdisciplinary approaches to financial stability.