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Working Memory In Children With Neurocognitive Effects From Sickle Cell Disease: Contributions Of The Central Executive And Processing Efficiency, Kelsey Erin Smith

Theses and Dissertations

Children with sickle cell disease (SCD) are at risk for neurocognitive impairment due to disease effects including stroke, sleep disordered breathing, anemia-induced hypoxia, and small vessel occlusion. In particular, problems in working memory are an area of concern due to the importance of this construct in determining intelligence and academic functioning. According to Baddely’s model, working memory is composed of verbal and spatial working memory, but it is unclear whether one aspect of working memory is more impacted than another in children with SCD. In addition, little is known about the role of two key components in SCD-related working memory …

Figure And Flora, Caleigh Eveleth Goold

Theses and Dissertations

‘Figure and Flora’ is an exploration of the visual relationship between the human figure and various forms of plant life. It is an exercise in appreciation of the subtle nuances in color, shape and form of the human body which can bear a striking resemblance to vegetation that one would encounter in everyday life. Because we are such visual creatures, recognizing the aesthetic similarities can be an effective first step in realizing the inherent and biological similarities as well. This exhibit is meant to remind people that they are related to many more varied life forms than they may be …

Bottomfeeders, William Linn

Theses and Dissertations

Bottomfeeders is a collection of short fiction. It includes stories concerning life, death, hoboes, wrestling, videogames, and cropdusters, among other things. It is both very serious and impossibly dumb, as is the way of things.

The Evolutionary Biology Of Vision In Daphnia, Christopher S. Brandon

Theses and Dissertations

Eyes have attracted the attention of evolutionary biologist since the field’s infancy. In On the Origin of Species, in fact, Darwin famously remarked on the proposition that natural selection could engineer the eye, saying “[it is] absurd in the highest possible degree.” Though, he goes on to explain, beautifully and simply, how his theory of evolution by natural selection could produce such an organ. Indeed, eyes are remarkable examples of complex information acquisition systems that have evolved from simple beginnings. Eyes allow animals to extract environmental information from light, which informs physiological and behavioral responses to resources, predation, and mates. …

Antecedents Of Adolescents' Hope: Personality, Parental Attachment, And Stressful Life Events, Kristin L. Otis

Theses and Dissertations

In the past decade, psychology has concentrated on the importance of identifying psychological qualities in individuals that indicate positive mental health and flourishing. Hope has been proposed to be one of these qualities (Day, Hanson, Maltby, Proctor, & Wood, 2010; Marques, & Lopez, 2014). This study examined the relations among parental attachment, stressful life events, personality variables, and hope in a sample of 647 middle school students from one middle school in a Southeastern US state. The results showed statistically significant correlations between hope and all four predictor variables as well as students’ grade levels and socioeconomic status (SES). The …

Map Kinase Signaling In Plant Responses To Biotic Stress, Carlton James Bequette

Theses and Dissertations

Plants must be able to perceive and properly respond to a multitude of environmental conditions and produce appropriate cellular responses for optimal growth and reproduction. Mitogen-activated protein kinase (MAPK) phosphorylation cascades are critical components of signal transduction networks that mediate cellular responses to a wide range of both biotic and abiotic extracellular stimuli. This thesis presents an investigation of three novel aspects of MAPK signaling, the role of MAPKs in the regulation of cell death, the organization of MAPKs in a multi-protein complex, and the negative regulation of MAPKs by MAPK phosphatases. In tomato, three MAPKs play an essential role …

Complexity In Overmarsh Circulation, Jessica Chassereau Sullivan

Theses and Dissertations

Overmarsh circulation is highly complex with variations in current direction over very short timescales and flowpaths that differ substantially between flood and ebb cycles. Understanding such flow complexities in salt marshes is important because they inherently impact the distribution of sediment, larvae and nutrients throughout the marsh, and hence, the ecogeomorphic feedbacks that control landscape evolution. The purpose this Ph.D. research is to quantitatively evaluate the effects of salt marsh topography on overmarsh circulation in a Georgia salt marsh. This dissertation is comprised of three parts. First, digital elevation models (DEMs) were compared to characterize how well airborne lidar (light …

Profiles Of African American College Students’ Risky Behaviors: General And Culturally-Specific Stress And Social Support As Factors Of Risk And Resilience?, Isha Walwina Metzger

Theses and Dissertations

Studies show that, while alcohol use and risky sexual activities increase during emerging adulthood, college students are more likely to engage in these behaviors than their non-student counterparts (Slutske et al., 2004). Researchers should explore risk behavior participation among African American youth, as they often face health disparities and more severe consequences of engaging in these acts than their White American counterparts (Sharma & Atri, 2006; Jackson, Hodge, & Vaughn, 2010). Although epidemiological and variable-centered studies often examine the drinking and sexual behavior of African American college students, there is a need for research utilizing a profile-oriented approach to explore …

Inquiry-Based Teaching In The College Classroom: The Nontraditional Student, Daniel A. Kiernan

Theses and Dissertations

Decline in the economic realm often bolsters an increase of nontraditional student enrollments in colleges and universities (Windolf, 1992). Many of these students, who do not desire to major in some scientific area, find themselves struggling in required science courses. Over the last decade, science departments of higher education have been adjusting their curriculum to include inquiry in the college science classroom. Although inquiry-based teaching has been shown to be very academically positive in science classrooms from K-12, “at the college level the data are mixed as to whether increasing inquiry instruction can significantly change students’ learning or attitudes toward …

Healthy Eating And Physical Activity Environmental And Policy Assessment – Measurement Issues And Implications, Rahma Jamea Yousef Ajja

Theses and Dissertations

Current research has suggested that supportive healthy eating and physical activity (HEPA) policy and practice environments play a significant role in shaping the physical activity levels and eating habits of youth. Subsequently, a wide array of audit tools assessing policy and practice environment characteristics across settings that care for youth were developed. However, the extent that available audit tools accurately reflect the policy environment characteristics of the settings that care for the youth population remains unknown. Therefore, this dissertation encompasses four studies. The purpose of the first study was to examine the measurement properties of audit tools currently in use …

Exploring Communication Patterns In The Discussion Of Maternal Pku Syndrome Between Parents And Daughters, Hannah Beth Andrews

Theses and Dissertations

Maternal PKU syndrome is the collection of features and birth defects that arise from uncontrolled phenylalanine levels in a pregnant woman with phenylalanine hydroxylase (PAH) deficiency, previously known as phenylketonuria (PKU). Currently, the literature is lacking in exploring what young women are being told about maternal PKU syndrome. In this study, communication patterns between parents and their daughters about maternal PKU syndrome were investigated through an online survey completed by parents. The survey assessed parents’ level of comfort with this topic, the information they discussed with their daughter and the resources they accessed. Followup interviews were conducted with participants to …

Evaluating Changes In Patient Anxiety Regarding Classic Cancer Genetic Testing Versus Expanded Multiplex Cancer Genetic Testing, Andrew Todd Alfonso

Theses and Dissertations

Multiplex cancer genetic testing by next generation sequencing (NGS) offers genetic counselors and patients new options for testing multiple genes beyond BRCA1 and BRCA2, increasing both the yield of positive results and the number of variants of uncertain significance (VUS). This pilot study explored three psychosocial questions related to multiplex cancer genetic testing: 1). Do anxiety levels differ in patients with results of familiar single gene testing versus those with results of multiplex cancer genetic testing of unfamiliar genes? 2). Do different results (i.e., negative, positive, or VUS) affect patient anxiety levels in the post-results period? 3). Is patient anxiety …

Characterization Of The Sufc Atpase During Fe-S Cluster Assembly By The Suf Pathway In Escherichia Coli, Khaleh Mykel Thomas

Theses and Dissertations

The gram-negative bacterium E. coli encodes the Suf pathway to assemble iron-sulfur (Fe-S) clusters under iron starvation and oxidative stress conditions. The ATPase activity of SufC is critical for in vivo Fe-S cluster assembly by the Suf pathway. SufC shares homology with the nucleotide binding domain (NBD) of ATP-binding cassette (ABC) transporters and belongs to the AAA+ (ATPases Associated with diverse cellular Activities) ATPase superfamily, a family of proteins that utilizes energy from ATP hydrolysis to perform a variety of cellular functions. SufC forms a stable SufBC2D complex with partner proteins SufB and SufD. The SufBC2D complex serves as a …

Evaluating Muscle Fiber Architecture, Morgan Ashley Flahive

Theses and Dissertations

Mastication is the first step in the preparation of food for digestion. The masticatory anatomy of several families of Carnivorans (i.e., Family Canidae, Family Mustelidae, Family Hyaenidae, and Family Ursidae of the order Carnivora) will be compared in this study. The goal is to better understand masticatory adaptations through an examination of bite force and muscle fiber architecture in the various groups of carnivores, and to provide a proper protocol in acid dissection of fiber architecture.

The Fancy Trade And The Commodification Of Rape In The Sexual Economy Of 19th Century U.S. Slavery, Tiye A. Gordon

Theses and Dissertations

The purpose of this research is to examine the Fancy Trade—the buying and selling of mixed-race enslaved women for the primary purpose of prostitution and concubinage—through an intersectionality lens. Therefore, I will explore a culture of rape through the lived experiences of fancy maids, the women who were sold as sex commodities in the 19th century domestic slave trade. Who was she? Using an intersectionality framework to answer the proposed questions will achieve the following. First, it will highlight the social constructions of race, gender, and sexuality within the 19th century southern context. Secondly, an intersectional methodology will explore the …

Fabrication And Characterization Of Graphene Based Biocompatible Ion-Sensitive Field Effect Transistor (Isfet), Rina Patel

Theses and Dissertations

Graphene, a two-dimensional material with a high surface to volume ratio, has drawn extensive research enthusiasm for applications in the field of electronic sensors. The special material properties that make graphene a highly promising material include its biocompatibility, very high mobility, low 1/f and thermal noise, modulation of carrier concentration and fermi level by electrical, optical, and chemical means. To exploit these properties for practical applications a large area high quality graphene, transferred on appropriate substrates, is required. In this work, high quality single monolayer graphene (determined from Raman spectroscopy) has been synthesized by chemical vapor deposition (CVD) technique for …

Addressing Disparity: One Unique School’S Efforts To Provide Holistic Education In A Low-Income, Black Community, Allison Anne Parsons

Theses and Dissertations

Schools are meant to provide an equal opportunity for achievement to all students. The reality is that school policies and practices, which govern not only child education but also child health, parenting practices, and other social issues, are based on ideologies of the dominant culture creating an environment the perpetuates current social hierarchies. By doing so, this not only limits minority populations’ access to the opportunities associated with education but also access to health, as education and health are strongly and positively linked.

This study used qualitative methods including ethnography to explore how racism was perpetuated through the dominant discourses …

Adiponectin And Selenium Rich Diet Can Act As A Complimentary Medicine In The Treatment Of Intestinal And Chronic Inflammation Induced Colon Cancer, Arpit Saxena

Theses and Dissertations

Colon cancer is the second largest cause of cancer death in United States. Chronic inflammation and obesity predispose patients to colon cancer. Adipose tissue is a source of bioactive substances called adipokines. Adiponectin (APN), an adipokine has anti-inflammatory property and found at lower levels in obese patients. Selenium (Se), a trace mineral and a dietary supplement, is inversely associated with cancer risk and possess anti-inflammatory and anti-carcinogenic properties. The overall purpose of this dissertation is to determine if chronic inflammation leading to colon and intestinal cancer are regulated by APN or Se rich diet or both. The working hypothesis is …

Engineered 3d Microenvironments To Direct Osteogenic Differentiation And Modulate Inflammation, Katherine Elizabeth Rutledge

Theses and Dissertations

Current methods of treating critical size bone defects (CSDs) include autografts and allografts, however both present major limitations including donor-site morbidity, risk of disease transmission, and immune-rejection. Tissue engineering provides a promising alternative to circumvent these shortcomings through the use of stem cells, three dimensional (3D) scaffolds, and growth factors. Cells receive signals from their microenvironment that determine cell phenotype, and a combination of physical cues and chemical factors is thought to have the most profound influence on stem cell behavior. A major focus of tissue engineering strategies is scaffold design to recapitulate in vivo microenvironmental architecture to direct stem …

Knowing In America: The Enlightenment, Science, And The Early Republic, Timothy K. Minella

Theses and Dissertations

This dissertation analyzes practices of science and technology in the early United States as windows onto the American Enlightenment. Although scholars have emphasized the important impact of Enlightenment thought on the American founding, the historiography tends to argue for the decreasing influence of the Enlightenment on American culture as the nineteenth century progressed. In addition, scholars tend to see a decline in American science after Benjamin Franklin as nineteenth-century Americans began to focus primarily on the practical problems of everyday life. I question these interpretations by connecting scientific practice in the Early Republic with transatlantic Enlightenment thought and analyzing American …

Species Responses To Climate Change And Environmental Heterogeneity: A Multi-Focal Approach, Megan Riley

Theses and Dissertations

Changes in global climate trends have the potential to influence diverse ecosystems at multiple levels of organization, from the species to the community. Changes in other environmental variables, such as those resulting from pollution and habitat modification, also have the potential to impact species fitness and alter species interactions. This dissertation employs a multi-focal approach to investigate species responses to two main topics: climate change and environmental heterogeneity. To investigate the first topic, this work focuses on the climate change-induced range expansion of the mangrove tree crab Aratus pisonii into novel salt marsh habitats. It investigates latitudinal patterns of life …

The Recovery Of Gut Barrier Function With Selenium Rich Diet In Acute Dss-Induced Colitis, Sarah Depaepe

Theses and Dissertations

Background: Acute Dextran Sodium Sulfate (DSS)-induced colitis is an inflammatory ailment limited to the colon. It works to destroy the morphology and gut barrier goblet and epithelial cells that aid in providing homeostasis. Selenium (Se) is an essential micronutrient that has anti-inflammatory and antioxidant properties and is known to play a role in reducing inflammation in areas elsewhere in the body. The current study is focused on how Se alters gut barrier permeability and functionality related to the recovery of tight junction regulation and mucin secretion. Methods: C57BL/6 mice were randomly placed into control (normal water) and 2% DSS water …

Trees, Partitions, And Other Combinatorial Structures, Heather Christina Smith

Theses and Dissertations

This dissertation contains work on three main topics.

Chapters 1 through 4 provide complexity results for the single cut-or-join model for genome rearrangement. Genomes will be represented by binary strings. Let S be a finite collection of binary strings, each of the same length. Define M to be the collection of medians – binary strings μ which minimize Sigma v belongs to S H(μ,v) where H is the Hamming distance. For any non-negative function f(x), define Z(f(x), S) to be (Sigma μ belongs to M) (Pi v belongs to S)f(H(μ,v)). We study the complexity of calculating Z(f(x), S), with respect …

Iii-V Nitride Based Microcantilever Heaters For Unique Multimodal Detection Of Volatile Organic Compounds At Low Temperature, Ifat Jahangir

Theses and Dissertations

Detection of volatile organic compounds (VOCs), which are widely used in industrial processes and household products, is very important due to significant health hazards associated with them. VOCs are commonly detected using photo-ionization detectors (PIDs), suspended hot bead pellistors, or heated metal oxide semiconductor functionalization layers. However, these techniques used for detecting VOCs often suffer from one or more of the following issues - high power consumption, limited selectivity, complicated functionalization technique and expensive characterization tools. On the other hand, microcantilevers offer excellent avenues for molecular sensing that arises out of their high sensitivity to various physical parameter changes induced …

Tropes Of Blood, Body And The Ground Of The Law: Becoming, Being And Beyond Wife On The Early Modern Stage, Emily Faye Murray

Theses and Dissertations

This project focuses on the representation of women on the early modern stage in three exemplary texts: the anonymous domestic tragedy Arden of Faversham, and two city comedies, Thomas Dekker’s The Shoemaker’s Holiday and Dekker and Thomas Middleton’s The Roaring Girl. Whether playing the role of adulterous wife, performing the role socially striving wife, or resisting the role of laboring wife, these female characters were on stage not only for entertainment, but also for examination and scrutiny by an early modern audience. Playwrights used characterizations of women and wives and their relationships to the economy as vehicles through …

Characterization Of Stard4 And Stard6 Proteins In Human Ovarian Tissue And Human Granulosa Cells And Cloning Of Human Stard4 Transcripts, Aisha Shaaban

Theses and Dissertations

Progesterone is essential hormone for pregnancy, which is produced by the human corpus luteum in early pregnancy until the placenta assumes this function. Transport of the cholesterol from the outer to the inner mitochondrial membrane is the rate limiting step for the de novo synthesis of pregnenolone (the precursor to progesterone), a process mediated by STARD1. STARD1 contains a C-terminal lipid binding domain which binds cholesterol and an N-terminal domain targeting STARD1 to the mitochondrial membrane. Unlike STARD1, STARD4 and STARD6 proteins lack a mitochondrial targeting sequence; however, they can bind cholesterol and increase steroidogenesis in model systems. In this …

The Association Of Gender, Age, And Coping With Internalizing Symptoms In Youth With Sickle Cell Disease, Laura Reinman

Theses and Dissertations

Youth with sickle cell disease (SCD) are at an elevated risk for having internalizing symptoms. Prior studies have suggested unique age by gender patterns of internalizing symptoms may be present in this population, however this pattern has not been thoroughly examined and the mechanisms underlying this pattern are not known. We examined rates of depression and anxiety symptoms between males and females with SCD across childhood and into adolescence in a cross-sectional design. We also considered the potential role of coping styles and health related locus of control for SCD morbidity that could account for age or gender patterns for …

Deeping Insolvency: A Cause Of Action, A Tool Of Measuring Damages, Or Nothing At All?, Nicholas Santoro

Bankruptcy Research Library

(Excerpt)

“Deepening Insolvency” is a rather new theory of either liability or damages in cases brought by a plaintiff (typically a bankruptcy trustee, litigation trust, or some other party “filling in” for an insolvent corporation, or debtor) against directors, officers, attorneys, or other professionals, based on their dealings with the debtor. “Deepening insolvency” has been defined as “injury to the debtors' corporate property from the fraudulent expansion of corporate debt and prolongation of corporate life.” The theory of deepening insolvency has become a highly debated by attorneys, creditors, and the courts.

The courts, both state and federal, have continued to …

The Role Of Pidd Protein In Adenoviral Induction Of Apoptosis, Iris Teresa Figueroa

Master's Theses

The Adenovirus E1A gene sensitizes cells to genetic insults and apoptosis, most notably in response to cytotoxic factors from innate immune cells. The mechanisms by which E1A sensitizes cells to apoptotic stressors have not been fully elucidated, however E1A actively represses NF-κB anti-apoptotic defenses, thereby sensitizing cells to alternative apoptotic cascades. Recent studies alternatively indicate that E1A also actively induces Caspase-2 activation and mitochondrial injury in the presence of certain cytotoxic injuries.

Caspase-2 is cleaved and activated in a large complex consisting of p53-inducible protein with a death domain (PIDD), an adaptor protein RAIDD, and pro-caspase 2. PIDD auto-proteolyzes into …

State Of The University, Fall 2015, John Pelissero

Loyola University Chicago Administration Publications

No abstract provided.