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2015

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Some Contributions To Bayesian Regularization Methods With Applications To Genetics And Clinical Trials, Himel Mallick Jan 2015

Some Contributions To Bayesian Regularization Methods With Applications To Genetics And Clinical Trials, Himel Mallick

All ETDs from UAB

Variable selection refers to the class of problems where one tries to find an optimal subset of relevant variables, which can be used to accurately predict the outcome of a certain response variable. Typically, a large number of variables are often collected; however, all but a few important variables are relevant for the prediction of the outcome, so the underlying representation is sparse. To this end, variable selection is fundamental in high-dimensional data analysis, playing a crucial role in important scientific discovery and decision-making, and has received enormous attention in the literature. Regularization method is one attractive approach that has …

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A New Form Of Rod Photoreceptor Light Adaptation, Alex S. Mckeown Jan 2015

A New Form Of Rod Photoreceptor Light Adaptation, Alex S. Mckeown

All ETDs from UAB

In the first step in light perception, rod and cone photoreceptors convert photon absorption into an electrical impulse that is transmitted through the visual pathway. While the biochemistry and the signaling physiology have largely been defined in dark-adapted, isolated mammalian rods, there are still unanswered questions regarding photoreceptor light adaptation processes that involve extracellular components. In particular, the proteins of the interphotoreceptor matrix have not been considered in the studies of rod signaling and adaptation. This thesis details a new form of light adaptation, now known as adaptive potentiation (AP), in which extracellular components act on rods to transiently increase …

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Dna Methylation Regulates Neuronal Synaptic Scaling And Intrinsic Membrane Excitability, Jarrod P. Meadows Jan 2015

Dna Methylation Regulates Neuronal Synaptic Scaling And Intrinsic Membrane Excitability, Jarrod P. Meadows

All ETDs from UAB

Learning and memory rely on long-lasting, experience-dependent adaptations in synaptic and non-synaptic forms of neuronal plasticity. Previous evidence implicates transcriptional and epigenetic mechanisms, including DNA cytosine methylation, as critical regulators of site-specific, Hebbian alterations in synaptic efficacy such as long-term potentiation (LTP) and long-term depression (LTD). However, whether DNA methylation modulates cell-wide, non-Hebbian homeostatic adaptations like synaptic scaling and intrinsic plasticity (IP) is unclear. Whereas synaptic scaling involves bidirectional changes in postsynaptic receptor density in response to chronic alterations in neuronal activity, IP involves the activity-dependent attunement of passive and/or active membrane properties that govern action potential (AP) firing. This …

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Nadph Oxidase-Derived Superoxide: A Potentiator Of Autoimmune Responses In Type 1 Diabetes, Lindsey E. Padgett Jan 2015

Nadph Oxidase-Derived Superoxide: A Potentiator Of Autoimmune Responses In Type 1 Diabetes, Lindsey E. Padgett

All ETDs from UAB

Type 1 Diabetes (T1D) is an autoimmune disease culminating in pancreatic β-cell destruction, inducing reactive oxygen species (ROS), pro-inflammatory cytokines, and islet-infiltrating leukocutes. Macrophages, one of the first islet-infiltrating cells in T1D, secrete ROS and pro-inflammatory cytokines, which lyse pancreatic β-cells and activate diabetogenic T cells to further propagate β-cell destruction, while autoreactive CD4 T cells recruit islet-infiltrating, pro-inflammatory, M1 macrophages, and enhance CD8 T cell cytotoxicity. We previously demonstrated the importance of NADPH oxidase (NOX)-derived ROS synthesis in T1D, as Non-obese diabetic (NOD) mice lacking NOX-derived superoxide (NOD.Ncf1m1J) exhibited a delay in spontaneous and adoptive transfer of T1D. In …

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The Role Of C-Reactive Protein In Acute Kidney Injury, Melissa A. Pegues Jan 2015

The Role Of C-Reactive Protein In Acute Kidney Injury, Melissa A. Pegues

All ETDs from UAB

Acute kidney injury (AKI), which manifests as an abrupt decline in renal function, occurs in ~1% of all hospitalization. Ischemia reperfusion injury (IRI), a common cause of AKI, can occur in any situation where blood flow to the kidney is significantly reduced such as hypertensive crisis, cardiovascular surgery, and inevitably during renal transplantation. Mortality from AKI is up to 80% due to incomplete knowledge of the pathogenesis of IRI and the lack of an effective therapy. It is thought that cellular damage as a result of hypoxia signals the release of proinflammatory cytokines that lead to a systemic inflammatory response. …

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A Prospective Randomized Clinical Trial To Assess The Performance Of Microtextured Dental Implants With Or Without A Machined Collar- 1 Year Results, Elizabeth Felts Randall Jan 2015

A Prospective Randomized Clinical Trial To Assess The Performance Of Microtextured Dental Implants With Or Without A Machined Collar- 1 Year Results, Elizabeth Felts Randall

All ETDs from UAB

Aim: To assess the performance of microtextured dental implants with or without a machined collar at one year after placement. Material and Methods: Fifty-eight patients received dental implant therapy to restore missing teeth in one area of the maxilla or man-dible at the UAB Department of Graduate Periodontology. Residents in the program placed microtextured implants with a microtextured collar with microgrooves (test group) and microtextured implants with a machined collar (control group). Sites were randomized to the test group or control group. Study visit protocol was followed and implants were restored by off-site dentists. Sixty-nine (69) implants were assessed at …

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Energy Metabolism Of Platelets During Activation, Oxidative Stress And Storage, Saranya Ravi Jan 2015

Energy Metabolism Of Platelets During Activation, Oxidative Stress And Storage, Saranya Ravi

All ETDs from UAB

The principal function of platelets is to regulate hemostasis, and dysfunction of platelet aggregation or activation can lead to either excessive thrombotic or hemorrhagic complications. It has been shown that the ability to generate ATP and exposure to oxidative stress can affect platelet thrombotic potential. While platelet metabolism has been extensively studied, the importance of substrate availability and metabolic plasticity in regulating aggregation under physiological or pathological conditions is not well understood. In this dissertation, we examined the reliance of platelets on different metabolic substrates, the importance of ATP production for aggregation in response to thrombin stimulation, metabolic stress following …

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Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert Jan 2015

Glutamate And The Biology Of Malignant Glioma, Stephanie Marie Robert

All ETDs from UAB

Malignant gliomas are the most prevalent primary brain tumor. They are highly aggressive and lack effective treatment options. Standard therapy includes a combination of radiation, chemotherapy, and tumor resection; however, even with aggressive treatment, median patient survival remains a dismal 12 – 14 months after diagnosis. Research has focused on understanding the unique biological mechanisms involved in glioma growth and survival in an effort to design novel therapies to treat this devastating disease. In the unique environment of the brain, gliomas have developed the ability to grow and survive at the cost of the normal surrounding brain tissue. Glutamate, the …

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Stress, Bullying, Cortisol, And Depresive Symptoms In 9th Grade Adolescents, Susan Gordon Williams Jan 2015

Stress, Bullying, Cortisol, And Depresive Symptoms In 9th Grade Adolescents, Susan Gordon Williams

All ETDs from UAB

ABSTRACT Stress and bullying are known contributors to depressive symptoms in adolescents. Prevalence of depressive symptoms in adolescents is estimated to range from13% to 34% in recent studies. Ninth graders are in a transitional period developmentally,biologically, physically, and psychosocially. Few studies have examined the relationship between stress, bullying, and depressive symptoms from a biobehavioral perspective in 9th graders. The purpose of this study was to examine stress, bullying, and depressive symptoms including a biomarker of stress, salivary cortisol diurnal rhythm, to determine if there is mediation between the individual variables of stressful life events, perceivedstress, bullying, and depressive symptoms. The …

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Exploring The Effects Of Direct Contact Compression On Osteogenesis, Shannel Wright Jan 2015

Exploring The Effects Of Direct Contact Compression On Osteogenesis, Shannel Wright

All ETDs from UAB

Clinically, the concept of bone building being the result of mechanical adaptation in healthy individuals has been accepted since Wollf’s Law in 1892. Despite many attempts to understand this mechanism, very little is known about the role mechanical forces play on bone molecularly. Current biomechanical theory supports the concept of osteocytes and bone lining cells creating a three-dimensional network that provides biochemical signaling as a result of mechanical loading. With pressure gradient and interstitial fluid flow models being used as methods of mechanical loading, yet there are still unanswered questions about the validity of both models. The suggested solution lies …

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Nonsense Suppression In A Cftr Mouse Model And Analysis Of Animo Acids Inserted At Cftr Premature Termination Codons In Mammalian Cells, Xiaojiao Xue Jan 2015

Nonsense Suppression In A Cftr Mouse Model And Analysis Of Animo Acids Inserted At Cftr Premature Termination Codons In Mammalian Cells, Xiaojiao Xue

All ETDs from UAB

A nonsense mutation introduces a premature terminations codon (PTC) into an open reading frame (ORF) upstream of a normal stop codon and results in truncated protein production. In frame PTCs account for ~11% of all mutations that cause human genetic diseases. To treat PTC-associated disorders, one approach is to use drugs that facilitate the insertion of amino acids carried by near-cognate aminoacyl-tRNAs at PTCs. Aminoglycosides were shown to suppress nonsense mutations and restore full-length protein production. This process is also termed as readthrough. However, their low efficiency and their potential to induce ototoxicity and nephrotoxicity limits their long-term application for …

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Domain Interactions And Structural Cooperativity In Two Classes Of Drug Targets Investigated By Differential Scanning Calorimetry: I. Abc Transporters: Cystic Fibrosis Transmembrane Conductance Regulator And P-Glycoprotein; Ii. Bacillus Subtilis Nad+Synthetase., Zhengrong Yang Jan 2015

Domain Interactions And Structural Cooperativity In Two Classes Of Drug Targets Investigated By Differential Scanning Calorimetry: I. Abc Transporters: Cystic Fibrosis Transmembrane Conductance Regulator And P-Glycoprotein; Ii. Bacillus Subtilis Nad+Synthetase., Zhengrong Yang

All ETDs from UAB

PART I. Mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) cause the lethal genetic disease cystic fibrosis (CF). The most common CF-causing mutation is the deletion of F508 (F508del) in its N-terminal nucleotide binding domain (NBD1), which causes CFTR misfolding and premature degradation. By studying the in vitro thermal unfolding of the isolated NBD1 ± F508del using differential scanning calorimetry (DSC), we show that F508del significantly reduces the thermodynamic and kinetic stability of NBD1. We propose that the non-native contact between the partially denatured F508del-NBD1 and other domains may cause the misfolding of F508del-CFTR. This work …

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Computational Studies On Alpha-Synuclein In Explicit Solvent: Implications In Parkinson’S Disease, Hongyi Yang Jan 2015

Computational Studies On Alpha-Synuclein In Explicit Solvent: Implications In Parkinson’S Disease, Hongyi Yang

All ETDs from UAB

α-Synuclein (αS) is a cytosolic protein expressed at high levels in the human brain and concentrated in presynaptic nerve terminals. Although the precise nature of αS in vivo remains unclear, the aggregation of αS, from its soluble, functional forms into highly organized amyloid fibrils, has been substantially implicated in the pathology of a number of neurodegenerative diseases collectively known as synucleinopathies. The long-term goal of this project is to understand the molecular mechanisms that initiate αS oligomerization in aqueous solution. A novel computational methodology involving protein modeling and atomistic molecular dynamics (MD) simulations is used in this work. The objective …

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Socs3 Deficiency In Myeloid Cells Promotes Tumor Development, Hao Yu Jan 2015

Socs3 Deficiency In Myeloid Cells Promotes Tumor Development, Hao Yu

All ETDs from UAB

STAT3 signaling is a major intrinsic pathway for cancer inflammation owing to its frequent activation in malignant cells, and key role in regulating many genes crucial for inflammation in the tumor microenvironment. Persistently activated STAT3 increases tumor cell proliferation, survival, and invasion while suppressing anti-tumor immunity. Suppressor Of Cytokine Signaling (SOCS) proteins are negative regulators of the JAK/STAT pathway, and generally function as tumor suppressors. The absence of SOCS3 in particular leads to heightened activation of the STAT3 transcription factor. In the present study, we demonstrate that genetic deletion of SOCS3 specifically in myeloid cells significantly enhances tumor growth, which …

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Orientalism Redux: Inci Eviner’S Harem, Pinar Zararsiz Jan 2015

Orientalism Redux: Inci Eviner’S Harem, Pinar Zararsiz

All ETDs from UAB

ORIENTALISM REDUX: INCI EVINER’S HAREM PINAR ZARARSIZ (ART HISTORY) ABSTRACT This thesis examines the 2009 video Harem by Turkish artist Inci Eviner (b. 1956). Eviner’s work centralizes issues of gender in Turkish culture, the history of colonialism, and how historical location informs society at large. Eviner lives and works in Turkey, but exhibits internationally. Harem has been exhibited in Turkey, France, and England. Harem is based on a series of nineteenth-century Orientalist engravings by Antoine Ignace Melling, entitled Intérieur d'une partie du Harem du Grand-Seigneur (Interior of Part of the Harem of the Grand Signor) (1803-1819). Melling’s Harem du Grand-Seigneur …

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Nanostructured Multilayer Hydrogels Of Regulated Architecture: Synthesis And Stimuli-Responsive Properties, Oleksandra Zavgorodnya Jan 2015

Nanostructured Multilayer Hydrogels Of Regulated Architecture: Synthesis And Stimuli-Responsive Properties, Oleksandra Zavgorodnya

All ETDs from UAB

Ultrathin temperature-responsive hydrogels offer fast (in a matter of seconds) response to external stimuli and precise control over the hydrogel composition that has proven to be extremely important for bio-related applications and sensing. These hydrogels can typically uptake ~ 90% of water by volume and are capable of drastic and reversible volume change in response to applied stimuli which makes them ideal candidates to host and deliver small molecules and proteins. The multilayer hydrogels are fabricated by first covalently cross-linking hydrogen-bonded layer-by-layer (LBL) films that serve as templates for hydrogel assembly. This is followed by release of the uncross-linked polymers …

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Functional Role Of Mepe In Tooth Mineralization: Mediation By Tgf-Beta1, Angela Gullard Jan 2015

Functional Role Of Mepe In Tooth Mineralization: Mediation By Tgf-Beta1, Angela Gullard

All ETDs from UAB

Transforming growth factor-β1 (TGF-β1) is one of the most abundant cytokines of the dentin-pulp complex that regulates a broad range of biological processes related to matrix synthesis and ultimately tooth formation, including secretion and mineralization of the dentin extracellular matrix (DECM). TGF-β1 mediates odontoblast cytodifferentiation from precursor dental pulp cells, being up-regulated in odontoblasts and then incorporated into the DECM as a reservoir that can be utilized in times of mechanical, chemical, or bacterial insult. Formation of the DECM is modulated by the actions of small integrin-binding ligand N-linked glycoproteins (SIBLINGs), which include DMP-1, DSPP, BSP, SPP1, and MEPE, with …

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Hospital-Based Skilled Nursing Facilities: Predictors Of Survival And Performance, Shivani Gupta Jan 2015

Hospital-Based Skilled Nursing Facilities: Predictors Of Survival And Performance, Shivani Gupta

All ETDs from UAB

This three-paper dissertation examined the organizational and market factors predicting the response of hospital-based skilled nursing facilities (HBSNFs) to the changes in their environment such as the implementation of prospective payment system in 1998 and their role in coordination of care for patients in transition from acute care to home or a post-acute care facility. In the first study, population ecology of organizations framework was used to evaluate the organizational and market factors associated with HBSNFs’ closure after 1998. The event histories of all acute-care hospitals which had an open HBSNF in 1998 were examined across 15 years (1998-2012) to …

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G Protein-Coupled Inwardly-Rectifying Potassium (Girk) Chanels Mediate Entrainment Of Circadian Rhythms, Lauren Marie Hablitz Jan 2015

G Protein-Coupled Inwardly-Rectifying Potassium (Girk) Chanels Mediate Entrainment Of Circadian Rhythms, Lauren Marie Hablitz

All ETDs from UAB

Circadian rhythms are 24-hour cycles in biological and behavioral processes. These cycles enable an organism to predict changes in its environment, like changes in food availability and seasonality. Although endogenously driven, these rhythms can entrain or synchronize to daily changes in the environment, allowing the animal to adapt. One way entrainment occurs is shifts in circadian phase following the presentation of nonphotic, or non-light, stimuli, such as exercise, arousal, or stress at certain times of day. The molecular mechanisms underlying nonphotic entrainment are poorly understood - specifically, how nonphotic cues alter excitability within the suprachiasmatic nucleus (SCN) of the hypothalamus, …

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Nutrient Intake, Nutrient Targets And Feed Application To Promote Optimal Production And Feed Efficiency In The Sea Urchin Lytechinus Variegatus (Echinodermata: Echinoidea), Laura Elizabeth Heflin Jan 2015

Nutrient Intake, Nutrient Targets And Feed Application To Promote Optimal Production And Feed Efficiency In The Sea Urchin Lytechinus Variegatus (Echinodermata: Echinoidea), Laura Elizabeth Heflin

All ETDs from UAB

Important considerations for the development of sea urchin aquaculture will include understanding nutrition and feed management. These reported investigations contribute to knowledge of dietary protein and carbohydrate requirements in Lytechinus variegatus and feed management strategies. The first evaluation of economic feasibility of sea urchin aquaculture as related to feed costs is presented and the geometric framework (GF) to assess nutrient intake targets is first applied to cultured aquatic organisms to yield recommendations for nutrient balancing in formulated urchin feed. Data- derived models for dietary protein and carbohydrate intake predict increased rates of growth and production among urchins fed diets containing …

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Cortisol Regulation, Perceived Discrimination, And Ethnic Differences In Pain Responses Among Persons With Knee Osteoarthritis, Matthew Herbert Jan 2015

Cortisol Regulation, Perceived Discrimination, And Ethnic Differences In Pain Responses Among Persons With Knee Osteoarthritis, Matthew Herbert

All ETDs from UAB

Plasma cortisol concentrations obtained directly after the Trier Social Stress test are negatively associated with subsequent pain tolerances during the cold pressor task (CPT) among healthy non-Hispanic whites (NHWs), but not healthy African Americans (AAs). It is possible frequent exposure to perceived discrimination, a marker of chronic stress, explains this lack of association between cortisol regulation and pain tolerances among AAs. Our aim was to determine if 1) ethnic differences in pain sensitivity during the CPT could be partially explained by differences in cortisol regulation among persons with knee osteoarthritis (OA), 2) perceived discrimination was related to cortisol dysregulation, which …

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Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez Jan 2015

Infant Feeding Practices, Weight Gain, And Blood Pressure In Toddlers Born Very Preterm, Doris Rodriguez

All ETDs from UAB

Little is known about how weight gain in those born very preterm is associated with blood pressure and if cortisol, a stress biomarker, plays a mediating role. Also, the influence of infant feeding practices on weight gain has been only sporadically addressed. The purpose of this exploratory, descriptive, cross-sectional study was to examine the relationships between infant feeding practices, weight gain, and blood pressure noting any mediating effect cortisol may have between weight gain and blood pressure in 18-to-24 month old corrected age toddlers born very preterm. A convenience sample of 36 18-to-24 month old corrected age toddlers were enrolled. …

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Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes Jan 2015

Bcla As An Adjunct To Current Bacillus Anthracis Vaccination And Therapy Protocols, Juan Bosco Rodriguez Barrantes

All ETDs from UAB

Bacillus anthracis (Ba) is a Gram,-positive zoonotic bacterium that causes inhala- tional, cutaneous and intestinal Anthrax Disease. Although the infectious form of Ba is its endospore (spore), only the tripartite toxin-producing vegetative bacteria causes disease pathology. While current vaccination strategies target the Protective Antigen (PA) com- ponent of this toxin, vaccine-elicited immunity to the spore form of Ba is lacking. How- ever, vaccines targeting spore components of Ba have the potential to neutralize the in- fectious form of Ba. We sought to determine if antibodies elicited through immunization with the main antigenic component of the spore surface- Bacillus collagen-like protein …

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Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach Jan 2015

Investigating The Role Of Myristoylated Alanine Rich C Kinase Substrate's (Marcks's) Effector Domain In Lung And Brain Cancer Biology, Timothy D. Rohrbach

All ETDs from UAB

In this study, we investigated the role MARCKS's Effector Domain plays in lung and brain cancer biology. Initially, we identified that MARCKS was present in a range of lung cancer histologies including: squamous cell, adenocarcinoma, and normal lung tissues among others. In addition, lung adenocarcinoma patients with a mutation in the MARCKS gene correlated with decreased survival as determined by The Cancer Genome Atlas. In vitro studies identified that the phosphorylation status of MARCKS's Effector Domain was able to influence lung cancer radiation sensitivity. When MARCKS's Effector Domain was in a non-phosphorylated state, A549 lung cancer cell lines experienced increased …

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Responses Of Marine Benthic Invertebrates Of The Western Antarctic Peninsula To Ocean Acidification And Elevated Temperature, Julie Schram Jan 2015

Responses Of Marine Benthic Invertebrates Of The Western Antarctic Peninsula To Ocean Acidification And Elevated Temperature, Julie Schram

All ETDs from UAB

Increases in atmospheric carbon dioxide (CO2) concentrations are continuing to increase and have been linked with decreasing seawater pH as well as atmospheric and seawater warming. Warming along the western Antarctic Peninsula is occurring at one of the fastest rates recorded to date and triggering further environmental changes. To date there are few records of the current seawater pH and temperature conditions experienced by benthic organisms in this region or how they will respond to shifts in pH and temperature predicted to occur by 2100 or sooner. The primary aim of this dissertation was to pa-rameterize the current seawater carbonate …

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Role Of Vapb/Als8 Signaling Through Lar Receptor, Jessica Lindsey Winek Schultz Jan 2015

Role Of Vapb/Als8 Signaling Through Lar Receptor, Jessica Lindsey Winek Schultz

All ETDs from UAB

In humans, a P56S point mutation in the VAPB/ALS8 MSP domain is associated with amyotrophic lateral sclerosis (ALS) and late-onset spinal muscular atrophy (SMA). The N-terminal MSP domain is cleaved from the C-terminus, and secreted through an unknown, nonconventional manner. The P56S mutation inhibits secretion of the MSP domain. We use Caenorhabditis elegans to study live secretion of VPR-1, as well as to understand vMSP receptor signaling in muscle and gonad. To study the secretion mechanism of VPR-1 we created a transgenic line of C. elegans with a fluorescently tagged VPR-1. Using this model, we were able to visualize live …

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A Randomized Trial Evaluating Child Dog-Bite Prevention In Rural China Through Video-Based Testimonials, Jiabin Shen Jan 2015

A Randomized Trial Evaluating Child Dog-Bite Prevention In Rural China Through Video-Based Testimonials, Jiabin Shen

All ETDs from UAB

Dog-bite injuries pose a significant threat to children around the world. School-aged children are especially at risk of injuries because of their cognitively immature tendency toward poor perception of vulnerability regarding risky behaviors. This risk is elevated further for millions of school-aged children living in rural China due to the large number of stray dogs, all potential rabies carriers. Effective intervention programs for pediatric dog-bite injuries are sparse. Most existing programs were based on public health concerns and only involve the impartment of safety knowledge to children. They produced mixed results in changing actual behaviors with dogs. Based on the …

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The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Changes In Body Composition, Corey Noles Jan 2015

The Effects Of 6 Weeks Of High Intensity Interval Training Vs. Moderate Intensity Training On Changes In Body Composition, Corey Noles

All ETDs from UAB

THE EFFECTS OF 6 WEEKS OF HIGH INTENSITY INTERVAL TRAINING VS. MODERATE INTENSITY TRAINING ON CHANGES IN BODY COMPOSITION COREY NOLES KINESIOLOGY ABSTRACT Background: It is important to identify strategies to promote exercise adherence and to identify an optimal exercise stimulus to prevent adverse health outcomes associated with obesity. Low-volume high-intensity interval training (HIIT) has recently been shown to improve a number of cardiometabolic health outcomes similarly to moderate intensity exercise training (MIT) despite requiring 1 hr of training per week for HIIT vs 6 hrs for ET. However, less is known about HIIT and its effects on body composition. …

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An Axisymmetric Finite Element Model To Study The Earplug Contribution To The Bone Conduction Occlusion Effect, Martin K. Brummund, Franck Sgard, Yvan Petit, Frédéric Laville, Hugues Nélisse Jan 2015

An Axisymmetric Finite Element Model To Study The Earplug Contribution To The Bone Conduction Occlusion Effect, Martin K. Brummund, Franck Sgard, Yvan Petit, Frédéric Laville, Hugues Nélisse

Études primaires

An axisymmetric linear elasto-acoustic finite element (FE) model of an occluded human external ear is proposed to simulate the bone conduction occlusion effect (OE). The model consists of a cylindrical ear canal cavity surrounded by layers of biological tissues (skin, cartilage and bone) in which an earplug is inserted. Geometrical and material properties are taken from the literature. OEs are predicted for foam and silicone earplug FE-models using COMSOL Multiphysics (COMSOL®, Sweden). The FE-model is shown to predict the experimental OE measured in two healthy human reference groups wearing foam or silicone earplugs, satisfactorily. Deviations between model and experiment are …

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Survey Of Compassion Fatigue Education In Apa-Accredited Clinical And Counseling Psychology Programs, Marissa Joy Scroggins Jan 2015

Survey Of Compassion Fatigue Education In Apa-Accredited Clinical And Counseling Psychology Programs, Marissa Joy Scroggins

Antioch University Dissertations & Theses

The purpose of this study was to examine the present state of compassion fatigue (CF) education in APA-accredited clinical and counseling doctoral level training programs. It also sought to identify the number of training programs that require CF training or offer it as optional, attempted to discern the type of setting in which it is taught (class, supervision, etc.), as well as identified some of the reasons why it may not have been included (cost, time, interest, etc.) in programs without CF training. A researcher-developed survey was designed and consisted of a mixture of yes/no and multiple choice questions. Program …

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