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2015

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Exploring The Relationship Between Study Abroad And Emotional Intelligence, Michael Joshua Carter Jan 2015

Exploring The Relationship Between Study Abroad And Emotional Intelligence, Michael Joshua Carter

All ETDs from UAB

EXPLORING THE RELATIONSHIP BETWEEN STUDY ABROAD AND EMOTIONAL INTELLIGENCE MICHAEL JOSHUA CARTER EDUCATIONAL LEADERSHIP ABSTRACT Given the increased interest in the academic and behavioral impact of university study abroad programs, the possible relationship between study abroad and emotional intelligence was evaluated. A paper-based survey packet consisting of a researcher-developed demographic questionnaire and the Bar-On EQ-i: 2.0 Emotional Intelligence Quotient Inventory (EQi) was administered to a convenience sample of 144 undergraduate students, ages 19-25, at the University of Alabama at Birmingham. The total sample consisted of two groups: (1) a sample group of undergraduate students who participated in the university study …

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The Adaptive Significance Of Phenotypic Plasticity In The Wild: An Experimental Test Using The Brown Anole Lizard (Anolis Sagrei), Corey Dale Cates Jan 2015

The Adaptive Significance Of Phenotypic Plasticity In The Wild: An Experimental Test Using The Brown Anole Lizard (Anolis Sagrei), Corey Dale Cates

All ETDs from UAB

The conditions that embryos experience during development have substantial effects on offspring phenotypes and fitness. Although plastic responses to developmental environments are widespread, whether they are adaptive is unknown in most cases. Developmental plasticity is often thought to be adaptive in heterogeneous environments, but it can also enhance fitness when environments experienced by embryos provide cues for the conditions they will eventually experience later in life. Under the latter scenario, early embryonic conditions could program an individual’s physiology to appropriately deal with predictable future conditions. This hypothesis has received support in the ecological and medical literature on diverse organisms. However, …

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Intra-Oral Scanning Devices Compared To Traditional Digital Impressions, Terpsithea Christou Jan 2015

Intra-Oral Scanning Devices Compared To Traditional Digital Impressions, Terpsithea Christou

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The aim of this study is to review the state of art concerning 3D optical acquisition techniques and devices currently used in Orthodontics, and determine whether a commercial intra-oral scanner is as accurate as traditional impressions for orthodontic purposes. Materials and Methods: Records of 30 subjects were prospectively acquired and digital models were obtained using an intra-oral scanner, LythosTM by Ormco, and an extra-oral scanner, GOM ATOS Triple Scan II by GOM. Seven parameters indicating linear measurements from predetermined landmarks were measured and analyzed. Paired t tests, plots and bars and Bland and Altman Analysis were used to compare and …

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The Utilization Of Blue - Green Algae Lyngbya Recovered From Local Ponds As Natural Reinforcement Of Composite Materials, Ninfa Alejandra Constante Perez Jan 2015

The Utilization Of Blue - Green Algae Lyngbya Recovered From Local Ponds As Natural Reinforcement Of Composite Materials, Ninfa Alejandra Constante Perez

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The abundance of blue - green algae (BGAs) has created a social and industrial problem. The overgrowth of algae blooms in water bodies across the U.S. reduces the quality of water for ecological and recreational purposes. The production of algae biofuels is forecasted to exponentially grow in the coming years, but waste residual algal biomass represents a challenge to biofuel producers. This work explores possible avenues for the utilization of BGAs as an effective reinforcement of natural fiber composites. Natural fiber composites (NFCs) are of great importance for the automotive industry in applications such as interior door panels, headliners, and …

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Mechanisms Of Npy-Induced Phase Shifts And Gsk3 Modulation Of Rhythmic Molecular Clock Gene Expression, Neurophysiological Function, And Memory., Rachel Besing Jan 2015

Mechanisms Of Npy-Induced Phase Shifts And Gsk3 Modulation Of Rhythmic Molecular Clock Gene Expression, Neurophysiological Function, And Memory., Rachel Besing

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The current set of studies addresses three main hypotheses. We first tested the hypothesis that NPY-induced phase advances are accompanied by persistent suppression of core circadian clock gene PER2 and are mediated by long-term depression of neuronal excitability in a phase-specific manner. We found that NPY induced phase advances in PER2::LUC cultures, as well as decreased neuronal firing in SCN slices, are largest when NPY is given in the early part of the day and PER2::LUC phase advances were blocked by depolarization with potassium chloride, suggesting that NPY-induced phase advances are mediated by long-term depression of neuronal excitability. The second …

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Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan Jan 2015

Synthesis And Characterization Of A Collagen Based Biodegradable Polymer Initiated By Hydroxyapatite Nanoparticle For Bone Regeneration, Didarul B. Bhuiyan

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Synthetic bone graft biomaterials are considered as a potential alternative to the conventional use of bone grafts, due to their limitless supply and lack of disease transmission. Current synthetic bone graft materials generally lack the necessary combination of biological and mechanical properties for use as a bone graft substitute. Bone is a dynamic tissue that serves biological, chemical and mechanical purpose in the body and it is unlikely that a single component synthetic biomaterial can provide the appropriate combination of mechanical integrity and biological stimulation to replace bone. Multicomponent biomaterials need chemical bonding between the components to prevent phase separation …

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Exploring First-Semester Medical Student Academic Self-Efficacy: A Mixed Methods Investigation, Deborah J. Blackstone Jan 2015

Exploring First-Semester Medical Student Academic Self-Efficacy: A Mixed Methods Investigation, Deborah J. Blackstone

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Academic self-efficacy has been empirically demonstrated to be related to academic performance over a wide range of grade levels and academic settings, but little research exists examining this relationship in medical school. This study sought to fill this gap by investigating academic self-efficacy in first-semester medical students using a sequential mixed methods approach. In the first, quantitative strand, 81 first-semester medical students completed an academic self-efficacy survey during the first science-based course and again at the end of the semester. Academic self-efficacy for out of class academic tasks decreased over the semester; academic self-efficacy for in class academic tasks was …

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The Effects Of Inter-Age Class Competition On Habitat Use In A Territorial Lizard, David Michael Delaney Jan 2015

The Effects Of Inter-Age Class Competition On Habitat Use In A Territorial Lizard, David Michael Delaney

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All organisms have specific habitat requirements that allow them to properly function in the environment. However, optimal habitats often differ across age classes, and accordingly, juveniles shift habitat choice as they age. Field observations of the brown anole lizard (Anolis sagrei) suggest that juveniles perch in open-canopy areas on low vegetation whereas adults reside in forest edges on higher vegetation. I hypothesized that this age-specific habitat variation is because adults force juveniles to less preferred habitat. To address these issues, I conducted a series of experiments to examine the role of inter-age class competition in driving variation in perch use …

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Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du Jan 2015

Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du

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recommended vitamin D intake, and perceived barriers to adequate calcium intake

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The Adhd Medication Process Model: A Qualitative Investigation Of Teaching Pedagogies, Ideal Student Behavior, Labeling Processes, And Attitudes Towards Adhd Medication., Zachary Robert Simoni Jan 2015

The Adhd Medication Process Model: A Qualitative Investigation Of Teaching Pedagogies, Ideal Student Behavior, Labeling Processes, And Attitudes Towards Adhd Medication., Zachary Robert Simoni

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The number of children diagnosed with and medicated for ADHD has increased within the last decades. In this study, I assert that ADHD is a serious mental health issue with a biological etiology which in many cases is alleviated by the use of medication. However, I also argue that powerful socio-cultural forces are important to understanding ADHD and medication use in the American Educational system. Physicians and psychiatrists are responsible for assigning medication as a treatment for ADHD. Nevertheless, teachers are at the front lines of the ADHD issue and handle it on a daily basis. Despite this fact, very …

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The Influence Of Personal, Interpersonal, And Community Factors On The Parenting Self-Efficacy Of First-Time Mothers, Tamika L. Smith Jan 2015

The Influence Of Personal, Interpersonal, And Community Factors On The Parenting Self-Efficacy Of First-Time Mothers, Tamika L. Smith

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The Social Ecological Model (SEM) allows for examining human behavior and the factors that influence behavior change in totality. In addition, the model offers guidance in identifying the factors that may lead to a change in or explanation of behavior. This study utilizes SEM to identify factors at the personal, interpersonal, and community level in order to determine the relationship between specific ecological factors and parenting self-efficacy. Furthermore, the study examines the predictive quality of the ecological factors on parenting self-efficacy. Data collected from the Parenting for the First-time Project (PFT) was used. PFT is a multi-site longitudinal study of …

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Exploiting The Glioblastoma Tumor Microenvironment For Enhanced Oncolytic Herpes Simplex Virus Therapy, Tyrel Talbert Smith Jan 2015

Exploiting The Glioblastoma Tumor Microenvironment For Enhanced Oncolytic Herpes Simplex Virus Therapy, Tyrel Talbert Smith

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Gliomas are the most common and fatal malignancy of the adult central nervous system. The need for new therapeutic options is clear, as standard of care therapies only extend median survival 12-14 months beyond diagnosis. Conditionally replication-competent oncolytic herpes simplex type-1 viruses (oHSV) have emerged as promising therapeutics for treating malignant gliomas. However, two factors that contribute to the dismal prognosis of malignant gliomas, immunosuppression and invasive growth, are also thought to limit virotherapeutic efficacy. We examined these factors in tumor microenvironments to explore novel strategies to treat malignant gliomas with oHSV for improved therapeutic response. In a Phase 1b …

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The Role Of Ribosome Biogenesis In Exercise-Induced Skeletal Muscle Anabolism In Aging, Michael Stec Jan 2015

The Role Of Ribosome Biogenesis In Exercise-Induced Skeletal Muscle Anabolism In Aging, Michael Stec

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Numerous chronic medical conditions, as well as normal aging result in a significant loss of skeletal muscle mass. This has profound effects on quality of life and can increase the risk of all-cause mortality. Currently, the most potent treatment for reversing the loss of muscle mass is resistance exercise training (RT); however, the human muscle fiber growth (hypertrophy) response to this treatment is quite variable, and older adults do not respond as favorably to this treatment as younger adults. The focus of this dissertation is to elucidate the role that ribosome biogenesis plays in regulating the RT-induced hypertrophic response. We …

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The Role Of Mammalian Tribbles Homolog 3 (Trb3) In Macrophage Biology; Evidence For Reciprocal Regulation Of Macrophage Function In Foam Cell Formation, Dennis Steverson Jan 2015

The Role Of Mammalian Tribbles Homolog 3 (Trb3) In Macrophage Biology; Evidence For Reciprocal Regulation Of Macrophage Function In Foam Cell Formation, Dennis Steverson

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Atherosclerosis is disease characterized by dysregulated lipid metabolism and chronic inflammation. Macrophages are critical to the progression of the disease and are involved in the pathophysiology at all stages of the disease. In the early stages, macrophages are responsible for fatty streak formation by becoming foam cells through lipid uptake. In the later stages, macrophages contribute to the degradation of the fibrous cap and are largely responsible for chronic inflammation in atherosclerotic plaques. Tribbles homolog 3 (TRB3) is a pseudokinase that inhibits Akt activation by blocking its phosphorylation site. TRB3 is expressed on numerous cell types in the body (pancreatic …

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Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley Jan 2015

Deleterious Effects Of Hyperglycemia On Cognitive Functioning In The Cardia Study Cohort, Michele Holland Talley

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DELETERIOUS EFFECTS OF HYPERGLYCEMIA ON COGNITIVE FUNCTIONING IN THE CARDIA STUDY COHORT MICHELE LYN HOLLAND TALLEY SCHOOL OF NURSING ABSTRACT With an aging society, maintaining cognitive functioning into older age is becoming more important. Because of the impact cognitive functioning has on daily activities, any disruption may inhibit the ability to perform such daily activities successfully. To prevent disruptions, determinants of cognitive functioning must be considered. Such determinants may or may not be modifiable. Some predictors may be demographic, metabolic, or inflammatory in nature. In addition, predictors or determinants may differ based on genetic predisposition to Alzheimer’s disease. As part …

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Characterization Of The Gtpase Rac1 As An Electrophilic-Sensitive Protein In Vascular Cells, Stephanie Brook Wall Jan 2015

Characterization Of The Gtpase Rac1 As An Electrophilic-Sensitive Protein In Vascular Cells, Stephanie Brook Wall

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The GTPase Rac1 is a protein which has been shown to be dysregulated in the context of a number of inflammatory diseases including atherosclerosis. Rac1 responds to extracellular signals and is involved in cellular cytoskeletal rearrangement, reactive oxygen species generation and cell cycle progression. When activated Rac1 interacts with effector proteins on the plasma membrane. This activation has recently been shown to be modulated by redox signaling via an active site cysteine. However, it is not known whether other redox signaling compounds can modulate Rac1 activity. An important redox signaling mediator is the electrophilic lipid, 15-deoxy-Δ12,14-prostaglandin J2 (15dPGJ2). This lipid …

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Mechanisms Of Heme Oxygenase-1-Mediated Protection Against Tissue Injury, Travis David Hull Jan 2015

Mechanisms Of Heme Oxygenase-1-Mediated Protection Against Tissue Injury, Travis David Hull

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Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in the catabolism of heme, which is released by necrotic cells in injured tissue. HO-1 expression is protective in cardiac and renal injury because it coordinates the degradation of pro-oxidant heme with the generation of equimolar quantities of iron (Fe2+) and the cytoprotective mole-cules carbon monoxide and biliverdin. While many studies have demonstrated that HO-1 expression is protective in numerous disease states, relatively few have examined the specific cellular compartment(s) through which HO-1 expression confers its protective effects. Our objective was to define the cellular compartments in which HO-1 expression is critical to …

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Mechanisms Of Resistance To Oncolytic Herpes Simplex Viruses In Malignant Peripheral Nerve Sheath Tumors, Joshua Douglas Jackson Jan 2015

Mechanisms Of Resistance To Oncolytic Herpes Simplex Viruses In Malignant Peripheral Nerve Sheath Tumors, Joshua Douglas Jackson

All ETDs from UAB

Malignant peripheral nerve sheath tumors (MPNSTs) are rare but highly aggressive cancer of the peripheral nervous tissue. Median patient survival is approximately two years following diagnosis due in part to the ineffective options for treatment. As an alternative therapeutic approach to conventional radio- and chemotherapy, oncolytic herpes simplex viruses type-1 (oHSVs) have been proposed to treat MPNSTs. These oHSVs have been shown safe in clinical trials with associated tumor regression. However, there is evidence that resistance to the therapy should be anticipated in a subset of patients. Therefore, the goal of this dissertation has been to identify the primary obstacles …

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Prevalence And Determinants Of High Risk Human Papillomavirus (Hpv) Among Wives Of Migrant Workers - A Study In Far - West Nepal, Derek Johnson Jan 2015

Prevalence And Determinants Of High Risk Human Papillomavirus (Hpv) Among Wives Of Migrant Workers - A Study In Far - West Nepal, Derek Johnson

All ETDs from UAB

This dissertation research focuses on the risk factors associated with high-risk HPV infection (HR-HPV) and abnormal cervical cytology in Nepali women residing in Nepal’s Far-West district of Achham. The first part of this dissertation assesses the HR-HPV test concordance of self-collected vs. clinician-collected cervico-vaginal specimens. Of 261 women with both clinician- and self-collected cervical samples, 25 tested positive for HR-HPV, resulting in an overall HR-HPV prevalence of 9.6% (95% Confidence Interval [CI]: 6.3 – 13.8). The overall Kappa value for clinician- and self-collected tests was 0.64 (95% CI: 0.48 – 0.84), indicating a “good” level of agreement. The second part …

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Joining And Assembly With Long Fiber Thermoplastic Composites, Danila Kaliberov Jan 2015

Joining And Assembly With Long Fiber Thermoplastic Composites, Danila Kaliberov

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Thermoplastic composites are used extensively in automotive, mass transit, aerospace and other commercial industries. Current industry usage is typically limited to short fiber composites formed by injection molding processes, and continuous fiber reinforced composites through processes such as autoclave molding, filament winding etc. Long fiber thermoplastics (LFT) are a class of composites known for their specific strength, corrosion resistance, impact and damping properties, as well as high production rates, recyclability, and ability for complex part fabrication. The overall objective of this research was to investigate viability of joining and assembly with long fiber thermoplastic composites. This research deals with (1) …

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Automated Processing Of Continuous Glucose Monitor (Cgm) Data To Study Onset Of Diabetes, Aman Khatri Jan 2015

Automated Processing Of Continuous Glucose Monitor (Cgm) Data To Study Onset Of Diabetes, Aman Khatri

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Diabetes is a long term condition that causes high levels of blood glucose, and it is necessary to get a complete picture of glucose levels which can lead to better treatment decision and better glucose control. The advent of Continuous Glucose Monitoring (CGM) is helping researches to track the blood glucose levels continuously and to understand the effects of impaired glucose levels on human body which in turn can lead to better treatment of diabetes. Current CGM systems process enormous amounts of data and have limitations in regards to data accuracy, precision, and reliability of raw glucose data. The inaccuracy …

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Regulation Of Cks1 Protein Turnover In Cancer Cells, Vinayak Khattar Jan 2015

Regulation Of Cks1 Protein Turnover In Cancer Cells, Vinayak Khattar

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Cks1 is a crucial cell cycle regulator which plays pleiotropic roles in cancer cell growth and is highly expressed at both the protein, and mRNA levels, in cancer cells. In contrast, normal cells exhibit barely detectable levels of this protein, even though they express substantial Cks1 mRNA. One reason for high Cks1 protein in cancers appears to be its stabilization in these cells. Cks1 is known to be ubiquitinated and degraded by the proteasome. Coordinated ubiquitination dependent proteasomal degradation of cell cycle proteins is a major mechanism that regulates their activity. Therefore aberrant accumulation of Cks1, frequently observed in cancer, …

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Evaluation Of Sample Size Re-Estimation Procedures For Non-Inferiority Designs With Time-To-Event Outcomes, Hwasoon Kim Jan 2015

Evaluation Of Sample Size Re-Estimation Procedures For Non-Inferiority Designs With Time-To-Event Outcomes, Hwasoon Kim

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Study designs that allow sample size review may potentially save a study by identifying misspecified assumptions, modifying the planned sample size, and reinforcing the study’s power. Most sample size re-estimation (SSR) methods in non-inferiority trials have been developed for continuous or binary outcomes. In many medical domains studying cancer, heart failure, and other chronic diseases, most phase III trials use censored endpoints (e.g. survival or event-free survival). Non-inferiority designs have inherent complexity by the introduction of the non-inferiority margin and therefore understanding of strategies in these methods is essential. In our first paper, we detail the issues related to misspecification …

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Impairment Of The Gliovascular Unit In Neurological Disease, Ian Kimbrough Jan 2015

Impairment Of The Gliovascular Unit In Neurological Disease, Ian Kimbrough

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Cerebral blood flow is regulated by vasoactive molecules released by astroglial cell processes that ensheath the entire cerebrovasculature. This regulation of blood flow in response to neuronal activity is a process known as functional hyperemia. Astrocytes, along with their associated neurons and microvessels, are organized into a functional system called the gliovascular unit (GVU). The astroglial component of the GVU is integral in both regulation of blood flow and maintenance of the blood-brain barrier (BBB). In disease, this system can be disrupted. We found that glioma cells displace astrocytic processes, called endfeet, and prevent their communication with associated vessels, leading …

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An Nphp-4 Enhancer Mutagenesis Screen For Modifiers Of Cilia Phenotypes Reveals Novel Mks Alleles, Uncovers, A Specific Genetic Interaction Between Osm-3 And Nphp-4, And A Novel Ciliary Calcium Channel., Dawn Landis Jan 2015

An Nphp-4 Enhancer Mutagenesis Screen For Modifiers Of Cilia Phenotypes Reveals Novel Mks Alleles, Uncovers, A Specific Genetic Interaction Between Osm-3 And Nphp-4, And A Novel Ciliary Calcium Channel., Dawn Landis

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Nephronophthisis (NPHP) is a ciliopathy with diverse clinical features likely caused by genetic modifiers. To identify NPHP modifiers, a screen was conducted on nphp-4(tm925) mutant C. elegans to reveal mutations that exacerbate the NPHP ciliary defects. Ten loci were generated, five of which have now been identified. Three are mutations in ciliopathy genes mks-1, mks-2, and mks-5. The fourth allele (yhw66) is a missense mutation (S316F) in OSM-3, a kinesin required for cilia distal segment assembly. As in osm-3 null mutants, nphp-4(tm925);osm-3(yhw66) mutants lack distal segments, are dye-filing defective (Dyf), and have osmotic avoidance defects (OSM). The osm-3(yhw66) mutant alone …

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14-3-3 Proteins Regulate Mutant Lrrk2 Kinase Activity And Neurite Shortening, Nicholas Lavalley Jan 2015

14-3-3 Proteins Regulate Mutant Lrrk2 Kinase Activity And Neurite Shortening, Nicholas Lavalley

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Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common known cause of inherited Parkinson’s disease (PD), and LRRK2 is a risk factor for idiopathic PD. How LRRK2 function is regulated is not well understood. Recently, the highly-conserved 14-3-3 proteins, which play a key role in many cellular functions including cell death, have been shown to interact with LRRK2. In this study, we investigated whether 14-3-3s can regulate mutant LRRK2-induced neurite shortening and kinase activity. In the presence of 14-3-3θ overexpression, neurite length of primary neurons from BAC transgenic G2019S-LRRK2 mice returned back to wildtype levels. Similarly, 14-3-3θ overexpression …

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Linking Adiponectin And Autophagy In The Regulation Of Breast Cancer Metastatic Potential, Emily Libby Jan 2015

Linking Adiponectin And Autophagy In The Regulation Of Breast Cancer Metastatic Potential, Emily Libby

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Curative approaches for metastatic breast cancer remain elusive. Adiponectin is the most abundant of the adipocyte-secreted adipokines, and there is recent interest in development of adiponectin-based therapies for this disease. Yet, while multiple epidemiological studies have indicated that low levels of circulating plasma adiponectin portend poorer prognosis, recent work has reported that elevated adiponectin expression in breast tissue correlates with advanced disease. Further, isoform-specific roles of this molecule are not well understood. Thus, the overarching purpose of this work was to elucidate how adiponectin isoforms contribute to the microenvironmental regulation of the early steps of breast cancer metastasis. We show …

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The Jak/Stat Pathway In Neuroinflammatory Diseases, Yudong Liu Jan 2015

The Jak/Stat Pathway In Neuroinflammatory Diseases, Yudong Liu

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Dysregulation of the Janus Kinase/Signal Transducer and Activator of Transcription (JAK/STAT) pathway is critically involved in the pathogenesis of multiple sclerosis (MS)/experimental autoimmune encephalomyelitis (EAE). Suppressor Of Cytokine Signaling (SOCS) proteins are the negative regulators of the JAK/STAT pathway. To determine the role of SOCS3 in myeloid cells in EAE, mice with conditional SOCS3 deletion in myeloid cells (LysMCre-SOCS3fl/fl) were created and tested. LysMCre-SOCS3fl/fl mice develop a severe, non-resolving atypical form of disease, characterized by lesions and extensive neutrophil and other inflammatory cell infiltrates in the cerebellum and brainstem, elevated STAT activation, elevated cytokine, chemokine and iNOS expression, and prominent …

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Structural And Biochemical Charactereization Of Lrrk2, Zhiyong Liu Jan 2015

Structural And Biochemical Charactereization Of Lrrk2, Zhiyong Liu

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Mutations in the leucine rich repeat kinase 2 (LRRK2) gene are the most common known genetic cause of Parkinson disease (PD) , with pathogenic mutations located within each of the two catalytic cores of the protein, the GTPase and kinase domains. The most prevalent pathogenic mutation, G2019S increases kinase activity up to 5-fold, causing significant changes in the protein’s biochemical behavior. Other mutations such as R1441G and I2020T have also been demonstrated to increase LRRK2 kinase activity, however, the detailed mechanisms remains unclear. A major limitation in the field is the lack of structural information of LRRK2. This dissertation detailed …

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Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman Jan 2015

Assessment Of Antipsychotic Medication Effects On Dynamic Functional Network Connectivity In Patients With Schizophrenia, Kristin Lottman

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Schizophrenia, a psychiatric disorder affecting approximately 1% of the population, is often characterized as a disorder of dysconnectivity. Evaluation of the dysconnectivity hypothesis of schizophrenia has been extensively examined via functional neuroimaging studies in order to enhance insight into the disorder’s pathology. In particular, resting-state functional connectivity analyses have reported widespread aberrant network connectivity between brain regions in patients; however, consistencies in the directionality of abnormalities are often variable across studies. Recent investigations have begun to analyze functional connectivity dynamically as it is likely these inconsistencies may be a result of the static nature of traditional connectivity measures. In this …

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