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2015

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The Biological And Conservational Implications Of Hatchling Biology In The Kemp's Ridley (Lepidochelys Kempii) Sea Turtle, Amy Nicole Bonka Jan 2015

The Biological And Conservational Implications Of Hatchling Biology In The Kemp's Ridley (Lepidochelys Kempii) Sea Turtle, Amy Nicole Bonka

All ETDs from UAB

The Kemp’s ridley sea turtle is currently listed as critically endangered, and has a very limited range, often found along the Atlantic coast though primarily inhabiting the Gulf of Mexico, with the majority of all nesting occurring near Rancho Nuevo, Mexico. Historically, large numbers of turtles have been reported to nest at Rancho Nuevo; though numbers dropped due to egg take and by-catch in the fishing and shrimping industries. Extensive conservation efforts over the last several decades significantly increased the number of nests; however the recovery status of the Kemp’s ridley is still in question, and the continued research and …

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Preliminary Characterization Of The Microbial Community In The Bonneville Salt Flats, Garner Lansing Boogaerts Jan 2015

Preliminary Characterization Of The Microbial Community In The Bonneville Salt Flats, Garner Lansing Boogaerts

All ETDs from UAB

Hypersaline environments (salt concentrations greater than two molar) are found on all continents and represent a woefully understudied ecosystem. To date, most of the hypersaline environments studied have been either lakes (e.g. The Great Salt Lake, Utah) or deep ocean/sea brine pools (e.g. Red Sea), both of which have an abundance of accessible water for the organisms living there. However, more extreme hypersaline environments have not been characterized as thoroughly. One of these environments is the Bonneville Salt Flats (BSF) in Western Utah. The BSF is 80 square miles in size and consists of a salt crust of varying thickness …

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Transferring Virtual Reality Training To Real World Settings In Individuals With Low Vision And Dual-Sensory Impairments, Ellen Lambert Bowman Jan 2015

Transferring Virtual Reality Training To Real World Settings In Individuals With Low Vision And Dual-Sensory Impairments, Ellen Lambert Bowman

All ETDs from UAB

TRANSFERRING VIRTUAL REALITY TRAINING TO REAL WORLD SETTINGS IN INDIVIDUALS WITH LOW VISION AND DUAL-SENSORY IMPAIRMENTS ELLEN LAMBERT BOWMAN VISION SCIENCE GRADUATE PROGRAM ABSTRACT The goal of this study was to determine if individuals with low vision could learn useful visual skills in Virtual Reality and could transfer these skills to the real world. To achieve this goal, one set of Orientation & Mobility (O&M) skills, using the near lane parallel traffic surge to decide the safest timing to cross a signal controlled street, was selected. Twelve participants with vision too poor to use pedestrian signals were randomly assigned to …

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Predictive Modeling Of Ocular Surface Disease States Using Multiple Inflammatory Biomarkers, John L. Bradley Jan 2015

Predictive Modeling Of Ocular Surface Disease States Using Multiple Inflammatory Biomarkers, John L. Bradley

All ETDs from UAB

ABSTRACT Purpose The aim of this study was to adapt conjunctival impression cytology (CIC) and RNA isolation and processing procedures for gene expression analysis of ocular surface inflammatory biomarkers. The RNA yield and quality should be sufficient to enable quantitative real-time PCR of no less than 12 key target genes, with the goal of differentiating among dry eye groups. This study used the optimized inflammatory biomarker gene expression assay in a patient study to identify differences between dry eye and control participants. Materials and Methods CIC was used to collect conjunctival surface cells from 53 qualifying dry eye and control …

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Transient-State Kinetic Analysis Of The Rna Polymerase I Nucleotide Incorporation Mechanism, Francis Dean Appling Jan 2015

Transient-State Kinetic Analysis Of The Rna Polymerase I Nucleotide Incorporation Mechanism, Francis Dean Appling

All ETDs from UAB

The diversity of enzymes and the reactions which they catalyze is enormous. Careful study of enzymatic reaction mechanisms has taught us a great deal about chemical reactivity and has given us insight into the chemical and physical basis of life. One particularly ubiquitous class of enzymes, the RNA polymerases, are expressed in all forms of life. RNA polymerases are central components of nucleic acid metabolism and display a variety of distinctive enzymatic features; two points which solicit their thorough study. The central theme of this dissertation is the use of kinetic techniques to describe enzymatic reaction mechanisms. Although the main …

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Assessment Of Streams And Aquatic Organisms In The Vicinity Of Birmingham, Alabama For The Presence And Biological Activity Of Endocrine-Disrupting Chemicals, Bryan Stuart Arwood Jan 2015

Assessment Of Streams And Aquatic Organisms In The Vicinity Of Birmingham, Alabama For The Presence And Biological Activity Of Endocrine-Disrupting Chemicals, Bryan Stuart Arwood

All ETDs from UAB

Freshwater ecosystems play a central role in the environment. Through various processes such as nutrient recycling, groundwater recharging, and the attenuation of many pollutants these biological systems help to maintain environmental health. Unfortunately, many recent studies have identified emerging threats to these special environments and the life they sustain. One source of mounting concern is a group of compounds that interact with the endocrine systems of humans and wildlife. Known as endocrine disrupting chemicals (EDCs), these natural and synthetic chemicals may mimic or interfere with the action of natural hormones—thus disrupting the endocrine system. Multiple studies have reported negative effects …

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Transcriptional Regulation Of The Human Ribosomal Rna Gene, Blake L. Atwood Jan 2015

Transcriptional Regulation Of The Human Ribosomal Rna Gene, Blake L. Atwood

All ETDs from UAB

The ribosome has the major role of synthesizing almost all the proteins of the cell. One of the main structural components of the ribosome are the ribosomal RNAs 18S, 28S, 5.8S and the 5S which are bound by numerous proteins to make up a fully functional unit. In the human genome there are approximately 400 copies of the rRNA gene, which contains all but the 5S rRNA in one long transcription unit. This gene is found in tandem repeats on the acrocentric arm of chromosomes 13, 14, 15, 21 and 22. It is critical that this gene is tightly regulated …

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The I507-Atc→Att Silent Codon Change Contributes To The Misfolding Of ∆F508 Cftr, Vedrana Bali Jan 2015

The I507-Atc→Att Silent Codon Change Contributes To The Misfolding Of ∆F508 Cftr, Vedrana Bali

All ETDs from UAB

Synonymous codon changes (SCCs) do not alter the amino acid sequence of proteins, but may significantly change the phenotype. The frequency of synonymous codons is species- and gene-specific, described as codon usage bias (CUB). Over the past 50 years, research has shown that SCCs affect protein biogenesis, development of human disorders and the function of recombinant proteins developed for therapeutic applications. However, the molecular mechanisms by which SCCs alter the function of gene products are not completely understood. In Chapter 2 we summarize present knowledge in this field. The most common cause of cystic fibrosis (CF) is the deletion of …

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In- Vitro Wear Of Four Cad-Cam Materials In The Uab Wear Simulating Device, Ritika Bansal Jan 2015

In- Vitro Wear Of Four Cad-Cam Materials In The Uab Wear Simulating Device, Ritika Bansal

All ETDs from UAB

In- vitro Wear of Four CAD- CAM Materials in the UAB Wear Simulating Device RITIKA BANSAL MS IN CLINICAL DENTISTRY ABSTRACT Hybrid ceramic/polymer blocks represent a new category of CAD/CAM materials that do not require heat treatment following milled fabrication and limited clinically relevant mechanical properties of these materials are available. Purpose: This study measures the hardness, flexural strength, modulus, and wear of 3 ceramic/polymer hybrid materials (LAVA Ultimate, Enamic, and Cerasmart), 2 reference glass ceramics (IPS e.max and Celtra Duo), and 1 reference composite material (Paradigm MZ100). Methods: Flexural strength specimens (n=10) (2.5 × 2.5 × 16 mm) were …

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Innovative Dart™ Ms Applications For Rapid Opioid Detection In Ante- And Post-Mortem Specimens, Rachel Crocker Beck Jan 2015

Innovative Dart™ Ms Applications For Rapid Opioid Detection In Ante- And Post-Mortem Specimens, Rachel Crocker Beck

All ETDs from UAB

The studies presented herein were born through the observations of the challenges that are faced by forensic toxicology laboratories. While these challenges were first observed in the forensic toxicology field, they are common across clinical, workplace drug testing, and pain management laboratories alike. The challenge is how to increase efficiency without sacrificing quality. Current drug screening protocols such as immunoassays (IA), gas chromatography mass spectrometry (GC/MS), and liquid-liquid chromatography tandem mass spectrometry (LC/MS/MS) are robust but inefficient and limited, with some analyses providing only class information. These analyses when coupled require up to four days to complete for a confirmed, …

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Modulation Of The Unfolded Protein Response To Delay Apoptosis In An Autosomal Dominant Retinitis Pigmentosa Animal Model, Yogesh Bhootada Jan 2015

Modulation Of The Unfolded Protein Response To Delay Apoptosis In An Autosomal Dominant Retinitis Pigmentosa Animal Model, Yogesh Bhootada

All ETDs from UAB

Retinitis pigmentosa (RP) is a group of retinal degenerative diseases characterized by the loss of rod photoreceptor cells that can be followed by cone degeneration eventually culminating in total photoreceptor cell loss. This disease affects approximately 1.5 million people worldwide and can be transmitted in an autosomal dominant (ADRP) manner accounting for nearly 30% of all RP cases. Dominant rhodopsin mutations have been divided into class I and class II based on the folding of rhodopsin protein, thermal stability, and chromophore regeneration. A threonine-17-methionine (T17M) mutation in rhodopsin is a class II mutation, characterized by a thermal instability/folding defect and …

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The Effect Of Bone-Implant Contact And Elastic Modulus In The Biomechanical Stability Of Temporary Anchorage Devices, Ghada Nimeri Jan 2015

The Effect Of Bone-Implant Contact And Elastic Modulus In The Biomechanical Stability Of Temporary Anchorage Devices, Ghada Nimeri

All ETDs from UAB

ABSTRACT The purpose of this study was to analyze the microstrains of compact and trabecular bone caused by loading of different miniscrews at different healing times, and to compare these results to the limits of bone stability maintenance based on the Frost Mechanostat Theory. Materials and Methods: Theoretical calculations of microstrains of bone surrounding 10 different miniscrews were done. These miniscrews were considered under loading forces of 500 gm., and the microstains of both trabecular and compact bone were calculated separately when the thickness of the compact bone was at 1mm or 2mm. The microstrains were calculated at 4 different …

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Presence And Mobilization Of Staphylococcus Aureus Pathogenicity Islands (Sapis) Among Bovine Mastitis Isolates, Laura Kate Parker Jan 2015

Presence And Mobilization Of Staphylococcus Aureus Pathogenicity Islands (Sapis) Among Bovine Mastitis Isolates, Laura Kate Parker

All ETDs from UAB

Bovine mastitis is inflammation of the mammary gland that occurs in cattle, as a result of invading bacteria. Staphylococcus aureus, a causative agent of bovine mastitis, produces toxins such as the toxic shock syndrome toxin (TSST-1) and the staphylococcal enterotoxins (SEs). The genes for these toxins are coded on S. aureus pathogenicity islands (SaPIs), which are mobile genetic elements associated with virulence factors. SaPIs can be mobilized by bacteriophages, resulting in the production of transducing particles that can spread virulence factors throughout a bacterial population. This research assessed the role and prevalence of SaPIs among bovine mastitis samples. In this …

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Gsk3 Regulation Of Suprachiasmatic Neuronal Excitability And Light Entrainment, Jodi Paul Jan 2015

Gsk3 Regulation Of Suprachiasmatic Neuronal Excitability And Light Entrainment, Jodi Paul

All ETDs from UAB

Circadian rhythms are approximately 24-hour cycles in behavioral and physiological processes, such as sleep/wake cycles and cognition. In mammals, these rhythms are endogenously generated and entrained to the external light cycle by the primary circadian pacemaker, the suprachiasmatic nucleus (SCN). A hallmark characteristic of SCN neurons is the daily rhythm in the spontaneous action potential frequency, with high activity during the day and low activity at night. These SCN firing rate patterns are critical for maintaining robust, consolidated behavioral rhythms, and persistent changes in SCN neuronal activity are involved light-induced behavioral shifts. Many of the ionic components underlying daily and …

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The Mspa Nanopore As A Sensor For Dna Sequencing, Mikhail Pavlenok Jan 2015

The Mspa Nanopore As A Sensor For Dna Sequencing, Mikhail Pavlenok

All ETDs from UAB

Nanopore sequencing is a novel and promising DNA sequencing method. This single molecule technique is capable of long reads, retains epigenetic information, and is inexpensive and fast. In this method ionic current is measured while single-stranded DNA is electrophoretically translocated through a nanometer-scale pore. Each passing nucleotide blocks current with characteristic amplitude and duration which are used to identify DNA sequence. MspA is the primary porin of M. smegmatis and mediates the diffusion of small, hydrophilic nutrients across the outer membrane. MspA is an octameric, channel-forming protein and represents the founding member of a new class of mycobacterial outer membrane …

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Exploiting Novel Interactions With Parp1 In Dna Repair Proficient Human Breast Cancers, Jennifer Anne Stanley Jan 2015

Exploiting Novel Interactions With Parp1 In Dna Repair Proficient Human Breast Cancers, Jennifer Anne Stanley

All ETDs from UAB

Breast cancer remains the most frequently diagnosed cancer amongst women worldwide. Despite advances in treatment, patients with more aggressive basal-like and HER2-positive cancer experience high rates of recurrence and necessitate novel therapeutic approaches. A class of inhibitors targeted against poly (ADP-ribose) polymerases (PARP), important DNA repair proteins, are effective in cancers with a defective DNA repair response. As such, extensive preclinical and clinical research has examined their efficacy in these cancers. Although this data is promising, it is only applicable to a lim-ited patient population. The main goal of this dissertation is to expand the utility of these well-tolerated drugs …

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C-Reactive Protein, Autoimmunity, And Inflammation In The Central Nervous System, Tyler T. Wright Jan 2015

C-Reactive Protein, Autoimmunity, And Inflammation In The Central Nervous System, Tyler T. Wright

All ETDs from UAB

C-reactive protein (CRP) is an acute phase reactant whose blood concentration rises in response all types of inflammation. And while CRP is widely used as a clinical marker of inflammation, it has several biological functions, e.g. activation of the classical complement cascade and binding Fcγ receptors in order to mediate multiple immune processes. The full extent of CRP’s physiological activities has not yet been fully elucidated, but there is significant evidence to establish that CRP plays an important role in the onset and progression of autoimmune disease. Seminal work from our lab showed that human CRP, hepatically expressed in transgenic …

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Examination Of The Dynamic Assembly Equilibrium For E. Coli Clpb, Jiabei Lin Jan 2015

Examination Of The Dynamic Assembly Equilibrium For E. Coli Clpb, Jiabei Lin

All ETDs from UAB

As a member of the Clp/Hsp 100 chaperone family, Escherichia coli ClpB is able to disaggregate denatured proteins with assistance of DnaKJE co-chaperones to help cell survive under stress. However, the working mechanism of ClpB disaggregation activity remains unclear. The active structure of ClpB is shown to be a hexameric ring and ATP binding and hydrolysis are required for ClpB to perform its chaperone activity. Thus, studying the energetics and kinetics of the ATP linked ClpB assembly equilibrium is essential for the quantitative examination of ClpB - protein substrate interaction to fully reveal its disaggregation mechanism. ATPgS (a slowly hydrolysable …

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Customizing Course Redesign And Flipped Classroom Models To Improve Learning Environment, Taeil Yi, Jerzy Mogilski Jan 2015

Customizing Course Redesign And Flipped Classroom Models To Improve Learning Environment, Taeil Yi, Jerzy Mogilski

School of Mathematical & Statistical Sciences Faculty Publications

This article is about a successful adoption of course redesign model of mathematics courses at the Department of Mathematics in the University of Texas at Brownsville (UTB), a Hispanic serve university in the south Texas. Around 2007 National Center for Academic Transformation (NCAT) recommended six models for using of information technology to redesign courses in mathematics: the supplemental model, the replacement model, the emporium model, the fully online model, the buffet model, and the linked workshop model. Because of the local educational environment and resources none of the six models could be implemented exactly like it was described by NCAT. …

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Troxel Revisited: A New Approach To Third Party Childcare, Jeffrey A. Parness Jan 2015

Troxel Revisited: A New Approach To Third Party Childcare, Jeffrey A. Parness

Faculty Articles, Papers, and Other Scholarship

In 2000 in Troxel v. Granville, four United States Supreme Court justices determined that the “liberty interests of parents in the care, custody, and control of their children” generally foreclose states from compelling requested grandparent childcare over current parental objections. Yet, these four justices recognized that “special factors” might justify judicial interference as long as the contrary contemporary wishes of parents were accorded “at least some special weight.” The plurality, and one concurring justice, reserved the question of whether any “nonparental” visitation, presumedly also encompassing stepparents, siblings and others, must “include a showing of harm or potential harm to the …

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Association Between Toxocariasis And Cognitive Function In Young To Middle-Aged Adults, Bruce L. Brown, Lance D. Erickson, Shawn D. Gale, Andrew Berrett, Dawson W. Hedges Jan 2015

Association Between Toxocariasis And Cognitive Function In Young To Middle-Aged Adults, Bruce L. Brown, Lance D. Erickson, Shawn D. Gale, Andrew Berrett, Dawson W. Hedges

Faculty Publications

The ascarid nematodes Toxocara canis (Werner, 1782) and Toxocara cati (Schrank, 1788) may infect humans resulting in toxocariasis. A prior study associated species of Toxocara Stiles, 1905 with cognitive deficits in children. To determine if a similar association between toxocariasis and cognition exists in adults, we analysed a large dataset from the United States’ Center for Disease Control’s National Health and Nutrition Examination Survey. We used linear-regression and multivariate models to examine the association between toxocariasis as assessed by the presence of anti-Toxocara IgG antibodies and three measures of cognitive function – simple reaction time (SRT), symbol-digit substitution (SDS) and …

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Modeling Light Gas And Tar Yields From Pyrolysis Of Green River Oil Shale Demineralized Kerogen Using The Chemical Percolation Devolatilization Model, Daniel Barfuss, Ronald J. Pugmire, Thomas H. Fletcher Jan 2015

Modeling Light Gas And Tar Yields From Pyrolysis Of Green River Oil Shale Demineralized Kerogen Using The Chemical Percolation Devolatilization Model, Daniel Barfuss, Ronald J. Pugmire, Thomas H. Fletcher

Faculty Publications

Recent detailed chemical structure analyses of three demineralized kerogens from Green River oil shale samples were used to generate input parameters for the chemical percolation devolatilization (CPD) model. This model uses a lattice network to describe pyrolysis of solid hydrocarbons, such as coal and biomass. It was necessary to modify the formulation of the CPD model to account for the long aliphatic carbon chains found in oil shale, because gases formed from these long chains condense at room temperature and are counted as tar. It was initially assumed that 20% of the aliphatic material was released as light gas during …

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Socioeconomic Status And Health: Education And Income Are Independent And Joint Predictors Of Ambulatory Blood Pressure, Wendy C. Birmingham, Jenny M. Cundiff, Bert N. Uchino, Timothy W. Smith Jan 2015

Socioeconomic Status And Health: Education And Income Are Independent And Joint Predictors Of Ambulatory Blood Pressure, Wendy C. Birmingham, Jenny M. Cundiff, Bert N. Uchino, Timothy W. Smith

Faculty Publications

Epidemiological research suggests that different indicators of socioeconomic status (SES) such as income and education may have independent and/or interactive effects on health outcomes. In this study, we examined both simple and more complex associations (i.e., interactions) between different indicators of SES and ambulatory blood pressure (ABP) during daily life. Our sample consisted of 94 married couples who completed a one-day ABP protocol. Both income and education were independently related to systolic blood pressure and only income was significantly related to diastolic blood pressure. There were also statistical interactions such that individuals with high levels of both income and education …

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The Dependability Of Electrophysiological Measurements Ofperformance Monitoring In A Clinical Sample: A Generalizability Anddecision Analysis Of The Ern And Pe, Scott A. Baldwin, Michael J. Larson, Peter E. Clayson Jan 2015

The Dependability Of Electrophysiological Measurements Ofperformance Monitoring In A Clinical Sample: A Generalizability Anddecision Analysis Of The Ern And Pe, Scott A. Baldwin, Michael J. Larson, Peter E. Clayson

Faculty Publications

Psychometric studies of the ERN, CRN, Pe, and Pc ERPs are increasing. Coherent integration of these results is difficultwith classical test theory because the definition of error depends on the measure of reliability. This study usedgeneralizability theory, which extends the ideas of classical test theory, as a framework for evaluating the influence ofpsychopathology and number of trials on dependability of measurement. Participants included 34 people meeting criteriafor major depression, 29 meeting criteria for an anxiety disorder, and 319 controls. For all ERPs, within-person variancewas larger than between-person variance across groups, indicating many trials are needed for adequate dependability (atleast 13). …

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Ebola Preparedness - An Ed Perspective, Bettina Laier Jan 2015

Ebola Preparedness - An Ed Perspective, Bettina Laier

All Publications

No abstract provided.

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Phonosys: Mobile Phonocardiography Diagnostic System For Newborns, Amir Mohammad Amiri, Giuliano Armano, Amir Mohammad Rahmani, Kunal Mankodiya Jan 2015

Phonosys: Mobile Phonocardiography Diagnostic System For Newborns, Amir Mohammad Amiri, Giuliano Armano, Amir Mohammad Rahmani, Kunal Mankodiya

Electrical, Computer, and Biomedical Engineering Faculty Publications

Heart murmurs have been found to be a life threatening condition for the newborns who are born with cardiac abnormalities. The first sign of pathological changes of heart valves appears in phonocardiogram which contains very useful information about cardiovascular system. It is a challenging venture to distinguish pathological murmurs from innocent ones. In this paper we have developed a diagnostic algorithm called PhonoSys to analyze PCG using random forest. PhonoSys algorithm will run on mobile devices for remote PCG analysis. We recorded PCG signals from 120 newborns who are either healthy or with cardiac abnormalities. Eventually, in this study, 97.6% …

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Modeling Onsite Wastewater Treatment System Contaminants In Current And Climate Changing Conditions, Ivan Morales Parra Jan 2015

Modeling Onsite Wastewater Treatment System Contaminants In Current And Climate Changing Conditions, Ivan Morales Parra

Open Access Dissertations

The use of onsite wastewater treatment system (OWTS) is a common practice in the U.S., especially in rural areas where the access to centralized wastewater treatment systems is limited. Onsite wastewater treatment systems include a soil treatment area or drainfield where contaminants are removed or attenuated. Ineffective OWTS are a source of microbial pathogens (bacteria and viruses), biological oxygen demand (BOD) and nutrients, which are among the major causes of contamination and water quality impairments in surface water in the U.S. The main objective of this research was to model the different chemical, physical processes, and removal mechanisms that influence …

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Casimir Effect Modified Surface Energy Of A Nanocavity In Homogeneous Media, Yi Zheng, Arvind Narayanaswamy Jan 2015

Casimir Effect Modified Surface Energy Of A Nanocavity In Homogeneous Media, Yi Zheng, Arvind Narayanaswamy

Mechanical, Industrial & Systems Engineering Faculty Publications

We determine the regularized van der Waals contribution to pressure within a spherical cavity of vapor in a homogeneous, isotropic, infinite medium. The spherical Hamaker function, , has been defined, for the first time, in contrast to the conventional Hamaker function for planar surfaces, . For the materials under consideration, the pressure inside the cavity varies as , where a is the radius of the cavity. For radii below a transition radius, the surface energy (or surface tension) becomes size dependent and could have important implications for homogeneous nucleation of nanosized bubbles in liquids, as well as cavitation of bubbles.

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Causes And Consequences Of Ecosystem Service Regionalization In A Coastal Suburban Watershed, Wilfred M. Wollheim, M. B. Green, B. A. Pellerin, Nathaniel B. Morse, Charles S. Hopkinson Jan 2015

Causes And Consequences Of Ecosystem Service Regionalization In A Coastal Suburban Watershed, Wilfred M. Wollheim, M. B. Green, B. A. Pellerin, Nathaniel B. Morse, Charles S. Hopkinson

Faculty Publications

The demand for ecosystem services and the ability of natural ecosystems to provide those services evolve over time as population, land use, and management practices change. Regionalization of ecosystem service activity, or the expansion of the area providing ecosystem services to a population, is a common response in densely populated coastal regions, with important consequences for watershed water and nitrogen (N) fluxes to the coastal zone. We link biophysical and historical information to explore the causes and consequences of change in ecosystem service activity—focusing on water provisioning and N regulation—from 1850 to 2010 in a coastal suburban watershed, the Ipswich …

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Long-Term Characterization Of The Chronic Dopamine Microelectrode And Effect Of Electrical Conditioning, Eric P. Marr Jan 2015

Long-Term Characterization Of The Chronic Dopamine Microelectrode And Effect Of Electrical Conditioning, Eric P. Marr

EWU Masters Thesis Collection

Background: Dopamine (DA) is a neurotransmitter involved in movement, reward learning and addiction. Fast-scan cyclic voltammetry (FSCV) has long been an indispensable tool for monitoring real-time DA signaling. Development of polyimide fused silica-encased FSCV microelectrodes have made the technique more suitable for chronic DA monitoring (months) in vivo. Methods: In this study, electrically stimulated DA signals were evoked weekly in an effort to characterize the recovery time and stability of DA signals recorded long-term with silica-encased chronic DA microelectrodes. Additionally, electrical conditioning (etching), previously shown to improve microelectrode sensitivity in vitro, was performed to investigate the long-term impact on DA …

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