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Patent Scope And Enablement In Rapidly Developing Arts, Alan L. Durham

Articles

The claims of a patent and its enabling disclosure must be commensurate in scope However because of the openended nature of most patent claims in fields of rapidlydeveloping technology it is almost inevitable that before the patent has expired the claims will read on embodiments that the specification does not teach The current law on scope enablement is the source of much confusion Because enablement must be judged from a filingdate perspective some cases dismiss later advancements eg a newlydiscovered species within a claimed genus as irrelevant Other cases in contrast hold patent claims invalid because they exceed the scope …

Interdisciplinary Connections Between Science & Theatre, Jessica N. Dotson

Theses and Dissertations

Abstract

INTERDISCIPLINARY CONNECTIONS BETWEEN SCIENCE & THEATRE

Jessica Nicole Dotson

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Fine Arts at Virginia Commonwealth University.

Virginia Commonwealth University, 2015.

Major Director: Dr. Noreen C. Barnes, Director of Graduate Studies, Associate Professor of Theatre

In the 1990s, astronomer Peter Usher was searching for new ways to teach his introductory astronomy class at Pennsylvania State University. He began to engage his students by searching for astronomical connections from other disciplines. His focus was turned to the arts, especially the works of William Shakespeare. Usher found, while …

Growing Up In Ireland: Factors Impacting Sleep Patterns Of Preterm Infants, Joanne Fallon

Theses and Dissertations

GROWING UP IN IRELAND: FACTORS IMPACTING SLEEP PATTERNS OF PRETERM INFANTS

By Joanne Fallon MS, OT, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2015.

Major Director: Shelly J. Lane, PhD, Professor, Department of Occupational Therapy

Preterm infants represent the largest child patient group in the European Union (EU), accounting for 5.5-11.4% of all births (European Foundation for the Care of Newborn Infants, 2011b). Preterm birth is defined as birth prior to 37 weeks gestation. Infants born late preterm (34-36 weeks) are considered more …

The Use Of Antibody-Coated Latex Beads To Determine Single Positive And Double Positive Mouse Spleen Cells Expressing Cd5 And/Or Cd19 Glycoproteins, Abdulrazzag Abdulaziz Othman

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Flow cytometry is the standard method used to diagnose, stage, and monitor patients' response to the treatment given by counting the numbers of CD5, CD19 and CD5+ CD19+ B lymphocytes. In this study, a comparison was done between numbers of single CD5+, single CD19+ and dual CD5+ CD19+ mouse spleen B lymphocytes using flow cytometry and antibody-latex beads. The bead method involved antibody-coated latex bead and yielded results similar to those of flow cytometry. For cells exhibiting both markers (CD5+ CD19+), the bead method used antibody-coated beads of two different colors yielded similar results to those of flow cytometry results. …

Efficacy Of Mastery-Based And Autonomy-Supportive Neuroanatomy Curriculum In Graduate Level Human Neurobiology Course, Corin Wolfgang Magee

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Anatomy provides scientists with a common vocabulary for discussing the human body, and is, therefore, an important aspect of science education. Literature shows that traditional teaching methods may be enhanced by the employment of mastery-based learning in an autonomy-supportive environment. The present study sought to determine the effects of these teaching strategies on the learning of neuroanatomy in a graduate neurobiology course.

These results show students learned and reportedly enjoyed learning a large amount of neuroanatomy. Experimentally taught students who completed the curriculum did well on the 30-item neuroanatomy quiz (mean score 81%), which was administered at the end of …

Water Quality Of The Upper Little Miami River Watershed In Ohio: Impacts Of Natural And Anthropogenic Processes, David Allan Huff

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Stream water quality is increasingly threatened by expanding anthropogenic activities, mainly through point source discharges and urban and agricultural runoffs of contaminants getting through a water body's watershed resulting in pollution. Concerns developed as to whether urban or agricultural type activities were causing most water quality impairment issues in the upper Little Miami River watershed in southwest Ohio.

Characterizing the upper Little Miami River (LMR) watershed with respect to water chemistry and Land Use/Land Cover (LULC) while evaluating the sources of any higher than expected natural parameter concentrations, with a strong emphasis on the nutrients phosphorus and nitrate, serves as …

Mechanisms Of Hyperglycemia-Induced Ros Production In Osmotically Swollen Glial Cells, Augusta K. Eduafo

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Cerebral edema is a potentially fatal complication of diabetes. There is evidence for increased Reactive Oxidative Species (ROS) production during cerebral edema in diabetics. This can lead to oxidative stress, thought to contribute to the onset and progression of diabetes and can cause cell injury and cell death. ROS, in moderate amounts, are involved in physiological processes within the body that produce favorable cellular responses. Unfortunately, high levels of ROS can lead to cellular damage of lipids, membranes, proteins and DNA. Hyperglycemia can cause an increase in ROS production due to activation of NADPH oxidases. The purpose of this study …

Regulation Of Motoneuron Firing Properties: Intrinsic And Circuit-Based Mechanisms, Adam S. Deardorff

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Body and limb movements are controlled by regulating the activity of motor pools and their constituent motoneurons. An extensive complement of tightly regulated ion channels and second messenger systems determine active motoneuron spiking behavior, while segmental propriospinal circuits ensure the faithful execution of motor commands by providing real time sensory feedback to motoneurons and other somatosensory centers. However, current mechanistic understanding is incomplete for critical factor regulating motoneuron firing properties. Fundamental gaps in knowledge exist regarding (a) the spatial distribution and organization of specific ion channels in motoneurons, (b) the contribution of specific channels to motoneuron intrinsic properties, (c) the …

Connectivity Of Monosynaptic Ia Afferents On Renshaw Cells In Neonatal Mice, Todd Joseph Rapetti

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Proprioception allows sensory information about muscle position and length to enter the CNS without the aid of visual cues. One type of fiber that carries this information is the Ia afferent, which innervates muscle spindles that respond to mechanical perturbation in muscle. Ia fibers are known to synapse with Ia interneurons (INs) and motor neurons (MNs), setting up important circuits which affect movement. Another type of IN is the Renshaw cell (RC), which is located in the ventral part of lamina VII of the spinal cord and is critical for the functionality of the recurrent inhibitory circuit. In addition to …

Evaluating Threats To The Rare Butterfly, Pieris Virginiensis, Samantha Lynn Davis

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Humans have caused drastic changes in ecosystems and communities through their modification of the natural landscape. Rare species, often highly specialized, are more impacted by these changes. Pieris virginiensis is a rare butterfly native to eastern North America that is a species of concern due to negative influences from habitat loss and plant invasion. This thesis discusses several threats to P. virginiensis, including habitat loss, climate change, competition, and the cascading effects of a novel European invasive plant, Alliaria petiolata, that attracts oviposition but does not allow for larval survival.

First, I examined a local extinction event and …

World-Wide Body Size Patterns In Freshwater Fish By Geography, Size Class, Trophic Level, And Taxonomy, Shishir Adhikari

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The unifying themes of my thesis are patterns in world-wide freshwater fish body sizes and their underlying mechanisms. First, I explored Bergmann's rule in unprecedented detail, which states that body size is negatively correlated to temperature. Categorizing species by body size into quantiles and by trophic levels, I regressed the classes against latitude, temperature, seasonality, minimum temperature and habitable space. I found that Bergmann's rule applies to freshwater fish in general but the strength varies by size class and trophic levels. I concluded that Bergmann's rule in fish is driven by the exclusion of small fish from cold climate due …

Testing In Adoption Evaluations: Selections And Usage Determined From Surveying Psychologists, Erin Marie Sylvester Nichting

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A significant amount of children are adopted each year both within the United States and internationally. In fact, the United States Department of State reported that 242,602 international adoptions had taken place from 1999 to 2012 and also indicated that in 2012 alone, 52,035 children had been adopted domestically. However, research is lacking in many areas of the adoption process. One such area includes an absence of knowledge in regards to adoption evaluations, even though they may be required for both prospective parents and adoptive children during the adoption process. Another area includes how psychological instruments are incorporated into these …

The Effectiveness Of "The Tunnel Of Oppression": An Exposure Approach To Increasing Awareness Of Oppression Among Freshman Students At Wright State University, Jennifer B. Stoyell

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While diversity-training programs have gained popularity in the US, limited research has been done to establish the effectiveness of these programs in increasing awareness of oppression. The present study explored the effectiveness of the Tunnel of Oppression in increasing awareness of oppression among freshman students at Wright State University. Participants (N= 1736) were given a survey before and after participating in the Tunnel where they rated their awareness of levels of oppression for nine different oppressed groups. Data for this survey was analyzed employing descriptive and non-parametric statistics to determine significance in change of scores (Wilcoxon Signed-Rank and Wilcoxon Rank-Sum) …

Purification Of Recombinant Δ Np63 Α And Characterization Of Peptide Binding, Amal Abdulah Albati

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δ NP63α, the primary p63 isoform of the p53 transcription factor family, is a proto-oncogene implicated in non-melanoma skin cancers. Expressed in the basal layer of the epidermis, δ NP63α promotes cell survival and proliferation. Inhibition of this protein could potentially be beneficial in non-melanoma skin cancer patients. The first goal of this project was the purification of recombinant δ NP63α in Escherichia Coli. Recombinant δ NP63α was expressed as GST-δ NP63α followed by GST cleavage using GST trap affinity column chromatography yielding pure δ NP63α The second objective of this project was to test the binding capabilities of peptides …

Factors Determining The Effects Of Human Interaction On The Cortisol Levels Of Shelter Dogs, Regina M. Willen

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Dogs admitted to animal shelters experience psychological stressors resulting in elevated plasma cortisol. We previously found 30 min of human interaction reduced this response. The present study further characterized this effect, with the aim of developing a practical means of reducing stress of shelter dogs. We found that a second day of 30 min of petting reduced cortisol levels as effectively as the first. Further, 15 min of this interaction was as effective as 30 min. During petting, signs of excitation (vocalizations) and anxiety (panting) as well as escaped attempts were reduced, and social solicitation (tail-wagging) increased. However, cortisol levels …

A Novel Function For Fancj Helicase In Microsatellite Stabilization During Replication Stress, Joanna Barthelemy

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Noncanonical DNA structure-forming sequences, such as hairpin structures, stall replication forks in vivo, expand or contract during DNA replication, and colocalize with chromosome fragile sites. Since the frequency of hairpin formation is higher than the frequency of expansion or contraction, the cell may possess mechanisms to resolve hairpin structures prior to replication fork stalling. One possible activity for hairpin resolution is the FANCJ DNA helicase, known to unwind noncanoncial DNA structures in vitro. Indeed, mutations or loss of any of the nineteen FANC genes, including FANCJ, leads to genome instability and the cancer-prone syndrome Fanconi anemia (FA). To test whether …

Accelerated Degradation Of Chlorinated Solvents By Nanoscale Zero-Valent Iron Coated With Iron Monosulfide And Stabilized With Carboxymethyl Cellulose, Shirin Ghahghaei Nezamabadi

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Nanoscale zero-valent iron (nZVI) injections have proven to be a promising approach for the remediation of aquifers contaminated by chlorinated organic pollutants. This study compares the efficacy of nZVI in sulfidated and unamended forms in degrading selected chlorinated hyrocarbons (CHCs). Results show that nZVI amended with iron monosulfide (FeS) increases the rate of dechlorination of CT, CF and 1,1,1-TCA compared to that by unamended nZVI. The focus of this research was to characterize degradation kinetics and degradation byproduct distributions of CT, CF and 1,1,1-TCA by nZVI coated by iron monosulfide, which is represented as nZVI/FeS. To prevent nZVI particles from …

Silver Nanoparticles: The Immediate Benefits Of Low Bacterial Resistance And The Long-Term Risk Of Persistent Stress In Mammalian Cells, David Harold Ellis

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Silver nanoparticles (AgNPs) are the fastest growing sector of nanotechnology, due mostly to their antibacterial properties. The antibacterial effectiveness of AgNPs is well known and derives from the shedding of silver ions which have multiple antibacterial targets in the bacterial cell. Due to their continuous release of ions and demonstrated antibacterial potency, some predict that AgNPs have a low potential for resistance development, which would make them a valuable asset in wound management. The ability for AgNPs to cause oxidative imbalance in mammalian cells is also well known, but the potential long-term impact of such a stress has not been …

Design Of A Low-Cost Wireless Nirs System With Embedded Linux And A Smartphone Interface, Diogo Da Silva Dias

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Wireless near-infrared spectroscopy (NIRS) systems can help to reduce movement artifacts, and distraction due cables. Utilizing Embedded Linux (EL) can reduce size, development time, cost of a project and allow portability. The goal of this project is to develop a low-cost wireless small-sized NIRS system using EL and a Smartphone as the interface. This was achieved using a BeagleBone Black (BBB) with a deployed custom EL that: (1) controls two sources, (2) receives data from photodetectors (PDs), (3) processes, stores and transmits data via Bluetooth to an Android Smartphone. This device was implemented in under US$150 and its dimension was …

The Effect Of Scalp Tissue On Current Shunting During Anodal Transcranial Direct Current Stimulation (Tdcs), Mark Patrick Jackson

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Transcranial Direct Current Stimulation (tDCS) has been used to treat various mental and neurological illnesses. Rodent models have been used to examine physiological changes in the brain after tDCS, as well as to develop safety standards. However, most animal tDCS studies implant an electrode on the brain, potentially altering the path of current during stimulation. Additionally, no studies have been completed specifically examining maximum safe anodal tDCS limits, and a pilot study conducted to determine an electrode montage to examine biological changes of learning and memory from anodal tDCS indicated brain lesion was occurring before a commonly cited lesion threshold …

Differences In Fecal Metabolite Profiles From Geographically Distinct Populations Of Adolescents, Jessica Moncivaiz

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Microbiota of the gastrointestinal tract have a variety of functions within the human body. They participate in protection of the host from pathogens, aid in immune system development and regulation, and carry out a variety of metabolic functions. This study focuses on the ability of gut microbiota to create metabolites through the degradation of food products. Using 1H NMR on fecal water extracts, I compared the metabolite profiles of two geographically distinct cohorts: healthy adolescents from Egypt (n=28) and healthy adolescents from the United States (n=14). Multivariate statistical analyses of binned NMR data confirmed that samples separated into groups corresponding …

Effects Of Agricultural Land Use On Stream Fish Communities In Ohio, Usa, Blythe Hazellief

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Ohio is a state dominated by agricultural land use. Such land use may directly alter stream waters and instream habitat, which may, in turn, affect fish communities. To examine the effects of agricultural land use on Ohio stream fish communities, I analyzed data compiled by the Ohio EPA, spanning 15 years and including 2,474 statewide sites. For 253 of these sites, I derived land use profiles from the 2011 USGS National Land Cover Database. While habitat quality was not correlated with agriculture, nutrient concentrations, alkalinity and total dissolved solids were positively correlated with agricultural land use within the catchment. Fish …

A Quasi-Experimental Study On The Impact Of Explicit Instruction Of Science Text Structures On Eighth-Grade English Learners' And Non-English Learners' Content Learning And Reading Comprehension In Three Inclusive Science Classrooms, Jelitza Rivera

Electronic Theses and Dissertations

The focus of this quasi-experimental study was to examine the impact of explicit instruction of science comparison and contrast macro text structures plus micro text structures on the content learning, sentence comprehension, and reading comprehension of eighth-grade English Learners (ELs) and non-English Learners (non-ELs) in three inclusive science classrooms. Although the results of this study did not show significant differences between groups in sentence comprehension, reading comprehension, or science content learning, the treatment group increased and maintained their science content learning scores over time, while the scores of the comparison group declined from post-test to delayed post-test. In addition, the …

Vertical Distribution Of Wetland Plant Roots And Their Associated Bacteria In Groundwater-Fed Wetlands, Jennifer Diane Bailey

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As part of the effort to understand the community structure of bacteria and archaea in groundwater fed wetlands, the vertical distribution of plant root density and species presence was studied in correlation with the change in associated bacterial and archaeal communities. Three sampling sites at a local groundwater fed wetland were selected based on surface plant community structure: Site 1 was dominated by Carex stricta, site 2 was dominated by Eleocharis erythropoda, and site 3 was dominated by a 50/50 mix of C. stricta and E. erythropoda. Core samples at 4 depths down to 1.2 m were taken to collect …

Neural Correlates Of Convergence Eye Movements In Convergence Insufficiency Patients Vs Normal Binocular Vision Controls: An Fmri Study, Chirag Bharatkumar Limbachia

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Convergence Insufficiency is a binocular vision disorder, characterized by reduced ability of performing convergence eye movements. Absence of convergence causes, eye strain, blurred vision, doubled vision, headaches, and difficulty reading due frequent loss of place. These symptoms commonly occur during near work. The purpose of this study was to quantify neural correlates associated with convergence eye movements in convergence insufficient (CI) patients vs. normal binocular vision (NBV) controls, and to examine statistical differences between them. Functional magnetic resonance imaging (fMRI) scans were collected using a 3T Siemens scanner. A disparity-driven convergence task was designed using a standard block design approach, …

Effects Of Sleep Deprivation On Performance In A Water Radial Arm Maze (Wram) Task, Saline Hughes

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Sleep deprivation causes many adverse effects on work performance. Many experiments in both human and rodent models reveal detriments that sleep deprivation has on learning and memory, including performance in a water radial arm maze (WRAM) task. This study utilizes the modified multiple platform method (MMPM) of sleep deprivation; rats were sleep deprived in order to study memory errors they may make during the WRAM task. The findings indicate that 6 hours of sleep deprivation for 2 five-day week periods did not affect performance in the WRAM task except on the initial day compared to the large platform group. The …

Facilitating Effective Communication Between First Responders And Older Adults During Fall Incidents, Krystin M. Beeman, Erica L. Berger, Isabel A. Cabezas, Nicole M. Mathews

Student Research Posters

PURPOSE. The purpose of this project was to provide first responders with communication strategies for older adults that may help when responding to fall- related calls. General information was also provided to First Responders on working with older adults with a focus on the aging process, fall risk factors, and communications strategies.

METHODS. A series of educational sessions to first responders at a local fire district were developed and presented by occupational therapy students. Materials were developed by presenters from evidence-based resources and tailored to the target population. Each presentation focused on statistics about older adults, the aging process, fall …

Freedom Of The Church And Our Endangered Civil Rights: Exiting The Social Contract, Robin West

Georgetown Law Faculty Publications and Other Works

In this comment I suggest that the “Freedom of the Church” to ignore the dictates of our various Civil Rights Acts, whether in the ministerial context or more broadly, created or at least newly discovered by the Court in Hosanna-Tabor, is a vivid example of a newly emerging and deeply troubling family of rights, which I have called elsewhere “exit rights” and which collectively constitute a new paradigm of both institutional and individual rights in constitutional law quite generally. The Church’s right to the ministerial exception might be understood as one of this new generation of rights, including some …

Precipice Regulations And Perverse Incentives: Comparing Historic Preservation Designation And Endangered Species Listing, J. Peter Byrne

Georgetown Law Faculty Publications and Other Works

The insight upon which this article is built is that the common structures of these two legal regimes create incentives toward destroying the resources they seek to protect. The shift from legal freedom to exploit resources to strict limitation on property modification and the lengthy and public process to designate or list specific resources for protection provide the motive and the opportunity to legally frustrate the application of the statutes. This article seeks to understand how these perverse incentives are created and how they can be lessened. The procedural and substantive provisions of both legal regimes have evolved to reduce …

What Patients With Disability Teach Us About The Everyday Ethics Of Healthcare, Elizabeth Pendo

Articles

In Healers: Extraordinary Clinicians at Work, by David Schenck and Dr. Larry Churchill, and in What Patients Teach: The Everyday Ethics of Health Care, their follow-up with Joseph Fanning, the authors look at the everyday experience of health care and the relationships that shape it. They call attention to the ethical dimensions of the clinical encounter and the hope for, and desirability of, a genuine human engagement between the clinician and the patient. In their view, healers are clinicians who cultivate a therapeutic relationship with their patients. They identify a set of skills that accomplish this, including welcoming …