Digital Commons Network^™

Erratum To: Hclp46 Increases Smad3 Protein Stability Via Inhibiting Its Ubiquitin-Proteasomal Degradation, Yingying Xing, Qiaoyun Chu, Run Feng, Wei Wang, Lixin Lu

Research outputs 2014 to 2021

No abstract provided.

The Potential Role Of Exercise In Neuro-Oncology, Prue Cormie, A.K. Nowak, Suzanne K. Chambers, Daniel A. Galvao, Robert U. Newton

Research outputs 2014 to 2021

Patients with brain and other central nervous system cancers experience debilitating physical, cognitive, and emotional effects, which significantly compromise quality of life. Few efficacious pharmacological strategies or supportive care interventions exist to ameliorate these sequelae and patients report high levels of unmet needs in these areas. There is strong theoretical rationale to suggest exercise may be an effective intervention to aid in the management of neuro-oncological disorders. Clinical research has established the efficacy of appropriate exercise in counteracting physical impairments such as fatigue and functional decline, cognitive impairment, as well as psychological effects including depression and anxiety. While there is …

The Effect Of Multidisciplinary Rehabilitation On Brain Structure And Cognition In Huntington's Disease: An Exploratory Study, Travis M. Cruickshank, Jennifer A. Thompson, Juan F. Dominguez D, Alvaro P. Reyes, Mike Bynevelt, Nellie Georgiou-Karistianis, Roger A. Barker, Mel R. Ziman

Research outputs 2014 to 2021

Background: There is a wealth of evidence detailing gray matter degeneration and loss of cognitive function over time in individuals with Huntington's disease (HD). Efforts to attenuate disease-related brain and cognitive changes have been unsuccessful to date. Multidisciplinary rehabilitation, comprising motor and cognitive intervention, has been shown to positively impact on functional capacity, depression, quality of life and some aspects of cognition in individuals with HD. This exploratory study aimed to evaluate, for the first time, whether multidisciplinary rehabilitation can slow further deterioration of disease-related brain changes and related cognitive deficits in individuals with manifest HD. Methods: Fifteen participants who …

A New Qualitative Typology To Classify Treading Water Movement Patterns, Christophe Schnitzler, Chris Button, James L. Croft, Ludovic Seifert

Research outputs 2014 to 2021

This study proposes a new qualitative typology that can be used to classify learners treading water into different skill-based categories. To establish the typology, 38 participants were videotaped while treading water and their movement patterns were qualitatively analyzed by two experienced biomechanists. 13 sport science students were then asked to classify eight of the original participants after watching a brief tutorial video about how to use the typology. To examine intra-rater consistency, each participant was presented in a random order three times. Generalizability (G) and Decision (D) studies were performed to estimate the importance variance due to rater, occasion, video …

The Ph Sensing Properties Of Rf Sputtered Ruo2 Thin-Film Prepared Using Different Ar/O2 Flow Ratio, Ali Sardarinejad, Devendra Kumar Maurya, Kamal Alameh

Research outputs 2014 to 2021

The influence of the Ar/O₂ gas ratio during radio frequency (RF) sputtering of the RuO₂ sensing electrode on the pH sensing performance is investigated. The developed pH sensor consists in an RF sputtered ruthenium oxide thin-film sensing electrode, in conjunction with an electroplated Ag/AgCl reference electrode. The performance and characterization of the developed pH sensors in terms of sensitivity, response time, stability, reversibility, and hysteresis are investigated. Experimental results show that the pH sensor exhibits super-Nernstian slopes in the range of 64.33-73.83 mV/pH for Ar/O₂ gas ratio between 10/0-7/3. In particular, the best pH sensing performance, in …

Effects Of Ambient Coarse, Fine, And Ultrafine Particles And Their Biological Constituents On Systemic Biomarkers: A Controlled Human Exposure Study, Ling Liu, Bruce Urch, Raymond Poon, Mieczyslaw Szyszkowicz, Mary Speck, Diane R. Gold, Amanda J. Wheeler, James A. Scott, Jeffrey R. Brook, Peter S. Thorne, Frances S. Silverman

Research outputs 2014 to 2021

Background: Ambient coarse, fine, and ultrafine particles have been associated with mortality and morbidity. Few studies have compared how various particle size fractions affect systemic biomarkers. Objectives: We examined changes of blood and urinary biomarkers following exposures to three particle sizes. Methods: Fifty healthy nonsmoking volunteers, mean age of 28 years, were exposed to coarse (2.5–10 μm; mean, 213 μg/m3) and fine (0.15–2.5 μm; mean, 238 μg/m3) concentrated ambient particles (CAPs), and filtered ambient and/or medical air. Twenty-five participants were exposed to ultrafine CAP (< 0.3 μm; mean, 136 μg/m3) and filtered medical air. Exposures lasted 130 min, separated by ≥ 2 weeks. Blood/urine samples were collected preexposure and 1 hr and 21 hr postexposure to determine blood interleukin-6 and C-reactive protein (inflammation), endothelin-1 and vascular endothelial growth factor (VEGF; vascular mediators), and malondialdehyde (lipid peroxidation); as well as urinary VEGF, 8-hydroxy-deoxy-guanosine (DNA oxidation), and malondialdehyde. Mixed-model regressions assessed pre- and postexposure differences. results: One hour postexposure, for every 100-μg/m3 increase, coarse CAP was associated with increased blood VEGF (2.41 pg/mL; 95% CI: 0.41, 4.40) in models adjusted for O3, fine CAP with increased urinary malondialdehyde in single- (0.31 nmol/mg creatinine; 95% CI: 0.02, 0.60) and two-pollutant models, and ultrafine CAP with increased urinary 8-hydroxydeoxyguanosine in single- (0.69 ng/mg creatinine; 95% CI: 0.09, 1.29) and two-pollutant models, lasting < 21 hr. Endotoxin was significantly associated with biomarker changes similar to those found with CAPs. conclusions: Ambient particles with various sizes/constituents may influence systemic biomarkers differently. Endotoxin in ambient particles may contribute to vascular mediator changes and oxidative stress.

Surveys Of Cancer Patients And Cancer Health Care Providers Regarding Complementary Therapy Use, Communication, And Information Needs, Ngaire King, Lynda G. Balneaves, Gregory T. Levin, Thao Nguyen, Jill G. Nation, Cynthia Card, Tracy Truant, Linda E. Carlson

Research outputs 2014 to 2021

Background. Complementary therapies (CTs) are increasingly utilized by cancer patients. Nonetheless, patients report insufficient support from health care practitioners (HCPs) and there is a general lack of patient-practitioner communication about CT use. Best care practices suggest that HCPs should address the needs of patients, including CT use. This study examined current practices of patients and HCPs as well as their interactions relating to CTs. Methods. A total of 481 cancer outpatients and 100 HCPs completed questionnaires. Patient questions addressed CT use and information needs; HCP questions addressed knowledge, opinions and beliefs about complementary and alternative medicine. Patient-practitioner communication around CT …

The Clinical Utility Of Multidisciplinary Rehabilitation In Individuals With Huntington’S Disease, Travis Miles Cruickshank

Theses: Doctorates and Masters

Background

Huntington’s disease (HD) is a chronic neurodegenerative disorder characterised by a progressive loss of cognitive function, motor control and psychiatric features. Individuals also display a variety of systemic features. Progressive neuronal dysfunction and neuronal cell death are thought to underlie the onset and progression of many clinical features of HD.

Despite scientific progress, there is still no cure or disease modifying therapy for HD, and available pharmaceutical agents only provide partial relief of motor and psychiatric features. An emerging body of evidence indicates that lifestyle enrichment may delay the onset and progression of clinical features, and exert favourable effects …

Boundaries Of Governance: Social Responsibility In Mining In Western Australia, Gemma L. Broderick

Theses: Doctorates and Masters

This research investigated the boundaries of governance of social responsibility in three multinational mining organisations based in Perth, Western Australia. The mining industry has economic, environmental and social impacts, both positive and negative. While most of the attention of the media and supporters in government seems to focus on the positive impacts, a growing concern regarding the social implications of mining is clearly evident in public discourse and the academic literature. In response to public concern, the mining industry has adopted terms such as ‘sustainability’, ‘sustainable development’, ‘social licence to operate’ and ‘social responsibility’. Such phrases are widely used in …

Ethical Research In Indigenous Contexts And The Practical Implementation Of It, Graeme Gower

Theses: Doctorates and Masters

Research in Indigenous Australia has historically been controlled and dominated by non-Indigenous researchers. However, recent national research guidelines which have been developed by the National Health and Medical Research Council (NHMRC) and together with a number of other research guidelines that have been developed by other institutions, including the Australian Institute for Aboriginal & Torres Strait Islander Studies (AIATSIS), have signalled a shift towards Indigenous ownership and control over research. However, despite these revised guidelines, researching in Indigenous contexts can still result in cultural insensitivities, neglect or disregard by researchers and mistrust by Indigenous participants. Similar issues have also been …

Compositions, Logratios And Geostatistics: An Application To Iron Ore, Clint Ward

Theses: Doctorates and Masters

Common implementations of geostatistical methods, kriging and simulation, ignore the fact that geochemical data are usually reported in weight percent, sum to a constant, and are thus compositional in nature. The constant sum implies that rescaling has occurred and this can be shown to produce spurious correlations. Compositional geostatistics is an approach developed to ensure that the constant sum constraint is respected in estimation while removing dependencies on the spurious correlations. This study tests the applicability of this method against the commonly implemented ordinary cokriging method. The sample data are production blast cuttings analyses drawn from a producing iron ore …

Undergraduate Catalog

Undergraduate & Graduate Catalogs

No abstract provided.

Temperature And Ph Responsive Microfibers For Controllable And Variable Ibuprofen Delivery, Toan Tran, Mariana Hernandez, Dhruvil Patel, Ji Wu

Chemistry: Faculty Publications (1990-2023)

Electrospun microfibers (MFs) composed of pH and temperature responsive polymers can be used for controllable and variable delivery of ibuprofen. First, electrospinning technique was employed to prepare poly(ε-caprolactone) (PCL) and poly(N-isopropylacrylamide-co-methacrylic acid) (pNIPAM-co-MAA) MFs containing ibuprofen. It was found that drug release rates from PCL MFs cannot be significantly varied by either temperature (22–40°C) or pH values (1.7–7.4). In contrast, the ibuprofen (IP) diffusion rates from pNIPAM-co-MAA MFs were very sensitive to changes in both temperature and pH. The IP release from pNIPAM-co-MAA MFs was highly linear and controllable when the temperature was above the lower critical solution temperature (LCST) …

The Role Of Apoe-Ε4 And Beta Amyloid In The Differential Rate Of Recovery From Ect : A Review, T. A. Sutton, Hamid R. Sohrabi, Stephanie Rainey-Smith, S. M. Bird, M. Weinborn, Ralph Martins

Research outputs 2014 to 2021

Individual biological differences may contribute to the variability of outcomes, including cognitive effects, observed following electroconvulsive treatment (ECT). A narrative review of the research literature on carriage of the apolipoprotein E ε4 allele (APOE-ε4) and the protein biomarker beta amyloid (Aβ) with ECT cognitive outcome was undertaken. ECT induces repeated brain seizures and there is debate as to whether this causes brain injury and long-term cognitive disruption. The majority of ECT is administered to the elderly (over age 65 years) with drug-resistant depression. Depression in the elderly may be a symptom of the prodromal stage of Alzheimer’s disease …

Apoe Ε4 Moderates Abnormal Csf-Abeta-42 Levels, While Neurocognitive Impairment Is Associated With Abnormal Csf Tau Levels In Hiv+ Individuals - A Cross-Sectional Observational Study, Cysique A. Lucette, Timothy Hewitt, Juliana Croitoru-Lamoury, Kevin Taddei, Ralph Martins, Constance S. Chew, Nicholas N. Davies, Patricia J. Price, Bruce J. Brew

Research outputs 2014 to 2021

Background: Cerebrospinal fluid (CSF) biomarkers Aβ1-42, t-tau and p-tau have a characteristic pattern in Alzheimer's Disease (AD). Their roles in HIV-associated neurocognitive disorder (HAND) remains unclear. Methods: Adults with chronic treated HIV disease were recruited (n = 43, aged 56.7 ± 7.9; 32% aged 60+; median HIV duration 20 years, >95% plasma and CSF HIV RNA /mL, on cART for a median 24 months). All underwent standard neuropsychological testing (61% had HAND), APOE genotyping (30.9% carried APOE ε4 and 7.1% were ε4 homozygotes) and a lumbar puncture. Concentrations of Aβ1-42, t-tau and p-tau were assessed in the CSF using commercial …

Diagnostic Value Of Subjective Memory Complaints Assessed With A Single Item In Dominantly Inherited Alzheimer's Disease: Results Of The Dian Study, Christoph Laske, Hamid R. Sohrabi, Mateusz S. Jasielec, Stephan A. Müller, Niklas K. Koehler, Susanne Gräber, Stefan L. Förster, Alexander E. Drzezga, Felix Mueller-Sarnowski, Adrian Danek, Mathias Jucker, Randall J. Bateman, Virginia D. Buckles, Andrew J. Saykin, Ralph Martins, John C. Morris

Research outputs 2014 to 2021

Objective. We examined the diagnostic value of subjective memory complaints (SMCs) assessed with a single item in a large cross-sectional cohort consisting of families with autosomal dominant Alzheimer's disease (ADAD) participating in the Dominantly Inherited Alzheimer Network (DIAN). Methods. The baseline sample of 183 mutation carriers (MCs) and 117 noncarriers (NCs) was divided according to Clinical Dementia Rating (CDR) scale into preclinical (CDR 0; MCs: n = 107; NCs: n = 109), early symptomatic (CDR 0.5; MCs: n = 48; NCs: n = 8), and dementia stage (CDR ≥ 1; MCs: n = 28; NCs: n = 0). These groups …

Failure Of Science, Death Of Nature, H.F. Recher

Research outputs 2014 to 2021

As a people, Australians have lost contact with the world of nature, Risking the collapse of civilization. One factor in the alienation of nature in Australia is the failure of the scientific community to take responsibility for the technology created by the knowledge generated from scientific research. Science has failed to protect Australia's flora and fauna. Scientists must communicate more widely with society, but need to be educated on how to communicate and on their ethical responsibilities to others and other species. Government needs to show leadership in environmental management and nature conservation, while conservationists need to 'invert the paradigm', …

Increasing Sediment Accumulation Rates In La Fonera (Palamós) Submarine Canyon Axis And Their Relationship With Bottom Trawling Activities, P. Puig, J. Martin, P. Masque, A. Palanques

Research outputs 2014 to 2021

Previous studies conducted in La Fonera (Palamós) submarine canyon (NW Mediterranean) found that trawling activities along the canyon flanks cause resuspension and transport of sediments toward the canyon axis. 210Pb chronology supported by 137Cs dating applied to a sediment core collected at 1750m in 2002 suggested a doubling of the sediment accumulation rate since the 1970s, coincident with the rapid industrialization of the local trawling fleet. The same canyon area has been revisited a decade later, and new data are consistent with a sedimentary regime shift during the 1970s and also suggest that the accumulation rate during the last decade …

A New Species Of Sphaerowithius (Pseudoscorpiones, Withiidae) From Namibia, Mark S. Harvey, V. Menhert

Research outputs 2014 to 2021

A new species of Sphaerowithius Mahnert, 1988, S. ansieae sp. n., is described from specimens collected in caves in northern Namibia. The specimens show some slight modifications to an obligate cavernicolous existence including small eyes and long, slender pedipalps.

Assessment Of Electrode Configurations Of Electrical Impedance Myography For The Evaluation Of Neuromuscular Diseases, Khondokar Mohammad Fazle Rabbi

College of Graduate Studies: Theses & Dissertations

Electrical impedance myography (EIM) is a painless, noninvasive approach to measure the neuromuscular disease status. EIM parameters- resistance (R), reactance (X) and phase (θ) depend significantly on subcutaneous fat thickness, muscle size and inter electrode distance. The objective of this research is to find an electrode configuration which can minimize the effects on EIM parameters due to subcutaneous fat thickness variation. In this study, a model of human upper arm was developed using finite element method (FEM), which has already been established as an appropriate approach for the analysis of non-symmetrical shape for assessing alternations of muscle in disease-induced changes …

Utilization Of B-Mode Ultrasound As A Body Fat Estimate In Collegiate Football Players, Parker Hyde

College of Graduate Studies: Theses & Dissertations

The purpose of the present study was to validate a 7-site ultrasound imaging protocol to predict percent body fat (%BF) in a Division I football team. Body composition was estimated by ultrasound, seven site skinfolds (SKINFOLD), and the three compartment-water (3C-W) model of Siri (1961), using Bioimpedance spectroscopy (BIS) to estimate total body water (TBW) and air-displacement plethysmography (BODPOD^®) to determine body density (Db). Pearson’s product-moment correlation analyses were run to determine between Σ_Ultrasound and the criterion 3C-W, and between the Σ_Skinfold and Σ_Ultrasound. Strong positive correlations were observed between Σ_Skinfold and Σ …

Design And Implementation Of An Interactive Animatronic System For Guest Response Analysis, Brian Burns

College of Graduate Studies: Theses & Dissertations

In theme park based entertainment applications, there is a need for interactive, autonomous animatronic systems to create engaging and compelling experiences for the guests. The animatronic figures must identify the guests and recognize their status in dynamic interactions for enhanced acceptance and effectiveness as socially interactive agents, in the general framework of human-robot interactions. The design and implementation of an interactive, autonomous animatronic system in form of a tabletop dragon and the comparisons of guest responses in its passive and interactive modes are presented in this work. The dragon capabilities include a four degrees-of-freedom head, moving wings, tail, jaw, blinking …

Female Social Rank And Steroid Production In Semi-Free Ranging Lemur Catta On St. Catherines Island, Georgia, Tiffany Burgess

College of Graduate Studies: Theses & Dissertations

Many mammalian species live in complex social groups that profoundly affect the behavior and ecology of their members. In ring-tailed lemurs (Lemur catta) these groups are characterized by female dominance, where females have priority over males for food, grooming, and space. Among females there is also a linear dominance hierarchy. L. catta have a strong matrilineal social core due to females staying within their natal group and males dispersing at sexual maturity. Daughters “inherit” their mother’s social rank. However, it is not known if the matrilineal lines are maintained through learned dominant/aggressive behavior or inherited via genetically determined hormonal …

Myosin 10 Is Required For Spinal Motor Axon Growth And Guidance In Zebrafish Embryos, Crystal Ivey

College of Graduate Studies: Theses & Dissertations

Neurodevelopmental disorders are disabilities caused by malfunctioning mechanisms within the developing nervous tissue. These abnormalities often result in conditions such as autism spectrum disorders, Attention Deficient Hyperactivity Disorder (ADHD), motor dysfunctions, learning disabilities and mental retardation. Recent surveys indicate that there will be a 12% increase of children in the United States alone who are affected by neurodevelopmental disorders. Thus, it is important to understand both the normal and abnormal mechanisms of neural development. Neural development involves specification of new neurons and formation of neural circuits that connect the nervous system to every organ of the developing embryo. Neural circuits …

Myosinx Is Required For Craniofacial Development In Danio Rerio, Cole Yancey

College of Graduate Studies: Theses & Dissertations

Craniofacial development is the process of laying early cartilage and bone patterns in the anterior region of the embryo, which ultimately results in shaping the structure of the face and head of an organism. Craniofacial abnormalities in humans, such as cleft lip and palate, are among the most common of all birth defects. Therefore, investigating the molecular mechanisms involved in craniofacial development will help us understand both evolutionary processes and genetic diseases. Craniofacial cartilage and bone structures are almost entirely derived from neural crest cells. Neural crest are a pluripotent migratory stream of cells that originate from the early developing …

Nonstructural Carbohydrate Concentrations Of Pine Trees As A Function Of Evolutionary History, Joshua T. Mims

College of Graduate Studies: Theses & Dissertations

Nonstructural carbohydrates (NSC) can supply substrate during periods when current photosynthate is unavailable or inadequate to meet metabolic demands. I hypothesized that natural selection has favored higher nonstructural carbohydrate concentrations ([NSC]) in species that have an evolutionary history of frequent disturbance and tested this using three southern pine species that have evolved under a continuum of disturbance frequencies (evolutionary history of fire ~ longleaf > slash > loblolly). Stem and root samples were collected from 12 similar-sized individual trees of each species during time periods that reflect the annual minimum and maximum [NSC]. A modified colorimetric method was performed on the samples …

Excessive Tanning As A Presentation Of Body Dsymorphic Disorder, Jennifer Headrick

College of Graduate Studies: Theses & Dissertations

Body dysmorphic disorder (BDD) involves a potentially debilitating preoccupation with an imagined or minor flaw in one’s appearance (American Psychiatric Association, 2013; Phillips, 2005). Common body areas of preoccupation include the skin, face, hair, and muscles (Castle, Ross, & Kyrios, 2006; Mosley, 2009; Phillips, 2005; Veale, 2003). With the publication of the Diagnostic and Statistical Manual of Mental Disorders—5th edition (APA, 2013), BDD was moved from the Somatoform Disorder classification to the new diagnostic category of Obsessive-Compulsive and related disorders. A new example of preoccupation with skin tone and an associated behavior of excessive tanning were added to the BDD …

African-American Males, African-American Female Principals, & The Opportunity Gap, Jennifer N. Dunbar

College of Graduate Studies: Theses & Dissertations

Over the past decade, research has been devoted to bridging the gap in academics and opportunity among African-American males. Missing from the dialogue however, are the voices of African-American female leaders. This voice will not only play an instrumental part in mediating cultural misunderstandings that occur in the classroom, but it will also facilitate a much needed conversation in understanding gender and race by displaying different views on educational leadership. Thus, the purpose of this study is to explore the perceptions of the opportunity gap among African-American female principals in Title I schools to raise the presence of their voice …

Utilizing Participatory Action Research To Assess The Interagency Collaboration Of A Community-Based After-School Program Partnership, Jessica L. Render

College of Graduate Studies: Theses & Dissertations

The study utilized a community-based participatory action research (PAR) approach to assess the development of an interagency collaborative and its replication at other locations. The partnership formed to provide a service-learning site for university students as well as a community-based after-school program for children living in a low-income housing community. Research participants completed the levels of collaboration scale developed by Frey and Colleagues (2006) along with a questionnaire about their desired level of collaboration, current and needed resources, and knowledge of other partners’ goals. Collaboration is loosely defined as a group of partners working together to reach shared goals. The …

The Physiological Stress Response Caused By Hypoxia And Reperfusion Injury In Striped Bass (Morone Saxatilis) And Nile Tilapia (Oreochromis Niloticus), Amanda C. Reynolds

College of Graduate Studies: Theses & Dissertations

Approximately five million people in the United States are affected by cardiovascular related diseases yearly contributing to 300,000 annual deaths, making CVD the leading cause of mortality worldwide. It has been suggested that apoptosis (programmed cell death) contributes to the pathogenesis of cardiovascular diseases. When blood flow is reduced or cut off from the heart, usually by a thrombus, this results in oxygen deprivation (hypoxia) to the cardiomyocytes (heart cells). In response to this hypoxic stress, cardiomyocytes will undergo apoptosis. Since many species of fish can survive levels of hypoxia that would be fatal to mammals, fish are an ideal …