Digital Commons Network^™

Arsenic Biosand Filters In Developing Countries, Jepkoech Kottutt

Honors Projects

Arsenic is a common pollutant in many developing countries and has been linked to cancer and cardiovascular disease. In this research, biosand filters (BSFs) were modified with iron filings to remove arsenic from contaminated water. Six BSFs (three with 1 kg of iron filings and three without iron filings) were simultaneously dosed with 20 liters of Muskegon Lake water that contained 100 μg/L of arsenic for 30 days. Arsenic concentrations were determined using a HACH low range arsenic test kit. The mean arsenic removal rate for all 3 BSFs with iron filings was 100% for 13 days, but later was …

Ftc V. Actavis: The Patent-Antitrust Intersection Revisited, Glynn S. Lunney Jr

Faculty Scholarship

In FTC v. Actavis, the Supreme Court determined that courts should apply a rule of reason analysis to determine whether using a reverse payment settlement to resolve pharmaceutical patent litigation violates the antitrust laws. Essentially unique to pharmaceutical-patent litigation, a reverse payment settlement involves a payment from the patent-holder to generic challengers in return for the generics dropping their challenge to the patent(s) at issue and agreeing to remain out of the market. Such a settlement agreement enables the patent-holder to maintain exclusivity in the relevant market and to keep prices of the associated pharmaceutical higher than they would …

Intellectual Property, Asian Philosophy And The Yin-Yang School, Peter K. Yu

Faculty Scholarship

As an introduction to a special issue on intellectual property philosophy, this article focuses on insights from Asian thought. Such a focus is needed not only to provide balance within this special issue, which includes articles focusing primarily on Western philosophy, but also to highlight the compatibility between Asian philosophy and the notion of intellectual property rights. More importantly, this article aims to demonstrate that Asian philosophy may suggest new ways to address the ongoing and highly complex intellectual property challenges confronting emerging economies and the digital environment.

This article begins by providing a brief discussion of the many different …

Annual Report 2014, Novo Banco

Documents

No abstract provided.

Cerium Dioxide Nanoparticle Exposure And Microvascular Dysfunction: Potential Mechanistic Links, Valerie C. Minarchick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cerium dioxide nanoparticles (CeO2 NP), an engineered nanomaterial, have great potential from a consumer and therapeutic perspective. Currently, CeO2 NP are added to diesel fuel to decrease the soot emissions commonly associated with diesel engines. CeO2 NP also have therapeutic applications (e.g. improve outcomes following stroke and radiation treatments) due to their anti-oxidant capabilities. These applications increase CeO2 NP exposure risk not only for manufacturers, but also for the general community; however, there are currently limited studies that investigated the effects of CeO2 NP exposure via multiple exposure routes. Furthermore, there are no studies that investigate the microvascular consequences of …

Biol 4903: Senior Capstone, Steelman Library, Jerm J. Day-Storms Dr.

Syllabus Repository

No abstract provided.

Analgesic And Anti-Inflammatory Effects Of Monoacylglycerol Lipase Inhibition In Mice Subjected To Collagen-Induced Arthritis, Sara R. Nass

Graduate Theses, Dissertations, and Problem Reports (ETD)

Rheumatoid arthritis (RA) is the most prevalent chronic inflammatory joint disease, affecting approximately 1% of the world population. This autoimmune disease is characterized by pain, stiffness, swelling, and breakdown of cartilage in synovial joints. Current RA analgesic treatments (i.e., pain reducing drugs) are ineffective or induce negative side effects, and so there are many concerted efforts to discover new RA treatments. Cannabinoids have analgesic and anti-inflammatory properties; however, the challenge remains to harness the medical potential of cannabinoids without inducing negative psychoactive effects (e.g., cognitive deficits, emotional disruption, and abuse potential). An alternative approach focuses on the endogenously produced cannabinoids …

Evaluation Of The Antidepressant Potential Of Dextromethorphan, Linda Nguyen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Depression affects more than 350 million people and is the leading cause of disability worldwide. Major challenges in the management of depression remain the 4-12 weeks of delayed efficacy and 30% of patients who are resistant to the therapeutic effects of current pharmaceutical treatments. We herein examined whether dextromethorphan (DM) may be able to take on these challenges, because 1) it has overlapping pharmacology with ketamine, which has shown rapid (within 24 hours) antidepressant effects, even in treatment-resistant individuals; 2) unlike ketamine with its notable abuse liability and adverse effects, DM is an over-the-counter antitussive with a high safety margin; …

Pyrolytic Fate Of Synthetic Cannabinoids, Corey Andrew Nida

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the introduction of herbal incense products into the illicit drug market, one of the most concerning factors has been the uncertainty regarding their health effects. Side effects such as anxiety/agitation, increased heartbeat, hallucinations, and suicidal tendencies are commonly reported with the use of products containing synthetic cannabinoid. However, a largely unknown toxicity and pharmacology is still associated with synthetic cannabinoids and long-term health effects have yet to be discussed.;Prior scientific studies have not focused on the big-picture in terms of the pyrolysis of traditional drugs of abuse that are smoked or the relatively new synthetic cannabinoids. Numerous agencies and …

Producer–Market Orientation Of Community-Based Tourism (Cbt) Products: A Case Study In Bali, Indonesia, Ni Made Ernawati

Theses: Doctorates and Masters

Community-based tourism (CBT) provides an attractive alternative to mass tourism. In Bali, Indonesia, it is a potentially significant contributor to tourism development. The aim of this research was to obtain a greater understanding of CBT through an examination of relevant issues, and the perceptions of the host communities and tourists regarding CBT products. This study used a mixed methods approach to collect data from the host communities and tourists who visited the villages in Bali.

Five main elements of CBT products came to light during a review of the literature in the preliminary phase of the research. Subsequently, aspects of …

Analysis Of Plant Analytes Using Capillary Electrophoresis And High Performance Liquid Chromatography, Umme Kalsoom

Theses: Doctorates and Masters

Plants contain an enormous array of organic and inorganic components, the analysis for which may involve a wide range of methods. The focus of this study was to develop high performance liquid chromatography and capillary electrophoresis methods for the analysis of three classes of analytes: osmoregulants, minerals and amino acids.

Firstly, this study explored the potential of capillary electrophoresis for the analysis of three very common osmoregulants (proline, glycine betaine and mannitol). A diverse array of methods has been reported for determining each of these analytes, however, the literature on osmoregulants and their analysis is quite disjointed and traverses both …

The Evolution Of Joint Management In Western Australia Parks And The Indigenous Tourism Nexus, Lori-Ann Shibish

Theses: Doctorates and Masters

Since the early 2000s, park management approaches to protected area governance have undergone a significant transformation, driven by the realisation that long-term conservation outcomes depend on participation in decision-making by stakeholders. To meet these challenges one of the measures being adopted by park managers is to engage in joint management arrangements. Recent changes to the conservation legislation in Western Australia provides the capacity for the Department of Parks and Wildlife (Parks and Wildlife) to enter into joint management arrangements with Aboriginal traditional owners and others for the management of protected areas, regardless of the land vesting or tenure. Joint management …

Maps For The Lost: A Collection Of Short Fiction And Human / Nature Ecotones: Climate Change And The Ecological Imagination: A Critical Essay, Susan Heather Greenhill

Theses: Doctorates and Masters

The thesis comprises a collection of short fiction, Maps for the Lost, and a critical essay, “Human / Nature Ecotones: Climate Change and the Ecological Imagination.” In ecological terms, areas of interaction between adjacent ecosystems are known as ecotones. Sites of relationship between biotic communities, they are charged with fertility and evolutionary possibility. While postcolonial scholarship is concerned with borders as points of cross-cultural contact, ecocritical thought focuses upon the ecotone that occurs at the interface between human and non-human nature.

In their occupation of the liminal zones between human and natural realms, the characters and narratives of Maps …

Saying ‘No’: A Biographical Analysis Of The Experiences Of Women With A Genetic Predisposition To Developing Breast/Ovarian Cancer Who Reject Risk Reducing Surgery, Doreen Molloy

Theses: Doctorates and Masters

Background: Genetic technologies have identified some of the genes implicated in cancer susceptibility. Women with mutations in breast/ovarian cancer-susceptibility genes (BRCA1 and 2) have a lifetime combined risk of breast/ovarian cancer of more than 80%. Risk reducing surgery (RRS) reduces cancer risk by as much as 90% in high risk populations. Despite this, some BRCA1/2 mutation-positive women say no to RRS.

Purpose: To illuminate an understanding of why women at high risk of developing breast/ovarian cancer say no to risk reducing surgery (RRS).

Design: Denzin’s (1989) interpretive biography was combined with Dolby-Stahl’s (1985) literary folkloristic methodology to provide a contextualised …

The Regulation Of Human Iron Metabolism In Hypoxia, Andrew Govus

Theses: Doctorates and Masters

Athletes commonly use altitude exposure in an attempt to improve their aerobic performance at sea level. Altitude exposure enhances erythropoiesis and iron-dependent oxidative and glycolytic enzyme production, for this reason, athletes must maintain a healthy iron balance at altitude. A negative iron balance at altitude may limit such physiological adaptations, potentially reducing the performance benefits of altitude exposure.

This thesis examined the regulation of iron metabolism during acute (~31 min, Study One) and prolonged altitude exposure (14 days, Study Two). Finally, Study Three examined how daily oral iron supplementation influenced haemoglobin mass (Hbmass) and iron parameter responses to prolonged, moderate …

An Examination Of Social Desirability Confounds In A New Ipsative Measure Of Murray's Psychogenic Needs, Lisa Harris

Theses: Doctorates and Masters

A reliable and valid instrument for the direct measurement of the relative strength of psychological needs is currently lacking. In response to this shortcoming, a new ipsative instrument, the Psychogenic Need Scale (PNS), is currently being developed; this is a 190-item forced-choice self-report measure that is based upon Murray’s psychogenic needs. For the development of a valid forced-choice instrument, it is critical to minimise the confounding effects of social desirability (the tendency for respondents to describe oneself in the most favourable light). Whilst other measures typically use specifically designed scales to detect social desirability confounds, this approach is unsuitable for …

Educative Curricula And Improving The Science Pck Of Teachers In Middle School Settings In Rural And Remote Australia, Arthur Townsend

Theses: Doctorates and Masters

Science is one of seven-mandated Key Learning Areas (KLAs) Foundation to Year 10 of the new Australian National Curriculum (ACARA, 2012). Not only, therefore, is science to be offered in every school as part of the curriculum, there is also the expectation that science is to be taught well to all students regardless of location, gender, cultural background or socio-economic status (ACARA, 2012). Studying science provides benefits to individuals by developing their scientific literacy skills (Goodrum, Hackling & Rennie, 2001; Hackling & Prain, 2008). Its study also benefits the national economy by equipping students with the innovative, inventive, and creative …

Heat Stress: A Risk Factor For Skin Carcinogenesis, Leslie Calapre

Theses: Doctorates and Masters

BACKGROUND: The incidence of skin cancer in Australia has increased rapidly in the last few decades. Ultraviolet radiation (UV) is a major risk factor for skin carcinogenesis. UV, particularly the UVB spectrum, causes formation of cyclobutane pyrimidine dimers (CPD) in cellular DNA. Persistent and incorrectly repaired CPDs lead to DNA mutations and consequently, formation of cutaneous lesions. Interestingly, recent epidemiological studies have shown a significant increase in skin cancer incidence in geographical locations with high environmental temperatures. Thus, heat stress may potentiate the effects of UV exposure and act as an additional risk factor for skin cancer. Previous studies …

Characterising The Effect Of A Novel Optical Delay Line And Light Sources On The Resolvability Of Time Domain Optical Coherence Tomography, Paul V. Jansz

Theses: Doctorates and Masters

Optical coherence tomography (OCT) is a reflection based imaging technique, with numerous applications, initially in medical diagnostics. Unlike ultrasound, another reflection imaging technique, OCT relies on light scattering in samples, low coherence near- infrared interferometry, and graphical image construction, to acquire 2D and 3D reflectogram images. OCT has resolution an order of magnitude greater than ultrasound, but its depth penetration is less than a few millimetres.

Axial resolution is a critical parameter in determining whether OCT can be used to resolve specific features in a sample image. Typically, measures of resolution have been attributed only to the light source’s characteristics, …

Peel, Fondle, Ogle: An Exhibition And Unfixed Parameters: A Creative Arts Praxis Investigation Of The In-Between Conditions Of The Corporeal Body: An Exegesis, Kimberley Simone Pace

Theses: Doctorates and Masters

This research emerged from a rejection of the corporeal body as a clean, sterile entity that can be neatly contained by the boundaries of skin. Informed by Lacan’s (1977, 1979) notions of the body and desire and Kristeva’s (1982) perspectives on the abject, I have developed a concept of the unfixed status of the body as an in-between condition. This investigation of the in-between condition of the body critically explores notions of the corporeal body as constructed physically, psychically and symbolically through my creative arts praxis concerning the body, garment, object and performance. This exegesis unveils the potential for a …

Cognitive Fatigue: Exploring The Relationship Between The Fatigue Effect And Action Video-Game Experience, James Brooks

Theses: Doctorates and Masters

the effects of cognitive fatigue. Despite this, there remain advantages to regularly playing action video games. In Study 1, VGPs were significantly better at multitasking on the MATB-II compared to the NVGPs. Further, VGPs also demonstrated superior multitasking when driving, as they made significantly fewer traffic violations compared to NVGPs when not fatigued. VGPs demonstrated eye-movements similar to those of expert drivers; however, this did not result in any difference in performance between the two groups. There was also some evidence of a positive effect of video game training, although there was no advantage of one training technique over the …

Dynamics Of Baseline Stable Isotopes Within A Temperate Coastal Ecosystem: Relationships And Projections Using Physical And Biogeochemical Factors, Andrew Mackey

Theses: Doctorates and Masters

Measurements of carbon (13C/12C; δ13C) and nitrogen (15N/14N; δ15N) stable isotope ratios have become important tools for: estimating energy flow and trophic positions in aquatic foodwebs; comparing food webs; and aiding in the tracking of wide-ranging consumers. However, each of these applications requires accurate measurements of isotopic signatures in organisms at or near the base of the food web (e.g. autotrophs and their consumers), which act as basal reference points from which to calibrate inferences. Therefore, understanding variations in isotopic baselines, and the mechanisms leading to their variability, is crucial for food web ecology.

Using the shallow temperate reefs along …

Education For Sustainability: An Ethnographic Study Of 15 Year-2/3 Rural Western Australian Children’S Attitudes On Sustainability, Cara Payne

Theses: Doctorates and Masters

The study occurred in rural Western Australia in 2011, during UNESCO‟s Decade of Education for Sustainability Development, when sustainability became one of three cross-curriculum priorities of the Australian Curriculum. The study involved the development and implementation of a sustainability focused science program embedded in a class of 15 Year-2/3primary participants. The study emphasised a qualitative approach, but also included embedded quantitative data analysis. The aim of the science program focussed on the enhancement of the children‟s attitudes towards sustainability, to equip them with the skills needed to change their behaviours in relation to practicing the principles of sustainability. The …

Learning To Teach: What Pre-Service Teachers Report, Dawn Naylor

Theses: Doctorates and Masters

With universities and schools of education receiving recurring criticism for being ineffective in preparing graduates for school teaching, this study sought to understand the phenomenon of learning to teach in order to investigate universal questions about who was learning to teach and what, where, when and how did they learn to teach during their initial learning to teach experiences at university. The topic was approached by listening to the voices and stories of those who ought to know the most about the phenomenon: the pre-service teachers. A multiple case study analysis was conducted with seven pre-service teachers, enrolled in their …

Fowl Feathered Fox: Monsters, Pipers, Families And Flocks, Michelle Aslett

Theses: Doctorates and Masters

Fowl Feathered Fox: Monsters, Pipers, Families and Flocks is a doctoral work consisting of a full-length stage play and an exegesis. An introduction outlines the scope of the doctoral work, while a concluding chapter reflects on research findings and considers staging issues and implications. Appendices include images incorporated into the play’s action as well as photographed excerpts from a series of visual diaries used to document the play’s evolution. The play, Fowl Feathered Fox, explores the nature of delusion, deception and the tragedy of The Beast Within. Borrowing as it does from the traditions of revenge tragedy, comedy and horror, …

An Appraisal Of Experiences Of Climate Change And Adaptive Response To Heat Stress By Farmers In Rural Ghana, Kwasi Frimpong

Theses: Doctorates and Masters

With the increase in average global temperatures, heat-related illnesses and deaths have unfolded as occupational and health issues. Periods of high to extreme temperatures are becoming more common and are a leading cause of weather-related deaths in many countries. In agricultural settings of African countries, heat stress is a major concern as many smallholder farmers work outdoors with limited access to cooling systems even in their resting and living environments. This study, conducted in the Bawku East part of Northern-East Ghana in 2013, examines, in the context of climate change, the trends and impacts of heat stress on smallholder farmers, …

Spatial And Temporal Patterns (1973-2012) Of Bushfire In An Arid To Semi-Arid Region Of Western Australia, Megan Ladbrook

Theses: Doctorates and Masters

Aim and background

The aim of this study was to reconstruct fire regimes/history of an extensive arid to semi-arid region of Western Australia for the last 40 years by studying temporal and spatial fire scar patterns using remote sensing in a Geographic Information System environment.

Methods

A fire history database was constructed, for the years 1973-2012 of an area of Western Australia between the Murchison and Minilya Rivers, of all bushfires greater than 1 ha that were visible from Landsat satellite imagery ranging from 30 – 60m ground resolution. The data was analysed to characterise a general bushfire regime for …

Evaluation Of A Modified Food Frequency Questionnaire To Measure Lignans In Australian Men And Women, Ying Qi Winnie Li

Theses: Doctorates and Masters

Phytoestrogens are plant compounds that possess estrogenic and biological properties that have been postulated to protect against chronic diseases. Isoflavonoids and lignans are two main classes of phytoestrogen that have been investigated for their estrogenic efficacy and occurrence in the human diet. Isoflavonoids are found in soy and related products, whereas lignans are found in a wider range of plant-based foods, such as cereals, vegetables, fruits, legumes, nuts and seeds; and in beverages such as tea, coffee and wine. In Western populations with low dietary intake of soy products, compared to the Asian counterparts, lignans could be a more important …

Ecology Of Feral Cats Felis Catus And Their Prey In Relation To Shrubland Fire Regimes, Tim S. Doherty

Theses: Doctorates and Masters

Invasive predators are major drivers of global biodiversity loss and their impacts may be worsened by other disturbances such as fire. I examined how the fire history of shrublands influences the ecology of feral cats Felis catus, dingoes Canis dingo and their prey species in Western Australia’s northern Wheatbelt region.

A review of the literature revealed that feral cats inhabit a diverse range of ecosystems worldwide, but are generally recorded most often in habitat types characterised by a mixture of plant growth forms close to ground level. Cat habitat use is influenced by predation/competition, prey availability, shelter availability and …

Carbon Storage And Preservation In Seagrass Meadows, Mohammad Rozaimi Jamaludin

Theses: Doctorates and Masters

Seagrass meadows are important ‘Blue Carbon’ sinks but many questions remain unaddressed in regards to the organic carbon (OC) sequestration capacity and processes leading to retention and persistence of OC in seagrass sediments. The research summarised in this dissertation examined 37 sediment cores from twelve Australian seagrass meadows (Posidonia australis and Halophila ovalis) in order to improve our understanding of OC storage and preservation in seagrass sediments. The research: quantified the OC storage in seagrass meadows and the reduction in stores after ecosystem degradation; the rates of OC accumulation; the roles of species composition and the depositional nature …