Digital Commons Network^™

Different Sites Of Alcohol Action In The Nmda Receptor Glun2a And Glun2b Subunits, Yulin Zhao, Hong Ren, Donard S. Dwyer, Robert W. Peoples

Biological Sciences Faculty Research and Publications

The NMDA receptor is a major target of alcohol action in the CNS, and recent behavioral and cellular studies have pointed to the importance of the GluN2B subunit in alcohol action. We and others have previously characterized four amino acid positions in the third and fourth membrane-associated (M) domains of the NMDA receptor GluN2A subunit that influence both ion channel gating and alcohol sensitivity. In this study, we found that substitution mutations at two of the four corresponding positions in the GluN2B subunit, F637 and G826, influence ethanol sensitivity and ion channel gating. Because position 826 contains a glycine residue …

Tumor Necrosis Factor Alpha Converting Enzyme Inhibition During Acute Colitis In Mice: A Regional Analysis, Brian Maddox

Graduate Theses/Dissertations

Tumor Necrosis Factor-a Converting Enzyme (TACE) induces active TNFa and may contribute to the development of colitis in humans. I hypothesized that pharmacological blockade of TNFa production would improve colitis scoring through decreased expression of inflammatory biomarkers. Acute colitis was induced in wild type BALB/c mice using 5% dextran sulfate sodium (DSS) in drinking water for 7 days. TACE inhibition was accomplished through twice daily intraperitoneal injection of DPC- 333 (10mg/kg; BSM Inc.) To determine the effects of TACE blockade during colitis, the following experimental groups (n=6-7/group) were tested: 1) vehicle; 2) DPC-333; 3) 5% DSS and vehicle; and 4) …

Genetics Of Kidney Disease And Related Cardiometabolic Phenotypes In Zuni Indians: The Zuni Kidney Project, Sandra L. Laston, V. Saroja Voruganti, Karin Haack, Vallabh O. Shah, Arlene Bobelu, Jeanette Bobelu, Donica Ghahate, Antonia M. Harford, Susan S. Paine, Francesca Tentori

School of Medicine Publications

The objective of this study is to identify genetic factors associated with chronic kidney disease (CKD) and related cardiometabolic phenotypes among participants of the Genetics of Kidney Disease in Zuni Indians study. The study was conducted as a community-based participatory research project in the Zuni Indians, a small endogamous tribe in rural New Mexico. We recruited 998 members from 28 extended multigenerational families, ascertained through probands with CKD who had at least one sibling with CKD. We used the Illumina Infinium Human1M-Duo version 3.0 BeadChips to type 1.1 million single nucleotide polymorphisms (SNPs). Prevalence estimates for CKD, hyperuricemia, diabetes, and …

After Cassirer: Art And Aesthetic Symbols In Langer And Goodman, Curtis L. Carter

Philosophy Faculty Research and Publications

No abstract provided.

Profit Maximization And The Death Of God: Theology And Economics In Benedict Xvi's Charity In Truth, D. Stephen Long

Theology Faculty Research and Publications

No abstract provided.

2015-2016 Undergraduate Catalog, Armstrong State University

Armstrong Office of the Registrar: Undergraduate Catalogs (Archived)

No abstract provided.

"In And Of Itself Nothing Is Finite": Schelling's Nature (Or So-Called Identity) Philosophy, Michael Vater

Philosophy Faculty Research and Publications

No abstract provided.

Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons: Appendix E. Results Of Gene Ontology Analysis For Differentially Methylated Genes, Trevor Fish, Abby D. Benninghoff

Browse all Datasets

This Microsoft Excel document provides complete results for AgriGo gene ontology analyses of differentially methylated genes in the form of three tables, as follows:

Table 1. AgriGO GO Slim Results for Biological Process, Molecular Function and Cellular Compartment for Sham, AdjDBC and TumDBC Tissues

Table 2. AgriGO GO Slim Results for Biological Process, Molecular Function and Cellular Compartment for Sham, AdjBaP and TumBaP Tissues

Table 3. AgriGO GO Slim Results for Biological Process, Molecular Function and Cellular Compartment for sham, TumDBC and TumBaP Tissues

African Liberative Theologies, Joseph Ogbonnaya

Theology Faculty Research and Publications

No abstract provided.

Effects Of The Algal Toxin Microcystin On Fishes In The James River, Virginia, Maxwell D. Haase

Theses and Dissertations

With the global rise in frequency of harmful algal blooms in estuarine environments comes an increase in prevalence of toxic metabolites, such as microcystin (MC), that some of the cyanobacteria involved will produce. At high concentrations, MC may accumulate in consumer tissues and have deleterious effects on organisms; however impacts of the toxin on aquatic living resources at ecologically relevant concentrations have not been widely documented. We analyzed the effects of MC on juveniles of five fish species from the James River, Virginia to determine if MC has the potential to impede growth. Using three separate experimental approaches, it was …

Effects Of Tgf-Β1 And Il-33 On Mast Cell Function, Victor S. Ndaw

Theses and Dissertations

TGFβ is involved in many pathological conditions, including autoimmune disorders, cancer, and cardiovascular and allergic diseases. We have previously found that TGFβ can suppress IgE-mediated mast cell activation in human and mouse mast cells in vitro. IL-33 is a recently discovered member of the IL-1 family capable of inducing mast cell responses and enhancing IgE-mediated activation. In this study, we investigated the effects of TGFβ on IL-33-mediated mast cell activation. Bone marrow-derived mast cells cultured in TGFβ -1, -2, or -3 showed reduced IL-33-mediated production of TNF, IL-6, IL-13 and MCP-1, in a concentration-dependent manner. Furthermore, TGFβ also reduced …

Race & Non-Racial Characteristics In Sentencing Length And Sentencing Type Disparity, Davis A. Estes

Theses and Dissertations

Utilizing data from the United States Department of Justice Bureau of Justice Statistics Survey of Inmates in State and Federal Correctional Facilities (SISCF) 2004, this research investigates the possibility that African American drug offenders receive lengthier prison sentences and are imposed more range of time or indeterminate sentences as opposed to flat sentences based on race and/or non-racial characteristics; specifically parole status prior to sentencing, plea agreement status, prior criminal history, education status prior to arrest, employment status prior to arrest, and parental incarceration. While regression analysis revealed racial sentencing disparity for length of sentence and type of sentence (p< .05 and p< .001 respectively), among non-racial characteristics, only education status prior to arrest proved a significant predictor for length of sentence (p≤ .001). African American drug offenders were more likely sentenced to indeterminate sentences as opposed to flat sentences and were less likely to receive short sentences of 0 to 4 years or medium sentences of 4 to 10 years as compared to long sentences of 10 or more years. Potential research implications include the necessity for additional research regarding racial sentencing disparity as length or type of sentences as opposed to disparity as a numerical or a percentage difference between racial groups as well as the utilizing of inmate data that encompasses recent changes in drug sentencing laws, e.g. crack cocaine versus powder cocaine. Future research might also consider the evolution of marijuana laws in the United States and the potential impact on racial sentencing disparity.

Characteristics, Audience Reception And Challenges In Malaysian Animation / Mohd Amir Bin Mat Omar, Mohd Amir Mat Omar

Student Works (2010-2019)

The creative content industry in Malaysia is a growing and developing business. Animation, being part of the creative industry, is also seeing a rise with the increasing number of studios being set up and the increase in numbers of animated series and films being produced. Facing powerhouses such as Japan and the United States, Malaysian animation content finds itself sandwiched in between foreign programs in channels such as Disney, Nickelodeon and Cartoon Network, though better opportunities may be found through local stations. With such an abundance of animated series and films, it is a challenge for Malaysian animation content to …

Production Of Reducing Sugars From Sago Waste Via Sequential Ionic Liquid Dissolution-Solid Acid Saccharification / Lee Kiat Moon, Kiat Moon Lee

Student Works (2010-2019)

Lignocellulosic biomass can be saccharified to produce reducing sugars that can be converted into various valuable products. This research aimed to produce reducing sugars from sago waste via sequential ionic liquid dissolution-solid acid saccharification process. The study included determining the best ionic liquid and solid acid catalyst combination, process optimisation, and kinetic study of the process, as well as product separation and catalyst recyclability. The ionic liquids investigated were 1-butyl-3-methylimidazolium chloride ([BMIM]Cl), 1-ethyl-3-methylimidazolium acetate ([EMIM][OAc]) and 1-ethyl-3-methylimidazolium diethyl phosphate ([EMIM][(EtO)2PO2]), while the solid acid catalysts investigated were Amberlyst 15 (A15), Amberlite IR120 and Nafion NR50. The study has provided a …

Solid State Synthesis Of Forsterite And Its Mechanical Properties / Christopher Chin Kong Ming, Christopher Kong Ming Chin

Student Works (2010-2019)

Forsterite (Mg2SiO4) has the potential for biomedical application. There were various synthesis methods developed over the years to produce nanocrystalline forsterite by conventional pressureless sintering. However, a systematic study on the factors controlling the properties of forsterite during powder processing and sintering has not been established. Hence, the aim of this research is to develop a well-defined phase pure forsterite ceramic employing conventional presureless sintering and to determine the optimum conditions to produce a sintered body with improved mechanical properties. In this study, 3 hours ball milling without heat treatment was determined as the optimum powder preparation method. There were …

Interlinked Population Balance And Cybernetic Models For The Simultaneous Saccharification And Fermentation Of Natural Polymers / Ho Yong Kuen, Yong Kuen Ho

Student Works (2010-2019)

The generation of important and useful products (e.g. ethanol, lactic acid etc.) through microbial fermentation often involves the breakdown of complex polymeric feedstock such as starch and cellulose through enzymatic scissions followed by subsequent metabolic conversion. The interplay between the kinetics of enzymatic depolymerization and the response of the microbes towards changes in the abiotic phase is critical for the adequate description of such a complex process. In this work, two unrelated frameworks, i.e. the Population Balance Modelling (PBM) and the Cybernetic Modelling (CM) were interlinked to model such a system. Specifically, the PBM technique was used to describe the …

Pemahaman Makna Tersirat Dalam Interaksi Kanak-Kanak Prasekolah / Noor Azmira Binti Mohamed, Noor Azmira Mohamed

Student Works (2010-2019)

Pemahaman makna tersirat bermaksud memahami maksud dalaman (tersirat) sesuatu ujaran iaitu maksud yang berbeza dari makna linguistik atau teks. Lenneberg mengatakan bahawa kebolehan kanak-kanak memahami ujaran telah wujud sebelum kanak-kanak boleh bertutur lagi. Lantaran itu, adalah tidak mustahil jika pemahaman makna tersirat juga telah wujud dalam diri kanak-kanak seawal usia tiga tahun lagi. Kajian ini dilakukan bagi membuktikan tahap sebenar pemahaman makna tersirat kanak-kanak prasekolah kerana kanak-kanak sering dianggap hanya memahami perkara-perkara ‘mudah’ yang diujarkan oleh orang dewasa. Dapatan kajian ini diharap dapat digunakan oleh ibu bapa untuk membantu memperkembangkan potensi diri kanak-kanak dalam kecekapan berbahasa serta membantu pihak yang …

Fuzzy Qualitative Approach To Address Uncertainty In Human Motion Analysis / Lim Chern Hong, Chern Hong Lim

Student Works (2010-2019)

Human motion analysis is one of the most active researches in computer vision society nowadays due to its wide spectrum of applications. Current researchers have been focused on implementing sophisticated algorithms with the goal to achieve good recognition rate but such work are limited to some constraints or assumptions. As a consequence, these systems are impractical to deploy in real-world environment due to the abounded uncertainties in the human motion analysis pipeline such as human size variation, viewpoint variation, and classification ambiguity. Failing in handling these uncertainties could affect the overall system performance. In this thesis, fuzzy qualitative reasoning is …

Imitation Learning Through Self-Exploration : From Body-Babbling To Visuomotor Association / Farhan Dawood, Farhan Dawood

Student Works (2010-2019)

Mirror neurons are visuo-motor neurons found in primates and thought to be significant for imitation learning. The proposition that mirror neurons result from associative learning while the neonate observes his own actions has received noteworthy empirical support. Imitation learning through self-exploration is essential in development of sensorimotor skills in infants. Self-exploration is regarded as a procedure by which infants become perceptually observant to their own body and engage in a perceptual communication with themselves. It is assume that crude sense of self is the prerequisite for social interaction rather than an outcome of it. However, role of mirror neuron in …

The Extent Of Environmental Management Accounting (Ema) Implementation And Environmental Reporting (Er) Practices : Evidence From Malaysian Public Listed Companies / Norsyahida Binti Mokhtar, Norsyahida Mokhtar

Student Works (2010-2019)

While the pressure of legitimacy was found to greatly influence companies’ environmental reporting (ER) practices, being environmentally responsible, however, is not necessarily reflected through positive and descriptive ER. Unless companies begin to truly commit to their business environmental impacts, the issue of incomprehensiveness and incredibility of ER will remain. Given it has been suggested that the deficiency of conventional accounting practices to capture environmental information contributes to the non-disclosure of complete and reliable information, the implementation of environmental management accounting (EMA) is thus necessary. Through EMA implementation, both monetary and physical environmental information can be generated, enabling the integration of …

Classification Of Acute Leukemia Using Image Processing And Machine Learning Techniques / Hayan Tareq Abdul Wahhab, Hayan Tareq Abdul Wahhab

Student Works (2010-2019)

Medical diagnosis is the procedure of identifying a disease by critical analysis of its symptoms and is often aided by a series of laboratory tests of varying complexity. Accurate medical diagnosis is essential in order to provide the most effective treatment option. The work presented in this thesis is focused on processing of peripheral blood smear images of patients suffering from leukemia based on blast cells morphology. Leukemia, a blood cancer, is one of the commonest malignancies affecting both adults and children. It is a disease in which digital image processing and machine learning techniques can play a prominent role …

Long Range Surface Plasmon Based Biosensor For Dengue Virus Detection / Wong Wei Ru, Wei Ru Wong

Student Works (2010-2019)

Dengue, a mosquito-borne disease caused by one of the four dengue virus serotypes, is of major public health interest in over 100 tropical and sub-tropical countries worldwide. Dengue infection causes flu-like symptoms and the severe cases can be fatal. Dengue cannot be reliably distinguished in its early stage using existing laboratory diagnostic techniques. In the absence of specific treatment for or vaccine against this disease, an early diagnosis of dengue infection is extremely important to reduce morbidity and mortality. The study in this thesis aimed to develop a compact, cost-effective, label-free, real-time biosensor based on long-range surface plasmon polariton (LRSPP) …

Psikologi Keperluan Remaja Dalam Novel-Novel Remaja Hadiah Sastera Kumpulan Utusan (Hsku) / Nurhamizah Hashim, Nurhamizah Hashim

Student Works (2010-2019)

Kajian ini menganalisis enam buah novel remaja Hadiah Sastera Kumpulan Utusan (HSKU), karya enam orang pengarang dengan menggunakan Pendekatan Hierarki Keperluan Remaja yang telah diubah suai dari Teori Hierarki keperluan Manusia. Novel- novel tersebut ialah Azfa Hanani (1995), Trilogi Cinta (2002) Merenang Gelora (2002), Merdekakan Cinta Ratna (2003), Beraraklah Awan Pilu (2006) dan Jendela Menghadap Jalan (2009). Analisis tersebut akan menggunakan lima peringkat utama yang terdapat dalam Pendekatan Hierarki Keperluan Remaja, iaitu pertama, keperluan fisiologi, kedua, keperluan keselamatan, ketiga, keperluan kasih sayang dan cinta, keempat, keperluan penghargaan kendiri dan akhir sekali kelima, keperluan penyempurnaan kendiri. Permasalahan kajian yang bertolak daripada …

Polymethacrylate Platforms With Controllable Surface Properties For Dengue Virus Detection / Samira Hosseini, Samira Hosseini

Student Works (2010-2019)

This thesis presents an effective method for synthesis and processing of polymethylmethacrylate-co-methacrylic acid (PMMA-co-MAA) biochips with controlled surface properties aimed for successful detection of the Dengue virus (DV). By variation of synthesis reaction parameters and using spin-coating technique, different compositions of the PMMA-co-MAA coated biochips were prepared. Designed coated chips have been employed for surface immobilization of the Dengue antibody molecules and further detection of DV through antibody/antigen coupling. Biomolecule immobilization on the functionalized surfaces of the chips was performed via different techniques including: 1) physical adsorption of the antibody on the surface; 2) covalent immobilization of the antibody on …

Sejarah Perkembangan Perusahaan Perikanan Di Negara Brunei Darussalam 1800-2008 / Pg Khairul Rijal Pg Hj Abdul Rahim, Pg Khairul Rijal Pg Hj Abdul Rahim

Student Works (2010-2019)

ini bertujuan untuk meneliti sejarah perkembangan perusahaan perikanan di Negara Brunei Darussalam antara tahun 1800 hingga 2008. Ketidakmampuan perusahaan perikanan memenuhi permintaan sumber perikanan dan kebergantungan Brunei kepada sumber perikanan import dari negara luar menjadi permasalahan utama yang diambil kira dalam kajian ini. Pengkajian mengenai sejarah perkembangan perusahaan perikanan ini dapat memperlihatkan satu gambaran yang lebih jelas dalam erti kata sebenar tentang ketidakmampuan perusahaan perikanan Brunei memenuhi permintaan sumber perikanan. Dalam mengenalpasti dan memahami kedudukan sebenar perubahan dan perkembangan yang telah berlaku dalam perusahaan perikanan Brunei, permasalahan kajian diteliti dalam konteks yang luas dan menyeluruh yang menitikberatkan sejarah secara kronologi …

Confidence Intervals (Ci) For Concentration Parameter In Von Mises Distribution And Analysis Of Missing Values For Circular Data / Siti Fatimah Binti Hassan, Siti Fatimah Hassan

Student Works (2010-2019)

This study is on circular statistics that is also known as directional statistics. Directional statistics is a branch of statistics which deal with the data in angle form in which the method of analysis is different from linear data. For example, the distribution analogues to the normal distribution in linear data is known as circular normal distribution. This study comprises of four parts. The first part of the study focuses on the efficient approximation for the concentration parameter in von Mises distribution. Here, a new method of approximating the concentration parameter is proposed, and the performance of the proposed method …

Development Of Canine Biomarker Based Detection And Quantification Assays For Determining Food Adulteration And Halal Authentication / Md. Mahfujur Rahman, Md. Mahfujur Rahman

Student Works (2010-2019)

The authentication of food product is an important issue to safeguard consumer rights, religious belief, and health and fair-trade economy. Proper labeling of food products allows consumers to make a well-informed purchase decision, commensurations his religious faith, health requirement and of course his personal budget. “Halal” logo on food products reflects both the ingredients and processing steps of the products confirm the Shariah Principles of Islam for hygienic foods. Since halal foods serve the health and religious requirements, their appeal is huge even to the non-Muslim customers. The huge turnover (US$700 billion/ annum) and expanding demands of halal food products …

Perspektif Islam Dan Sains : Kesan Madu Terhadap Memori Spatial / Mohd Amiruddin Bin Kamarulzaidi, Mohd Amiruddin Kamarulzaidi

Student Works (2010-2019)

Madu, pemanis semulajadi, dianggap oleh sains sebagai makanan yang berkhasiat kerana mengandungi gula dan pelbagai bahan fitokimia. Penggunaan madu dari kedua-dua perspektif sains dan tradisi Islam, dengan memfokus tentang kaitannya dengan memori, menjadi topik kajian ini. Kajian juga melibatkan kerja makmal yang menggunakan model tingkah laku haiwan. Konsep madu sebagai penawar dalam tradisi Islam adalah berdasarkan pernyataan khusus di dalam surah al-Nahl (Lebah), iaitu surah al-Qur’an yang ke-16. Ayat 68-69 menyatakan tentang penghasilan madu dalam pelbagai warna, pembuatan sarang oleh lebah di pelbagai tempat dan juga kebolehan madu “menyembuh”. Beberapa hadith turut menyokong peranan madu sebagai penawar dan sarjana-sarjana Muslim …

Development Of Multiplex Pcr Assay For The Detection Of Five Non-Halal Species In Islamic Foods / Md. Abdur Razzak, Md. Abdur Razzak

Student Works (2010-2019)

Food forgery is one of the most concerning socio-economic issues having impact on health, religions and hard earned wages. The recent scandals on horse meat in Europe, rat meat in China have given consumers apprehension on the detection, differentiation and identification of ingredients, especially the meat items, in foods, medicine and other consumers’ products. A range of analytical methods based on lipid, protein and DNAbiomarkers have been proposed for meat species authentication. However, lipid and protein-based examinations are less trustworthy since protein can be easily denatured and the level of lipids can be significantly modified through the processing treatments. On …

Role Of Nigella Sativa Oil On Histological Features And Androgenicity Of Nicotine Treated Male Sprague Dawley Reproductive System / Lina Binti Samsudin, Lina Samsudin

Student Works (2010-2019)

Tobacco is a plant from which nicotine, the alkaloid in cigarette is known to have detrimental effects on male reproductive system, can be sourced. As for Nigella sativa is a plant which has been used in culinary and also as traditional medicine since the antiquity by worldwide society. The remedial value of Nigella sativa has been attributed to its antioxidant properties. This study was conducted to investigate the protective effects of Nigella sativa oil on spermatogenic, leydig and sertoli cell count, histological features and androgenicity of nicotine treated male rat reproductive system. Thirty male Sprague dawley rats, aged 7 – …