Digital Commons Network^™

Neural Dynamics Of Social Tie Formation In Economic Decision-Making, Nadège Bault, Benjamin Pelloux, Johannes J. Fahrenfort, K. Richard Ridderinkhof, Winden F Van

School of Psychology

No abstract provided.

Correlates Of Rarity In Uk Bumblebee (Bombus Spp.) Populations, Sarah Elizabeth Rustage

School of Biological and Marine Sciences Theses

The decline of bumblebee (Bombus spp.) populations in the UK and worldwide has been well reported. It has been generally assumed that such declines result in the genetic impoverishment of some species, potentially leading to reduced fitness and increased extinction risk. This study tested the fundamental assumption linking population fragmentation with fitness, in a model system of two Bombus species native to the UK. Bombus monticola has declined significantly in range across the UK in recent years and occupies fragmented upland areas, while Bombus pratorum has remained abundant and widespread over many habitat types. The effects of genetic diversity on …

Investigation Of The Risks Of Entry And Spread Of Bvd In Herds Participating In A Regional Bvd Control Programme In The South West, Rebecca Mary Butland

School of Biological and Marine Sciences Theses

Bovine Viral Diarrhoea (BVD) is estimated to cost the UK cattle industry £40 million annually, the third most costly disease facing the agricultural industry. BVD produces a range of symptoms in cattle including scouring, pneumonia, poor fertility, reduced growth rates and lowered milk yields. The most common route of transmission is through persistently infected (PI) animals shedding the virus to other cattle. PI animals can only develop pre-partum when the BVD virus crosses the placenta from the dam to the foetus. If infection occurs during the first 110 to 150 days of gestation, the foetus is immune-incompetent and the lymphocytes …

Relationships Between Iron, Oxidative Stress, Glycated Proteins And The Development Of Atherosclerosis In Type 2 Diabetes, Husam O. Dakhil Aljwaid

School of Biological and Marine Sciences Theses

Hyperglycaemia stimulates a variety of biochemical abnormalities. The area of particular interest in this study is the influence of non-enzymatic glycation of proteins on iron homeostasis, and particularly on non-transferrin-bound iron (NTBI) and its possible relation to atherogenesis in both Type 2 diabetic and obese non diabetic subjects. The link between non-enzymatic glycation of proteins and iron homeostasis, and development of macrovascular disease may be mechanistically different in Type 2 diabetic and obese non diabetic subjects due to a difference in the protein glycation pattern. Because the following in vivo study required storage of samples for up to two years …

Assessing The Effects Of Long-Term Ocean Acidification On Benthic Communities At Co2 Seeps, Cecilia Baggini

School of Biological and Marine Sciences Theses

Ocean acidification has the potential to profoundly affect marine ecosystems before the end of this century, but there are large uncertainties on its effects on temperate benthic communities. Volcanic CO2 seeps provide an opportunity to examine and improve our understanding of community responses to ocean acidification. In this thesis, two Mediterranean CO2 seeps (Methana in Greece and Vulcano in Italy) were used to investigate the responses of macroalgae and their epifaunal communities to increased CO2. Changes in plant-herbivore interactions at elevated CO2, as well as adaptation potential of dominant macroalgae and responses of macroalgae and epifauna to concurrent exposure to …

Effects Of Dietary Ingredients And Feed Additives On The Health And Production Of European Sea Bass (Dicentrarchus Labrax) For Applications In Aquaculture, David Luke Peggs

School of Biological and Marine Sciences Theses

Experiment one revealed fishmeal (FM) replacement with soy protein concentrate (SPC) alone, and in combination with pea protein concentrate (PPC) and saponins (S) modulated the intestinal bacterial communities of D. labrax, increasing the presence of lactic acid bacteria. Intestinal histology revealed significantly reduced goblet cell’s (GC’s) in fish fed the SPC+S, epithelial microvilli densities (MD) in fish fed the SPC+PPC, SPC+PPC+S and SPC+S after two weeks feeding. Significant reductions in GC’s and intraepithelial leukocytes (IEL’s) in fish fed the SPC+S, and MD’s in fish fed the SPC+S and SPC+PPC+S after four weeks feeding, relative to fish fed the FM control. …

Managing The Retreat: Understanding The Transition To Salt Marsh In Coastal Realignment Projects, Anissia White

School of Biological and Marine Sciences Theses

Managed realignment is now widely seen as an important part of coastal management strategy, as an environmentally sustainable, cost-effective alternative to traditional, hard defences. However, the trajectory of salt marsh development in managed realignment schemes remains uncertain and it is unclear how sites should be managed to fulfil both coastal defence and biodiversity objectives. In this study, the overarching aim is to find out ways in which we can create salt marshes that are self-sustaining and function as closely to natural ecosystems as possible, by considering the linked biogeomorphological processes in salt marsh ecosystems. Such an approach will improve predictions …

The Gastrointestinal Uptake Of Titanium Dioxide Nanoparticles: Studies On Caco-2 Cells, Perfused Intestine And In Vivo Dietary Intake In The Rat (Rattus Norvegicus), Constantinos Gitrowski

School of Biological and Marine Sciences Theses

The use of nanomaterials (NMs) in orally ingestible products raises concerns about potential hazards. Titanium dioxide (TiO2) particles (of which some are incidentally produced at the nanoscale) are used in cosmetics, biological remediation (photo-catalysis), toothpastes, ingestible pharmaceuticals and food products. The increased surface area to mass ratio of nanoparticles (NPs) potentially makes them more biologically reactive than their coarser (bulk) material counterparts. There is limited data available on the uptake kinetics across the mammalian gastrointestinal tract, and the potential hazard posed to humans. In this study, the uptake and accumulation of TiO2 (nano and bulk) into and across the human …

Habitat Assessment And Ecological Restoration Design For An Unnamed Tributary Of Stone Dam Creek, Conway, Arkansas, Paige E. Boyle, Mary C. Savin, James A. Mccarty, Marty D. Matlock

Discovery, The Student Journal of Dale Bumpers College of Agricultural, Food and Life Sciences

Urbanization can lead to increased sedimentation, erosion, pollution, and runoff into streams. The United States Environmental Protection Agency’s (USEPA) Rapid Bioassessment Protocols (RBPs) are sets of guidelines that can be used to assess a habitat’s sedimentology, hydrology, vegetation, and geomorphology to determine impairment. An unnamed tributary of Stone Dam Creek on the University of Central Arkansas (UCA) campus in Conway, Arkansas runs partially underground and through the urbanized UCA campus watershed. The stream was assessed using the USEPA’s RBPs to determine impairment of the stream, and received a RBP score of 71.2 out of 200 compared to 153.5 in a …

Nonlethal Weapons, Noncombatant Immunity, And The Principle Of Participatory Liability, Michael L. Gross

Case Western Reserve Journal of International Law

No abstract provided.

Challenges For Implementing A Ptsd Preventive Genomic Sequencing Program In The U.S. Military, Gabriel Lázaro-Muñoz, Eric T. Juengst

Case Western Reserve Journal of International Law

No abstract provided.

Active Landing Velocity: "Pawing Motion", Erin Dean Blind

Graduate Research Papers

The significance of this study is to newly examine a factor of sprint performance. Previous studies have examined the limiting factor of vertical force of contact during a sprint. Studies have yet to look at the horizontal velocity of the foot with respect to the center of mass prior to contact in a sprint. This study will look at this horizontal velocity to examine if that is also a limiting factor during the sprint. Past studies have shown that vertical forces of sprinters are as big two to three times the body weight during a sprint then when trying to …

Understanding By Design Unit Lesson Plans For The Next Generation Science Standards: Life Science, Arie Schiller

Graduate Research Papers

The project that I focused on for my Creative Component is the creation of Understanding by Design (UbD) unit lesson plans that address the Next Generation Science Standards (NGSS) in the topic of Evolution. When the final framework was released of the NGSS in 2011, the need for teachers to revisit and align their curriculum became a necessary step to ensure appropriate content was taught. In the fall of 2013, Keokuk Community School District decided science teachers would begin implementing the new NGSS, anticipating that the state of Iowa will adopt the standards.

This creative component includes lesson plans correlated …

The Inclusion Of Engineering Design Into The High School Biology Curriculum, Cody D. Lakose

Graduate Research Papers

The purpose of this project is to develop engineering-based lessons for a life science course,i.e. biology, in order to meet the NGSS standards as well as increase student interest in engineering by incorporating the principles of engineering design into the traditional science classroom.

Examining Variations In Technology Use For K-12 Students Of Different Gender And Socioeconomic Status, Nikki Lyons

Graduate Research Papers

The purpose of this paper is to review the literature currently published on how members of different genders and socioeconomic classes use technology to suit their needs in and out of the classroom learning environment. It will focus on the use of digital technologies by students in elementary, middle, and high schools. This was done by examining 30 research-based, peer-reviewed journal articles, books, published papers, documents, and observational analyses. The research indicates there are clear differences in how members of different subpopulations such as gender and socioeconomic groups choose to use technology to suit their communication, collaboration, instructional, and entertainment …

Y Chromosome Genetic Diversity And Breed Relationships In Native Polish Cattle Assessed By Microsatellite Markers, Beata Prusak, Wioletta Sawicka-Zugaj, Agnieszka Korwin-Kossakowska, Tomasz Grzybowski

Turkish Journal of Biology

Cattle provide a wide range of products and services to humans; thus the significance of conservation of livestock genetic resources is evident. We analyzed the genetic variability of five Y-chromosomal microsatellites in 395 bulls representing six cattle breeds (Polish Red, Polish Whitebacks, Polish Red-and-White, Polish Black-and-White, Polish Holstein Friesian, and Simmental). We identified three haplotypes in the paternal gene pool of analyzed populations. Haplotype diversity was low and frequencies ranged from 9.87% to 100%. In Polish autochthonous breeds (Polish Red, Polish Whitebacks), we detected two and three haplotypes. The network analysis revealed that tested bulls of both breeds were distributed …

Expression, Purification, And Characterization Of Recombinant Humanparaoxonase 1 (Rhpon1) In Pichia Pastoris, Yağmur Ünver, Esabi̇ Başaran Kurbanoğlu, Orhan Erdoğan

Turkish Journal of Biology

The main purpose of the present study was to perform the expression in Pichia pastoris X-33 of the human paraoxonase 1 (hPON1) enzyme, which is a mammalian serum protein. Extracellular hPON1 enzyme was expressed with the pPICZ?A vector using a strong AOX promoter, and enzyme secretion in the fermentation medium was achieved by means of Saccharomyces cerevisiae alpha factor signal sequence. The recombinant cells were grown in a shaking flask containing production medium. SDS-PAGE and Western blot analysis illustrated that the molecular mass of extracellular hPON1 enzyme produced by the recombinant P. pastoris strain was 59.1 kDa. Biochemical characterization of …

Reduction Behavior Of Fenoxaprop-P-Ethyl And Its Voltammetric Determination, Zeki̇ Eş, İbrahi̇m Hüdai̇ Taşdemi̇r

Turkish Journal of Chemistry

The reduction behavior of fenoxaprop-p-ethyl (FNX) was studied on a hanging mercury drop electrode. FNX showed 2 reduction peaks at about --0.7 V and at about --0.9 V versus Ag/AgCl/3.0 M KCl in Britton--Robinson buffer at pH 4.8. Both reductions were irreversible and adsorption was effective. The reduction peaks were assigned to the reduction of C=N to CH--NH and the reduction of C=O to CH--OH. Square-wave voltammetry has been proposed and validated for quantification of FNX in different samples. The linear working range was established as 0.30--15.0 \mu M. Limit of detection and limit of quantification were calculated as 0.07 …

Molecular Docking Analysis And Molecular Dynamics Simulation Study Of Ameltolide Analogous As A Sodium Channel Blocker, Maryam Iman, Atefeh Saadabadi, Asghar Davood

Turkish Journal of Chemistry

Fifteen compounds related to ameltolide with sodium channel inhibitory activity were subjected to a molecular docking study. The chemical structures of all compounds were built using the program HyperChem and conformational studies were performed with a semiempirical method followed by the PM3 method. A docking study was performed using the program AutoDock on all the compounds. To confirm the binding mode of inhibitors, molecular dynamics simulations were performed using GROMACS 4.5.5, based upon the docked conformation of ameltolide. The docking analyses indicated that these compounds interacted mainly with residues II-S6 and III-S6 of NaV1.2 by making hydrogen bonds and (\pi …

Ring Opening And Ring Closure Reactions Of Chromone-3-Carboxylic Acid: Unexpected Routes To Synthesize Functionalized Benzoxocinones And Heteroannulated Pyranochromenes, Magdy Ahmed Ibrahim, Tarik El-Sayed Ali

Turkish Journal of Chemistry

Unexpected routes to synthesize functionalized benzoxocinones and heteroannulated pyranochromenes were achieved via transformations of the \gamma-pyrone ring in chromone-3-carboxylic acid throughout its reactions with some acyclic and cyclic carbon nucleophiles. A key part of the reaction mechanisms is discussed. Structures of the new synthesized products were established on the basis of elemental analysis and spectral data (IR, MS, and ^1H and ^{13}C NMR).

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Two New Coordination Polymers Containing Dicyanidoargentate(I) And Dicyanidoaurate(I): Synthesis And Characterization, And A Detailed In Vitro Investigation Of Their Anticancer Activities On Some Cancer Cell Lines, Ali̇ Aydin, Ahmet Karadağ, Şaban Teki̇n, Nesri̇n Korkmaz, Aslihan Özdemi̇r

Turkish Journal of Chemistry

Two novel cyanido-bridged bimetallic polymeric complexes, [Ni(edbea)Ag$_{3}$(CN)$_{5}$]$_{n} $(C1) and [Ni(bishydeten) Au$_{2}$(CN)$_{4}$]$_{n}$ (C2), where edbea = [2,2$' $-(ethylenedioxy)bis(ethylamine)] and bishydeten = [($N$,$N' $-bis(2-hydroxyethyl) ethylenediamine)] are ligands, were synthesized and characterized by elemental, infrared, and thermal measurement techniques and investigated for their biological activity in cultured cancer cell lines. The results show that both compounds and free anions, [Ag(CN)$_{2}$]$^{-}$ and [Au(CN)$_{2}$]$^{-}$, exhibited very high antiproliferative activity compared to the anticancer drug 5FU against the cancer cell lines tested. The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free …

Synthesis Of Bis-Thiazoles, Bis-Pyrazoles, Bis-Hydrazonates, And Bis-Triazolothiadiazoles Based On Bis-Hydrazonoyl And Bis-Hydrazones, Abdelwahed Sayed

Turkish Journal of Chemistry

A facile synthesis of bis-thiazoles, bis-pyrazoles, and bis-hydrazonates from the reaction of bis-hydrazonoyl dichlorides with different moieties is described. Bis-triazolothiadiazoles were synthesized via oxidative cyclization of bis-hydrazones. Structures of the final product were elucidated by elemental analyses and spectral data.

Optimization Of The Adsorption Of A Textile Dye Onto Nanoclay Using A Central Composite Design, Aydin Hassani, Murat Kiranşan, Reza Darvishi Cheshmeh Soltani, Alireza Khataee, Semra Karaca

Turkish Journal of Chemistry

The main aim of this study was to evaluate the efficacy of montmorillonite clay for the adsorption of C.I. Basic Yellow 2 (BY2) dye from aqueous media. The experimental results were processed by response surface methodology based on a central composite design (CCD). The effect of four main variables, including initial BY2 concentration, adsorbent dosage, reaction time, and temperature on the removal of BY2 was evaluated by the model. The accuracy of the model and regression coefficients was appraised by employing analysis of variance. The results demonstrated a good agreement between the predicted values obtained by the model and the …

Conversion Of Racemic Allylic Hydroperoxides Into Corresponding Chiral 1/2,3-Triols By Using Catalytic Oso$_{4}$ And Chiral Cinchona Ligands In The Absence Of Co-Oxidant, Haydar Göksu, Mehmet Serdar Gülteki̇n

Turkish Journal of Chemistry

For the first time, removal of oxygen atoms from allylic hydroperoxide functionality and reintroduction to the double bond was achieved using catalytic OsO$_{4}$ and chiral cinchona alkaloid derivatives in an acetone-water mixture to give corresponding chiral 1/2,3-triol with an enantioselectivity up to 99% ee. The hydroperoxide group was used as both a co-oxidant and a source of hydroxyl groups. This protocol is thought to have potential to provide opportunities for chiral synthesis of 1/2,3-triols from corresponding allylic hydroperoxides in the absence of co-oxidant in one stage for the first time in the literature.

Microwave-Assisted Synthesis Of Condensed 1,4-Dihydropyridines As Potential Calcium Channel Modulators, Erdem Kami̇l Özer, Mi̇yase Gözde Gündüz, Ahmed El-Khouly, Mehmet Yildirim Sara, Rahi̇me Şi̇mşek, Alper Bektaş İski̇t, Osman Ci̇hat Şafak

Turkish Journal of Chemistry

This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications of nifedipine, which is a calcium channel blocker. The compounds were achieved by one-pot microwave-assisted reaction of 4,4-dimethyl-1,3-cyclohexanedione, 5-chlorosalicylaldehyde/3,5-dichlorosalicylaldehyde, an appropriate alkyl acetoacetate, and ammonium acetate in ethanol according to a modified Hantzsch reaction. The structures of the compounds were confirmed by spectral methods and elemental analysis. To evaluate their relaxant activities, the maximum relaxant response (E$_{\max})$ and pD$_{2}$ values of the compounds and nifedipine were determined on isolated …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Properties And Some In Vitro Studies Of 6-Phosphogluconate Dehydrogenase Purified From The Liver Of Chalcalburnus Tarichi, The Only Fish Living In Lake Van's Highly Alkaline Water (Ph 9.8), Muhammet Güler, Vedat Türkoğlu, Mehmet Riza Kivanç

Turkish Journal of Chemistry

In this study, some enzymology parameters and some antibiotics affecting the enzyme activity of 6-phosphogluconate dehydrogenase (6PGD) extracted from t the livers of fish from Lake Van (\textit{Chalcalburnus tarichi}) were investigated because it is an important enzyme-producing NADPH, a reductive power, protecting the cell against the oxidative agents by producing reduced glutathione. The crude enzyme solution was obtained by using the affinity chromatography method. The native molecular weight of the enzyme is $\sim $90,000 $\pm $ 3000 Da and it is composed of two subunits with identical molecular weights of $\sim $46,000 Da as exhibited on sodium dodecyl sulfate-polyacrylamide gel …

Cover And Contents

Turkish Journal of Chemistry

No abstract provided.

Development Of High Capacity Hyperbranched Nitric Oxide Donors For Controlling Subcutaneous Inflammation, Sean Hopkins

Dissertations, Master's Theses and Master's Reports

Implanted medical devices undergo complications the longer they remain in contact with tissue or blood. This rejection of foreign materials by our body is one of the largest reasons innovations in biomedical sensors and implanted technology are being held back. One means to hold off this unwanted response is through the utilization of nitric oxide (NO) releasing materials. Two unique NO releasing polymeric materials were synthesized and characterized before being implanted subcutaneously. Both NO releasing materials described used S-nitrosothiol (RSNO) chemistry as the main mechanism for NO release. The first material described covalently links an RSNO to the backbone of …