Digital Commons Network^™

Endothelin-B Receptor Activation In Astrocytes Regulates The Rate Of Oligodendrocyte Regeneration During Remyelination., Timothy R. Hammond, Brian Mcellin, Paul D Morton, Matthew Raymond, Jeff Dupree, Vittorio Gallo

Medicine Faculty Publications

Reactive astrogliosis is an essential and ubiquitous response to CNS injury, but in some cases, aberrant activation of astrocytes and their release of inhibitory signaling molecules can impair endogenous neural repair processes. Our lab previously identified a secreted intercellular signaling molecule, called endothelin-1 (ET-1), which is expressed at high levels by reactive astrocytes in multiple sclerosis (MS) lesions and limits repair by delaying oligodendrocyte progenitor cell (OPC) maturation. However, as ET receptors are widely expressed on neural cells, the cell- and receptor-specific mechanisms of OPC inhibition by ET-1 action remain undefined. Using pharmacological approaches and cell-specific endothelin receptor (EDNR) ablation, …

Disney’S Female Gender Roles: The Change Of Modern Culture, Mckenzie Barber

University Honors College

Disney Animation and their films are a huge part of the entertainment industry in America. They influence and reach children through many avenues, not just with movies, but through clothing, games, and toys. Disney has been around for over 80 years, and during that time, they have played a role in how society displays gender roles. As modern culture goes through changes, Disney can also be seen making changes in the way they represent their characters, especially females. While looking specifically at Disney princesses, the depiction of females and their gender roles can be described in at least one of …

Kopchick Awards Provide $87,795 To Ohio Student, Faculty And Staff Researchers, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Psychology Undergrad Gets Kopchick Award To Study Neurodegenerative Diseases, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Influence Of Macular Pigment Optical Density Spatial Distribution On Intraocular Scatter/Influencia De La Distribución Espacial De La Densidad Óptica Del Pigmento Macular Sobre La Dispersión Intraocular, Christopher M. Putnam, Pauline J. Bland, Carl Bassi

Educator Preparation & Leadership Faculty Works

Purpose

Methods

Doe V. Friedman, Neal Hendel, Anat Baron, Uri Shoham

Translated Opinions

[This abstract is not part of the Court's opinion and is provided for the reader's convenience. It has been translated from a Hebrew version prepared by Nevo Press Ltd. and is used with its kind permission.]

A transgender woman ended her life, and, in documents she left behind, she made clear that she wished for her body to be cremated and that most of her ashes be scattered at sea and some be buried in a place for her memory. In her will she asked that the First Respondent act to execute her wishes – this, among others, because she …

Biology Undergrad Gets Kopchick Award For Obesity Gene Expression In Mice, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Biology Grad Student Gets Kopchick Fellowship Award, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Meaning As A Buffer Against Adolescent Psychopathology, Ellen Shaina Dulaney

College of Science and Health Theses and Dissertations

This thesis investigates the function of meaning in life in adolescence to ascertain whether specific psychological resources may protect youths against threats to subjective well-being. Meaning in life and the search for the meaning in stressful occurrences were independently examined for their influence on stress impact and depression symptomatology. 201 American middle-school and high-school students between 12 and 19 years of age were recruited for this study. Participants reported on questionnaires targeting frequency of negative life events; depressive symptoms; sense of meaning; and tendency to reframe stressors in terms of their meaning, termed “stressor meaning seeking”. It was expected that …

Prevalence Of Blood Parasites In Damselfishes And Blennies Of The Eastern Caribbean And Their Detection Using Molecular Techniques, Lance Pierre Renoux

Student Theses and Dissertations

This study built on the recent discovery of Apicomplexan blood parasites in damsel and blennioid fishes in the Caribbean (Cook et al. 2015), by elucidating their geographical distribution, species and life history stages of damselfishes they infect, and developing specific molecular primers to identify them. From 2013-2015, eight damselfish species from three genera were sampled from 11 localities (n = 807), and eight blenny species from two genera (n = 114) were sampled from 7 of these sites. Damselfish parasites appeared only in Stegastes species and at all localities, except Curacao (n = only 6), but were rare in the …

Study Finds Genetic Risk Factor Can Lead To Hyperinflammatory Disorder, Death After Viral Infection, Staff

Browse All News

No abstract provided.

Estudios En Biodiversidad, Volumen I, Griselda Pulido-Flores, Scott Monks, Maritza López-Herrera

Zea E-Books Collection

Este libro es el producto del trabajo colegiado que han desarrollado los profesores, investigadores, y estudiantes que conforman la Red Temática de Calidad Ambiental y Desarrollo Sustentable, a través del macroproyecto “Evaluación del impacto ambiental por actividades antropogénicas: Alternativas de mitigación”. El cual fue apoyado con recursos financieros por parte del Programa para el Desarrollo Profesional Docente (PRODEP), de la Secretaria de Educación Pública (SEP) en México. Las instituciones de educación superior y cuerpos participantes en la red temática son la Universidad Autónoma del Estado de Hidalgo (Uso, Manejo y Conservación de la Biodiversidad UAEHCA- 10; Ciencias Ambientales UAEH-CA-59); Universidad …

Carroll Part Of Kopchick Award For Microbiota Research, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Attentional Bias In Moderate And Heavy College Drinkers: An Eye-Tracking Study, Ansley Victoria Geno

Electronic Theses and Dissertations Archive

Behavioral economic research regarding alcohol use aims to understand how substance use becomes favored over other rewarding non-substance activities (Meshesha, Dennhardt, & Murphy, 2014). The present study investigated attentional bias as an objective index of the relative valuation of substance-related rewards versus substance-free rewards among college students categorized as either heavy or moderate drinkers. The primary goal of this study was to assess the relative valuation of alcohol-related and alcohol-free rewards using multiple behavioral methods, such as attentional bias for alcohol measured via eye-tracking device, subjective ratings of the pleasantness of alcohol-related and alcohol-free stimuli, and measurement of recent activit …

Dual Drug Delivery With Calcium Sulfate-Chitosan Based Scaffolds For Bone Regeneration And Infection Control, Heather Alisa Doty

Electronic Theses and Dissertations Archive

The incidence of infection and non-union in severe musculoskeletal fractures continues to plague the medical community. This work investigated calcium sulfate (CS)-chitosan composite scaffolds with dual drug delivery capabilities. The aim of this dissertation is to investigate potential strategies for a dual delivery composite scaffolds that will allow for sufficient delivery of two therapeutic agents to control infection and regrow bone. Initial work focused on a chitosan microspheres-composite for delivery of antibiotics and growth factors. The dual delivery of antibiotics from both the CS and chitosan components was an approach to treat polymicrobial infections, while the dual delivery of an …

Implementation And Assessment Of Novel Functional Hemodynamic Mri Measurements In The Brain For Evaluation Of Disease And Treatment, Adam Martin Winchell

Electronic Theses and Dissertations Archive

The characterization and quantification of cerebral hemodynamics can provide critical biological information of current physiology. Divergent hemodynamic processes can provide integral knowledge into different pathophysiologies and aid in the diagnosis and evaluation of treatment. A variety of different magnetic resonance (MR) imaging techniques were implemented to quantify cerebral hemodynamics in a diverse set of neurological conditions. The first study investigated the association of blood flow and blood volume of a diffuse intrinsic pontine glioma tumor by arterial spin labeling (ASL) and dynamic susceptibility weighted contrast MR as a predictive marker of survival. Higher tumor blood flow and maintenance of higher …

An Assessment Of Haplotype And Nucleotide Diversity In The Southern Short-Tailed Shrew (Blarina Carolinensis), Anthony Christopher Grow

Electronic Theses and Dissertations Archive

The control region of mitochondrial DNA in the southern short-tailed shrew (Blarina carolinensis) was examined to further understand haplotype and nucleotide diversity of the species within a chromosomal-polymorphic zone in western Tennessee, as well as, in populations west of the Mississippi River. A congruent 214 base-pair region of 78 aligned sequences was analyzed from populations in western Tennessee, eastern Arkansas, eastern Texas, and eastern Oklahoma. Of the 78 sequences, 54 unique haplotypes were found. High haplotype and nucleotide diversity were reported for each locality and for the area sampled as a whole. Fixation indices also further support the degree of …

Nucleotide-Induced Conformational Changes In Escherichia Coli Dnaa Protein Are Required For Bacterial Orc To Pre-Rc Conversion At The Chromosomal Origin, Rahul K. Saxena, Sona Vasudevan, Digvijay Patil, Norah Ashoura, Julia E. Grimwade, Elliott Crooke

Biomedical Engineering and Sciences Faculty Publications

DnaA oligomerizes when bound to origins of chromosomal replication. Structural analysis of a truncated form of DnaA from Aquifex aeolicus has provided insight into crucial conformational differences within the AAA+ domain that are specific to the ATP- versus ADP- bound form of DnaA. In this study molecular docking of ATP and ADP onto Escherichia coli DnaA, modeled on the crystal structure of Aquifex aeolicus DnaA, reveals changes in the orientation of amino acid residues within or near the vicinity of the nucleotide-binding pocket. Upon limited proteolysis with trypsin or chymotrypsin ADP-DnaA, but not ATP-DnaA generated relatively stable proteolytic fragments of …

Systematic Analysis Of Hematopoietic Gene Expression Profiles For Prognostic Prediction In Acute Myeloid Leukemia, Frederick S. Varn, Erik H. Andrews, Chao Cheng

Dartmouth Scholarship

Acute myeloid leukemia (AML) is a hematopoietic disorder initiated by the leukemogenic transformation of myeloid cells into leukemia stem cells (LSCs). Preexisting gene expression programs in LSCs can be used to assess their transcriptional similarity to hematopoietic cell types. While this relationship has previously been examined on a small scale, an analysis that systematically investigates this relationship throughout the hematopoietic hierarchy has yet to be implemented. We developed an integrative approach to assess the similarity between AML patient tumor profiles and a collection of 232 murine hematopoietic gene expression profiles compiled by the Immunological Genome Project. The resulting lineage similarity …

Compositions Including Triciribine And Bortezomib And Derivatives Thereof And Methods Of Use Thereof, Jin Q. Cheng, Said M. Sebti

USF Patents

This application relates to combination therapies including triciribine and related compounds and bortezomib and derivatives thereof analogs and compositions with reduced toxicity for the treatment and prevention of tumors, cancer, and other disorders associated with abnormal cell proliferation.

Stream Daylighting Restoration As Green Infrastructure: A Visual Preference Survey For The Future Revitalization Of Dallas' Mill Creek, Ryan Matthew Brown

Landscape Architecture Masters & Design Theses - Archive

The purpose of this research is to study the visual design elements of stream daylighting through a visual preference survey and apply them to a site along the Mill Creek flowline in Dallas, Texas. This research begins with a study on identifying a specific site location within the Mill Creek watershed. From that study, a visual preference survey determined which visual design elements of stream daylighting were found to be the most desirable. The most desirable visual design elements were then used to digitally depict a suggested stream daylighting outcome through the use of before and after images of the …

The Impeccable Timing Of The Apple Maggot Fly, Rhagoletis Pomonella (Dipetera: Tephritidae), And Its Implications For Ecological Speciation, Monte Arthur Mattsson

Dissertations and Theses

Speciation is the process by which life diversifies into discrete forms, and understanding its underlying mechanisms remains a primary focus for biologists. Increasingly, empirical studies are helping explain the role of ecology in generating biodiversity. Adaptive radiations are often propelled by selective fitness tradeoffs experienced by individuals that invade new habitats, resulting in reproductive isolation from ancestral conspecifics and potentially cladogenesis. Host specialist insects are among the most speciose organisms known and serve as highly useful models for studying adaptive radiations. We are just beginning to understand the pace and degree with which these insects diversify. The apple maggot, Rhagoletis …

Genetic And Morphological Diversity Along Altitudinal Gradients In The Genus Rhoadsia (Teleostei: Characidae: Rhoadsiinae), Grace Malato

College of Science and Health Theses and Dissertations

The Neotropics have the highest fish species diversity of any area in the world, with some experts estimating that as many as 4000 species of fishes are present in freshwater ecosystems. Elevational gradients are partially responsible for this diversity due to the rapidly changing ecological conditions associated with changes in altitude in rivers. One area where elevational gradients are particularly important is Western Ecuador; this region forms part of a biodiversity hotspot extending south from Panama along the western side of the Andes. Fish species diversity is relatively low because of the small size of most of the river drainages …

Unh Scientist Receives $2.47m To Study Ocean's Smallest Creatures And Help Assess Damage Caused By Oil Spills, Lori Wright

Media Relations

No abstract provided.

Changsheng Li (1941 – 2015), Perry Smith

UNH Today Archive

No abstract provided.

Synthesis And Application Of Silica Based Mesoporous Materials For Removal Of Endocrine Disrupting Compounds In Aqueous Solution / Shanmuga Suntharam Kittappa, Kittappa Shanmuga Suntharam

Student Works (2010-2019)

The economical synthesis route of silica based mesoporous materials using eco-friendly and cheaper chemicals and material was studied. Three mesoporous silica-based materials were successfully synthesized and applied for the removal of endocrine disrupting compounds (EDCs): mesoporous silica materials (MSMs) synthesized by reacting pore templating agent Pluronic P123® with silica (SiO2) powder instead of organometallic precursors [i.e. tetraethyl orthosilicate (TEOS)]; magnetised nanocomposite silica material (MNCM) synthesized by incorporating MSMs with nano magnetite; and N1-(3-Trimethoxysilylpropyl) diethylenetriamine (Tris) coated magnetised nanocomposite silica materials (MNCMT) synthesized by incorporating MNCM with Tris. The synthesized materials were characterized by X-ray diffraction (XRD), Brunauer–Emmett–Teller (BET)/Barrett-Joyner-Halenda (BJH) surface …

Effects Of Preventative Ankle Taping On Planned Change-Of-Direction And Reactive Agility Performance And Ankle Muscle Activity In Basketballers, Matthew D. Jeffriess, Adrian B. Schultz, Tye S. Mcgann, Samuel J. Callaghan, Robert G. Lockie

Research outputs 2014 to 2021

This study investigated the effects of preventative ankle taping on planned change-of-direction and reactive agility performance and peak ankle muscle activity in basketballers. Twenty male basketballers (age = 22.30 ± 3.97 years; height = 1.84 ± 0.09 meters; body mass = 85.96 ± 11.88 kilograms) with no ankle pathologies attended two testing sessions. Within each session, subjects completed six planned and six reactive randomized trials (three to the left and three to the right for each condition) of the Y-shaped agility test, which was recorded by timing lights. In one session, subjects had both ankles un-taped. In the other, both …

Prospective Predictors Of Adolescent Bmi: Parenting Style, Gender, And Weight Perception, Trey V. Dellucci

College of Science and Health Theses and Dissertations

Obesity affects both adolescents and adults worldwide (Popkin & Doak, 1998). Determining which factors contribute to risk factors to the high prevalence of obesity in America is important because excess weight can negatively affect both physical health and psychosocial functioning (Kolotkin, Meter, & Williams, 2001). Few longitudinal studies have assessed the association between parenting styles and adolescent’s body mass index (BMI; Rhee et al, 2006). Past research has shown that parents greatly influence adolescent’s body image (Al Sabbah et al., 2009). Using data from the National Longitudinal Study of Adolescent Health, the current study examined the influence of parenting styles …

Minutes From The November 24, 2015 Meeting Of The University Of Montana Faculty, University Of Montana--Missoula. Faculty

University of Montana Faculty Senate Meeting Minutes

Meeting minutes from the November 24, 2015 meeting of the University of Montana faculty.

Epithelial Neoplasia Coincides With Exacerbated Injury And Fibrotic Response In The Lungs Of Gprc5a-Knockout Mice Following Silica Exposure, Xiaofei Wang, Dongliang Xu, Yueling Liao, Shuangshuang Zhong, Hongyong Song, Beibei Sun, Binhua P. Zhou, Jiong Deng, Baohui Han

Markey Cancer Center Faculty Publications

Exposure to crystalline silica is suggested to increase the risk for a variety of lung diseases, including fibrosis and lung cancer. However, epidemiological evidences for the exposure-risk relationship are ambiguous and conflicting, and experimental study from a reliable animal model to explore the relationship is lacking. We reasoned that a mouse model that is sensitive to both lung injury and tumorigenesis would be appropriate to evaluate the exposure-risk relationship. Previously, we showed that, Gprc5a^-/- mice are susceptible to both lung tumorigenesis and endotoxin-induced acute lung injury. In this study, we investigated the biological consequences in Gprc5a^-/- mouse model …