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Indium Tin Oxide With Zwitterionic Interfacial Design For Biosensing Applications In Complex Matrices, N.T. Darwish, Y. Alias, S.M. Khor

Research Publications (2011 to 2015)

Biosensing interfaces consisting of linker molecules (COOH or NH2) and charged, antifouling moieties ((SO3 and N+(Me)3) for biosensing applications were prepared for the first time by the in situ deposition of mixtures of aryl diazonium cations on indium tin oxide (ITO) electrodes. A linker molecule is required for the attachment of biorecognition molecules (e.g., antibodies, enzymes, DNA chains, and aptamers) close to the transducer surface. The attached molecules improve the biosensing sensitivity and also provide a short response time for analyte detection. Thus, the incorporation of a linker and antifouling molecules is an important interfacial design for both affinity and …

Integration Of Biosensors Based On Microfluidic: A Review, A.T. Yousefi, Samira Bagheri, Nahrizul Adib Kadri

Research Publications (2011 to 2015)

Purpose - Biotechnology is closely associated to microfluidics. During the last decade, designs of microfluidic devices such as geometries and scales have been modified and improved according to the applications for better performance. Numerous sensor technologies existing in the industry has potential use for clinical applications. Fabrication techniques of microfluidics initially rooted from the electromechanical systems (EMS) technology. Design/methodology/approach - In this review, we emphasized on the most available manufacture approaches to fabricate microchannels, their applications and the properties which make them unique components in biological studies. Findings - Major fundamental and technological advances demonstrate the enhancing of capabilities and …

Investigation On The Soundscape Preference And Perception Of Highlands Environment: A Preliminary Study, Nazli Che Din, Engku Mastura Engku Ahmad, Hazreena Hussein

Research Publications (2011 to 2015)

No abstract provided.

Mangrove Associated Algae From The Coastlines Of Malaysia, South-East Asia, Jelveh Sohrabipour, Siew Moi Phang, Phaik Eem Lim, Reza Rabiei

Research Publications (2011 to 2015)

No abstract provided.

Motion Corrected Lv Quantification Based On 3d Modelling For Improved Functional Assessment In Cardiac Mri, Yih Miin Liew, R.A. Mclaughlin, B.T. Chan, Y.F.A. Aziz, K.H. Chee, N.M. Ung, L.K. Tan, K.W. Lai, S. Ng, E. Lim

Research Publications (2011 to 2015)

Cine MRI is a clinical reference standard for the quantitative assessment of cardiac function, but reproducibility is confounded by motion artefacts. We explore the feasibility of a motion corrected 3D left ventricle (LV) quantification method, incorporating multislice image registration into the 3D model reconstruction, to improve reproducibility of 3D LV functional quantification. Multi-breath-hold short-axis and radial long-axis images were acquired from 10 patients and 10 healthy subjects. The proposed framework reduced misalignment between slices to subpixel accuracy (2.88 to 1.21 mm), and improved interstudy reproducibility for 5 important clinical functional measures, i.e. end-diastolic volume, end-systolic volume, ejection fraction, myocardial mass …

Muscle Spindles Provide Servo-Assistance To Jaw-Closing Muscles For Chewing Hard Foods, Mohammad Zakir Hossain, J. Kitagawa, Fathilah Abdul Razak, M.M. Bakri

Research Publications (2011 to 2015)

The fundamental pattern of chewing induced by the network of neurons called central pattern generator has been reported to be modified by the information arising from the various oro-facial sensory receptors including muscle spindles of jaw closing muscles. The cell bodies of primary afferent neurons from these muscle spindles lie in mesencephalic trigeminal nucleus (MTN) in the brainstem. The aim of the study was to understand whether muscle spindles from jaw-closing muscles play any role in hard food chewing. Single neuronal discharge of muscle spindle afferents was recorded from the MTN simultaneous with jaw-movement and electromyograpic (EMG) activities of the …

Nanonickel Catalyst Reinforced With Silicate For Methane Decomposition To Produce Hydrogen And Nanocarbon: Synthesis By Co-Precipitation Cum Modified Stober Method, U.P.M. Ashik, W.M.A.W. Daud

Research Publications (2011 to 2015)

Co-precipitation cum modified Stober method is a continuous process avoiding application of higher temperature treatment before supporting nanometal with SiO2, irrespective of pre-preparation methods. We have conducted the co-precipitation process without undertaking calcination under air in order to avoid even a partial particle agglomeration and hence maintained average particle size similar to 30 nm after enforcing with SiO2. This is the first report adopting such an unceasing preparation for preparing metal/silicate nanostructures. Furthermore, n-Ni/SiO2 nanostructured catalysts were used for thermocatalytic decomposition of methane to produce hydrogen and carbon nanotubes. The catalyst was found to be very stable and the methane …

Penggunaan Kaedah Platelet-Rich Plasma (Prp) Dalam Rawatan Kecantikan Menurut Perspektif Halal Haram, M.S. Nurhidayah, M.A. Nur Fadhilah, R. Mohd Anuar

Research Publications (2011 to 2015)

No abstract provided.

Plastic Debris In The Coastal Environment: The Invincible Threat? Abundance Of Buried Plastic Debris On Malaysian Beaches, Shahul Hamid Fauziah, I.A. Liyana, Pariatamby Agamuthu

Research Publications (2011 to 2015)

Studies on marine debris have gained worldwide attention since many types of debris have found their way into the food chain of higher organisms. Thus, it is crucial that more focus is given to this area in order to curb contaminations in sea food. This study was conducted to quantify plastic debris buried in sand at selected beaches in Malaysia. Marine debris was identified according to size range and distribution, and this information was related to preventive actions to improve marine waste issues. For the purpose ofthis study, comparison of plastic waste abundance between a recreational beach and fish-landing beaches …

Rawatan Kecederaan Berasaskan Teknik Platelet-Rich Plasma (Prp) Menurut Perspektif Halal Haram, S. Nurhidayah, M.N. Nurul Hidayah, C.S. Siti Aisyah, R. Mohd Anuar

Research Publications (2011 to 2015)

Kepakaran perubatan dan kecanggihan teknologi masa kini dalam dunia perubatan telah menghasilkan pelbagai penemuan baharu. Misalnya dalam rawatan kecederaan, terdapat berbagai kaedah rawatan yang ditawarkan dengan kesan penyembuhan yang efisien dan kos yang kompetitif. Antaranya teknik rawatan yang berasaskan darah atau dikenali sebagai Platelet-Rich Plasma (PRP). Sehubungan itu, kajian ini akan menfokuskan terhadap hukum rawatan PRP dengan mengambilkira empat elemen asas, iaitu sumber bahan, teknik rawatan, tujuan rawatan serta hasil rawatan. Pengkaji akan merujuk literatur berkaitan dengan rawatan PRP dan menganalisis pandangan ulama berkaitan hukum penggunaan darah dalam rawatan kecederaan. Hasil dapatan kajian mendapati bahawa sumber asas yang digunakan di …

Revealing Glycoproteins In The Secretome Of Mcf-7 Human Breast Cancer Cells, A.A. Tan, W.M. Phang, S.C.B. Gopinath, Onn Haji Hashim, Lik Voon Kiew, Yeng Chen

Research Publications (2011 to 2015)

Breast cancer is one of the major issues in the field of oncology, reported with a higher prevalence rate in women worldwide. In attempt to reveal the potential biomarkers for breast cancer, the findings of differentially glycosylated haptoglobin and osteonectin in previous study have drawn our attention towards glycoproteins of secretome from the MCF-7 cancer cell line. In the present study, further analyses were performed on the medium of MCF-7 cells by subjecting it to two-dimensional analyses followed by image analysis in contrast to the medium of human mammary epithelial cells (HMEpC) as a negative control. Carboxypeptidase A4 (CPA4), alpha-1-antitrypsin …

The Antineoplastic Properties Of Fty720: Evidence For The Repurposing Of Fingolimod, S.N. Patmanathan, L.F. Yap, P.G. Murray, I.C. Paterson

Research Publications (2011 to 2015)

Almost all drugs approved for use in humans possess potentially beneficial off-target' effects in addition to their principal activity. In some cases this has allowed for the relatively rapid repurposing of drugs for other indications. In this review we focus on the potential for re-purposing FTY720 (also known as fingolimod, Gilenya), an immunomodulatory drug recently approved for the treatment of multiple sclerosis (MS). The therapeutic benefit of FTY720 in MS is largely attributed to the immunosuppressive effects that result from its modulation of sphingosine 1-phosphate receptor signalling. However, this drug has also been shown to inhibit other cancer-associated signal transduction …

The Effect Of Nicotine Dependence On Psychopathology In Patients With Schizophrenia, A. Yee, N.N.N. Mohamed, A.H. Hashim, H.S. Loh, M.K.H. Singh, C.G. Ng, S.T. Jambunathan

Research Publications (2011 to 2015)

Introduction. Our study aims to determine the prevalence of nicotine dependence and investigate the effect of nicotine dependence on psychopathology among schizophrenia patients. Methods. A cross-sectional study was carried out in an outpatient psychiatric clinic at a general hospital in Malaysia. 180 recruited subjects were administered the Malay version of Mini International Neuropsychiatric Interview (MINI), the Positive and Negative Symptom Scale (PANSS), and the Malay version of Fagerstrom Test for Nicotine Dependence (FTND-M) questionnaires. Results. The prevalence of nicotine dependence among the subjects was 38.1% () and they were mainly composed of male gender, Malay ethnicity, being treated with atypical …

The Implication Of Feed-In Tariff Funding Structure And The Sustainability Of Renewable Energy In Malaysia, S. Yusoff, A. Syafiq Rosli

Research Publications (2011 to 2015)

With the anticipated increase in energy use and its implication toward sustainable development, Malaysia has put renewable energy at the forefront of Malaysia's energy policy to address environmental issues such as climate change and fossil fuel depletion. Drawing from successful case-studies from around the globe, Malaysia implemented its own version of the Feed-in Tariff (FIT) mechanism in a bid to achieve energy security and environmental prosperity. After three years of success, the growth of the renewable energy market under FIT is under threat due to the small size of the Renewable Energy Fund. Since FIT is funded by electricity consumers, …

Weight Optimization In Recurrent Neural Networks With Hybrid Metaheuristic Cuckoo Search Techniques For Data Classification, N.M. Nawi, A. Khan, M.Z. Rehman, H. Chiroma, T. Herawan

Research Publications (2011 to 2015)

Recurrent neural network (RNN) has been widely used as a tool in the data classification. This network can be educated with gradient descent back propagation. However, traditional training algorithms have some drawbacks such as slow speed of convergence being not definite to find the global minimum of the error function since gradient descent may get stuck in local minima. As a solution, nature inspired metaheuristic algorithms provide derivative-free solution to optimize complex problems. This paper proposes a new metaheuristic search algorithm called Cuckoo Search (CS) based on Cuckoo bird’s behavior to train Elman recurrent network (ERN) and back propagation Elman …

Youth's Well-Being: A Mediation Model Of Personality, Irrational Beliefs, And Spirituality In Malaysian Context, M. Haslina, R. John, W.M. Dennis

Research Publications (2011 to 2015)

No abstract provided.

Development Of A New Polymeric Material With Controlled Surface Micro-Morphology Aimed For Biosensors Applications, E. Farahmand, F. Ibrahim, S. Hosseini, I. Djordjevic, L.H. Koole

Research Publications (2011 to 2015)

Compositions of different molar ratios of POlymethyLmethacrylate-co-methacrylic acid (pMMA-co-MAA) Were synthesized via free- radical polymerization. Polymer coated Surfaces have been produced on silicon wafers. Coated samples were analyzed by atomic force microscopy (AfM). The results have shown that the roughness of the surfaces have increased by increasing the molar ratio of monomer methacrylic acid (MAA). This study reveals that the gadual increase in surface roughness is due to the fact that carbocxylic functional groups have been generated by MAA segments. Such surfaces can be desirable platforms for fabrication of the biosensors for detection of the viruses and diseases.

Defusing The Bug Bomb: Legal Strategies To Combat Antibiotic Resistant Infections, Andrew Geltman

Journal of Health Care Law and Policy

The overuse of antibiotics has created a potential public health menace—the growth of microbial infections resistant to them. Antibiotic resistance stems from many causes that include the use of antibiotics in animal feed, medical practitioners’ over-prescription, the general public’s misuse of the drugs, and the failure to develop new antibiotics. This has led to the development of so called “super bugs” that are often immune to first line antibiotic therapies, such as penicillin, and to more powerful, broad-spectrum treatments.

The CDC considers the primary source of antibiotic resistant infections in humans to come from our overuse of antibiotics and the …

2015 - 2016, Gardner-Webb University Graduate Academic Catalog, Gardner-Webb University

Graduate Academic Catalogs

2015 - 2016, Gardner-Webb University Graduate Academic Catalog. A. Frank Bonner, president.

Independent Drug Testing To Ensure Drug Safety And Efficacy, Marc A. Rodwin

Journal of Health Care Law and Policy

This Article explores a proposal that would preclude biased drug testing by removing all drug sponsor influence on the design and conduct of clinical trials for new drug applications (“NDAs”), a reform that would address the root of institutional corruption. Recently advocated by leading scholars, the idea has a long history, yet was neglected for over half a century due to pharmaceutical industry opposition.

Transfer Rna Comes Of Age, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

"The year the journal RNA was founded was slated by some in scientific publishing to be the year that one particular type of RNA's run in the spotlight would end. In 1995 I had recently started as a post-doc with Dieter Söll at Yale when he came into the lab to solemnly inform us all that an editor at a certain (S)cience journal had just told him “we won't be publishing any more tRNA papers.” For a post-doc who had migrated across the Atlantic for the sole purpose of furthering his career by working on tRNA this was not great …

Review Of The Millipede Genus Eutrichodesmussilvestri, 1910, In China, With Descriptions Of New Cavernicolous Species (Diplopoda, Polydesmida, Haplodesmidae), Sergei I. Golovatch, Jean-Jacques Geoffroy, Jean-Paul Mauries

KIP Articles

The Eutrichodesmus fauna of mainland China, by far the largest genus in the Indo-Australian family Haplodesmidae, is reviewed and shown to encompass 23 species (of a total of 45), all keyed. The following nine new species, all presumed troglobites, are described: E. triangularis sp. n., from Sichuan, E. lipsae sp. n., from Guangxi, E. tenuis sp. n., E. trontelji sp. n., E. latellai sp. n., E. obliteratus sp. n. and E. troglobius sp. n., all from Guizhou, E. sketi sp. n., from Hunan, and E. apicalis sp. n., from Hubei.

The White-Nose Syndrome Transcriptome: Activation Of Anti-Fungal Host Responses In Wing Tissue Of Hibernating Little Brown Myotis, Kenneth A. Field, Joseph Johnson, Thomas M. Lilley

KIP Articles

White-nose syndrome (WNS) in North American bats is caused by an invasive cutaneous infection by the psychrophilic fungus Pseudogymnoascus destructans (Pd). We compared transcriptome-wide changes in gene expression using RNA-Seq on wing skin tissue from hibernating little brown myotis (Myotis lucifugus) with WNS to bats without Pd exposure. We found that WNS caused significant changes in gene expression in hibernating bats including pathways involved in inflammation, wound healing, and metabolism. Local acute inflammatory responses were initiated by fungal invasion. Gene expression was increased for inflammatory cytokines, including interleukins (IL) IL-1β, IL-6, IL-17C, IL-20, IL-23A, IL-24, and G-CSF and chemokines, such …

Exogenous Administration Of Lipids To Steers Alters Aspects Of The Innate Immune Response To Endotoxin Challenge, Nicole C. Burdick Sanchez, Jeffery A. Carroll, Janet R. Donaldson, Joe O. Buntyn, Ty B. Schmidt

Department of Animal Science: Faculty Publications

This study examined the effects of increasing energy availability from both dextrose and lipid treatments on the proinflammatory response to LPS in Holstein steers. Steers were randomly assigned to one of three groups: saline at 0.5 ml/ kg body weight (Control) or 50% dextrose [0.5 ml/kg body weight (Dextrose) to mimic calm cattle’s response to LPS] administered immediately prior to LPS (0.5 mg/kg body weight at 0 h) or continuous lipid emulsion infusion from –1 to 6 h [Intralipid 20% (Baxter, Deerfield, IL USA); 0.5 ml/kg/hr (Lipid) to mimic temperamental cattle]. Concentrations of non-esterified fatty acids (NEFA) were greater in …

Mesh Ora Framework: R/Bioconductor Packages To Support Mesh Over-Representation Analysis, Koki Tsuyuzaki, Gota Morota, Manabu Ishii, Takeru Nakazato, Satoru Miyazaki, Itoshi Nikaido

Department of Animal Science: Faculty Publications

Background: In genome-wide studies, over-representation analysis (ORA) against a set of genes is an essential step for biological interpretation. Many gene annotation resources and software platforms for ORA have been proposed. Recently, Medical Subject Headings (MeSH) terms, which are annotations of PubMed documents, have been used for ORA. MeSH enables the extraction of broader meaning from the gene lists and is expected to become an exhaustive annotation resource for ORA. However, the existing MeSH ORA software platforms are still not sufficient for several reasons.

Results: In this work, we developed an original MeSH ORA framework composed of six types of …

A Cooperative Study On The Standardized Total-Tract Digestible Phosphorus Requirement Of Twenty-Kilogram Pigs, O. Adeola, M. J. Azain, S. D. Carter, T. D. Crenshaw, M. J. Estienne, B. J. Kerr, M. D. Lindemann, C. V. Maxwell, P. S. Miller, M. C. Shannon, E. Van Heugten

Department of Animal Science: Faculty Publications

A cooperative study comprising growth performance, bone mineralization, and nutrient balance experiments was conducted at 11 stations to determine the standardized total-tract digestible (STTD) P requirement of 20-kg pigs using broken-line regression analysis. Monocalcium phosphate and limestone were added to a corn–soybean meal–based diet at the expense of cornstarch to establish 6 concentrations of STTD P from 1.54 to 5.15 g/kg in increments of 0.62 g/kg at a constant Ca:total P of 1.52:1.0. Diets were fed to 936 pigs (average initial BW of 19 kg) in 240 pens for 20 replicate pens of barrows and 20 replicate pens of gilts …

Yield And Forage Value Of A Dual-Purpose Bmr-12 Sorghum Hybrid, Melinda K. Yerka, Andrea K. Pederson, J. J. Toy, Galen E. Erickson, Jeffrey F. Pedersen, Rob B. Mitchell

Department of Animal Science: Faculty Publications

Grain sorghum [Sorghum bicolor (L.) Moench] is an important crop for rainfed production systems with 2.7 million ha grown in the United States in 2013. The brown-midrib (bmr) mutations, especially bmr-12, have resulted in low stover lignin and high fiber digestibility without reducing grain yield in some sorghum lines. However, the effect of the bmr trait on beef cattle (Bos taurus) performance when grazing crop residue is unknown. Our objectives were to validate previous small-plot results reporting no grain yield difference between near-isogenic bmr-12 (BMR) and wild-type control (CON) A Wheatland × R

Tx430 …

Identification Of The Conformational Transition Pathway In Pip2 Opening Kir Channels, Junwei Li, Shouqin Lü, Yuzhi Liu, Chunli Pang, Yafei Chen, Suhua Zhang, Hui Yu, Mian Long, Hailin Zhang, Diomedes E. Logothetis, Yong Zhan, Hailong An

Physiology and Biophysics Publications and Presentations

The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2regulates Kir channels remains obscure. Here, we performed a series of Targeted molecular dynamics simulations on the full-length Kir2.1 channel and, for the first time, were able to achieve the transition from the closed to the open state. Our data show that with the upward motion of the cytoplasmic domain (CTD) the structure of the C-Linker changes from a loop to a helix. The twisting of the C-linker triggers the rotation of the CTD, which induces a small downward movement of the CTD …

Starvation-Induced Collective Behavior In C. Elegans, Alex B. Artyukhin, Joshua J. Yim, Mi Cheong Cheong, Leon Avery

Physiology and Biophysics Publications and Presentations

We describe a new type of collective behavior in C. elegans nematodes, aggregation of starved L1 larvae. Shortly after hatching in the absence of food, L1 larvae arrest their development and disperse in search for food. In contrast, after two or more days without food, the worms change their behavior—they start to aggregate. The aggregation requires a small amount of ethanol or acetate in the environment. In the case of ethanol, it has to be metabolized, which requires functional alcohol dehydrogenase sodh-1. The resulting acetate is used in de novo fatty acid synthesis, and some of the newly made …

Uri Undergraduate And Graduate Course Catalog 2015-2016, University Of Rhode Island

URI Course Catalogs Archive

This is a downloadable PDF version of the University of Rhode Island course catalog.