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Distal Femoral Osteotomy With Reflex Sympathetic Dystrophy: A Multifaceted Therapeutic Approach, Mark Laraway

Physical Therapy Scholarly Projects

Background and Purpose: The surgical procedure known as a distal femoral osteotomy has been shown to be effective in treating valgus deformities of the knee with osteoarthritis in younger, active patients. But with any procedure, unsuspected complications such as Complex Regional Pain Syndrome (CRPS) can make rehabilitation for the patients and their therapists challenging. This study focuses on taking a multifaceted approach to treating all of the underlying impairments of a patient with recurring knee pathologies and an underlying secondary diagnosis of CRPS.

Case Description: The patient is a 38-year-old female who has had multiple surgeries on her …

Breeding Sites Of Aedes Species Mosquito In Mandaue City, Cebu, Philippines, Butch Lanticse, Milagros Greif

CNU Journal of Higher Education

A survey on the breeding sites of Aedes species mosquito in Mandaue City, Cebu, Philippines, was conducted for the development of an integrated community-based dengue control program. The study included the identification of Aedes species breeding sites and an interview of households on their practices towards dengue prevention. Villages of six Barangays (lowest level of formal local administration) with the highest and lowest dengue incidences based on 2013 to August 2014 record of City Health Office were sampled for the study. Barangays with the highest dengue incidences include Banilad, Canduman and Subangdako, while the three remaining Barangays with the lowest …

Science Literacy-Focused Materials On Achievement And Attitude Toward Learning Chemistry, Maria Teresa M. Fajardo

CNU Journal of Higher Education

The study evaluated the effect of researcher developed science literacy instructional materials on pre-service elementary teachers’ attitude and achievement in chemistry during the first semester of school year 2012-2013. Using quasi-experimental design, 14 validated reading materials that were developed by the researcher were utilized as supplemental reading materials in a chemistry classroom. The experimental group was exposed to 30 minute PowerPoint presentation followed by reading infusion activity while the control group was exposed to the same PowerPoint presentation followed by either seat work or class discussion. English Proficiency Test was also given to determine if groups are comparable. Descriptive statistics …

"The Crescent" Student Newspaper, October 15, 2015, George Fox University Archives

"The Crescent" Student Newspaper

Student newspaper of George Fox University.

"Student Collective" Yearbook 2014-2015, George Fox University Archives

Yearbooks

No abstract provided.

New York Times V. Sullivan And The Rhetorics Of Race: A Look At The Briefs, Oral Arguments, And Opinions, Carlo A. Pedrioli

Faculty Scholarship

No abstract provided.

Adopting An International Convention On Surrogacy—A Lesson From Intercountry Adoption, Seema Mohapatra

Faculty Scholarship

No abstract provided.

Virginia Commonwealth University Fall Commencement Program [2015], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Virginia Commonwealth University Commencement Program [2015], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Environmental Resource Management In Borderlands: Evolution From Competing Interests To Common Aversions, Patrick Henry Buckley, John Belec, Jason Levy

L. Douglas Wilder School of Government and Public Affairs Publications

Great enthusiasm is attached to the emergence of cross-border regions (CBRs) as a new institutional arrangement for dealing with local cross-border environmental resource management and other issues that remain too distant from national capitals and/or too expensive to be addressed in the traditional topocraticmanner requiring instead local adhocratic methods. This study briefly discusses the perceived value of CBRs and necessary and sufficient conditions for the successful and sustainable development of such places. Then, assuming that necessary conditions can be met, the study investigates an intriguing hypothesis concerning the catalyzing of sustainable consensus for cross-border resource management based on a …

Progressive Cognitive Deficit, Motor Impairment And Striatal Pathology In A Transgenic Huntington Disease Monkey Model From Infancy To Adulthood, Anthony W. S. Chan, Jie Jiang, Yiju Chen, Chunxia Li, Melinda S. Prucha, Yijuan Hu, Tim Chi, Sean Moran, Tayeb Rahim, Shihua Li, Xiaojiang Li, Stuart M. Zola, Claudia M. Testa, Hui Mao, Rosa Villalba, Yoland Smith, Xiaodong Zhang, Jocelyne Bachevalier

Neurology Publications

One of the roadblocks to developing effective therapeutics for Huntington disease (HD) is the lack of animal models that develop progressive clinical traits comparable to those seen in patients. Here we report a longitudinal study that encompasses cognitive and motor assessment, and neuroimaging of a group of transgenic HD and control monkeys from infancy to adulthood. Along with progressive cognitive and motor impairment, neuroimaging revealed a progressive reduction in striatal volume. Magnetic resonance spectroscopy at 48 months of age revealed a decrease of N-acetylaspartate (NAA), further suggesting neuronal damage/loss in the striatum. Postmortem neuropathological analyses revealed significant neuronal loss in …

Culture-Centered Approaches: The Relevance Of Assessing Emotional Health For Latinos With Type 2 Diabetes, Jeannie Belinda Concha, Brianna Mezuk, Bonnie Duran

Family Medicine and Population Health Publications

Objective

Within Latino culture, there is a belief that strong emotions can cause diabetes. Because of this belief and evidence regarding the bi-directional relationship between depression and diabetes, the objectives of this study were to determine if medical doctors are asking Latinos with diabetes about emotional problems and to assess attitudes toward professional help for emotional problems.

Research design and methods

Data come from the nationally representative National Latino and Asian American Study and the National Comorbidity Survey Replication study. Only Latino subsamples were included (n=3076). A smaller subsample with complete data (n=2568) was used for the inquiry outcome variable. …

Comparison Of Effectiveness Of Cefovecin, Doxycycline, And Amoxicillin For The Treatment Of Experimentally Induced Early Lyme Borreliosis In Dogs, Bettina Wagner, John Johnson, David Garcia-Tapia, Nicole Honsberger, Vickie King, Catherine Strietzel, John M. Hardham, Thomas J. Heinz, Richard T. Marconi, Patrick F.M. Meeus

Microbiology and Immunology Publications

Background

While Koch’s postulates have been fulfilled for Lyme disease; causing transient fever, anorexia and arthritis in young dogs; treatment of sero-positive dogs, especially asymptomatic animals, remains a topic of debate. To complicate this matter the currently recommended antibiotic treatments of Lyme Disease in dogs caused by Borrelia burgdorferi require daily oral administrations for 31 days or longer, which makes non-compliance a concern. Additionally, there is no approved veterinary antimicrobial for the treatment of Lyme Disease in dogs in the USA and few recommended treatments have been robustly tested.

In vitro testing of cefovecin, a novel extended-spectrum cephalosporin, demonstrated inhibition …

Identification Of Small-Molecule Inhibitors Against Meso-2, 6-Diaminopimelate Dehydrogenase From Porphyromonas Gingivalis, Victoria N. Stone, Hardik I. Parikh, Fadi El-Rami, Xiuchun Ge, Weihau Chen, Yan Zhang, Glen E. Kellogg, Ping Xu

Microbiology and Immunology Publications

Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingivalis as a model. Through our knowledge of metabolic networks and essential genes we identified a “druggable” essential target, meso-diaminopimelate dehydrogenase, which is found in a limited number of species. We adopted a highthroughput virtual screen method on the ZINC chemical library to select a group of potential small-molecule inhibitors. Meso-diaminopimelate dehydrogenase from P. gingivalis was first expressed and purified in …

Explaining The Frequency Of Alcohol Consumption In A Conflict Zone: Jews And Palestinians In Israel, Zohar Massey, Karen G. Chartier, Mary B. Stebbins, Daphna Canetti, Stevan E. Hobfoll, Brian J. Hall, Kerem Shuval

Social Work Publications

Experiencing stress and exposure to terrorism may have an adverse effect on health risk behaviors. Few studies have examined alcohol use among adults living in Israel under chronic, stressful terrorism-related conditions. In this study, we examined the relationships of demographics, past stressful events, and terrorism exposure to the frequency of alcohol use and the mediating roles of depressive and post-traumatic stress disorder (PTSD) symptoms. We used three waves of data from a 2007–2008 nationally representative sample of Jewish and Palestinian adults in Israel. We assessed past stressful events, in addition to direct and indirect exposures to terrorism. Results indicated that …

A Baseline Study Of Edaphic Characteristics, Vegetation Structure, And Recruitment Of Native Baldcypress (Taxodium Distichum (L). Rich. Var. Distichum) In The Newly Restored Wetland Of The Vcu Rice Rivers Center, Melissa J. Davis, Matthew S. Schibner

Rice Rivers Center Research Symposium

In theory, the ideal of ecological restoration is to reestablish a completely functioning ecosystem, however restoration success is often elusive (Stanturf et al. 2001). There is a significant gap in the current research on the impacts of restoration management of restored wetlands on ecosystem functions, especially biogeochemical cycling (Bernal & Mitsch 2013). Furthermore, there are many questions about management techniques when it comes to ecological engineering versus self-design (Bernal & Mitsch, 2013). However, we do know that it is critical to understand the species' life history, habitat template, and spatio temporal scope when attempting to re-establish populations (Lake et al. …

Using The Past To Restore The Future: Quantifying Historical Vegetation To Assist In Tidal Freshwater Wetland Restoration Former Lake Charles At The Vcu Rice Rivers Center, Christopher D. Gatens, Edward R. Crawford

Rice Rivers Center Research Symposium

Wetlands have been providing humans with critical natural ecosystem services throughout our time on Earth. Nevertheless, these invaluable ecosystems have been habitually altered as a cost of human progression. Two of the most common alterations to wetlands are hydrologic, in the form of damming, and filling. Both occurred along Kimages Creek in Charles City County, VA during the 19th and 20th centuries. In 2010 the Lake Charles dam was partially removed, restoring the creek's tidal communication with the James River and beginning tidal forested freshwater wetland restoration. Upon the recession of the body of water, numerous woody stumps were revealed.

Behavioral Observations: Foraging And Aggression Of Neotropical Migrants And Resident Birds In Panama, Jessica M. Johnston, Samuel B. King, Ryan A. Levering

Rice Rivers Center Research Symposium

Lyons suggests that foraging data in songbirds can be an indicator of food abundance, with higher attack rate= higher habitat quality; higher foraging speed= lower habitat quality (2005). Territorial behavior such as interspecific aggression among songbirds may also be related to food availability. Previous studies have documented variation in the extent of territorial and aggressive behaviors among resident and Neotropical migratory species on tropical wintering grounds. This research gathered foraging and aggression data at two coastal angroves sites in central Panama, one on the Caribbean Coast (Galeta) and one on the Pacific Coast (Juan Diaz-East). Foraging data was used an …

Redox Regulation Of Nlrp3 Inflammasomes: Ros As Trigger Or Effector?, Justine M. Abais, Min Xia, Yang Zhang, Krishna M. Boini, Pin-Lan Li

Pharmacology and Toxicology Publications

Significance: Inflammasomes are multiprotein complexes localized within the cytoplasm of the cell that are responsible for the maturation of proinflammatory cytokines such as interleukin-1β (IL-1β) and IL-18, and the activation of a highly inflammatory form of cell death, pyroptosis. In response to infection or cellular stress, inflammasomes are assembled, activated, and involved in host defense and pathophysiology of diseases. Clarification of the molecular mechanisms leading to the activation of this intracellular inflammatory machinery may provide new insights into the concept of inflammation as the root of and route to human diseases. Recent Advances: The activation of inflammasomes, specifically the most …

Use Of Prescription Drugs And Future Delinquency Among Adolescent Offenders, Tess K. Drazdowski, Lena Jäggi, Alicia Borre, Wendy L. Kliewer

Psychology Publications

Non-medical use of prescription drugs (NMUPD) by adolescents is a significant public health concern. The present study investigated the profile of NMUPD in 1349 adolescent offenders from the Pathways to Desistance project, and whether NMUPD predicted future delinquency using longitudinal data. Results indicated that increased frequency and recency of NMUPD in adolescent offenders are related to some demographic factors, as well as increased risk for violence exposure, mental health diagnoses, other drug use, and previous delinquency, suggesting that severity of NMUPD is important to consider. However, ANCOVA analyses found that NMUPD was not a significant predictor of drug-related, non-aggressive, or …

Integrating Mrna And Mirna Weighted Gene Co-Expression Networks With Eqtls In The Nucleus Accumbens Of Subjects With Alcohol Dependence, Mohammed Mamdani, Vernell Williamson, Gowon O. Mcmichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D. Van Der Vaart, Bradley Todd Webb, Silviu-Alin Bacanu, Gursharan Kalsi, Coga Consortium, Kenneth S. Kendler, Michael F. Miles, Danielle Dick, Brien P. Riley, Catherine Dumur, Vladimir I. Vladimirov

Psychology Publications

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls (N = 18), six mRNA and three miRNA modules significantly correlated with AD were identified (Bonferoni-adj. p≤ 0.05). Cell-type-specific transcriptome analyses revealed two of the mRNA modules to be enriched for neuronal specific marker genes and downregulated in AD, whereas the remaining four mRNA modules were enriched for astrocyte and microglial specific marker genes and …

Genome-Wide Association Data Suggest Abcb1 And Immune-Related Gene Sets May Be Involved In Adult Antisocial Behavior, J E. Salvatore, A. C. Edwards, J. N. Mcclintik, T. B. Bigdeli, A. Adkins, F. Aliev, H. J. Edenburg, T. Foroud, V. Hesselbrock, J. Kramer, J. I. Nurnberger, M. Schuckit, J. A. Tischfield, X. Xuei, D. M. Dick

Psychiatry Publications

Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case–control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for …

Genetic Network Properties Of The Human Cortex Based On Regional Thickness And Surface Area Measures, Anna R. Docherty, Chelsea K. Sawyers, Matthew S. Panizzon, Michael C. Neale, Lisa T. Eyler, Christine Fennema-Notestine, Carol E. Franz, Chi-Hua Chen, Linda K. Mcevoy, Brad Verhulst, Ming T. Tsuang, William S. Kremen

Psychiatry Publications

We examined network properties of genetic covariance between average cortical thickness (CT) and surface area (SA) within genetically-identified cortical parcellations that we previously derived from human cortical genetic maps using vertex-wise fuzzy clustering analysis with high spatial resolution. There were 24 hierarchical parcellations based on vertex-wise CT and 24 based on vertex-wise SA expansion/contraction; in both cases the 12 parcellations per hemisphere were largely symmetrical. We utilized three techniques—biometrical genetic modeling, cluster analysis, and graph theory—to examine genetic relationships and network properties within and between the 48 parcellation measures. Biometrical modeling indicated significant shared genetic covariance between size of several …

Genome-Wide Association Data Suggest Abcb1 And Immune-Related Gene Sets May Be Involved In Adult Antisocial Behavior, J E. Salvatore, A C. Edwards, J N. Mcclintick, T B. Bidgeli, A Adkins, F Aliev, H J. Edenberg, T Foround, V Hesselbrock, J Kramer, J I. Nurnberger, M Schuckit, J A. Tischfield, X Xuei, D Dick

Psychiatry Publications

Adult antisocial behavior (AAB) is moderately heritable, relatively common and has adverse consequences for individuals and society. We examined the molecular genetic basis of AAB in 1379 participants from a case–control study in which the cases met criteria for alcohol dependence. We also examined whether genes of interest were expressed in human brain. AAB was measured using a count of the number of Antisocial Personality Disorder criteria endorsed under criterion A from the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV). Participants were genotyped on the Illumina Human 1M BeadChip. In total, all single-nucleotide polymorphisms (SNPs) accounted for …

Spag17 Deficiency Results In Skeletal Malformations And Bone Abnormalities, Maria Eugenia Teves, Gobalakrishnan Sundaresan, David J. Cohen, Sharon L. Hyzy, Illya Kajan, Melissa Maczis, Zhibing Zhang, Richard M. Costanzo, Jamal Zweit, Zvi Schwartz, Barbara` D. Boyan, Jerome F. Strauss Iii

Obstetrics and Gynecology Publications

Height is the result of many growth and development processes. Most of the genes associated with height are known to play a role in skeletal development. Single-nucleotide polymorphisms in the SPAG17 gene have been associated with human height. However, it is not clear how this gene influences linear growth. Here we show that a targeted mutation in Spag17 leads to skeletal malformations. Hind limb length in mutants was significantly shorter than in wild-type mice. Studies revealed differences in maturation of femur and tibia suggesting alterations in limb patterning. Morphometric studies showed increased bone formation evidenced by increased trabecular bone area …

Sperm Associated Antigen 6 (Spag6) Regulates Fibroblast Cell Growth, Morphology, Migration And Ciliogenesis, Wei Li, Abir Mukherjee, Jinhua Wu, Ling Zhang, Maria E. Teves, Hongfei Li, Shanti Nambiar, Scott C. Henderson, Alan R. Horwitz, Jerome F. Strauss Iii, Xianjun Fang, Zhibing Zhang

Obstetrics and Gynecology Publications

Mammalian Spag6 is the orthologue of Chlamydomonas PF16, which encodes a protein localized in the axoneme central apparatus, and regulates flagella/cilia motility. Most Spag6-deficient mice are smaller in size than their littermates. Because SPAG6 decorates microtubules, we hypothesized that SPAG6 has other roles related to microtubule function besides regulating flagellar/cilia motility. Mouse embryonic fibroblasts (MEFs) were isolated from Spag6-deficient and wild-type embryos for these studies. Both primary and immortalizedSpag6-deficient MEFs proliferated at a much slower rate than the wild-type MEFs, and they had a larger surface area. Re-expression of SPAG6 in the Spag6-deficient MEFs …

Giftedness As Property: Troubling Whiteness, Wealth, And Gifted Education In The Us, Katherine Cumings Mansfield

Educational Leadership Publications

The purposes of this article are to illumine the racist genealogy of gifted education policies and practices in the United States, to demonstrate how deficit discourses continue today, and to provide personal examples from the field of how educators can begin to question the status quo, resist taken-for-granted assumptions, and alternatively make substantive changes at the local level. I also aim to demonstrate how giftedness is an example of whiteness as property, or unearned white privilege, that, unintentionally or not, maintains a social caste system in schools

Using Natural Language Processing Techniques To Inform Research On Nanotechnology, Nastassja A. Lewinski, Bridget T. Mcinnes

Chemical and Life Science Engineering Publications

Literature in the field of nanotechnology is exponentially increasing with more and more engineered nanomaterials being created, characterized, and tested for performance and safety. With the deluge of published data, there is a need for natural language processing approaches to semi-automate the cataloguing of engineered nanomaterials and their associated physico-chemical properties, performance, exposure scenarios, and biological effects. In this paper, we review the different informatics methods that have been applied to patent mining, nanomaterial/device characterization, nanomedicine, and environmental risk assessment. Nine natural language processing (NLP)-based tools were identified: NanoPort, NanoMapper, TechPerceptor, a Text Mining Framework, a Nanodevice Analyzer, a Clinical …

Tracy L. Galarowicz : Distinguished Achievement In Natural Sciences, St. Norbert College

Alumni Award Bios

Tracy L. Galarowicz ’91 won the Distinguished Achievement in Natural Sciences in 2015, her bio is the archived from the SNC website.

Common Data Set, Office Of Institutional Research And Effectiveness, Mississippi State University

Common data set

No abstract provided.