Digital Commons Network^™

The Effects Of Clay On Glycerol/Carboxylic Acid Polymerization: Implications Of Mineral Controls In Prebiotic Chemistry, Joseph T. Romero

Geology: Student Scholarship & Creative Works

Proto-enzymatic catalysis on early Earth is an important consideration in prebiotic chemistry research as it leads to the understanding of the emergence of the metabolic reaction networks. Contemporary enzymes are comprised of either organic or inorganic factors scaffolded by globular protein structure whereas we consider hyperbranched polyesters as a possible extant scaffold that is easier assembled than the peptide one. The goals of this project are to consider prebiotically plausible starting materials for such structure formation utilizing a subset of conditions for polymer synthesis involving the presence of mineral surfaces as well as temperature and hydration differential. As likely candidates …

Evaluating The Validity And Applicable Domain Of The Toxic Load Model: Impact Of Concentration Vs. Time Profile On Inhalation Lethality Of Hydrogen Cyanide, Lisa M. Sweeney, Douglas R. Summerville, Stephen R. Channel, Brian C. Sharits, Nathan M. Gargas, Chester P. Gut Jr.

United States Army: Publications

The ten Berge model (or ‘‘toxic load’’ model) is often used to estimate the acute toxicity for varying combinations of inhaled concentration and duration. Expressed as Cn X t = toxic load (TL), TLs are assumed constant for various combinations of concentration (C) and time (t). Experimental data in a recent acute inhalation study of rats exposed to time-varying concentrations of hydrogen cyanide (HCN) supported the validity of the toxic load model except under very brief, discontinuous, high concentration exposures. In the present investigation, experiments were conducted to extend the evaluation of the applicable domain of the model for acute …

Research Notes On Bayside And Jacoby Creek, Susie Van Kirk

Susie Van Kirk Papers

Newspaper references on Bayside and Jacoby Creek from the Humboldt Times, Arcata Union, Blue Lake Advocate and more. Bulk dates cover 1860-1930.

Urinformed Summer 2015, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Urinformed Winter 2015, Urinformed

URInformed: The URI Employees' Newsletter

No abstract provided.

Design, Synthesis, Antiviral Activity, And Pre-Formulation Development Of Poly-L-Arginine-Fatty Acyl Derivatives Of Nucleoside Reverse Transcriptase Inhibitors, Bhanu P. Pemmaraju, Swapnil Malekar, Hitesh K. Agarwal, Rakesh K. Tiwari, Donghoon Oh, Gustavo F. Doncel, David R. Worthen, Keykavous Parang

Biomedical and Pharmaceutical Sciences Faculty Publications

The objective of this work was to design conjugates of anti-HIV nucleosides conjugated with fatty acids and cell-penetrating poly-L-arginine (polyArg) peptides. Three conjugates of polyArg cell-penetrating peptides with fatty acyl derivatives of alovudine (FLT), lamivudine (3TC), and emtricitabine (FTC) were synthesized. In general, the compounds exhibited anti-HIV activity against X4 and R5 cell-free virus with EC₅₀ values of 1.5–16.6 μM. FLT-CO-(CH₂)₁₂-CO-(Arg)₇ exhibited EC₅₀ values of 2.9 μM and 3.1 μM against X4 and R5 cell-free virus, respectively. The FLT conjugate was selected for further preformulation studies by determination of solution state …

More With Less, Fr. Randy Roche

Spiritual Essays

No abstract provided.

Elucidating The Conservation Status Of Michigan's Red-Eared Slider (Trachemys Scripta Elegans): A Phylogeographic Approach, Patrick J. Terry

Master's Theses and Doctoral Dissertations

The geographic origin of Michigan’s Trachemys scripta elegans has been a contentious subject since its first description in 1934. At that time two explanations were proposed: 1) populations of T. s. elegans are native to Michigan and naturally expanded their range from Ohio and Indiana; or 2) populations are non-native and have been introduced by humans via the pet-trade from throughout the United States. To differentiate between these possibilities, I compare the genetic structure of six populations throughout Indiana, Michigan, and Ohio, using six microsatellite markers. No isolation-by-distance was detected and model-based statistics support two genetic clusters with five populations …

An Introduction To Conservation Easements In The United States: A Simple Concept And A Complicated Mosaic Of Law, Federico Cheever, Nancy A. Mclaughlin

Sturm College of Law: Faculty Scholarship

The idea of a conservation easement – restrictions on the development and use of land designed to protect the land’s conservation or historic values – can be relatively easily understood. More significant and more challenging is the complex body of state and federal laws that shapes the creation, funding, tax treatment, enforcement, modification, and termination of conservation easements.

The explosion in the number of conservation easements over the past four decades has made them one of the most popular land protection mechanisms in the United States. The National Conservation Easement Database estimates that the total number of acres encumbered by …

Integrating The Thematic Approach Into Information Literacy, Elizabeth Price

Selected Works

Purpose. The purpose of this paper is to review selected publications in library-related literature and discuss the thematic approach to course design in colleges and universities and how it has been implemented into information literacy (IL) courses. Design/methodology/approach. A literature review of peer-reviewed journals, professional journals, magazines and blogs contextualizes the thematic approach to instruction at the college and university levels. Search terms included “thematic approach”, “thematic approach in education” and “theme-based instruction”; the search was restricted to articles published in the past 20 years. Findings. In addition to the IL courses, thematic-based instruction has been used in biology, chemistry, …

Where Knowledge Meets Experience: Emphasizing The Library's Role In An Experiemental Learning Iniative., Elizabeth Price

Selected Works

No abstract provided.

Volume 3, 2015, Csusb

Psychology Student Research Journal (PSRJ)

• Information about the Psychology Student Research Journal p.1
• Letter from the Journal President p.2
  Ryan L. Radmall
• Letter from the Editor-in-Chief p.3
  Lace M. Riggs
• Words of Wisdom from a College Chair: A Brief Biography and Interview with Dean Jamal Nassar p.4
• Infidelity and HIV in South Africa p.6
  Kamalpreet K. Padda
• Nothing to LOL About: Texting (Mis)communications in Intimate Relationships p.11
  Kirk Fortini
• 2014-2015 Student Conference Presentations p.17
• The Influence of Emotion Regulation Strategies in the Relationship between Social Support and Posttramatic Stress Disorder Symptoms among Survivors of Sexual Assault p.20
  Seallong Sechang, Jason Alipio, Monica Aguilar, and Christina …

Harpur Palate, Volume 15 Number 2, Winter & Spring 2015, Harpur Palate .

Harpur Palate: a Literary Journal

Contributors: Lucy Maddux Alford | Kendra Allen | Michael Bazzett | Emily Benton | Colleen Carias | Justin Carter | Carrie Chappell | Krista Christensen | Clayton Adam Clark | Adam Clay | Libby Cudmore | Carol V. Davis | Jim Davis | Leonora Desar | Chelsea Dingman | Laura Donnelly | Jordan Durham | Nausheen Eusuf | Benjamin Glass | Jenna Kilic-Somers | Peter Laberge | RC Luria | Stephen Massimilla | Linda Michel-Cassidy | Jed Myers | Patty Nash | John A. Nieves | Daniel Ruiz | Linwood Rumney | Amy Woschek Schmidt | JL Schneider | Joel …

By Degrees, Krista Christensen

Harpur Palate: a Literary Journal

pages 24-34

Four Houses Down, Rebecca Turkewitz

Harpur Palate: a Literary Journal

pages 111-124

A Response To Denver Snuffer’S Essay On Plural Marriage, Adoption, And The Supposed Falling Away Of The Church Part 2: Façade Or Reality?, Brian C. Hales

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Part 2 of this response to Denver Snuffer’s essay entitled “Plural Marriage” posted on March 22, 2015, will primarily address non-plural marriage issues as discussed in the last twenty pages.1 Snuffer’s portrayal of adoption teachings and practices is analyzed and shown to be in error, along with his interpretation of presiding priesthood quorums as described in the Doctrine and Covenants. His primary thesis, that The Church of Jesus Christ of Latter-day Saints is in apostasy, is also examined including Snuffer’s personal need for the Church to have fallen away in order to create an opening for his new visionary voice. …

2015 Annual Report Department Of Biological Sciences, Ronald L. Frank, Chen Hou, Yue-Wern Huang, Adam R. Martin, Melanie R. Mormile, Dev Niyogi, Julie A. Semon, Katie S. Shannon, Matthew S. Thimgan, David J. Westenberg, Terry Wilson

Biological Sciences Faculty Research & Creative Works

No abstract provided.

2015-2016 - Tuition/Fee Tables And Refund Calendars, Bursar's Office, East Tennessee State University

Tuition/Fee Tables and Refund Calendars

No abstract provided.

2015 - Etsu Fact Book, Institutional Research, East Tennessee State University

ETSU Fact Books

No abstract provided.

Optimizing The Melanoma Tropism Of Mouse Parvovirus 1a For Use As A Viral Immunotherapy Vector, Matthew Marr

Yale Medicine Thesis Digital Library

Melanoma is a prevalent, deadly disease with poor outcomes following metastasis. It is an immunogenic cancer with many unique tumor antigens, but the tumor microenvironment inhibits the immune system. Current monoclonal antibody treatment has been shown to be beneficial in metastatic melanoma by blocking inhibitory immune signals such as PD-1 or CTLA-4. The expression of immunostimulatory proteins such as B7.1 by tumor cells could provide additional immune targeting. Viral vectors based on the parvovirus genome could efficiently and selectively express B7.1 in melanoma cells, such that they become competent to directly activate cognate T cells. Once activated, T cells will …

T Cell Calcium Flux And Clonal Proliferation Report On Antigen-Specific Myeloid Cell Encounters, Nour Kibbi

Yale Medicine Thesis Digital Library

Despite its clinical success, the mechanism underlying extracorporeal photopheresis (ECP) is not well understood, however, the plate-passage (PP) step appears integral to generating activated monocytes. In the first part of the project, we developed a functional assay to evaluate the efficacy of plate-passed myeloid cells (PPM) compared with freshly isolated, unstimulated monocytes (UM) and conventional dendritic cells derived from blood monocytes cultured with GM-CSF/IL4 (DC). Each of these three antigen presenting cell (APC) was co-cultured with purified, autologous CD8 cells, with or without CD4 cells. Cultures were carried out using melanoma antigen MART-1 "long peptide (LP)," a 25-amino acid peptide …

Isolation Of Bone Marrow Mononuclear Cells For Fabrication Of Tissue-Engineered Vascular Grafts: Evaluation Of Two Methods, Paul S. Bagi

Yale Medicine Thesis Digital Library

Objective: Tissue engineered vascular grafts (TEVGs) are useful in the surgical treatment of congenital heart defects. The development of TEVGs requires seeding of scaffolds composed of biodegradable polymers with bone marrow-derived mononuclear cells (BM-MNCs). The most common method used to isolate BM-MNCs involves density centrifugation in Ficoll. This process requires an International Organization for Standardization (ISO) class 7 clean room, is labor intensive, time intensive, and susceptible to operator variability. A recently developed filtration-based method for BM-MNC isolation uses a closed, sterile, and disposable system that removes the need for a clean room, decreases processing time, and is operator-independent. This …

Smarcb1-Mutant Intracranial Meningiomas: A Distinct Subtype Of Nf2-Mutant Tumors, Jacob Francis Baranoski

Yale Medicine Thesis Digital Library

Meningiomas are the most common central nervous system primary tumors. Mutations in the tumor suppressor gene Neurofibromin 2 (NF2), located on chromosome 22 (Chr22), are present in 40-50% of sporadic meningiomas. In a subset of non-NF2-mutant meningiomas, recent studies have identified tumorigenesis driver mutations in the genes TRAF7, AKT1, KLF4, and SMO. However, the genetic basis for the marked clinical and histological heterogeneity that exists among NF2-mutant/Chr22-loss meningiomas remains to be established. In this study, we utilized next-generation sequencing techniques to identify and screen a large cohort of NF2-mutant/Chr22-loss meningiomas for concurrent co-driver mutations in novel genes that may contribute …

Reporting Of Results In Clinicaltrials.Gov And High-Impact Journals: A Cross-Sectional Study, Jessica Elizabeth Becker

Yale Medicine Thesis Digital Library

In 2007, the FDA Amendments Act expanded requirements for ClinicalTrials.gov, a public clinical trial registry maintained by the U.S. National Library of Medicine, mandating results reporting within 12 months of trial completion for all FDA regulated drugs. We compared clinical trial results reported on ClinicalTrials.gov with corresponding published articles. We conducted a cross-sectional analysis of clinical trials published from July 1, 2010 through June 30, 2011 in high impact journals (impact factor 10 or higher) that were registered and reported results on ClinicalTrials.gov. We compared trial results reported on ClinicalTrials.gov and within published articles for the following: cohort characteristics, trial …

Gender And Depression Among Veterans Of Operation Enduring Freedom, Iraqi Freedom, And New Dawn, Nkemka Esiobu

Yale Medicine Thesis Digital Library

The Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) Veterans utilizing Veterans Affairs (VA) services are medically and psychosocially complex, diverse, and rapidly growing. A significant portion of women Veterans seek out mental health services and they are more likely to be diagnosed with major depression than men, however the majority of prior studies informing Veteran mental health services have been done with predominantly male study populations (16,18,19). Our objectives were 1) to identify characteristics associated with a major depression diagnosis among OEF/OIF/OND men and women Veterans after stratifying by gender and 2) to identify gender differences in the nature …

2015-2016 - Quillen College Of Medicine Operating Budget (October), Budget And Financial Planning, East Tennessee State University

College of Medicine Operating Budgets and Analysis

No abstract provided.

2015-2016 - Etsu General Academic Operating Budget (October), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

2015-2016 - Etsu General Academic Operating Budget (July), Budget And Financial Planning, East Tennessee State University

ETSU General Academic Operating Budgets and Analysis

No abstract provided.

2015-2016 - Quillen College Of Medicine Operating Budget (July), Budget And Financial Planning, East Tennessee State University

College of Medicine Operating Budgets and Analysis

No abstract provided.

Ohio Northern University Catalog, 2015-2017, Ohio Northern University

University Catalogs

No abstract provided.