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2015

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Diversification And Speciation Across Sundaland And The Philippines: The Effects Of 30 Million Years Of Eustatic Flux, Luke J. Welton Dec 2015

Diversification And Speciation Across Sundaland And The Philippines: The Effects Of 30 Million Years Of Eustatic Flux, Luke J. Welton

Theses and Dissertations

I highlight two squamate lineages endemic to Southeast Asia, the Asian water monitors (Varanus salvator Complex) and the Angle-headed lizards (Agamidae: Gonocephalus), and elucidate their systematic affinities and historical biogeography. My results represent novel phylogenetic inferences, with biogeographic histories and diversification events corresponding to major climatic fluctuations over the past 30 million years. Additionally, I solidify the taxonomy and systematics of the Varanus salvator Complex, and enumerate more than a dozen Gonocephalus lineages as candidate species in need of taxonomic scrutiny. Lastly, I investigate contemporary and historical patterns of dispersal throughout Sundaland, and between Sundaland and the Philippines.

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Non-Suitable Habitat A Cause For Declining Bobolink Populations In Northern Utah, Bethany Q. Unger Dec 2015

Non-Suitable Habitat A Cause For Declining Bobolink Populations In Northern Utah, Bethany Q. Unger

Undergraduate Honors Capstone Projects

Bobolink, Dolichonyx oryxivories, populations are declining in Utah. I characterized the habitat conditions of known bobolink nesting sites in Utah and compared these conditions to those for nest sites in Wisconsin where bobolinks are abundant. My habitat assessment included identifying vegetation species, vegetation cover, pH, temperature, and precipitation at each site location. Vegetation cover different between Utah and Wisconsin nest sites. Precipitation varied for both locations with no correlation between water availability and bobolink presence. One possible driver for the reduction in bobolinks throughout Utah is the drastic increase in temperature. Other possible external factors include livestock grazing, edge distance, …

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Consumer Assessment Of New Creative Products Across China And The United States, Eva Teruzzi Dec 2015

Consumer Assessment Of New Creative Products Across China And The United States, Eva Teruzzi

Creative Studies Graduate Student Master's Theses

This cross-cultural research investigates how consumers assess creativity in new products and if their assessment impacts desire to own. Implicit and explicit scale-based measures were tested in China and the U.S. in online consumer samples and were positively correlated. Novelty, affect and importance dimensions of creative products were tested through Horn and Salvendy’s (2006, 2009) Product Creativity Measurement (PCM) scale. Findings point to a different role of novelty in determining desirability of creative new products across-cultures.In fact, novelty and affect are key to explain desire to own in China, while affect and importance are the drivers in the U.S. Affect, …

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Management And Impacts Of Wild Hogs (Sus Scrofa) In South Carolina, Susan Sullivan Dec 2015

Management And Impacts Of Wild Hogs (Sus Scrofa) In South Carolina, Susan Sullivan

All Theses

Wild hogs (Sus scrofa) are an invasive species that can damage native ecosystems, negatively impact native wildlife, and potentially act as disease reservoirs in the U.S. To better understand how natural resource professionals in South Carolina approach wild hog management, I conducted a web-based survey of natural resource professionals focused on aspects of wild hog impacts and management. Generally, there was agreement among natural resource professionals regarding the approaches used to control wild hog populations and their subsequent effectiveness. The majority of respondents indicated high priority impacts needing to be addressed in wild hog management were agricultural damage …

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Weeds, Nitrogen, And Yield: Measuring The Effectiveness Of An Organic No-Till System, David Robb Dec 2015

Weeds, Nitrogen, And Yield: Measuring The Effectiveness Of An Organic No-Till System, David Robb

All Theses

Previous research in the mid-Atlantic and midwestern USA has identified advantages and drawbacks of "organic no-till" vegetable production, but few studies have been conducted in the warmer southeastern region. The purpose of this study was to examine the effects of tillage [no-till (NT) vs. conventional tillage (CT) of a cereal rye/crimson clover cover crop] and three nitrogen fertilization rates on organic tomato (Solanum lycopersicum L.) and summer squash (Cucurbita pepo L.) yield, weed suppression, and soil N dynamics in two years in a soil series in Clemson, SC. Squash yields were similar between tillage treatments in both years. NT tomato …

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Single Particle And Biological Cell Detection By A Radio Frequency Interferometer, Zheng Wang Dec 2015

Single Particle And Biological Cell Detection By A Radio Frequency Interferometer, Zheng Wang

All Theses

This thesis presents a series of studies on single particle and biological cell detection and differentiation by a radio frequency (RF) interferometer system. Several techniques, such as dielectrophoresis (DEP), time domain method and 3D focusing have been illustrated and investigated to demonstrate the capacity of interrogating the electric property of single particle or biological cell by the RF interferometer. Silica particles and live yeast cells are trapped at the sensing area by DEP force and detected by the RF sensor. Solutions of particle mixtures (~4 μm silica and ~10 μm polystyrene) and cell mixtures (viable and non-viable yeast cells, normal …

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Tracking Anisotropic Optical Tracers To Study Biophysical Processes And Cytotoxicity, Khanh Van Nguyen Dec 2015

Tracking Anisotropic Optical Tracers To Study Biophysical Processes And Cytotoxicity, Khanh Van Nguyen

All Dissertations

We use anisotropic optical tracers (also called magnetically modulated optical nanoprobes – MagMOONs or MOONs for non-magnetic nanoprobes in this dissertation) to study biophysical processes such as enzyme-catalyzed cleavage through tissue, intracellular transport of these tracers and cytotoxicity based on this transport. The anisotropic optical properties cause these tracers to blink when rotating. This blinking is distinguishable from the background and can be tracked on a single-particle level in the absence of tissue, or for an ensemble average of tracers blinking through tissue. An alginate gel containing these tracers in the form of a thin film can be used as …

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The Detection And Characterization Of Some Viruses Infecting Blackberry And Cherry In South Carolina, Bindu Poudel Dec 2015

The Detection And Characterization Of Some Viruses Infecting Blackberry And Cherry In South Carolina, Bindu Poudel

All Dissertations

Three separate virus research projects were conducted. Blackberry yellow vein disease (BYVD), a disorder caused by virus complexes, has become a major threat to blackberry production in the United States, especially in the southeastern part of the country where blackberries are grown for the fresh market. More than 30 viruses have been found to be associated with the disease. Most of these induce no symptoms when infecting the plant alone. However, when more than a single virus is present in the host visible symptoms are displayed. The incidence of 6 different viruses (Blackberry yellow vein-associated virus, Blackberry virus Y, Blackberry …

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Examining The Space-Time Constraints Concept On Tourist Behavior For Visitors To The South Carolina Coastal Area Of The United States, Sanghoon Kang Dec 2015

Examining The Space-Time Constraints Concept On Tourist Behavior For Visitors To The South Carolina Coastal Area Of The United States, Sanghoon Kang

All Dissertations

This dissertation explored three themes with regard to the spatial aspects of tourist behavior, conducting three independent analyses. For these analyses, this dissertation research adapted Shoval's (2012) definition of the space-time constraints concept developed by Hagerstrand (1970): the purpose of trip (i.e., authority constraints), the length of visit (i.e., capability constraints), and the composition of travel party (i.e., coupling constraints). The purposes of the three analyses were to examine the relationships 1) between the space-time constraints and the spatial patterns of travel; 2) between ICT use (i.e., smartphones) and the spatial patterns of travel, space-time constraints, tourists' unplanned destination visits, …

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Nematicidal Activity Of Extracts From Phytolacca Americana On Five Plant-Pathogenic Nematode Species Of Economic Importance, Saleh Ahmed Dec 2015

Nematicidal Activity Of Extracts From Phytolacca Americana On Five Plant-Pathogenic Nematode Species Of Economic Importance, Saleh Ahmed

All Dissertations

Plant-parasitic nematodes cause significant losses to plant agriculture annually. The limited availability and high cost of synthetic nematicides, along with the environmental risks associated with their use, have created a renewed interest in the search for alternative management tactics. One such alternative tactic is the use of plant extracts. The focus of this research is the evaluation of the nematicidal activity of water extracts from Pokeweed (Phytolacca americana). In vitro and greenhouse tests were performed to evaluate the effects of the extracts on five species of plant-pathogenic nematodes of economic importance: Aphelenchoides fragariae, Ditylenchus dispsaci, Meloidogyne incognita, Pratylenchus penetrans, and …

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Leisure, Obesity And Weight Loss: An Exploration Of Leisure, The Public Health Ecological Model Of Obesity And Identity Theory, Weber Player Dec 2015

Leisure, Obesity And Weight Loss: An Exploration Of Leisure, The Public Health Ecological Model Of Obesity And Identity Theory, Weber Player

All Dissertations

Obesity is a global health crisis with complex causal relationships. From the mid 1990s to 2010, obesity related research in the clinical and social sciences has exploded. This expansion has resulted in a proliferation of obesity-related articles published in top-tier journals and the creation of new journals solely devoted to obesity research. In contrast within leisure scholarship, a review of leisure journals reveals that published research on the relationship of leisure, obesity and weight loss is minimal. However, numerous leisure scholarship/theory principles are relevant to obesity prevention and treatment. Similarly, public health officials have developed numerous systems-oriented multilevel framework models …

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Effects Of Semi-Rigid Plastic Tray Geometry On Thermal Processing And Quality Factors In Retorted Foods, Curtis Stowe Dec 2015

Effects Of Semi-Rigid Plastic Tray Geometry On Thermal Processing And Quality Factors In Retorted Foods, Curtis Stowe

All Dissertations

This research studied the effect of packaging geometry changes on heat penetration and quality attributes of a food system processed in a rotary retort vessel. Studies were conducted to determine the effect of package geometry in a rotary retort on heat penetration, analytical, and physical properties of a model food system processed at optimum conditions. Additionally, heat mapping for each shape was used to determine the heating profiles during retorting. Retort-able trays were filled with a tomato based food simulate and thermally processed in a water immersion, automated batch retort system (ABRS) using rotational speeds of 6 RPM and 11 …

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Robust Model Development For Evaluation Of Existing Structures, Saurabh Prabhu Dec 2015

Robust Model Development For Evaluation Of Existing Structures, Saurabh Prabhu

All Dissertations

In the context of scientific computing, validation aims to determine the worthiness of a model in supporting critical decision making. This determination must occur given the imperfections in the mathematical representation resulting from the unavoidable idealizations of physics phenomena. Uncertainty in parameter values furthers the validation problems due to the inevitable lack of information about material properties, boundary conditions, loads, etc. which must be taken into account in making predictions about structural response. The determination of worthiness then becomes assessing whether an unavoidably imperfect mathematical model, subjected to poorly known input parameters, can predict sufficiently well in its intended purpose. …

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Electrospray Deposition Of Chalcogenide Glass Films For Gradient Refractive Index And Quantum Dot Incorporation, Spencer Novak Dec 2015

Electrospray Deposition Of Chalcogenide Glass Films For Gradient Refractive Index And Quantum Dot Incorporation, Spencer Novak

All Dissertations

Chalcogenide glasses (ChGs) are well-known for their optical properties, making them ideal candidates for emerging applications of mid-infrared microphotonic devices, such as lab-on-a-chip chemical sensing devices, which currently demand additional flexibility in processing and materials available to realize new device designs. Solution-derived processing of ChG films, initially developed in the 1980s by Chern and Lauks, has consisted mainly of spin-coating and offers unique advantages over the more traditional physical vapor deposition techniques. In the present effort, the nanoparticles of interest are luminescent quantum dots (QDs), which can be used as an on-chip source of light for a planar chemical sensing …

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Optimization Of Pyrochlore Catalysts For The Dry Reforming Of Methane, Felipe Polo Garzon Dec 2015

Optimization Of Pyrochlore Catalysts For The Dry Reforming Of Methane, Felipe Polo Garzon

All Dissertations

The conversion of methane into syngas (a mixture of CO and H2), which can be further converted into a variety of chemicals and particularly liquid fuels, is of growing importance given recent increases in methane production world-wide. Furthermore, since using CO2 as the co-feed offers many environmental advantages, dry reforming of methane (DRM, CH4 + CO2 ⇌ 2CO + 2H2) has received renewed attention. In recent years, experimentalists have shown that the Rh-substituted lanthanum zirconate pyrochlore (LRhZ) material is catalytically active for DRM, exhibits long-term thermal stability and resists deactivation; however, previous to this doctoral work, a detailed understanding of …

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Development And Validation Of A Novel In Vitro Model For The Assessment Of Heterocellular Interactions Mediated By Connexin43, Emily Ongstad Dec 2015

Development And Validation Of A Novel In Vitro Model For The Assessment Of Heterocellular Interactions Mediated By Connexin43, Emily Ongstad

All Dissertations

The injury border zone (IBZ), a region of transitional tissue between intact myocardium and the ischemic area, is often the site of lethal reentrant arrhythmia generation in post-myocardial infarction (MI) patients. Disruption to normal connexin43 (Cx43) localization at the intercalated disc (ID), separation of myocytes by activated fibroblasts and deposited scar tissue are thought to be factors that render the IBZ a pro-arrhythmic substrate, though there is a current need to better understand these changes so directed therapies can be developed. There are no clinically available therapies focused on the mechanistic changes in the IBZ. Additionally, generation of new compounds …

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Arsenic Inhibits P19 Stem Cell Differentiation By Altering Microrna Expression And Repressing The Sonic Hedgehog Signaling Pathway, Jui Tung Liu Dec 2015

Arsenic Inhibits P19 Stem Cell Differentiation By Altering Microrna Expression And Repressing The Sonic Hedgehog Signaling Pathway, Jui Tung Liu

All Dissertations

Arsenic is a naturally-occurring toxicant that exists in bedrock and can be leached into ground water. Humans can be exposed to arsenic via contaminated drinking water, fruit, rice or crops. Epidemiological studies have shown that arsenic is a developmental toxicant, and in utero exposure reduces IQ scores, verbal learning ability, decreases long term memory, and increases the likelihood of dying from a neurological disorder. Arsenic can also reduce birth weight, weight gain, and muscle function after an in utero exposure. Although the mechanism behind these physiological changes is not known, in vitro studies have shown that arsenic can reduce muscle …

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The Creation And Validation Of An Instrument To Measure School Stem Culture, Christopher White Dec 2015

The Creation And Validation Of An Instrument To Measure School Stem Culture, Christopher White

All Dissertations

Although current research exists on school culture, there is a gap in the literature on specialized aspects of culture such as STEM Culture defined as the beliefs, values, practices, resources, and challenges in STEM fields (Science, Technology, Engineering and Mathematics) within a school. The objective of this study was to create a valid and reliable instrument, the STEM Culture Assessment Tool (STEM-CAT), that measures this cultural aspect based on a survey of stakeholder groups within the school community and use empirical data to support the use of this instrument to measure STEM Culture. Items were created and face validity was …

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High Temperature Synthesis And Characterization Of Reduced Polyoxometalate Salt-Inclusion Solids, Dino Sulejmanovic Dec 2015

High Temperature Synthesis And Characterization Of Reduced Polyoxometalate Salt-Inclusion Solids, Dino Sulejmanovic

All Dissertations

Herein, several new salt-inclusion solids (SISs) featuring electronically reduced Keggin polyoxometalate (POM) clusters were isolated for the first time using molten-salt high temperature (> 500 oC) synthetic method. These POM-based SISs are novel all-inorganic materials featuring an integrated lattice of ionic halide salt and covalent metal oxide clusters. Due to the weak interactions at the interface between these two chemically dissimilar lattices, these POM SISs are soluble in aqueous and polar solvents. While POM compounds are well-studied and are routinely synthesized in solution, the synthetic method presented in this dissertation yielded several POM solids with interesting structures and infrequently observed, …

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Electrochemical Enhancement Of Butanol Production And Xylose Consumption In Pure And Mixed Culture Fermentations, Jovan Popovic Dec 2015

Electrochemical Enhancement Of Butanol Production And Xylose Consumption In Pure And Mixed Culture Fermentations, Jovan Popovic

All Dissertations

The volatility of foreign and domestic petroleum markets has prompted initiatives for the development of alternative liquid energy carriers which have the capacity to accommodate our current transportation infrastructure. Butanol, which has an energy density similar to that of gasoline and can be produced through the fermentation of carbohydrates by solventogenic Clostridia, has been investigated as a supplement or direct replacement to gasoline. However, most butanol fermentations rely on glucose as a feedstock which is in direct competition with our food supply, and this requires the exploration of alternative fermentable substrates. This study investigates the use of electrochemical fermentation modifications …

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Evaluation Of Blue Tilapia (Oreochromis Aureus) For Duckweed (Lemna Minor) Control In South Carolina's Private Waters, William Heaton Dec 2015

Evaluation Of Blue Tilapia (Oreochromis Aureus) For Duckweed (Lemna Minor) Control In South Carolina's Private Waters, William Heaton

All Dissertations

ABSTRACT We investigated the potential of Blue Tilapia (Oreochromis aureus) as a means for biological control of duckweed in agricultural impoundments, and assessed the potential for naturalization of this non-native fish in coastal regions of South Carolina. Additionally, we studied growth characteristics and nutrient accumulation abilities of duckweed (Lemna minor) growing in agricultural impoundments in the piedmont and coastal plain. Observations of tank feeding trials indicated juvenile Blue Tilapia consumed 36 – 86% of their body weight in fresh duckweed every 24 hours. Tilapia were stocked in agricultural impoundments in the piedmont and coastal plain during the 2012 and 2013 …

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Effects Of Growth Factor Supplementation And Environmental Conditions On Human Adipose-Derived Stem Cell Differentiation Towards Urothelial Lineage, James Turner Dec 2015

Effects Of Growth Factor Supplementation And Environmental Conditions On Human Adipose-Derived Stem Cell Differentiation Towards Urothelial Lineage, James Turner

All Dissertations

In recent years, tissue engineering of the bladder has undergone many technological advances. Autologous urothelial cells have been used in animal models and have shown increased performance for ureteral reconstruction compared to unseeded grafts. However, since patients may lack a reliable source of native urothelial cells due to the nature of their specific bladder disease, autologous cells are not an ideal source clinically, and an alternate cell source must be explored. Adipose derived stem cells (ADSCs) are an attractive cell source for such regenerative medicine applications as they have been extensively studied for their multipotential differentiation, immunosuppressive properties, ease of …

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Understanding How Synthetic Organic Chemistry Graduate Students Navigate Scifinder, Lindsey Whitfield Cain Dec 2015

Understanding How Synthetic Organic Chemistry Graduate Students Navigate Scifinder, Lindsey Whitfield Cain

All Dissertations

Students pursuing a Ph.D. degree are expected to contribute research to their field, for which the success depends, in part, on their ability to find, interpret, and use scholarly information from the primary literature. However, studies from the information sciences show that graduate students from a variety of fields, including the sciences, frequently struggle to comprehensively search their respective dissertation topics because of insufficient prior content knowledge and lack of guidance from their disciplinary community. This body of literature is consistent with the results of my previous research of chemistry graduate students’ laboratory decision-making processes. Specifically, that study showed their …

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Anisotropic Stimuli-Responsive Polymeric Nanoparticles: Synthesis And Characterization, Chunliang Lu Dec 2015

Anisotropic Stimuli-Responsive Polymeric Nanoparticles: Synthesis And Characterization, Chunliang Lu

All Dissertations

This dissertation focuses on the design, synthesis and characterization of stimuli-responsive anisotropic nanoparticles with various morphologies. Size- and shape-tunable Janus nanoparticles consisting of poly(methyl methacrylate/n-butyl acrylate) (p(MMA/nBA)), poly(pentafluorostyrene/nBA) (p(PFS/nBA) and poly(2-(N,N′-dimethylamino) ethyl methacrylate/nBA) (p(DMAEMA/nBA)) phases were synthesized via consecutive seeded emulsion polymerization. These Janus nanoparticles are capable of changing size and morphology in response of temperature and/or pH changes, which may have potential applications as solid surfactants. Gibbous and inverse-gibbous nanoparticles were synthesized viacopolymerization of fluorinated monomers in the presence of pMMA or polystyrene (pSt) seed particles. The morphology of the gibbous nanoparticles can be controlled by polymerization conditions. Incorporation …

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A Lipidomics Approach To The Viral–Host Dynamics Of The Unicellular, Eukaryotic Alga Chlorella Variabilis And Its Viral Pathogen, Pbcv-1, Suzanne L. Rose Dec 2015

A Lipidomics Approach To The Viral–Host Dynamics Of The Unicellular, Eukaryotic Alga Chlorella Variabilis And Its Viral Pathogen, Pbcv-1, Suzanne L. Rose

School of Biological Sciences: Dissertations, Theses, and Student Research

This thesis focuses on the sterol and sphingolipid composition in the unicellular, green alga Chlorella variabilis and the lipidomic changes that occur during viral infection. Using lipid analysis by mass spectrometry, we have identified the major sterol, ergosterol and sphingolipid, glucosyl inositol phosphoceramide (GIPC) as constituents of C. variabilis cell membranes. Sterols and sphingolipids have essential biological functions such as hormone-based signaling, plant defense, and apoptosis as well as critical roles in structural components of the cell and organelle membranes. In chapters two and three, we focus on the characterization of sterol composition among both freshwater and marine alga …

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President’S Newsletter, Jean Bartels Dec 2015

President’S Newsletter, Jean Bartels

President's Newsletter

No abstract provided.

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Oncogene-Dependent Regulation Of Autophagic Flux In Melanoma, Kirsten Anne Meyer White Dec 2015

Oncogene-Dependent Regulation Of Autophagic Flux In Melanoma, Kirsten Anne Meyer White

Biomedical Sciences ETDs

Skin cancer is the one of the most diagnosed cancers in the United States with increasing incidence of 6% every year. In 2015, it is estimated 73,870 new cases of melanoma will be identified and 9,480 individuals will die of their disease. While melanoma only accounts for approximately 2.4% of all cancer related deaths and is the 5th leading diagnosed cancer (US) it is the one of the most common cancers in young adults, age 25-29, particularly for young women. Of particular importance, the mean survival rate of patients diagnosed with metastatic melanoma is six months, with five-year survival rates …

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Geometric Algorithms And Data Structures For Simulating Diffusion Limited Reactions, Shaun Bloom Dec 2015

Geometric Algorithms And Data Structures For Simulating Diffusion Limited Reactions, Shaun Bloom

Computer Science ETDs

Radiation therapy is one of the most effective means for treating cancers. An important calculation in radiation therapy is the estimation of dose distribution in the treated patient, which is key to determining the treatment outcome and potential side effects of the therapy. Biological dose — the level of biological damage (e.g., cell killing ratio, DNA damage, etc.) inflicted by the radiation is the best measure of treatment quality, but it is very difficult to calculate. Therefore, most clinics today use physical dose - the energy deposited by incident radiation per unit body mass - for planning radiation therapy, which …

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Expansion Of The Chlorovirus Genus By Studies On Virus Natural History And Chlorella Host Metabolism, Cristian F. Quispe Dec 2015

Expansion Of The Chlorovirus Genus By Studies On Virus Natural History And Chlorella Host Metabolism, Cristian F. Quispe

School of Biological Sciences: Dissertations, Theses, and Student Research

Inland waters cover about 2.5 percent of our planet and harbor huge numbers of known and unknown microorganisms including viruses. Viruses likely play dynamic, albeit largely undocumented roles in regulating microbial communities and in recycling nutrients in the ecosystem. Phycodnaviruses are a genetically diverse, yet morphologically similar, group of large dsDNA-containing viruses (160- to 560-kb) that inhabit aquatic environments. Members of the genus Chlorovirus are common in freshwater. They replicate in eukaryotic, single-celled, chlorella-like green algae that normally exist as endosymbionts of protists in nature. Very little is known about the natural history of the chloroviruses and how they achieve …

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Genome-Wide Significant Linkage Of Schizophrenia-Related Neuroanatomical Trait To 12q24, Emma Sprooten, Cota Navin Gupta, Emma Knowles, D. Reese Mckay, Samuel R. Mathias, Joanne E. Curran, Jack W. Kent Jr., Melanie A. Carless, Marcio Almeida, Thomas D. Dyer, Harald H. H. Goring, Rene L. Olvera, Peter T. Fox, Ravi Duggirala, Laura Almasy, John Blangero Dec 2015

Genome-Wide Significant Linkage Of Schizophrenia-Related Neuroanatomical Trait To 12q24, Emma Sprooten, Cota Navin Gupta, Emma Knowles, D. Reese Mckay, Samuel R. Mathias, Joanne E. Curran, Jack W. Kent Jr., Melanie A. Carless, Marcio Almeida, Thomas D. Dyer, Harald H. H. Goring, Rene L. Olvera, Peter T. Fox, Ravi Duggirala, Laura Almasy, John Blangero

School of Medicine Publications

The insula and medial prefrontal cortex (mPFC) share functional, histological, transcriptional and developmental characteristics and they serve higher cognitive functions of theoretical relevance to schizophrenia and related disorders. Meta-analyses and multivariate analysis of structural magnetic resonance imaging (MRI) scans indicate that gray matter density and volume reductions in schizophrenia are the most consistent and pronounced in a network primarily composed of the insula and mPFC. We used source-based morphometry, a multivariate technique optimized for structural MRI, in a large sample of randomly ascertained pedigrees (N = 887) to derive an insula-mPFC component and to investigate its genetic determinants. Firstly, we …

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