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Mitochondria-Associated Micrornas In Rat Hippocampus Following Traumatic Brain Injury, Wang-Xia Wang, Nishant P. Visavadiya, Jignesh D. Pandya, Peter T. Nelson, Patrick G. Sullivan, Joe E. Springer

Sanders-Brown Center on Aging Faculty Publications

Traumatic brain injury (TBI) is a major cause of death and disability. However, the molecular events contributing to the pathogenesis are not well understood. Mitochondria serve as the powerhouse of cells, respond to cellular demands and stressors, and play an essential role in cell signaling, differentiation, and survival. There is clear evidence of compromised mitochondrial function following TBI; however, the underlying mechanisms and consequences are not clear. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally, and function as important mediators of neuronal development, synaptic plasticity, and neurodegeneration. Several miRNAs show altered expression following TBI; however, the …

Life Line March 2015, Otterbein Biology And Earth Science Department

Life Line - The Biology Department Newsletter

Trees - Erin Miller '97, Young Alumni Award Winner - Dave Sheridan joins the faculty - Melinda S. Phinney MD Award - OU Heritage Dr. of Osteopathy Early Assurance Program - China Visit

Addressing Misconceptions About Evolution, Sarah O'Leary-Driscoll, Don Dosch

Evolution

"Leave with effective ways to identify and address misconceptions about evolution, with a particular focus on supporting explanations with evidence."

Mexico’S Real Wages In The Age Of The Great Divergence, 1730-1930, Amilcar Challú

History Faculty Publications

This study builds the first internationally comparable index of real wages for Mexico City bridging the eighteenth and the early twentieth century. Real wages started out in relatively high international levels in the mid eighteenth century, but declined from the late 1770s on, with some partial and temporal rebounds after the 1810s. After the 1860s real wages recovered and eventually reached eighteenth-century levels in the early twentieth century. Real wages of Mexico City’s workers slid behind those of high-wage economies to converge with the lower fringes of middle-wage economies. The age of the global great divergence was Mexico’s own age …

The Role Of Parenting In The Prediction Of Criminal Involvement: Findings From A Nationally Representative Sample Of Youth And A Sample Of Adopted Youth, Kevin M. Beaver, Joesph A. Schwartz, Eric J. Connolly, Mohammed Said Al-Ghamdi, Ahmed Nezar Kobeisy

Criminology and Criminal Justice Faculty Publications

The role of parenting in the development of criminal behavior has been the source of a vast amount of research, with the majority of studies detecting statistically significant associations between dimensions of parenting and measures of criminal involvement. An emerging group of scholars, however, has drawn attention to the methodological limitations—mainly genetic confounding—of the parental socialization literature. The current study addressed this limitation by analyzing a sample of adoptees to assess the association between 8 parenting measures and 4 criminal justice outcome measures. The results revealed very little evidence of parental socialization effects on criminal behavior before controlling for genetic …

Comparison Of Cortisol Samples In The First Two Weeks Of Life In Preterm Infants, Tiffany A. Moore, Kendra K. Schmid, Jeffrey French

Psychology Faculty Publications

Background: Growing literature on negative childhood stress emphasizes the need to understand cortisol values from varying biomarker samples.

Objective: This work aimed to examine cortisol samples for usability, associations, and individual stability in neonates.

Subjects: The sample consisted of preterm infants (n=31).

Materials and methods: Analyses on cortisol collected from cord blood and from saliva and urine samples on days 1, 7, and 14 included Spearman correlations and paired t-tests.

Results: Usability rates were 80.6% (cord blood), 85.9% (saliva), and 93.5% (urine). Salivary and urinary cortisol levels had significant correlation on day 1 only (p=0.004). Significant differences in individual stability …

Common Data Set 2014, Uno Office Of Institutional Effectiveness

Common Data Sets

Common Data Set (2014 - 2015) for the University of Nebraska at Omaha.

Biology Textbooks And The Decentering Of The Scopes Trial, William Vance Trollinger

History Faculty Publications

I was reminded of this while reading Adam Shapiro’s fine book, Trying Biology: The Scopes Trial, Textbooks, and the Antievolution Movement in American Schools. Central to Trying Biology is the argument that the Scopes Trial was not the inevitable result of an eternal conflict between science and religion, but instead grew out of "debates over American education that had little to do with either science or religion" (12). As Shapiro nicely articulates, the school antievolution movement that emerged in the early 1920s was a backlash against schools teaching evolution "in a politically charged way" and "to a new population of …

Refraction Of Scroll-Wave Filaments At The Boundary Between Two Reaction-Diffusion Media, Christian W. Zemlin, Frency Varghese, Marcel Wellner, Arkady M. Pertsov

Bioelectrics Publications

We explore the shape and the dynamics of scroll-wave filaments in excitable media with an abruptly changing diffusion tensor, important for cardiac applications. We show that, similar to a beam of light, the filament refracts at the boundary separating domains with different diffusion. We derive the laws of filament refraction and test their validity in computational experiments. We discovered that at small angles to the interface, the filament can become unstable and develop oscillations. The nature of the observed instabilities, as well as overall theoretical and experimental significance of the findings, is discussed.

A Teaching Tool To Visually Illustrate How Manipulating The Physiology Of The Ventilatory Muscle Pump Alters Functional Performance, Dennis Sobush

Physical Therapy Faculty Research and Publications

This clinical perspective article describes an inexpensive pedagogical tool intended for use in a laboratory setting as part of a cardiovascular and pulmonary physical therapy course. It uses a dual balance scale schematic/model. As a teaching resource, physical therapy students can use it to visually reinforce their understanding of the complex cause-and-effect interplay between physiological factors that affect ventilatory muscle pump (VMP) performance for sustained breathing or contribute to VMP fatigue/failure.

Incidence Of Medical Disputes And Trend In Criminal Versus Civil Medical Litigation In Taiwan, Shu-Yu Lyu, Shih-Feng Chiu, Shang-Ta Tsai, Feng-Chou Tsai, Joseph Jordan Keller, Chiehfeng Chen, Ming-Been Lee

Journal of Medical Education

Background: While the prevalence of malpractice dispute reporting has been decreasing in Taiwan, the gravity of their consequences has been increasing with physicians being increasingly likely to meet litigation, both civilly and criminally, as well as to pay out ever larger settlements. Previous studies have investigated the prevalence of medical malpractice litigation cases in the past few decades; however, no study has focused on the incidence of medical malpractice disputes in Taiwan. Objectives: The purpose of this study was to explore the incidence of medical disputes in Taiwan and to describe the proportion of criminal to civil litigation in medical …

In Vivo Assessments Of Bioabsorbable Az91 Magnesium Implants Coated With Nanostructured Fluoridated Hydroxyapatite By Mao/Epd Technique For Biomedical Applications, Mehdi Razavi, Mohammadhossein Fathi, Omid Savabi, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Although magnesium (Mg) is a unique biodegradable metal which possesses mechanical property similar to that of the natural bone and can be an attractive material to be used as orthopedic implants, its quick corrosion rate restricts its actual clinical applications. To control its rapid degradation, we have modified the surface of magnesium implant using fluoridated hydroxyapatite (FHA: Ca₁₀(PO₄)₆OH_{2 − x}F_x) through the combined micro-arc oxidation (MAO) and electrophoretic deposition (EPD) techniques, which was presented in our previous paper. In this article, the biocompatibility examinations were conducted on the coated AZ91 …

Tennessee Farm Bureau News - March 2015, Tennessee Farm Bureau Federation

Tennessee Farm Bureau News

No abstract provided.

Openness In International Adoption, Malinda L. Seymore

Faculty Scholarship

After a long history of secrecy in domestic adoption in the United States, there is a robust trend toward openness. That is, however, not the case with international adoption. The recent growth in international adoption has been spurred, at least in part, by the desire of adoptive parents to return to closed, confidential adoptions where the identity of the birth mother is secret and there is no ongoing contact with her. There is, however, an emergent interest in increased openness in international adoption, spurred by the success of domestic open adoptions, health concerns when an adoptee's genetic history is important, …

Progressive Legal Thought, Herbert Hovenkamp

Washington and Lee Law Review

No abstract provided.

The Admissibility Of Trueallele: A Computerized Dna Interpretation System, Katherine L. Moss

Washington and Lee Law Review

No abstract provided.

First Record Of A Spotted Fever Group Rickettsia Sp. And Theileria Annulata In Hyalomma Dromedarii (Acari: Ixodidae) Ticks In The United Arab Emirates, Mohammad Ali Al-Deeb, Sabir Bin Muzaffar, Yousif Ali Abu-Zeid, Mohamed Rizk Enan, Shahid Karim

Faculty Publications

Rickettsiosis and theileriosis can cause mortalities in camel populations. This study was conducted to achieve 2 objectives: (1) to detect the presence of SFG Rickettsia sp. and Theileria sp. in Hyalomma dromedarii Koch, 1844 (Acari: Ixodidae) ticks and (2) to determine their prevalence in the tick population on the sampled camel farms in Al-Ain, United Arab Emirates (UAE). Camel ticks (H. dromedarii) were collected from a total of 625 one-humped camels (Camelus dromedarius) in 22 sampling locations in Al-Ain, UAE. Tick samples were analyzed by Polymerase Chain Reaction (PCR). An SFG Rickettsia sp., which was 99% …

Measuring The Impact Of A Ninth Grade Academy On Tenth Grade Performance In Academics, Attendance, And Behavior, Dan Snipes

Dissertations, Theses and Capstone Projects (Full IR Collection)

Ninth Grade Academies were designed to smooth the transition of rising ninth graders academically and behaviorally. Current research has addressed the long-term effects of Ninth Grade Academies on academics, behavior, and graduation rates. This literature has shown the Ninth Grade Academy to be moderately effective in improving graduation rates but have only limited success in retention, disciplinary action rates, and academic performance. To measure the impact a Ninth Grade Academy has on tenth grade performance in academics, behavior, and attendance data was compared from two schools: School A (which has a Ninth Grade Academy) and School B (which has a …

The U.S.-Japan Alliance: Review Of The Guidelines For Defense Cooperation, James J. Przystup

INSS Strategic Perspectives

This paper is focused on the U.S.-Japan alliance as reflected in the evolution of the U.S.-Japan Guidelines for Defense Cooperation. It begins with consideration of the October 3, 2013, 2+2 Statement released by Secretary of State John Kerry, Secretary of Defense Chuck Hagel, Foreign Minister Fumio Kishida, and Minister of Defense Itsunori Onodera. The statement reaffirmed the critical importance of the alliance to international stability and security, the U.S. commitment to the security of Japan, and a common strategic vision based on shared values. The statement also tasked the two governments to review the existing 1997 U.S.-Japan Guidelines for Defense …

Rab Proteins And Alzheimer's: A Current Review Of Their Involvement In Amyloid Beta Generation With Focus On Rab10 Expression In N2a-695 Cells, Ivan Arano Rodriguez

Theses and Dissertations

This thesis work describes the role of Rab proteins in amyloid processing and clearance in different cell pathways. It also describes an experimental approach used to analyze the expression effects of Rab10 in amyloid beta production. Since the main theory behind neurodegeneration in Alzheimer's disease claims that high levels of amyloid beta 42 (Aβ42) molecules trigger widespread neuronal death, control of Aβ42 has been a main target in Alzheimer's disease research. In addition, several studies show increased levels of particular Rab proteins in Alzheimer's pathogenesis. However, no review consolidates current findings in neurodegeneration of Alzheimer's with Rab protein dysfunction. The …

Shakespeare's Art And Artifice: Passing For Real In As You Like It, Kristen Nicole Cardon

Theses and Dissertations

Gender performativity, detailed by Judith Butler and accepted by most contemporary queer theorists, rests on an agentive model of gender wherein “genders are appropriated, theatricalized, worn, and done” (“Imitation and Gender Insubordination” 716). This academic orthodoxy is challenged, however, by the increasing presence of transgender persons joining the theoretical discourse, many of whom experience an essential gender as a central facet of their identity. I respond to Katie R. Horowitz’s recent modification of Butler’s theories—a theory of omniperformance to dissolve the distinction between performance and performativity, and thereby between artifice and “real life.” I argue that gender-as-art, a schema that …

External Validity Of Grammatical Word Category Classification Using An Adaptation And Selection Model, Michelle Chatterton

Theses and Dissertations

The process of acquiring language requires children to learn grammatical categories and apply these categories to new words. Researchers have proposed various explanations of this process in the form of algorithms and computational modeling. Recently, adaptation and selection models have been tested and applied as a possible explanation to the process of acquiring grammatical categories. These studies have proven promising, however, the external validity of this approach has not been examined by grammatically coding samples outside the training corpus. The current thesis applies an adaptation and selection model, which pauses the evolution of dictionaries after every thousand cycles to allow …

Betende Hande: Albrecht Durer's Self-Portrait As A Gothic Church, Christine Heathcote

Theses and Dissertations

In 1508 Albrecht Dürer, famed German printmaker and Nürnberg citizen, was commission by Jakob Heller of Frankfurt to paint a large altarpiece for a new church. The Heller Altarpiece was the second commission of the printer since his training in Venice, Italy (1504-1507) to paint like an Italian master. In order to prepare for such a commission, Dürer spent over a year creating drawings of black ink and white chalk on blue Venetian paper to serve as inspiration for the large painting. However once the painting was complete, the artist held onto these ink and chalk drawings as part of …

Women With Disabilities In The Workplace: A Need For Advancement Opportunities, Susan Stuntzner

Counseling Faculty Publications

Women in the workplace is not a new concept, particularly given the fact they constitute about half of the workforce in many countries. Despite their increased presence, women continue to be challenged in their ability to advance within the workplace or, in some instances, acquire solid, well-paying, meaningful positions. Reasons for this are varied. Women continue to find themselves charged with the responsibility of maintaining their home and raising their children while also being a part of the workforce; thus, causing them to consider a non-linear career or employment path. Others may not have been raised or encouraged from a …

The Biology Of Claudin 6 (Cldn6) In The Developing Mouse Lung, Felix Ruben Jimenez Rondan

Theses and Dissertations

The tight junctions (TJ), which are located in the apical region between epithelial and endothelial cells, regulate the paracellular diffusion of ions and small molecules and play an important role in maintaining cell polarity, cell-cell integrity, and permeability. In the lung, epithelial cells are attached by TJ structures. They provide a permeable barrier and cell communication. The loss of barrier integrity, which is maintained by the expression of claudins (Cldn), results in cellular permibilization and leads to paracellular diffusion of solutes and harmful molecules. There are 27 known Cldn homologous members in mice and human. Cldn6 is mostly expressed in …

The Role Of Receptors For Advanced Glycation End-Products (Rage) And Ceramide In Cardiovascular Disease, Michael Bruce Nelson

Theses and Dissertations

Type 2 diabetes and cigarette smoke exposure are associated with an increased risk of cardiovascular complications. The role of advanced glycation end-products (AGEs) is already well-established in numerous comorbidities including cardiomyopathy. Given the role of AGEs and their receptor, RAGE, in activating inflammatory pathways, we sought to determine whether ceramides could be a mediator of RAGE-induced altered heart mitochondrial function. Using an in vitro model, we treated H9C2 cardiomyocytes with carboxy-methyl lysine-BSA, followed by mitochondrial respiration assessment. We found that mitochondrial respiration was significantly impaired in AGE-treated cells, but not when co-treated with myriocin, an inhibitor of de novo …

A Diachronic Analysis Of North And South Korean Monophthongs: Vowel Shifts On The Korean Peninsula, Jessica M. Morgan

Theses and Dissertations

The linguistic situation on the Korean peninsula is one ripe for research. For the past 70 years the two halves of the peninsula have been isolated from one another, thus creating two very different environments for development and change within the Korean language. It is hypothesized that due to conflict, divide, and social turmoil on the peninsula, the Korean language will have undergone a period of change in the last 70 years. This particular investigation looks at North and South Korean monophthong systems for evidence of a phonological shift. Studies of North Korea's language planning (Yong, 2001; Kumatani, 1990) will …

Modeling Children's Acquisition Of Grammatical Word Categories From Adult Input Using An Adaptation And Selection Algorithm, Nicole Adele Stenquist

Theses and Dissertations

It is understood that children learn the use of grammatical categories in their native language, and previous models have only been partially successful in describing this acquisition. The present study uses an adaptation selection algorithm to continue the work in addressing this question. The input for the computer model is child-directed speech towards three children, ages ranging from 1;1 to 5;1 during the course of sampling. The output of the model consists of the input words labeled with a grammatical category. This output data was evaluated at regular intervals through its ability to correctly identify the grammatical categories of language …

Clinical Trial For Evaluation Of A Human Immunodeficiency Virus Nosode In The Treatment For Human Immunodeficiency Virus-Infected Individuals, Rajesh Shah

Indian Journal of Research in Homoeopathy

Introduction: Identifying the need for strengthening of the immune system, the investigator has developed new Human Immunodeficiency Virus (HIV) nosode and evaluated its effect on HIV positive individuals through a clinical trial. Methods: Standardized and the scientific method of HIV nosode preparation has been described and documented. Thirty-seven HIV-infected persons were registered for the trial, and ten participants were dropped out from the study, so the effect of HIV nosode 30C and 50C, was concluded on 27 participants under the trial. Results: Out of 27 participants, 7 (25.93%) showed a sustained reduction in the viral load from 12 to 24 …

On The Transport Modes Of Fine Sediment In The Wave Boundary Layer Due To Resuspension/Deposition: A Turbulence-Resolving Numerical Investigation, Zhen Cheng, Xiao Yu, Tian Jian Hsu, Celalettin E. Ozdemir, S. Balachandar

Faculty Publications

Previous field observations revealed that the wave boundary layer is one of the main conduits delivering fine sediments from the nearshore to continental shelves. Recently, a series of turbulence-resolving simulations further demonstrated the existence of a range of flow regimes due to different degrees of sediment-induced density stratification controlled by the sediment availability. In this study, we investigate the scenario in which sediment availability is governed by the resuspension/deposition from/to the bed. Specifically, we focus on how the critical shear stress of erosion and the settling velocity can determine the modes of transport. Simulations reveal that at a given wave …