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Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study | Lost And Found: Transgender Elders’ Journey Toward Authenticity. A Constructionist Grounded Theory Study, Donna Barbara Riley

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

While theoretical models of transgender identity development exist, theoretical models of post-transition social identity development are limited, and theoretical models of transgender individuals transitioning in later life are absent. As such, the purpose of this study is to explore the experience of transgender individuals coming out later in life, often after decades of hiding. Their experiences give voice to the trans community to define self-fulfillment as a transgender person post-transition. Additionally, this study explores the obstacles transgender elders navigate in middle and later life. Using a semi-structured interview guide with 42 transgender elders 55 years and older, respondents constructed chronological …

Formal Verification Of Nonlinear Biological Systems, Md Ariful Islam

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

Abstraction and composition have proved to be particularly useful in extending the reach of formal verification. Abstraction reduces the size of the system under investigation by neglecting details irrelevant to the properties of interest. Compositionality allows us to decompose large-scale system into smaller components and verify each component individually and reason about the verification of entire system from verified components. Together, these two techniques permit us to substitute a component with its equivalent abstraction such that the overall system retains the property of interest. In this thesis, we first show that in the context of the Iyer et al. (IMW) …

Synthetic Gene Design: Optimization And Analysis, Rukhsana Yeasmin

Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions)

With the advance of synthetic biology has come increased interest in designing synthetic genes which optimize protein expression. We propose new algorithms for gene design under several different constraints. Our optimization criteria include finding minimum energy and maximum energy RNA structures for a given gene sequence, optimizing the amount of tRNA auto-correlation in genes and designing maximum and minimum auto-correlated sequences. We also develop methods to analyze and interpret tiled microarray genome expression data. Statistical analysis of the viral genome expression data enables us to discover unknown facts about its life cycle, its impact on the host cell shutoff mechanism. …

Semi-Automated Object-Based Classification Of Coral Reef Habitat Using Discrete Choice Models, Steven Saul, Samuel J. Purkis

Marine & Environmental Sciences Faculty Articles

As for terrestrial remote sensing, pixel-based classifiers have traditionally been used to map coral reef habitats. For pixel-based classifiers, habitat assignment is based on the spectral or textural properties of each individual pixel in the scene. More recently, however, object-based classifications, those based on information from a set of contiguous pixels with similar properties, have found favor with the reef mapping community and are starting to be extensively deployed. Object-based classifiers have an advantage over pixel-based in that they are less compromised by the inevitable inhomogeneity in per-pixel spectral response caused, primarily, by variations in water depth. One aspect of …

Misconceptional Views About Epilepsy Exist Across Social Class System Of Society, Shoaib Rao, Bakhtyar Ali Shah, Nimra Altaf, Fazal M. Arain

Pakistan Journal of Neurological Sciences (PJNS)

Epilepsy affects over 1% of population worldwide. Studies have shown that although our understanding about epilepsy has come a long way, misconceptions about its etiology and treatment exist in rural slums. However, no study has been conducted to see whether such misconceptions exist in middle and upper socio-economic class. This study aims to explore the existence of misconceptions and social stigma in the middle and upper socio-economic class. Materials and Methods: We conducted a survey-based study about epilepsy on 227 participants, belonging to middle and upper socio-economic class. Results: The symptoms of generalized tonic-clonic seizures were correctly described by participants. …

The Effects Of Ketorolac And Its Enantiomers On Breast Cancer Proliferation And Metastasis, Amanda Sheree Peretti

Biomedical Sciences ETDs

Breast cancer is the second leading cause of cancer related deaths in women. Advanced breast cancer can metastasize to the lungs, liver, bones and brain becoming fatal conditions for many patients. There is a dire need for metastasis preventing medications, however the process required for a medication to become FDA approved for clinical use is long and arduous. Studies have found promising benefits for breast cancer patients given ToradolTM, or racemic ketorolac, as an NSAID during resection surgery. However, long-term use of racemic ketorolac is not recommended. Currently FDA-approved for use in the racemic form, ketorolac has the potential to …

University Of Dayton Magazine, Winter 2015-16, University Of Dayton Magazine

University of Dayton Alumni Publications

This issue includes articles "Still Crazy After All These Years"; "What the Pope Says (And Why We Care)"; and "Seeking to be Safe".

The Current Volume 26 : Issue 14, Nova Southeastern University

Student Newspapers

No abstract provided.

Implementation Of Broad Band Ambient Light Activated Opsins To Treat Neurodegenerative Diseases In Retinal Cells, Gregory Cervenka

2015 Fall Honors Capstone Projects - Archive

Retinitis Pigmentosa is a degenerative eye disease that can eventually lead to blindness. This disease is caused by light desensitization of retinal cells resulting in a lack of neural impulses from the eye to the brain to form an image. Scientists are attempting to treat this condition by bringing light sensitivity back to retinal cells. They are accomplishing this by transfecting the cell with light activated channel proteins called opsins. However, researchers are facing a difficulty using these opsins as the proteins can only be activated by intense narrow band light that can damage cells further. Our objective was to …

Exploring The Issue Of Drug Shortages In The U.S. And The Impact It Has On The Healthcare Industry, Lenaiya Kydd

2015 Fall Honors Capstone Projects - Archive

The idea of American hospitals running out of medicine was not perceived to be possible, but it is a current reality. The impact of high demands and low supplies of some drugs has delivered a tough financial blow to healthcare facilities. In recent years, the number of recorded drug shortages has continuously grown and has created challenges in the healthcare industry. Delayed treatments, adverse outcomes or even death, with the use of alternative medicine have led to patients being negatively impacted. The reasons for drug shortages are multi-faceted, ranging from manufacturers challenged by FDA inspections to inadequate access to raw …

Nanopore Biosensor For Quantification Of The Isomers Of Platelet-Derived Growth Factor Protein, Maryam Alam

2015 Fall Honors Capstone Projects - Archive

Our project’s goal is to use nanopore analysis to detect cancers from the expression of protein for early screenings of cancer. Preliminary work uses a nanopore chip to detect specific proteins. Our research targeted the platelet-derived growth factor (PDGF) protein that is an important biomarker for certain cancers like leukemia and lymphoma. Discrimination between two isomers of the PDGF protein, PDGF AA and PDGF AB, was the target of experiments through the nanopore. For selectivity, an aptamer, a molecule made up of specific RNA nucleotides, was introduced in the solution. The aptamer had a very high affinity for PDGF AB, …

Heat Dissipation During Hovering And Forward Flight In Hummingbirds, Don Powers, Bret W. Tobalske, J. Keaton Wilson, Keeley R. Corder

Faculty Publications - Department of Biological & Molecular Science

Flying animals generate large amounts of heat, which must be dissipated to avoid overheating. In birds, heat dissipation is complicated by feathers, which cover most body surfaces and retard heat loss. To understand how birds manage heat budgets during flight, it is critical to know how heat moves from the skin to the external environment. Hummingbirds are instructive because they fly at speeds from 0 to more than 12ms−1, during which they transit from radiative to convective heat loss. We used infrared thermography and particle image velocimetry to test the effects of flight speed on heat loss from specific body …

Commencement Program 2015 December: College Of Science, The University Of Texas At Arlington

Commencement Programs, Photos, and Video

No abstract provided.

Bumetanide Demonstrates Amelioration Of Learning And Memory Deficits Induced By Ketamine Administration In A Neonatal Rat Model, Ryan Stevens

McNair Scholars Research Journal

No abstract provided.

Thermal Transgenerational Plasticity And Its Effect On Competitive Ability And Consumer-Resource Dynamics In A Population Of Daphnia Ambigua, Holmes Julian

Biology Theses - Archive

Global temperature increases are predicted to quicken in pace this century, and with them so will the likely impact on natural populations. The extent to which organisms will be able to keep pace with and adapt to these environmental changes is an unanswered question. It has been demonstrated that changing environments can induce changes in phenotypes that persist across generations. TGP may be an important means for populations to cope with climate change stress, but our understanding of these interactions is incomplete. Prior work showed that Daphnia program their offspring for faster development when reared under cooler temperatures. Here I …

Controlled Hydrosilylations Of Carbonyl Compounds And Computational Investigations Of A Hydride Shuttle Mechanism For Alkene Hydrosilylation, Gabriela Trog

Chemistry & Biochemistry Theses - Archive

Chapter 1 describes tandem dual hydrosilylations of α,β-unsaturated enals. Hydrosilylations of both carbonyl compounds and alkenes have been utilized to create chiral alcohols. Tandem dual hydrosilylations (TDH) of α,β-unsaturated carbonyl compounds create five-membered oxasilacycles that can be further converted to 1,3- diols, which are a common structural motif in the polyketide natural product family. We present preliminary data and a substrate scope for the formation of these oxasilacycles en route to the 1,3-diol compounds. Chapter 2 describes hydrosilylations of esters that result in silyl acetals. The silyl acetals are chemical synthons of the corresponding aldehyde. This reaction can be coupled …

Evaluation Of Activated Carbon As A Commercial Drug Disposal Product Using Liquid Chromatography–Tandem Mass Spectrometry, Veronica B. Waybright

Chemistry & Biochemistry Theses - Archive

At present, pharmaceuticals, synthetic organic compounds, and endocrine disrupting compounds are ubiquitous in our environment. These have been introduced by consumers and manufacturers directly and indirectly for decades. There is plenty of published literature addressing the presence of these compounds, the development of newer and more sensitive techniques to detect them at low concentrations, as well as studies showing their effects in the environment and in human health. However, these studies are based on the measurement and detection of these compounds after the fact; and even though some have addressed the need to decrease these pollutants in the environment, procedures …

Determination Of Total And D-Amino Acid Content In Mice Brain Tissue By Achiral-Chiral Heart-Cutting Two-Dimensional Liquid Chromatography: Diagnostic And Clinical Relevance And A Comparison Between Non-Perfused And Perfused Tissue, Curran Parpia

Chemistry & Biochemistry Theses - Archive

A heart-cutting two dimensional liquid chromatographic method for the quantification of free amino acid enantiomers from mouse brain tissue is demonstrated. Evidence to support the occurrence of D-amino acids in significant concentrations in physiological samples has spurred studies toward the elucidation of their importance and function. In this work, the level and regional distribution of select amino acids were determined by achiral-chiral LC/LC. Additionally, the effect of tissue perfusion on these levels was investigated. The free amino acid extracts were analyzed as their 9-fluorenylmethyloxycarbonyl derivatives and separated in the reverse phase mode on superficially porous C18. In the second dimension, …

No Major Changes On Paleoclimate And Paleoenvironment Across The Eocene–Oligocene Transition In The Central Rocky Mountains, Sara Ayyash

Earth & Environmental Sciences Theses - Archive

Earth’s climate has experienced dramatic cooling during the Eocene-Oligocene Transition (EOT) based on well-constrained marine geological records, however, a consensus on the terrestrial responses to this event has not been reached. The White River Formation in the central Rocky Mountains, western U.S.A., is a well-dated stratigraphic unit covering the EOT. The formation contains tuffaceous mudrock and sandstone that were deposited in fluvial and eolian depositional environments. Here I study oxygen isotope ratios and clumped isotope temperatures of carbonate cements and bulk organic carbon isotope ratios in order to reconstruct the paleoenvironment and paleoclimate across the EOT. These carbonate cements were …

Development, Testing And Characterization Of Electronic Skins For Robots, Ritvij Sahasrabuddhe

Electrical Engineering Theses - Archive

The main purpose of this thesis is to test and characterize newly developed pressure sensors integrated into robot skin and understand their behavior for different testing parameters such as sensor and skin materials and geometry. Flexible electronic skin is meant to behave similar to human skin acting as a tactile interface with the robot environment. Before placing electronic skin onto robots, it is important to test and characterize such structures. Since the behavior of our pressure sensors embedded in robot skin was still unknown, an experimental setup has been developed in order to test and characterize the sensors and collect …

Two Phase Flow Cfd Analysis Of Refrigerants In A Condenser Pipe For Prediction Of Pressure Drop And Pumping Power, Aniket Ramchandra Kalambe

Mechanical and Aerospace Engineering Theses - Archive

With the ever growing need of achieving optimum cooling at chip level at the expense of low input pumping power and keeping in check the Global Warming Potential (GWP) & Ozone Depletion Potential (ODP) has given rise to “two-phase on chip cooling” with nature friendly refrigerants. Currently, “air-cooling” and “single-phase water on-chip cooling” using copper micro-channel coolers are being used but “two-phase on chip cooling” with refrigerants have a very large scale & long lasting advantages over the prior. However, due to the perceived complexity of modelling two-phase flow, this solution is not yet well understood. Modelling of two phase …

Nanoparticle-Bridge Assay For Amplification-Free Electrical Detection Of Oligonucleotides, Manouchehr Teimouri

Material Science and Engineering Dissertations - Archive

The aim of this research is to investigate a highly sensitive, fast, inexpensive, and field-applicable amplification-free nanoparticle-based oligonucleotide detection method which does not rely on any enzymatic or signal amplification process. In this approach, target oligonucleotide strands are detected through the formation of nanoparticle satellites which make an electrical path between two electrodes. This method enables an extremely sensitive oligonucleotide detection because even a few oligonucleotide strands can form a single nanoparticle satellite which can solely generates an electrical output signal. Results showed that this oligonucleotide detection method can detect oligonucleotide single strands at concentrations as low as 50 femtomolar …

Material Changes Of Bone Following Ishcemia Of The Immature Femoral Head, Olumide O. Aruwajoye

Material Science and Engineering Dissertations - Archive

Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder resulting from the loss of blood flow to the femoral head. In severe cases of the disease, the femoral head can develop a flattening deformity; additionally, if the disease is diagnosed at a later stage, it leaves most patients to develop early osteoarthritis of the hip. Due to a lack of pathological specimen from patients, an experimental piglet model of femoral head ischemia was developed. The model closely follows the radiographic changes seen in LCPD patients, where there is subchondral fracture, resorption, and a flattening deformity of the femoral head. After ischemia, …

Merging Radar-Only Qpe And Rain Gauge Data Via Conditional Bias-Penalized Optimal Estimation, Beomgeun Kim

Civil Engineering Theses - Archive

A new technique for merging radar precipitation estimates and rain gauge data is developed and evaluated to improve multisensor quantitative precipitation estimation (QPE). Various types of linear and nonlinear techniques have been used to combine rain gauge and radar data. Linear cokriging and its variants, for example, may be considered as the best linear unbiased estimators which minimize the error variance in the unconditional sense. They are, however, subject to conditional biases (CB) that may be unacceptably large for estimation of heavy-to-extreme precipitation. In this work, I develop, apply, and evaluate conditional bias-penalized cokriging (CBPCK) for spatial estimation of precipitation …

Finding Deaf Gain: Changing Languages, Changing Lenses, Changing Society, Edward Henry Bart

English Theses - Archive

Most literature is analyzed through various lenses, or more accurately, schools of thought informed by life experience and cultural knowledge. Literature created in American Sign is no different than any other literature in spite of it being a visual-spatial language rather than a sound-based language. It requires scholars able to access the Deaf Lens, cognizant of the linguistic and historical context that informed Deaf artists in the creation of their work. This context is embedded in their ASL literature, and often requires scholars to approach their work as the product of a colonized group. Though the Deaf Community does not …

Mitigating Climate Change By Zoning For Solar Energy Systems: Embracing Clean Energy Technology In Zoning’S Centennial Year, John R. Nolon

Elisabeth Haub School of Law Faculty Publications

Adopting land use regulations that encourage solar and other clean energy systems is an essential strategy for promoting clean power and one that focuses on the essential role that local governments play in mitigating climate change. This article explores efforts at the state and local level to reform zoning and land use regulations to permit, encourage, require, and incentivize rapidly-evolving clean energy systems, particularly solar, that, in the aggregate, have the ability to significantly increase power generation and decrease carbon emissions. The article illustrates how zoning, as it approaches its 100th anniversary, is encrusted with provisions that prohibit or discourage …

The Center For Teaching & Learning: July 1, 2014 - December 2015, Liz Mikita

Annual Reports & Administrative Documents

Contents:

• From the Director
• New Center Supports Teaching and Learning
• CTL Supports Scholarly Publishing
• iCE Platform Fosters Interactive Learning Experience
• A Physical and Virtual Makeover for Scott Library
• Reaching Out to Our Users
• Exhibits & Special Events
• Staff Highlights

Tatiana Soboleva Honors Portfolio, Tatiana Soboleva

Honors Capstone Portfolios

Tatiana Soboleva's honors portfolio captured in December 2015.

Efficacy And Safety Of Vorapaxar In Non-St-Segment Elevation Acute Coronary Syndrome Patients Undergoing Noncardiac Surgery, Sean Van Diepen, Pierluigi Tricoci, Mohua Podder, Cynthia M. Westerhout, Philip E. Aylward, Claes Held, Frans Van De Werf, John Strony, Lars Wallentin, David J. Moliterno, Harvey D. White, Kenneth W. Mahaffey, Robert A. Harrington, Paul W. Armstrong

Gill Heart & Vascular Institute Faculty Publications

Background—Perioperative antiplatelet agents potentially increase bleeding after non–ST‐segment elevation (NSTE) acute coronary syndromes (ACS). The protease‐activated receptor 1 antagonist vorapaxar reduced cardiovascular events and was associated with increased bleeding versus placebo in NSTE ACS, but its efficacy and safety in noncardiac surgery (NCS) remain unknown. We aimed to evaluate ischemic, bleeding, and long‐term outcomes of vorapaxar in NCS after NSTE ACS.

Methods and Results—In the TRACER trial, 2202 (17.0%) patients underwent major or minor NCS after NSTE ACS over 1.5 years (median); continuing study treatment perioperatively was recommended. The primary ischemic end point for this analysis was cardiovascular …

The Volta Grande Do Xingu: Reconstruction Of Past Environments And Forecasting Of Future Scenarios Of A Unique Amazonian Fluvial Landscape, A. O. Sawakuchi, G. A. Hartmann, H. O. Sawakuchi, F. N. Pupim, D. J. Bertassoli, M. Parra, J. L. Antinao, L. M. Sousa, M. H. Sabaj Pérez, P. E. Oliveira, R. A. Santos, J. F. Savian, C. H. Grohmann, V. B. Medeiros, Michael M. Mcglue, D. C. Bicudo, S. B. Faustino

Earth and Environmental Sciences Faculty Publications

The Xingu River is a large clearwater river in eastern Amazonia and its downstream sector, known as the Volta Grande do Xingu (“Xingu Great Bend”), is a unique fluvial landscape that plays an important role in the biodiversity, biogeochemistry and prehistoric and historic peopling of Amazonia. The sedimentary dynamics of the Xingu River in the Volta Grande and its downstream sector will be shifted in the next few years due to the construction of dams associated with the Belo Monte hydropower project. Impacts on river biodiversity and carbon cycling are anticipated, especially due to likely changes in sedimentation and riverbed …