Digital Commons Network^™

Institutionalized Racism And The Death Penalty, Ashleigh Ellis

Student Scholar Symposium Abstracts and Posters

Overtime, support for capital punishment has evolved. Compared to previous decades, support has changed amongst different variables such as: age, race, gender, and political perspective; therefore, today, these variables have changed the amount of support for it. For example, as of today, 6 states have repealed the death penalty with New Jersey being the first in 2007 to do so in 40 years. As memories of Jim Crow and the Civil Rights era have faded due to generational replacement, American society today still has this racial gap, however it is due to this racial resentment or symbolic resentment that the …

Exploring Egr-1 As A Master Regulator Of Prostate Field Cancerization, Kristin Gabriel, Marco Bisoffi

Student Scholar Symposium Abstracts and Posters

Field cancerization denotes the presence of molecular aberrations (genetic, epigenetic, biochemical) in structurally intact cells residing in histologically normal tissues adjacent to tumors. Markers of field cancerization in prostate tissues have the potential to improve the clinical management of this malignancy through their potential to act as indicators of early disease and to serve as molecular targets for early intervention. However, for this, a detailed understanding of the functional pathways underlying field cancerization is necessary. We have recently identified four protein markers of prostate field cancerization, i.e. the key transcription factor early growth response 1 (EGR-1), the lipogenic enzyme fatty …

Effects Of Ecologically Realistic Heating Profiles On Feeding In The Intertidal Hermit Crab, Pagurus Sameulis, Paige Davis

Student Scholar Symposium Abstracts and Posters

The intertidal zone is an ideal habitat to investigate effects of global warming because species living in it are very close to their physiological limits. Initial studies of invertebrate physiological responses to heat stress have employed relatively abrupt increases in temperature. My research investigates effects of ecologically more realistic temperature profiles on feeding in the intertidal hermit crab, Pagurus sameulis. Recent work in the Wright lab showed that feeding in this species is inhibited by an abrupt increase in temperature. Because temperature change in the natural environment of Pagurus is much more gradual, I hypothesize that such a gradual temperature …

Moving Back To The 18th Century View's Of Women's Role And Perception Of Their Lives: The Case Of Motherhood, Yelena Liepelt

Student Scholar Symposium Abstracts and Posters

This project will explore the role of French women of the 18th century, and specifically the problems they faced due to their gender. I will analyze the obstacles that made it difficult for strong women, such as physicist and author Madame du Châtelet, to obtain happiness. These include the complicated identity of educated and ambitious women who lived within a strict gender binary system.

I will compare Châtelet’s concept of happiness from a female perspective to Jean-Jacques Rousseau’s view of women’s happiness and maternity. Rousseau believed women played an important role in society; however, their existence was always relative to …

Clinical Applications Of A Combination Chemotherapy Using 8-Chloro Camp And 8-Chloro Adenosine, Erik Munoz, Andrea Saich, Andrew Cox, Yu-An Peter Chang

Student Scholar Symposium Abstracts and Posters

Dr. Cho-Chung from the NIH first thought to use halogenated cAMP derivatives as competitive inhibitors of cAMP to slow down cancer cell mitosis. While the iodine and bromine substituted versions showed very little therapeutic actions, 8-Chloro cAMP has been shown to have strong anti-cancer effects. This has been shown in the phase II clinical trials this drug has undergone. However, these trials have had issues with solubility and toxicity. The drug is similar to vitamin C and is excreted quickly. Scientists tried to overcome this by using a peristaltic pump to give patients a continuous dosage, but this proved too …

Biological Degradation Of Acetaldehyde In Southern California Coastal Waters, Mary Senstad, Sovanndara Hok, Ori Barashy, Catherine D. Clark, Warren J. De Bruyn

Student Scholar Symposium Abstracts and Posters

Oxygenated hydrocarbons are ubiquitous in the atmosphere with levels ranging from low ppt (acetaldehyde) to low ppb (methanol). As an OH sink and an atmospheric HOx and ozone source, oxygenated hydrocarbons have a direct impact on the oxidative capacity of the atmosphere. The oceans are one of the largest sources of uncertainty in current atmospheric budget estimates of these species. A better understanding of the processes that produce and destroy these species in seawater would improve our understanding of the role of the oceans in cycling these species into or out of the atmosphere. We have measured the degradation rate …

Effects Of El Niño On Ecological Growth Along Californian And Peruvian Coasts, Alexandra Sidun

Student Scholar Symposium Abstracts and Posters

This study examines the mechanisms of El Niño to further understand the ecological effects it may have along the Californian and Peruvian coasts. El Niño is the warm phase of the El Niño Southern Oscillation (ENSO). While it is a global phenomenon, these two locations were investigated for their nearly equal and opposite conditions during storm months. California, which is in an extreme state of drought, often receives heavy rainfall during El Niño and understanding its potential effects is crucial. El Niño causes upwellings along the CA coast and warm water from the region displaces the normally cool waters along …

Prostate Field Cancerization – Thinking Outside The Tumor, Dor Shoshan

Student Scholar Symposium Abstracts and Posters

Analysis of tumor adjacent tissue is assumed to reveal a temporal record of molecular pathways that define oncogenesis. The present study determines expression of the key transcription factor and potential marker of field cancerization early growth response 1 (EGR-1) in human prostate tissues derived from prostatectomies and biopsies. Expression was detected using immunofluorescence and quantified using ImageJ software. Accordingly, EGR-1 expression was similar in cancerous and in histologically normal adjacent tissues from prostatectomy and biopsy specimens. EGR-1 could be exploited as pre-surgical disease indicator in false negative biopsies, identify areas of repeat biopsy, and add molecular information to surgical margins.

Assessing Water Quality In The Gulf Of Mexico Using Remote Sensing Data., Alliyah Thomas

Student Scholar Symposium Abstracts and Posters

Hypoxia, or oxygen depletion, is a process that occurs in conjunction with eutrophication. In hypoxic conditions the dissolved oxygen levels in the water column sink to unlivable conditions for the marine organisms causing them to flee or die. Despite efforts of improvement, the annual summer Gulf of Mexico dead zone continues to be a serious threat to aquatic ecosystems. The 2012 smaller than usual dead zone was a false indicator of future improvement. The 2012 dead zone decrease was connected to the drought and inability of large amounts of runoff to flow into the gulf. Water quality analysis was done …

Analyzation Of Metabolic Reprogramming In Drug-Resistant Mcf-7 Cells, Derick Han, Ho Leung, Andrew Vo

Student Scholar Symposium Abstracts and Posters

The Warburg effect states that cancer cells mainly receive their energy from anaerobic glycolysis. Thus, mitochondria play a different role in the metabolism of cancer cells as opposed to normal, healthy cells. In chemotherapy, there is always a chance of the cancer regressing. Making drug-resistant cancer cells to analyze their metabolism may change how cancer is treated. This study aimed to create drug-resistant MCF-7 cell lines with doxorubicin in order to determine the metabolic changes that have occurred in the process of becoming resistant to drug treatments.

Modeling Shape Representation In Area V4, Wyeth Bair, Dina Popovkina, Abhishek De, Anitha Pasupathy

MODVIS Workshop

Our model builds on a convolutional-style neural network with hierarchical stages representing processing steps in the ventral visual pathway. It was designed to capture the translation-invariance and shape-selectivity of neurons in area V4. The model uses biologically plausible linear filters at the front end, normalization and sigmoidal nonlinear activation functions. The max() function is used to generate translation invariance.

A Recurrent Multilayer Model With Hebbian Learning And Intrinsic Plasticity Leads To Invariant Object Recognition And Biologically Plausible Receptive Fields, Michael Teichmann, Fred H. Hamker

MODVIS Workshop

Much effort has been spent to develop biologically plausible models for different aspects of the processing in the visual cortex. However, most of these models are not investigated with respect to the functionality of the neural code for the purpose of object recognition comparable to the framework of deep learning in the machine learning community.
We developed a model of V1 and V2 based on anatomical evidence of the layered architecture, using excitatory and inhibitory neurons where the connectivity to each neuron is learned in parallel. We address learning by three different mechanisms of plasticity: intrinsic plasticity, Hebbian learning with …

Astrocytes Infected With Chlamydia Pneumonia Alter Amyloid Processing Implicated In Alzheimer’S Disease, Zein Al-Atrache, Ahmad Cader, Susan Hingley, Denah Appelt

Research Day

Alzheimer’s Disease (AD) is a chronic, progressive neurodegenerative disease whose pathogenesis centers around the abnormal processing of amyloid precursor protein (APP) by proteases, resulting in the formation of neuritic plaques composed of toxic, insoluble fragments of amyloid protein (Aβ), including Aβ1-40 and Aβ1-42. Previously, our laboratory identified Chlamydia pneumoniae (Cpn) in autopsied sporadic AD brains. Additionally, an infection based animal model was developed using BALB/c mice that were intranasally inoculated with Cpn, in which the deposition of amyloid was consistent with that observed in the human AD brain. These studies have led to the pathogen hypothesis of AD that implicates …

The Relationship Of Chlamydia Antigen, Ad-Like Pathology, And Inflammation In The Brains Of Intranasally Infected Balb/C Mice: A Comparative Study, Brittany L. Kane, Lindsey V. Weidmann, Brian J. Balin, Denah M. Appelt, Justin H. Schripsema, Christopher L. Smith, Kyle Ramsey, C. Scott Little

Research Day

Background and Significance: Alzheimer’s Disease (AD) is characterized by amyloid deposition and inflammation. Chlamydia pneumoniae (Cpn) intranasal infection of BALB/c mice has been shown to induce AD like pathology in brain tissue. Preliminary data suggests that other species of Chlamydia induce similar pathology in mice. Objectives: (1) identify and localize Chlamydia antigen and amyloid pathology in specific AD-related brain regions of intranasally inoculated BALB/c mice infected with Cpn or Chlamydia muridarum (Cmu) and (2) evaluate the degree of glial cell activation in these regions. Methods: Non-transgenic BALB/c mice were intranasally inoculated with Cpn AR-39 (n=3) or Cmu (in vivo passaged …

A Computational Model To Account For Dynamics Of Spatial Updating Of Remembered Visual Targets Across Slow And Rapid Eye Movements, Yalda Mohsenzadeh, J. Douglas Crawford

MODVIS Workshop

Despite the ever-changing visual scene on the retina between eye movements, our perception of the visual world is constant and unified. It is generally believed that this space constancy is due to the brain’s ability of spatial updating. Although many efforts have been made to discover the mechanism underlying spatial updating across eye movements, still there are many unanswered questions about the neuronal mechanism of this phenomenon.

We developed a state space model for updating gaze-centered spatial information. To explore spatial updating, we considered two kinds of eye movements, saccade and smooth pursuit. The inputs to our proposed model are: …

Modeling Visual Features To Recognize Biological Motion: A Developmental Approach, Giulio Sandini, Nicoletta Noceti, Alessia Vignolo, Alessandra Sciutti, Francesco Rea, Alessandro Verri, Francesca Odone

MODVIS Workshop

In this work we deal with the problem of designing and developing computational vision models – comparable to the early stages of the human development – using coarse low-level information.

More specifically, we consider a binary classification setting to characterize biological movements with respect to non-biological dynamic events. To this purpose, our model builds on top of the optical flow estimation, and abstract the representation to simulate the limited amount of visual information available at birth. We take inspiration from known biological motion regularities explained by the Two-Thirds Power Law, and design a motion representation that includes different low-level features, …

Adaptive Motion Pooling And Diffusion For Optical Flow, Naga Venkata Kartheek Medathati, Pierre Kornprobst, Guillaume Masson, Manuela Chessa, Fabio Solari

MODVIS Workshop

We study the impact of local context of an image (contrast and 2D structure) on spatial motion integration by MT neurons. To do so, we revisited the seminal work by Heeger and Simoncelli (HS) [4] using spatio-temporal filters to estimate optical flow from V1-MT feedforward interactions. However, the HS model has difficulties to deal with several problems encountered in real scenes (e.g., blank wall problem and motion discontinuities). Here, we propose to extend the HS model with adaptive processing by focussing on the role of local context indicative of the local velocity estimates reliability. We set a network structure representative …

Long Term Capsaicin Administration Effects On Skeletal Muscle Function In Aging Mice, M C. Benson, C R. Receno, A Le, S Ruby, C Liang, L R. Deruisseau, K C. Deruisseau

International Journal of Exercise Science: Conference Proceedings

Please view abstract in the attached PDF file

We Are...Marshall, May 13, 2015, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Acupuncture And Assisted Reproductive Technology: The Effect On Clinical Pregnancy Rates, Hannah K. Holland

Yale School of Medicine Physician Associate Program Theses

Acupuncture has become an increasingly common concurrent therapy for women undergoing assisted reproductive technology. The effect of acupuncture on clinical pregnancy rates, however, remains unclear due to inconclusive study results and a lack of proper comparisons to all possible controls. In this three arm, single-blinded, randomized controlled trial, we propose to compare clinical pregnancy rates of women under age 35 undergoing in vitro fertilization with or without intracytoplasmic sperm injection in combination with either true acupuncture, sham acupuncture, or standard medical care. We hypothesize there will be a statistically significant difference in clinical pregnancy rates six to eight weeks following …

Dance/Movement Therapy And The Journey Of Infertility: A Phenomenological Study, Sara Ogawa

Creative Arts Therapies Theses

The purpose of this phenomenological study is to understand the holistic phenomenon of infertility in order to assess the basic needs of women who struggle with infertility and the associated medical treatments. In order to address a comprehensive understanding of the experience of infertility, this study employed a body-mind perspective, which is based on the dance/movement therapy principle that “the body and the mind are inseparable”. Five women, who had experience with infertility, were invited to the study, and each participated in individual verbal and movement interviews. Kvale’s interview analysis was utilized to analyze verbal data, and the researcher’s kinesthetic …

Moving Thru: Dance/Movement Therapy Based Program For Direct Caregivers Of Childhood Survivors Of Human Trafficking And Commercial Sexual Exploitation In Belize, Amy Vanbecelaere

Creative Arts Therapies Theses

The purpose of this project was to; identify the biopsychosocial needs of child survivors of human trafficking and commercial sexual exploitation in Belize and to develop a dance/movement therapy based program that Belizean caregivers can utilize to better serve the children they work with. The Moving THRU (Trauma Healing, Recovery + Understanding) program was developed based on current literature regarding post-trafficking mental health care and information provided in interviews by Belizean direct caregivers currently working with youth who have been trafficked and exploited in the Cayo District of central Belize. The curriculum is designed to help direct caregivers utilize techniques …

Multifaceted Role Of Matrix Metalloproteinases (Mmps), Divya Singh, Sanjeev K. Srivastava, Tapas K. Chaudhuri, Ghanshyam Upadhyay

Publications and Research

Matrix metalloproteinases (MMPs), a large family of calcium-dependent zinc-containing endopeptidases, are involved in the tissue remodeling and degradation of the extracellular matrix. MMPs are widely distributed in the brain and regulate various processes including microglial activation, inflammation, dopaminergic apoptosis, blood-brain barrier disruption, and modulation of α-synuclein pathology. High expression of MMPs is well documented in various neurological disorders including Parkinson's disease (PD), Alzheimer's disease (AD), Japanese encephalitis (JE), and Glaucoma. Although potentially critical, the role of MMPs in neuronal disorders is under-investigated. The present review summarizes the role of MMPs in neurodegeneration with a particular emphasis on PD, AD, JE, …

Board Of Trustees Minutes Regular Meeting May 13, 2015, Central Washington University

Board of Trustees Meeting Minutes

No abstract provided.

Revealing Important Nocturnal And Day-To-Day Variations In Fire Smoke Emissions Through A Multiplatform Inversion, Pablo E. Saide, David A. Peterson, Arlindo Da Silva, Bruce Anderson, Luke D. Ziemba, Glenn Diskin, Glen Sachse, Johnathan Hair, Carolyn Butler, Marta Fenn, Jose L. Jimenez, Pedro Campuzano-Jost, Anne E. Perring, Joshua P. Schwarz, Milos Z. Markovic, Phil Russell, Jens Redemann, Yohei Shinozuka, David G. Streets, Fang Yan, Jack Dibb, Robert Yokelson, O. Brian Toon, Edward Hyer, Gregory R. Carmichael

Chemistry and Biochemistry Faculty Publications

We couple airborne, ground-based, and satellite observations; conduct regional simulations; and develop and apply an inversion technique to constrain hourly smoke emissions from the Rim Fire, the third largest observed in California, USA. Emissions constrainedwithmultiplatform data show notable nocturnal enhancements (sometimes over a factor of 20), correlate better with daily burned area data, and are a factor of 2–4 higher than a priori estimates, highlighting the need for improved characterization of diurnal profiles and day-to-day variability when modeling extreme fires. Constraining only with satellite data results in smaller enhancements mainly due to missing retrievals near the emissions source, suggesting that …

Names Are Words: A Study Of Age, Gender, Class And Race, Alexandria Michelle Baker

Communication & Leadership Dissertations and Theses

Just over 4 million babies are born in the United States each year, and as many people know each baby eventually gets a name. In an extension of research demonstrating both Symbolic Interaction Theory and the Coordinated Management of Meaning, through the use of semantics and pragmatics, the present study examined what names communicate about age, race, gender and class. Using data obtained from the first group of participants in Survey 1(i.e. names of each individual and their demographics), Survey 2 participants, a random sampling of Americans, were asked to look at 14 names and determine what those names communicated. …

May 13, 2015 Cal Poly Report, Public Affairs Office

Cal Poly Report

No abstract provided.

Spartan Daily, May 13, 2015, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 144, Issue 42

Applications Of Latin Hypercube Sampling Scheme And Partial Rank Correlation Coefficient Analysis To Mathematical Models On Wound Healing, Hannah M. Pennington

Mahurin Honors College Capstone Experience/Thesis Projects

Latin hypercube sampling and Partial Rank Correlation Coefficient procedure (LHS/PRCC) can be used in combination to perform a sensitivity analysis that assesses a model over a global parameter space. Through this analysis, the uncertainty of the parameters and therefore the variability of the model output in response to this uncertainty can be observed. Latin hypercube sampling divides the parameter space into equiprobable regions and sample without replacement, producing a global, unbiased selection of parameter values. For montonic, non-linear relationships, the correlation between the outputs and parameters can be understood by performing a Partial Rank Correlation Coefficient procedure. This sensitivity analysis …

First Steps Of Putting Research Into Practice: Utilizing Concept Inventories To Identify Biochemistry Misconceptions And The Development Of A Guided Inquiry Activity To Correct The Identified Misconceptions, Ellen Humphreys

Master of Science in Chemical Sciences Theses

It is known that students leave science classes with an incomplete or incorrect understanding of some of the concepts covered in the courses. Identification of these misconceptions is difficult, as it usually involves conducting an hour long one-on-one interview with a student. Concept inventories were developed as a way for professors to identify misconceptions in their classroom in an efficient manner. However, there is no collection of biology, chemistry and biochemistry concept inventories and there has been no analysis of the quality of these inventories. One goal of the research was to collect these inventories and do the much needed …