Digital Commons Network^™

A Stand-Alone Dna Hybridization Detection System, Sinan S. Sayood

Department of Electrical and Computer Engineering: Dissertations, Theses, and Student Research

The goal of this project was to design a portable device that can quickly and accurately detect the difference between single and double stranded DNA. This was accomplished by analyzing the capacitive properties of DNA solutions and implementing a charge-based capacitive monitoring system to detect and analyze the solutions. The detection system was designed without reliance on expensive functionalized electrodes, and instead is able to detect the properties of free- oating DNA. This approach greatly reduces the cost of the materials needed to construct the device. It also decouples the main sensor apparatus from the bulk of the electronics, reducing …

A Survey Of Software-Based String Matching Algorithms For Forensic Analysis, Yi-Ching Liao

Annual ADFSL Conference on Digital Forensics, Security and Law

Employing a fast string matching algorithm is essential for minimizing the overhead of extracting structured files from a raw disk image. In this paper, we summarize the concept, implementation, and main features of ten software-based string matching algorithms, and evaluate their applicability for forensic analysis. We provide comparisons between the selected software-based string matching algorithms from the perspective of forensic analysis by conducting their performance evaluation for file carving. According to the experimental results, the Shift-Or algorithm (R. Baeza-Yates & Gonnet, 1992) and the Karp-Rabin algorithm (Karp & Rabin, 1987) have the minimized search time for identifying the locations of …

Academic Senate - Agenda, 5/19/2015, Academic Senate

Academic Senate Agendas

No abstract provided.

2015-05-19-Etsu To Offer Minor In Culture And Health Beginning This Fall, University Marketing And Communications, East Tennessee State University

Accent [newsletter]

No abstract provided.

Effects Of Selective Logging And Roads On Instream Fine Sediments And Macroinvertebrate Assemblages In The Clackamas Basin, Oregon, Paula Elizabeth Hood

Dissertations and Theses

Logging and associated skid trails, haul routes, and roads can have significant impacts on the magnitude and timing of sediments in streams in forested watersheds. Loss of vegetation, soil compaction, use of heavy logging equipment, and alteration of natural hydrologic patterns within the watershed can increase landslide rates, create erosion, and generate fine sediments. Selective logging, also called thinning, is a logging practice that leaves some trees within sale units unharvested. The ecological impacts of thinning on stream ecosystems are not fully understood and need further study. My hypothesis was that macroinvertebrate assemblages would be different in streams in non-reference …

Modelling Hereditary Spastic Paraplegias Using Human Pluripotent Stem Cells, Kyle Denton

Doctoral Dissertations

Hereditary spastic paraplegias (HSP) comprise a large, heterogeneous group of genetic neurodegenerative disorders. The unifying symptom present among HSP patients is lower limb spasticity, which is caused by the degeneration of cortical spinal motor neuron (CSMN) axons. Research on various HSP subtypes has identified a number of common cellular pathways that are weak points for long projection neurons, particularly CSMNs. The focus of this work has been to generate novel cellular models of several HSP subtypes using human pluripotent stem cells (hPSCs). Stem cell models were chosen because of their ability to use cells that have the same genetic background …

Genetic Basis For Rheumatic Heart Disease In High Risk Families In Western Samoa, Eleni Tukuafu, John S.K. Kauwe

Journal of Undergraduate Research

Rheumatic heart disease (RHD) is the most common form of acquired cardiovascular disease among children worldwide and results in 233,000 deaths annually. Although genetic and environmental factors are known to contribute to RHD, not much is known about genes that increase susceptibility. RHD results from untreated rheumatic fever (RF). RF develops when a Streptococcus pyogenes infection, such as streptococcal pharyngitis, goes untreated. About 34% of children with an untreated Streptococcus pyogenes infection develop rheumatic fever. Only 1/3 of those children acquire RHD¹. This suggests that there is a genetic basis for why some children are prone to the …

A Method Of Introducing Site Specific Mutations Into The Phor Gene Of The E. Coli Chromosome, Cameron Woodward, William Mccleary

Journal of Undergraduate Research

Phosphate intake by Escherichia coli serves as a good model system to study phosphate intake by other bacteria. The pho phosphate uptake system used by E. coli is well conserved in pathogens like Vibrio cholerae (1). To better understand this important mode of phosphate uptake a study was performed to examine the interactions between the phoR and phoU proteins of this system. PhoU interacts with the pstSCAB complex, which brings phosphate into the cell. After communicating with pstSCAB the phoU protein interacts with phoR to tell it if phosphate is present in the environment or not. PhoR has been shown …

Suggestion, Perception, Reality: A Study Into The Relationship Between Suggestion And The Reality It May Produce, Perception, Reality: A Study Into The Relationship Between Suggestion And The Reality It May Produce., Scott Whippo

Communication & Leadership Dissertations and Theses

Suggestion is a part of communication that cannot be stripped from or be considered separate from verbal and nonverbal communication. It is through the need to view the communication processes from a complete understanding that this study investigated the possible influence that suggestion may have on an individual’s perception of reality. The existing literature was reviewed with various results from different researchers, however, much of the literature supported previous research done by Spanos et al. (1984) and Bartels et al. (2006). Their research showed some indications that suggestion, and possibly priming may have an influence on an individual’s perception. Using …

Ferritin Levels In The Cerebrospinal Fluid Predict Alzheimer's Disease Outcomes And Are Regulated By Apoe, Scott Ayton, Noel G. Faux, Ashley I. Bush, Charles D. Smith, Greg A. Jicha, Peter A. Hardy, Partha Sinha, Elizabeth Oates, Gary Conrad, Alzheimer's Disease Neuroimaging Initiative

Neurology Faculty Publications

Brain iron elevation is implicated in Alzheimer's disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index, we explored whether brain iron status impacts longitudinal outcomes in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. We show that baseline CSF ferritin levels were negatively associated with cognitive performance over 7 years in 91 cognitively normal, 144 mild cognitive impairment (MCI) and 67 AD subjects, and predicted MCI conversion to AD. …

Transport Of Bovine Milk Exosomes In Human Endothelial Cell, Rio Jati Kusuma

Department of Nutrition and Health Sciences: Dissertations, Theses, and Student Research

MicroRNAs (miRNAs) can be synthesized endogenously and cause gene repression. Encapsulation of miRNAs in exosomes confers protection against degradation and a vehicle for shuttling between cells and tissues, and cellular uptake by endocytosis. Exosomes can be found in biological fluids and foods including milk. Evidence suggests that humans absorb cow’s milk exosomes and deliver the microRNA cargo to peripheral tissues, consistent with gene regulation by nucleic acids across species boundaries. There is strong evidence that milk exosomes may cross the mucosa without re-packaging in mice. Here, we tested the hypothesis that human vascular endothelial cells transport milk exosomes by endocytosis, …

Flow Cytometry And K-Mer Analysis Estimates Of The Genome Sizes Of Bemisia Tabaci B And Q (Hemiptera: Aleyrodidae), Li T. Guo, Shao L. Wang, Qing J. Wu, Xuguo Zhou, Wen Xie, You J. Zhang

Entomology Faculty Publications

The genome sizes of the B- and Q-types of the whitefly Bemisia tabaci (Gennnadius) were estimated using flow cytometry (Drosophila melanogaster as the DNA reference standard and propidium iodide (PI) as the fluorochrome) and k-mer analysis. For flow cytometry, the mean nuclear DNA content was 0.686 pg for B-type males, 1.392 pg for B-type females, 0.680 pg for Q-type males, and 1.306 pg for Q-type females. Based on the relationship between DNA content and genome size (1 pg DNA = 980 Mbp), the haploid genome size of B. tabaci ranged from 640 to 682 Mbp. For k-mer analysis, genome …

Local Patterns In Host-Selection By Anemone Symbionts In Bocas Del Toro, Panama, Samantha Mercer

Undergraduate Honors Theses

The associations made between many symbiotic cleaner shrimps and their host anemone species are influenced by local ecological factors, resulting in regional variations in symbiont-host preferences. These relationships are crucial parts of aquatic ecosystems, and as we face rapid global environmental change, understanding the local patterns of this host specificity will be essential to maintaining healthy marine environments. However, sea anemones, as well as their symbiotic relationships, from the Caribbean coasts of Panama have been poorly studied and are largely under-represented in the current literature. The purpose of this study is to identify the local host-selection patterns, specifically regarding host-size …

Restoring Semi-Arid Thornscrub Forests: Seeding Growth And Survival In Response To Shelter Tubes, Grass-Specific Herbicide, And Herbivore Exclosures, Krysten Noelle Dick

Theses and Dissertations - UTB/UTPA

This thesis is a compilation of two studies, which I have called ‘chapters.’ The first chapter, “Restoring Semi-Arid Thornscrub Forests: Seedling Growth and Survival in Response to Shelter Tubes, Grass-Specific Herbicide, and Herbivore Exclosures,” was a large study involving multiple techniques used to improve revegetation success, and the second chapter, “Shelter Tube Effects on Microclimate and Seedling Growth in Semi-arid Thornscrub Forests,” focused on the use of shelter tubes in semi-arid forest revegetation. These studies were concurrent evaluations of restoration efforts in thornscrub forests of South Texas. Revegetation is a common effort used to restore forest ecosystems that have been …

Nsf Grant Helps Preserve Parasite Collections [Press Release], Scott Gardner, Leslie Reed

Scott L. Gardner Publications

The National Science Foundation has awarded a $500,000 grant that will allow four major parasite collections to be digitized. The collections are part of UNL's Harold W. Manter Laboratory of Parasitology. Scott Gardner (pictured) is the curator and director of the Manter Laboratory.

A $500,000 grant from the National Science Foundation will allow the Harold W. Manter Laboratory of Parasitology to digitally preserve four major collections of parasite specimens donated to the University of Nebraska-Lincoln during the past five years.

Investigation Of Oxidopyrylium-Alkene [ 5 +2 ] Cycloaddition Conjugate Addition Cascades And Extension To Chiral Auxiliary-Based Variants, Chunyin Marshall Law

Theses and Dissertations

Oxidopyrylium-based [5+2] cycloadditions have been extensively utilized to construct oxabridged seven-membered ring systems that often serve as the core structures in numerous biologically active natural products. By investigating these processes, we hope to reveal the highest potentials of [5+2] cycloaddition as a synthetic tool.

A novel oxidopyrylium-alkene [5+2] cycloaddition conjugate addition cascade (C3) sequence, which allows rapid build-up of molecular complexity with excellent diastereocontrol, was investigated. The scope and limitation of this process were explored as mixed results were shown for various acetoxypyranone-alkene substrates. In addition, oxidopyrylium [5+2] cycloadditions of ï?¢-silyloxy-ï?§-pyrones were investigated which revealed the accelerating role of carbonyl …

Uab Grad Named Alabama's Teacher Of The Year, Staff

Browse All News

No abstract provided.

Conceiving A National Gamete Donor Registry: Policy Considerations, Privacy Concerns, And Legal Authority, Lauren Nussbaum

Health Law and Policy Brief

No abstract provided.

‘The House That Generosity Built’, Melissa A. Patricio

Featured News Story

Donor-funded sailing center to debut on RWU campus early this summer.

Ada News - 05/18/2015, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Assessment Of Estrogenic Compounds In A Wastewater Treatment Plant Influent And Effluent, Alexandra L. Hunter

Mahurin Honors College Capstone Experience/Thesis Projects

Estrogenic compounds have been found in surface waters downstream from wastewater treatment plant effluents. In the aquatic environment, these hormones are shown to cause feminization and sterility of aquatic organisms, thus altering aquatic ecosystems upon which human health depends. In order to assess estrogenic compounds at a local wastewater treatment facility in Franklin, KY, Environmental Protection Agency Method 539 [Determination of Hormones in Drinking Water by Solid Phase Extraction (SPE) and Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC/ESI-MS/MS)] was modified to measure levels of these contaminants in wastewater influent and effluent. This method requires use of LC/ESI-MS/MS analysis. A …

Marie Olivieri Russell And Sarah Sundborg Long, Sarah Long, Marie Russell, Kelsey Duinkerken

First Women at Jefferson Oral Histories

Marie Olivieri Russell

Dr. Russell attended Jefferson Medical College where she graduated top of her class in 1970. In addition to being the first woman to receive the Alumni Prize for highest cumulative GPA, in 1971 she became the first student to serve as a full voting member of the Board of Trustees at Jefferson. After graduation she completed both a residency in Pediatrics and a fellowship in Pediatric Hematology Oncology at Children’s Hospital of Philadelphia before continuing on as a part of their academic staff until 1981 and managing the Comprehensive Sickle Cell Program. After leaving Children’s and academic …

Custom Fluorophores For Investigating The Cellular Uptake Mechanisms And Side-Effects Of Pharmaceuticals, Yu-Hsuan Chu

Dissertations and Theses

There is a significant current need to elucidate the molecular mechanisms of the side-effects caused by widely-used pharmaceuticals. Examples include the acute nephrotoxicity and irreversible ototoxicity promoted by the cationic drugs gentamicin and cisplatin. Gentamicin is an aminoglycoside antibiotic used for the prevention and treatment of life-threatening gram-negative bacterial infections, such as tuberculosis and meningitis. Cisplatin is used to treat a broad spectrum of cancers including head and neck, ovarian, cervical, stomach, bladder, sarcoma, lymphoma, testicular cancer and others.

The objective of this study is to design and synthesize rhodamine derivatives that can be used for the construction of geometrically …

An Analytical Model Of Leakage Neutron Equivalent Dose For Passively-Scattered Proton Radiotherapy And Validation With Measurements, Christopher Schneider, Wayne Newhauser, Jad Farah

Faculty Publications

Exposure to stray neutrons increases the risk of second cancer development after proton therapy. Previously reported analytical models of this exposure were difficult to configure and had not been investigated below 100 MeV proton energy. The purposes of this study were to test an analytical model of neutron equivalent dose per therapeutic absorbed dose at 75 MeV and to improve the model by reducing the number of configuration parameters and making it continuous in proton energy from 100 to 250 MeV. To develop the analytical model, we used previously published H/D values in water from Monte Carlo simulations of a …

Week Of May 18, 2015, New York Medical College

InTouch

• Dr. Jan K. Richardson Will Address the Class of 2015
• NYMC Celebrates 27th Annual Employee Recognition Program
• View the NYMC Corporate Citizenship Award Video
• NYMC Ranks in Top Ten Med Schools with the Most Applicants

Prevalence Of School Nurses In Kentucky And Student Outcomes, Teena Darnell

Graduate Theses, Dissertations, and Capstones

Objective: The purpose of this study was to identify whether the presence of a nurse in the public high school setting was associated student outcomes. Data gleaned from the study will be used to enact a new legislative policy mandating the presence of a nurse in all public schools in the state of Kentucky.

Background: Nurses employed in the school setting support both the educational mission of the institution, as well as the health and well-being of students. Studies have explored the relationships between school nurse presence and student health. It has been suggested that when children experience poor …

Using Neural Networks For Image Classification, Tim Kang

Master's Projects

This paper will focus on applying neural network machine learning methods to images for the purpose of automatic detection and classification. The main advantage of using neural network methods in this project is its adeptness at fitting non­linear data and its ability to work as an unsupervised algorithm. The algorithms will be run on common, publically available datasets, namely the MNIST and CIFAR­10, so that our results will be easily reproducible.

Insole Antenna For On-Body Telemetry, Domenico Gaetano, Patrick Mcevoy, Max Ammann, Matthias John, Colm Brannigan, Louise Keating, Frances Horgan

Articles

A 433 MHz antenna is proposed for integration with the insole of footwear for a body area network. The folded dipole design with an asymmetric groundplane radiates from its edges and considers the close proximity of the human foot and ground surfaces. It functions for different ground conductivity conditions and an on-body communication link with an Inverted F Antenna in the upper body area was evaluated on a static and dynamic human subject. The antenna solution was compliant with Specific Absorption Rate requirements, remains matched and links with upper-body nodes regardless of the body posture and node location.

Between Arts And Biological Science. Green Technology And The Concept Of Phytomining, M Gapševičius, Diaz J Pablo, L Rukevičiūtė, B Degger, Jf Tredinnick-Rowe

Peninsula Medical School

No abstract provided.

Sensitive Chaos, Dw Strang

School of Art, Design and Architecture

This paper describes the life (and death) of the interface in the installation Tiny Moments by David Strang. Tiny Moments is a sound and light interactive installation that explores natural phenomena surrounding heat, ice and presence/ proximity. This installation explores the process of natural materials in computer interaction in a way beyond simple hardware devices available to users. What is created is a space filled with ever changing rhythms of light and sound in complete synchronicity that no user feels to have any control of.