Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (1327)
- Social Work (558)
- Education (549)
- Medicine and Health Sciences (353)
- Arts and Humanities (313)
-
- Sociology (270)
- Higher Education (247)
- Psychology (201)
- Law (192)
- Public Affairs, Public Policy and Public Administration (133)
- Communication (92)
- Library and Information Science (90)
- Business (83)
- History (79)
- Educational Administration and Supervision (78)
- Mental and Social Health (78)
- Public Health (73)
- Nursing (69)
- Feminist, Gender, and Sexuality Studies (67)
- Religion (67)
- Family, Life Course, and Society (64)
- Higher Education Administration (57)
- Other Social and Behavioral Sciences (56)
- Counseling (53)
- Medical Specialties (50)
- Educational Assessment, Evaluation, and Research (45)
- Social Welfare (44)
- Race, Ethnicity and Post-Colonial Studies (41)
- Curriculum and Instruction (40)
- Quantitative, Qualitative, Comparative, and Historical Methodologies (38)
- Institution
-
- Western Michigan University (117)
- Smith College (107)
- Eastern Michigan University (77)
- Portland State University (74)
- Washington University in St. Louis (74)
-
- Nova Southeastern University (61)
- California State University, San Bernardino (58)
- Utah State University (57)
- Walden University (53)
- City University of New York (CUNY) (50)
- Murray State University (45)
- Virginia Commonwealth University (44)
- Western Kentucky University (44)
- University of Kentucky (41)
- Grand Valley State University (40)
- University of North Dakota (39)
- University of Montana (38)
- University of Nebraska - Lincoln (37)
- University of New Hampshire (36)
- University of Southern Maine (36)
- University of Northern Iowa (35)
- University of South Florida (35)
- East Tennessee State University (34)
- Marshall University (34)
- University of Texas at Arlington (33)
- George Fox University (32)
- University of South Carolina (32)
- Wright State University (32)
- San Jose State University (31)
- James Madison University (29)
- Keyword
-
- Newsletter (58)
- Qualitative research (51)
- Education (41)
- Children (39)
- Social work (37)
-
- Commencement (35)
- LGBTQ (32)
- Newspaper (30)
- 2015 (28)
- Psychology (28)
- Mental health (27)
- Maine (26)
- Community (25)
- Events (24)
- Family Affairs Newsletter (24)
- GLBTI (24)
- Job postings (24)
- Personals (24)
- Poverty (24)
- Social Work (24)
- Social groups (24)
- Support groups (24)
- United States (24)
- Gender (23)
- Higher education (23)
- Student newspaper (23)
- Women (23)
- Counseling (22)
- Race (22)
- Student Newspaper (21)
- Publication
-
- Theses, Dissertations, and Projects (102)
- The Journal of Sociology & Social Welfare (61)
- EMU Today (56)
- Theses and Dissertations (49)
- Center for Social Development Research (46)
-
- Walden Dissertations and Doctoral Studies (45)
- Electronic Theses, Projects, and Dissertations (44)
- Contemporary Rural Social Work Journal (36)
- Electronic Theses and Dissertations (35)
- Dissertations (33)
- Publications and Research (28)
- The Qualitative Report (28)
- Faculty Publications (25)
- Family Affairs newsletter (2004-2016) (24)
- Commencement Programs (23)
- Pediatrics Faculty Publications (19)
- 2015 (17)
- Akron Law Review (17)
- Faculty Scholarship (17)
- Dissertations, Theses, and Capstone Projects (16)
- University Letter Archive (16)
- Loma Linda University Electronic Theses, Dissertations & Projects (15)
- Commencement Programs, Photos, and Video (14)
- Faculty Work Comprehensive List (14)
- Social Work Faculty Publications (14)
- University Announcements - ISU Today (14)
- Admissions Reports (13)
- Articles (13)
- Doctoral Dissertations (13)
- ScholarWorks Reports (13)
- Publication Type
- File Type
Articles 3301 - 3330 of 3440
Full-Text Articles in Entire DC Network
Statement, Winter 2015, Office Of Alumni Relations. Morehead State University
Statement, Winter 2015, Office Of Alumni Relations. Morehead State University
Morehead State Alumni Association Publications
Statement Magazine of Morehead State University from Winter of 2015.
Talk Don’T Touch? Considerations For Children’S Attorneys On The Physical Touch Of Clients, Andrea L. Dennis
Talk Don’T Touch? Considerations For Children’S Attorneys On The Physical Touch Of Clients, Andrea L. Dennis
Scholarly Works
Researchers focused on the representation of children and attorneys for children have taken great pains to explore issues surrounding the attorney-child client relationship and recommend strategies and policies supporting positive development of the relationship. Notwithstanding the breadth of available information, almost no attention has been aimed at whether attorneys should physically touch their clients. This article fills that gap.
This Article consists of three parts. Part I describes the literature commanding attorneys for children to develop quality relationships with their clients. These works recognize that young clients seek good relationships with their attorneys, but that barriers to creating quality relationships …
Counselor Supervisors' Perceptions Of Tertiary Trauma, Eric David Jett
Counselor Supervisors' Perceptions Of Tertiary Trauma, Eric David Jett
Walden Dissertations and Doctoral Studies
Vicarious trauma impacts counselors in various ways: by diminishing their feelings of importance in the profession, hindering their completion of adequate work with clients, and negatively affecting their personal life choices. Although numerous qualitative and quantitative studies have been conducted on vicarious trauma over the past 20 years, there is a rarity of research investigating the implications of trauma for counseling supervisors. The purpose of this study was to examine the lived experiences and perceptions of tertiary trauma among 11 counselor supervisors from Oklahoma and Missouri who were providing active supervision. This study was approached through a hermeneutic phenomenological methodology. …
Sel In Higher Education, Colleen S. Conley
Sel In Higher Education, Colleen S. Conley
Psychology: Faculty Publications and Other Works
No abstract provided.
Vocational Readiness: The Effect Of Pre-Prison And Incarceration-Based Trauma On Cognitive Appraisals And Self-Perceptions Of Incarcerated Women, Joi Dykes Anderson
Vocational Readiness: The Effect Of Pre-Prison And Incarceration-Based Trauma On Cognitive Appraisals And Self-Perceptions Of Incarcerated Women, Joi Dykes Anderson
Theses and Dissertations
The number of women incarcerated in the United States has grown at an alarming rate. This research study presents a conceptual framework for examining pre-prison and incarceration-based trauma and its effects on cognitive appraisals and self-perceptions. Literature from psychology, feminist psychology and neuropsychiatry are integrated to discuss how pre-prison trauma creates pathways to crime for females, how incarceration serves as a form of traumatization (or retraumatization), how the social dynamics of the prison environment potentially exacerbates mental health issues (i.e., PTSD, anxiety, depression), how this negatively affects a female inmates vocational readiness—the ability to obtain and maintain employment once engaged …
What Do We Know About Technical Assistance? Enhancing The Science And Practice Of Technical Assistance Via A Research Synthesis, Jason S. Katz
What Do We Know About Technical Assistance? Enhancing The Science And Practice Of Technical Assistance Via A Research Synthesis, Jason S. Katz
Theses and Dissertations
Introduction. Each year billions of dollars are spent on providing technical assistance (TA) to build the capacity of host settings (e.g., organizations, communities) to implement innovations, but there is little consensus (or even discussion) about: what the essential features of TA are, how to provide TA with quality, and how a quality-based accountability perspective can help us to enhance the science and practice of TA. To begin to address these needs, a research synthesis methodology was used for conducting a content analysis of the current evidence base for TA using three frames: (1) applying a conceptual and operational model (Getting …
Detention Center To Home School: The Path Of Transition, Sarah Hogeveen
Detention Center To Home School: The Path Of Transition, Sarah Hogeveen
Dissertations
This study examined the way a juvenile detention center and local feeder high schools worked in conjunction with each other to educate students that are incarcerated and then transition back to their home school. The goal of this study was to determine the adequacy of the transition/re-entry plan and then develop a template to assist high schools in the transition process. The transition/re-entry process into the home high school can be difficult and often involves several agencies. The evidence has suggested that there is not a solid transition plan available or in place for this process. This evidence allowed for …
An Examination Of Hiv/Aids Complacency, Attitudes And Sexual Risk Behavior Among Men Who Have Sex With Men: Implications For Community Based Prevention Efforts, Practitioners And Social Work Education, Michael Richard Lloyd
An Examination Of Hiv/Aids Complacency, Attitudes And Sexual Risk Behavior Among Men Who Have Sex With Men: Implications For Community Based Prevention Efforts, Practitioners And Social Work Education, Michael Richard Lloyd
Dissertations
The following study examines the role of HIV/AIDS complacency and substance use on sexual risk behavior among men who have sex with men. The study analyzes data collected at a bathhouse over a seven day period beginning on June 9, 2014 and ending on June 15, 2014. The independent variables of HIV/AIDS complacency and substance use, along with the dependent variable of sexual risk behavior are examined through the lens of protection motivation theory. Protection motivation theory posits that response efficacy and threat appraisal influence how a person makes decisions. The implications and findings of the study related to direct …
Factors Impacting Student Outcomes In Multicultural Counseling Courses, Kathleen Kordesh
Factors Impacting Student Outcomes In Multicultural Counseling Courses, Kathleen Kordesh
Dissertations
This study explored how complex factors related to student characteristics (e.g., demographics, levels of racism) and instructor characteristics (e.g., demographics, level of multicultural competence, teaching strategies) are related to student outcomes in multicultural counseling courses (e.g., levels of racism and levels of multicultural competence at the end of the semester). Data collection yielded a sample of 21 students and six instructors. Findings suggest that instructors are a significant factor in how much students develop with regards to gaining multicultural knowledge, but not in how much students develop with regards to gaining multicultural awareness. Multivariate analysis of student responses suggest that …
Dbt And Bereavement: A Multiple Baseline Design, Marissa Marshak
Dbt And Bereavement: A Multiple Baseline Design, Marissa Marshak
Dissertations
This is an interpretive, single-subject design study, which followed a non-concurrent multiple baseline design to understand the processes of bereavement treatment. The study comprised six groups (n=29) enrolled in the General Adult Loss Groups after the loss of a family member. The researcher used mixed methodologies to understand the bereavement process, group work process, and DBT process. The objective was to evaluate whether the timing of implementing DBT, or DBT at all, improved coping outcomes. Two groups served as control groups, and the remaining four groups received a 5-weeklong 45-minute voluntary modified intervention of DBT at staggered intervention start points. …
Easing My Burden: A Grounded Theory Study Of Kidney Transplant Recipients' Experience With Their Transplant Coordinators, Gwen E. Mcnatt
Easing My Burden: A Grounded Theory Study Of Kidney Transplant Recipients' Experience With Their Transplant Coordinators, Gwen E. Mcnatt
Dissertations
Organ transplantation holds the promise of new life or better life for thousands of Americans every year. Transplantation involves a process that stretches over time beginning at referral, moving to transplantation and long term care. The transplant coordinator is considered an integral part of this care. Transplant coordinators are considered so important to the care of these patients that transplant centers are required to have at least one transplant coordinator by federal regulations.
The role of the transplant coordinator, however, is not well defined. Although many of the role dimensions attributed to transplant coordinators are consistent with nursing practice, the …
Censorship And Intolerance In Medieval England, Richard Obenauf
Censorship And Intolerance In Medieval England, Richard Obenauf
Dissertations
Censorship is difficult to prove conclusively in the Middle Ages because manuscript culture is susceptible to the destruction of evidence, namely by burning works deemed unacceptable. Moreover, medieval authors were subject to many forms of intolerance which shaped their literary decisions. This dissertation proposes that the roots of formal print censorship in England are to be found in earlier forms of intolerance which sought to enforce conformity and that censorship is not distinct from intolerance, but rather is another form of intolerance. I draw on political writings by Peter Abelard, John of Salisbury, and William of Ockham to establish a …
The Experiences Of Lesbian, Gay, Bisexual, Transgender And Queer Students In Social Work Programs. A Study Report From The Cswe Council On Sexual Orientation And Gender Identity And Expression, Shelley L. Craig, Lauren B. Mcinroy, Michael P. Dentato, Ashley Austin, Lori Messinger
The Experiences Of Lesbian, Gay, Bisexual, Transgender And Queer Students In Social Work Programs. A Study Report From The Cswe Council On Sexual Orientation And Gender Identity And Expression, Shelley L. Craig, Lauren B. Mcinroy, Michael P. Dentato, Ashley Austin, Lori Messinger
Social Work: School of Social Work Faculty Publications and Other Works
This online North American study of lesbian, gay, bisexual, transgender, and queer (LGBTQ) social work students (n=1,018) in bachelor of social work (BSW; 24%) or master’s of social work (MSW; 76%) programs explored educational experiences in 126 programs in 44 U. S. states and 7 Canadian provinces. Forty-four percent of students reported limited inclusion of LGBTQ content in classes, yet 64% indicated some degree of support for their LGBTQ identities in their programs. One-third reported homophobic experiences in programs, yet many (63%) were aware of “out” LGBTQ faculty. Overall, students reported fairly low levels of self-assessed practice readiness …
Child And Adolescent Psychiatric Emergencies: Mobile Crisis Response, Jonathan B. Singer
Child And Adolescent Psychiatric Emergencies: Mobile Crisis Response, Jonathan B. Singer
Social Work: School of Social Work Faculty Publications and Other Works
This chapter describes the application of Roberts's (2005) seven-stage crisis intervention model (R-SSCIM) and Myer's (2001) triage assessment model to youth experiencing a psychiatric crisis, defined as a suicidal, homicidal, or actively psychotic episode. Although most children have their first contact with mental health services during a crisis (Burns, Hoagwood, & Mrazek, 1999), there is relatively little research on crisis intervention, and almost nothing written on mobile crisis response for children and adolescents (Singer, 2006). This chapter is an effort to bridge that gap by presenting three case studies of youth experiencing suicidal, homicidal, or psychosis-driven crises. This chapter provides …
Professional Development And Beyond: A Participative Study Of A Self-Facilitated Learning Group, Helen Goodall
Professional Development And Beyond: A Participative Study Of A Self-Facilitated Learning Group, Helen Goodall
Plymouth Institute of Education Theses
This is a participative case study of a self-facilitating, collaborative, women’s learning group. The group’s longevity afforded a unique opportunity to investigate, in depth, both what encouraged its members to join at its outset, and what has sustained the participation of its current members for thirteen years. Its longevity also provided an opportunity to explore the impact of sustained membership on the women in the group. These two components of the study are its most significant original contributions to the existing literature which does not appear to cover anything similar. The initial raison d’étre of the group was its members’ …
Law And People With Disabilities, Janet E. Lord, Deepti S. Raja, Peter Blanck
Law And People With Disabilities, Janet E. Lord, Deepti S. Raja, Peter Blanck
All Faculty Scholarship
This article describes the progressive development of disability law, particularly in light of international developments that are transforming domestic disability law frameworks. It provides an overview of the conceptualization of disability in law, charting the shift from a medical model to a social model of disability and more recently to a human rights model. The abstract covers the implications of the Convention on the Rights of Persons with Disabilities (CRPD), and the processes and approaches for translating international disability law standards into national level law. It sheds light on the contemporary disability rights landscape in the light of dramatic legislative …
Poverty, Dignity, And Public Housing, Jaime Alison Lee
Poverty, Dignity, And Public Housing, Jaime Alison Lee
All Faculty Scholarship
Antipoverty efforts are persistently subverted by broad societal contempt for poor people. The belief that poor people are morally and behaviorally inferior, and that their personal failings are the cause of their own poverty, is a staple of American opinion polls and political rhetoric. This presumption is so widespread that it even permeates antipoverty programs, which treat poor people with disdain even as they offer aid and assistance.
Income discrimination creates not just social stigma, but legal inequalities. The Supreme Court recognized some forty years ago that welfare law promoted wealth-based Constitutional inequalities, and responded by invoking the doctrines of …
Clinician Perspectives Of Behavioral Health Service Delivery In Patient-Centered Medical Homes, Melanie L. Cox
Clinician Perspectives Of Behavioral Health Service Delivery In Patient-Centered Medical Homes, Melanie L. Cox
Theses, Dissertations, and Projects
The need to reform health care in the U.S. is evidenced by exorbitant costs that for many patients, fails to produce better outcomes (McCarthy, How, Fryer, Radley, and Schoen, 2011). Provisions within the Patient Protection and Affordable Care Act (PPACA) intend to decrease spending while enhancing the quality of care provided, thus improving patient satisfaction. Notably, the PPACA promotes the patient-centered medical home (PCMH), a model of health care in which a team of practitioners coordinate care for each patient as to ensure that all health needs are addressed (PPACA, 2009a, 2009b). The use of the PCMH model has major …
Narratives Of Thriving : Black Lesbian And Queer Women Negotiating Racism, Sexism, And Heterosexism, Arianne J. Napier
Narratives Of Thriving : Black Lesbian And Queer Women Negotiating Racism, Sexism, And Heterosexism, Arianne J. Napier
Theses, Dissertations, and Projects
This qualitative exploratory study explores the narratives that Black lesbian and queer women age 21 to 35 tell about their lived experience by addressing racism, sexism, and heterosexism and how Black lesbian and queer women live and negotiate in the world. In exploring these narratives, the research focused on the following questions: What are the ways in which Black Lesbian and Queer Women create their own story as they negotiate at the margins of society? How do Black lesbian women create meaning out of their experiences in the face of racism, sexism, and heterosexism? The study found that these 12 …
The Settlement Stage: How Hull House Bridged Leisure, Creativity, And Play, Ann Goodson
The Settlement Stage: How Hull House Bridged Leisure, Creativity, And Play, Ann Goodson
Master's Theses
Of the settlement house movement in the United States at the turn of the century, perhaps the most famous of these houses was Chicago's Hull House. Founded in a slum by Jane Addams, Hull House provided healthcare, education, recreation, and childcare services to recent European immigrants living in extreme poverty . While the impact of Addam's work at Hull House on modern sociology, education, social work, welfare and child labor laws have been well documented, less celebrated are the contributions made by the arts education programs at Hull House to modern creative dramatics.
This thesis examines the presence of arts …
Development Of The Personal And Professional Self-Care Scale, Katherine Elizabeth Dorociak
Development Of The Personal And Professional Self-Care Scale, Katherine Elizabeth Dorociak
Master's Theses
In recent years, there has been an increased emphasis on the importance of self- care for psychologists and other mental health professionals. However, the research on self-care is limited because of the lack of an empirically based, psychometrically sound measure of this construct. Thus, the purpose of this project was to develop a measure of personal and professional self-care. The preliminary phase involved the development of a self-care definition and a two-factor framework that divided self-care into personal and professional activities. Based on this definition and framework, self-care items were generated for expert evaluation. After incorporating the expert feedback, 52 …
Returning Citizens? The Path From Prison To Politics Among The Formerly Incarcerated, Quintin A. Williams
Returning Citizens? The Path From Prison To Politics Among The Formerly Incarcerated, Quintin A. Williams
Master's Theses
This project examines the experiences of a group of formerly incarcerated persons involved in community organizing efforts for felon empowerment. Scholarly works often focus on what is being done on behalf of the formerly incarcerated, this work highlights how men and women with records advocate for themselves. Drawing on 18 months of participant observation and 18 in-depth interviews with a Chicago based group called FORCE (Fighting to Overcome Records and Create Equality) I found that meanings of redemption were essential to advocacy and operated as an imperative. The redemption imperative both constrained and enabled advocacy. It constrained advocacy in its …
Social Policy Shifts And The Relationship Between Snap Workers And Their Clients, Latrese Annette Monden
Social Policy Shifts And The Relationship Between Snap Workers And Their Clients, Latrese Annette Monden
Master's Theses
In an effort to better understand how federal social policy changes shape the ways in which public service workers assist their clients in obtaining food benefits through Supplemental Nutrition Assistance Programs (SNAP), previously known as food stamps, this study uses ethnography and interviews to capture the experiences of workers and their clients. Specifically, it examines how public service workers implement new policies while maintaining their professional identities and responding to the mission of their organization. These goals may be in tension. The key findings are that workers do not resist changes in policy because of the limitations of their job …
Moral Injury In Veterans : A Theoretical Investigation Of The Psychic, Moral And Social Sequelae Of War Trauma, Sarah C. Towers
Moral Injury In Veterans : A Theoretical Investigation Of The Psychic, Moral And Social Sequelae Of War Trauma, Sarah C. Towers
Theses, Dissertations, and Projects
Although the idea that a violation of deeply held moral and ethical values can result in a profound psychic, social and spiritual wounding is an ancient one, the exploration of the phenomenon of moral injury in the field of mental health has only recently gained traction. Moral injury is increasingly being regarded as its own psychological phenomenon, one that shares symptomology with PTSD, but is also distinct, and as yet not sufficiently accounted for in current PTSD criteria. This theoretical thesis charts the evolving clinical construct of moral injury and draws on two bodies of theory, narrative theory and adult …
Catalog 2015-2016, University Of North Florida
Catalog 2015-2016, University Of North Florida
UNF Course Catalogs
No abstract provided.
The Impact Of The Carer Support Needs Assessment Tool (Csnat) In Community Palliative Care Using A Stepped Wedge Cluster Trial, Samar Aoun, Gunn Grande, Denise Howting, Kathleen Deas, Chris Toye, Lakkhina Troeung, Kelli Stajduhar, Gail Ewing
The Impact Of The Carer Support Needs Assessment Tool (Csnat) In Community Palliative Care Using A Stepped Wedge Cluster Trial, Samar Aoun, Gunn Grande, Denise Howting, Kathleen Deas, Chris Toye, Lakkhina Troeung, Kelli Stajduhar, Gail Ewing
Medical Papers and Journal Articles
Family caregiving towards the end-of-life entails considerable emotional, social, financial and physical costs for caregivers. Evidence suggests that good support can improve caregiver psychological outcomes. The primary aim of this study was to investigate the impact of using the carer support needs assessment tool (CSNAT), as an intervention to identify and address support needs in end of life home care, on family caregiver outcomes. A stepped wedge design was used to trial the CSNAT intervention in three bases of Silver Chain Hospice Care in Western Australia, 2012-14. The intervention consisted of at least two visits from nurses (2-3 weeks apart) …
The Role Of Psychology In Integrated Primary Care For Complex Patients: Effects On Mental Health, Utilization Of Medical Services, And Physiological Markers Of Health, Danielle C. Worthington
The Role Of Psychology In Integrated Primary Care For Complex Patients: Effects On Mental Health, Utilization Of Medical Services, And Physiological Markers Of Health, Danielle C. Worthington
Theses and Dissertations
This study served as an initial evaluation of integrated psychology services within a clinic designed to serve uninsured patients with complex medical concerns and high utilization histories at the Medical College of Virginia in Richmond, Virginia. The current study evaluates patient outcomes, and more specifically, it further quantifies and describes the role that psychologists play in the primary care setting and their impact on utilization of medical care and in improved health outcomes. Additionally, the study evaluates psychologists’ success at treating mental and behavioral health conditions within the primary care model. The present study demonstrates that patients with complex medical …
Exploring Dimensions Of Well-Being Among Spouses Of Active-Duty Service Members, Lisa A. Gray
Exploring Dimensions Of Well-Being Among Spouses Of Active-Duty Service Members, Lisa A. Gray
Theses and Dissertations
During an era when the United States has been engaged in the longest waging wars in U.S. history, military families have been exposed to extraordinary amounts of stress and have had to learn to adapt in a culture where repeated deployments, recurrent family separations, and frequent relocations have become the norm. A surge in research in recent years on the families of Service members has brought increased attention to the unique challenges and demands of spouses, raising concerns about how to best meet their needs. Despite the increased attention, few studies have focused on spousal well-being. Acknowledging this lack of …
Measuring Mental Health Provider Stigma: The Development Of A Valid And Reliable Self-Assessment Instrument, Jennifer L.K. Charles
Measuring Mental Health Provider Stigma: The Development Of A Valid And Reliable Self-Assessment Instrument, Jennifer L.K. Charles
Theses and Dissertations
Provider-based stigma is defined as the negative attitudes, beliefs, and behaviors of mental health providers toward clients they serve. Often unintentional and unknowingly conveyed, this phenomenon has been indicated in previous research (e.g. Lauber, Nordt, Braunschweig, & Rössler, 2006; Nordt, Rössler, & Lauber, 2006; Hugo, 2001; Schulze, 2007). Other instruments crafted to measure provider stigma have utilized theory in their development, without incorporating the voice of the client (e.g. Wilkins & Abell, 2010; Kennedy, Abell, & Mennicke 2014). To better address the social injustice posed by provider stigma, the profession requires a valid and reliable measure, guided by theory, which …
Dual Pi3k/Mtor Inhibition With Bez235 Augments The Therapeutic Efficacy Of Doxorubicin In Cancer Without Influencing Cardiac Function, David E. Durrant
Dual Pi3k/Mtor Inhibition With Bez235 Augments The Therapeutic Efficacy Of Doxorubicin In Cancer Without Influencing Cardiac Function, David E. Durrant
Theses and Dissertations
Cancer continues to be a leading cause death in the United States despite improved treatments. Cancerous lesions form after acquiring oncogenic driver mutations or losing tumor suppressor function in normal cells. Traditional therapies have included use of genotoxic substances that take advantage of the increased growth rate and loss of tumor suppressor function to cause cell death. One such drug is the anthracycline antibiotic doxorubicin (DOX). DOX interchelates into DNA and disrupts transcriptional machinery while also poisoning topoisomerase II. This results in single and double stranded DNA breaks, which if severe enough leads to either necrotic or apoptotic cell death. …