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Articles 82441 - 82449 of 82449
Full-Text Articles in Entire DC Network
Uncoupling Protein-2 Attenuates Palmitoleate Protection Against The Cytotoxic Production Of Mitochondrial Reactive Oxygen Species In Ins-1e Insulinoma Cells., Jonathan Barlow, Jensen V Hirschberg, Charles Affourtit
Uncoupling Protein-2 Attenuates Palmitoleate Protection Against The Cytotoxic Production Of Mitochondrial Reactive Oxygen Species In Ins-1e Insulinoma Cells., Jonathan Barlow, Jensen V Hirschberg, Charles Affourtit
School of Biomedical Sciences
High glucose and fatty acid levels impair pancreatic beta cell function. We have recently shown that palmitate-induced loss of INS-1E insulinoma cells is related to increased reactive oxygen species (ROS) production as both toxic effects are prevented by palmitoleate. Here we show that palmitate-induced ROS are mostly mitochondrial: oxidation of MitoSOX, a mitochondria-targeted superoxide probe, is increased by palmitate, whilst oxidation of the equivalent non-targeted probe is unaffected. Moreover, mitochondrial respiratory inhibition with antimycin A stimulates palmitate-induced MitoSOX oxidation. We also show that palmitate does not change the level of mitochondrial uncoupling protein-2 (UCP2) and that UCP2 knockdown does not …
The Expression Of Toll-Like Receptor 4, 7 And Co-Receptors In Neurochemical Sub-Populations Of Rat Trigeminal Ganglion Sensory Neurons, M. P. Helley, W. Abate, S. K. Jackson, J. H. Bennett, S. W.N. Thompson
The Expression Of Toll-Like Receptor 4, 7 And Co-Receptors In Neurochemical Sub-Populations Of Rat Trigeminal Ganglion Sensory Neurons, M. P. Helley, W. Abate, S. K. Jackson, J. H. Bennett, S. W.N. Thompson
School of Biomedical Sciences
No abstract provided.
Third-Generation Cephalosporin Resistance Conferred By A Chromosomally Encoded Blacmy-23 Gene In The Escherichia Coli St131 Reference Strain Ec958., Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Brian M. Forde, Alvin W. Lo, Mitchell Stanton-Cook, Leah W. Roberts, Mathew Upton, Scott A. Beatson, Mark A. Schembri
Third-Generation Cephalosporin Resistance Conferred By A Chromosomally Encoded Blacmy-23 Gene In The Escherichia Coli St131 Reference Strain Ec958., Minh Duy Phan, Kate M. Peters, Sohinee Sarkar, Brian M. Forde, Alvin W. Lo, Mitchell Stanton-Cook, Leah W. Roberts, Mathew Upton, Scott A. Beatson, Mark A. Schembri
School of Biomedical Sciences
OBJECTIVES: Escherichia coli ST131 is a globally disseminated MDR clone originally identified due to its association with the blaCTX-M-15 gene encoding an ESBL. It is thus assumed that blaCTX-M-15 is the major determinant for resistance to β-lactam antibiotics in this clone. The complete sequence of EC958, a reference strain for E. coli ST131, revealed that it contains a chromosomally located blaCMY-23 gene with an upstream ISEcp1 element as well as several additional plasmid-encoded β-lactamase genes. Here, we examined the genetic context of the blaCMY-23 element in EC958 and other E. coli ST131 strains and investigated the contribution of blaCMY-23 to …
Antibiotic-Resistant St38, St131 And St405 Strains Are The Leading Uropathogenic Escherichia Coli Clones In Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani Sm Al, Hanan H. Balkhy, Mathew Upton
Antibiotic-Resistant St38, St131 And St405 Strains Are The Leading Uropathogenic Escherichia Coli Clones In Riyadh, Saudi Arabia., Majed F. Alghoribi, Tarek M. Gibreel, Garry Farnham, Johani Sm Al, Hanan H. Balkhy, Mathew Upton
School of Biomedical Sciences
OBJECTIVES: We investigated the molecular epidemiology of uropathogenic Escherichia coli (UPEC) from a tertiary care hospital in Riyadh, Saudi Arabia, revealing, for the first time, the population structure of UPEC in the region. METHODS: A total of 202 UPEC isolates were recovered from hospital and community patients with urinary tract infection in December 2012 and January 2013. Strains were characterized by MLST, antibiotic susceptibility determination and virulence gene detection. RESULTS: The most common lineages were ST131 (17.3%), ST73 (11.4%), ST38 (7.4%), ST69 (7.4%), ST10 (6.4%), ST127 (5.9%), ST95 (5.4%), ST12 (3.5%), ST998 (3.5%) and ST405 (3%). ST131 and ST405 isolates …
Molecular Characterization Of A Multidrug Resistance Incf Plasmid From The Globally Disseminated Escherichia Coli St131 Clone., Minh Duy Phan, Brian M. Forde, Kate M. Peters, Sohinee Sarkar, Steven Hancock, Mitchell Stanton-Cook, Zakour Nl Ben, Mathew Upton, Scott A. Beatson, Mark A. Schembri
Molecular Characterization Of A Multidrug Resistance Incf Plasmid From The Globally Disseminated Escherichia Coli St131 Clone., Minh Duy Phan, Brian M. Forde, Kate M. Peters, Sohinee Sarkar, Steven Hancock, Mitchell Stanton-Cook, Zakour Nl Ben, Mathew Upton, Scott A. Beatson, Mark A. Schembri
School of Biomedical Sciences
Escherichia coli sequence type 131 (E. coli ST131) is a recently emerged and globally disseminated multidrug resistant clone associated with urinary tract and bloodstream infections. Plasmids represent a major vehicle for the carriage of antibiotic resistance genes in E. coli ST131. In this study, we determined the complete sequence and performed a comprehensive annotation of pEC958, an IncF plasmid from the E. coli ST131 reference strain EC958. Plasmid pEC958 is 135.6 kb in size, harbours two replicons (RepFIA and RepFII) and contains 12 antibiotic resistance genes (including the blaCTX-M-15 gene). We also carried out hyper-saturated transposon mutagenesis and multiplexed transposon …
Aspergillus Nidulans Protein Kinase A Plays An Important Role In Cellulase Production, Assis Lj De, Laure Nicolas Annick Ries, Marcela Savoldi, Reis Tf Dos, Neil Andrew Brown, Gustavo Henrique Goldman
Aspergillus Nidulans Protein Kinase A Plays An Important Role In Cellulase Production, Assis Lj De, Laure Nicolas Annick Ries, Marcela Savoldi, Reis Tf Dos, Neil Andrew Brown, Gustavo Henrique Goldman
School of Biomedical Sciences
No abstract provided.
Traffic Lights Control Using Wireless Ad-Hoc Sensor Networks, Abdulmomen Kadhim, Muayad Sadik Croock Ph.D., Shaimaa Hameed Shaker
Traffic Lights Control Using Wireless Ad-Hoc Sensor Networks, Abdulmomen Kadhim, Muayad Sadik Croock Ph.D., Shaimaa Hameed Shaker
Iraqi Journal of Computers, Communications, Control and Systems Engineering
Wireless sensor networks undergo tremendous applications to be utilized for. In this paper, we propose a wireless ad hoc sensor network architecture that does not depend on a centralized unit to urban city’s vehicular control, by applying different sensors distribution for main and side streets. On this architecture, we define and evaluate through simulation the effectiveness of our work against the traditional fixed-time traffic light model. Traffic lights coordination is addressed in master and local controllers by executing green-wave algorithm at our architecture. Simulation results show that this architecture achieves great reduction in total waiting time on the city been …
Thermal Damping And Retardation In Karst Conduits, A. J. Luhmann, Matthew D. Covington, J. M. Myre, Matija Perne, S. W. Jones, E. C. Alexander Jr., M. O. Saar
Thermal Damping And Retardation In Karst Conduits, A. J. Luhmann, Matthew D. Covington, J. M. Myre, Matija Perne, S. W. Jones, E. C. Alexander Jr., M. O. Saar
Geosciences Faculty Publications and Presentations
Water temperature is a non-conservative tracer in the environment. Variations in recharge temperature are damped and retarded as water moves through an aquifer due to heat exchange between water and rock. However, within karst aquifers, seasonal and short-term fluctuations in recharge temperature are often transmitted over long distances before they are fully damped. Using analytical solutions and numerical simulations, we develop relationships that describe the effect of flow path properties, flow-through time, recharge characteristics, and water and rock physical properties on the damping and retardation of thermal peaks/troughs in karst conduits. Using these relationships, one can estimate the thermal retardation …
Consider A Cylindrical Cave: A Physicist's View Of Cave And Karst Science, Matthew D. Covington, Matija Perne
Consider A Cylindrical Cave: A Physicist's View Of Cave And Karst Science, Matthew D. Covington, Matija Perne
Geosciences Faculty Publications and Presentations
We review the current understanding of the physics of caves and karst. Our review focuses on research that has used simple physically based models to improve understanding of processes that occur in karst. The topics we cover include cave atmosphere dynamics, transport within karst conduits, and models of speleogenesis and related processes. We highlight recent advances in these subjects and attempt to identify promising areas for future work. In our judgment, many of the most intriguing open questions relate to the interactions between these three groups of processes.