Digital Commons Network^™

Constitutive Activity In Orphan G Protein Coupled Receptors, Adam Lee Martin

Doctoral Dissertations

"The goal of this research was to use a distal signaling pathway analysis to evaluate the extent of agonist independent constitutive signaling among orphan class-A G protein coupled receptors (GPCRs). These receptors translate extracellular signals via conformational change into intracellular activation of different G proteins and subsequent second messenger synthesis. These small molecules regulate cellular biochemistry, eventually leading to nuclear signaling that results in changes in gene expression. Some GPCRs are capable of signaling in the absence of an activating ligand, a phenomenon called constitutive activity that is inhibited via an "inverse-agonist". The use of cAMP dependent Luciferase expression is …

Design Studies Of Infrastructural Development For Applications Of Hydrogen Energy Technologies, Yousif M. H. Hamad

Doctoral Dissertations

"Countries around the world are trying to reduce their energy consumption, fossil fuel usage, and greenhouse gas (GHG) emissions. According to the International Energy Outlook 2012 released by the U.S. Energy Information Administration (EIA), the estimated fuel economy and greenhouse gas emissions standards proposed for light-duty vehicles for model years 2017-2025 has an increase of 44% in fuel economy and a reduction of 34% in GHG emissions. The use of alternative fuel vehicles and renewable energy sources are, therefore, inevitable toward achieving this goal. Biogas has untapped potential as an alternative energy source. This immediately available resource would allow countries …

Modeling Supply Chain Interdependent Critical Infrastructure Systems, Varun Ramachandran

Doctoral Dissertations

"While strategies for emergency response to large-scale disasters have been extensively studied, little has been done to map medium- to long-term strategies capable of restoring supply chain infrastructure systems and reconnecting such systems from a local urban area to national supply chain systems. This is, in part, because no comprehensive, data-driven model of supply chain networks exists. Without such models communities cannot re-establish the level of connectivity required for timely restoration of goods and services. This dissertation builds a model of supply chain interdependent critical infrastructure (SCICI) as a complex adaptive systems problem. It defines model elements, data needs/element, the …

Enabling Near-Term Prediction Of Status For Intelligent Transportation Systems: Management Techniques For Data On Mobile Objects, Lasanthi Nilmini Heendaliya

Doctoral Dissertations

"Location Dependent Queries (LDQs) benefit from the rapid advances in communication and Global Positioning System (GPS) technologies to track moving objects' locations, and improve the quality-of-life by providing location relevant services and information to end users. The enormity of the underlying data maintained by LDQ applications - a large quantity of mobile objects and their frequent mobility - is, however, a major obstacle in providing effective and efficient services. Motivated by this obstacle, this thesis sets out in the quest to find improved methods to efficiently index, access, retrieve, and update volatile LDQ related mobile object data and information. …

Synthesis, Characterization And Application Of Acrylic Colloidal Unimolecular Polymer (Cup), Ameya Manohar Natu

Doctoral Dissertations

"Colloidal Unimolecular Polymer (CUP) particles were prepared by the process of water reduction on amphiphilic acrylic copolymers prepared via free radical polymerization technique. The formation of CUP particles was driven by the polymer-polymer interaction being greater than the polymer-solvent interaction and entropically favored by release of the water. It was demonstrated by Dynamic Light Scattering technique that CUP particles based on copolymers below 13,000 MW were unstable and the particles aggregated to a higher particle size. For the polymers with molecular weight (MW) above 13,000, a good correlation between the theoretical and experimental CUP particle size was observed. The rheology …

Printed Circuit Board Power Distribution Network Modeling, Analysis And Design, And, Statistical Crosstalk Analysis For High Speed Digital Links, Ketan Shringarpure

Doctoral Dissertations

"High-speed digital systems are moving to higher data rates and smaller supply voltages as the scale of integration goes smaller. With the smaller bit periods and the smaller operating voltages, the tolerable timing and noise margins are reducing. There are many sources of disturbances contributing to the tolerance margins. These margins have to account for inter symbol interference (ISI), reflections, jitter, noise from power distribution networks (PDN) and crosstalk. An important task during the design phase of the system is to find and mitigate the noise from such sources. This thesis proposes modeling and analysis methodology to resolve some of …

Models Predicting The Performance Of Ic Component Or Pcb Channel During Electromagnetic Interference, Chunchun Sui

Doctoral Dissertations

"This dissertation is composed of three papers, which cover the prediction of the characteristics of jitter due to crosstalk and due to simultaneous switching noise, and covers susceptibility of delay locked loop (DLL) to electromagnetic interference.

In the first paper, an improved tail-fit de-convolution method is proposed for characterizing the impact of deterministic jitter in the presence of random jitter. A Wiener filter de-convolution method is also presented for extracting the characteristics of crosstalk induced jitter from measurements of total jitter made when the crosstalk sources were and were not present. The proposed techniques are shown to work well both …

Advancements In Uncertainty Quantification With Stochastic Expansions Applied To Supersonic And Hypersonic Flows, Thomas Kelsey West Iv

Doctoral Dissertations

"The primary objective of this study was to develop improved methodologies for efficient and accurate uncertainty quantification with stochastic expansions and apply them to problems in supersonic and hypersonic flows. Methods introduced included approaches for efficient dimension reduction, sensitivity analysis, and sparse approximations. These methods and procedures were demonstrated on multiple stochastic models of hypersonic, planetary entry flows, which included high-fidelity, computational fluid dynamics models of radiative heating on the surface of hypersonic inflatable aerodynamic decelerators during Mars and Titan entry. For these stochastic problems, construction of an accurate surrogate model was achieved with as few as 10% of the …

Computational Intelligence Based Complex Adaptive System-Of-Systems Architecture Evolution Strategy, Siddharth Agarwal

Doctoral Dissertations

The dynamic planning for a system-of-systems (SoS) is a challenging endeavor. Large scale organizations and operations constantly face challenges to incorporate new systems and upgrade existing systems over a period of time under threats, constrained budget and uncertainty. It is therefore necessary for the program managers to be able to look at the future scenarios and critically assess the impact of technology and stakeholder changes. Managers and engineers are always looking for options that signify affordable acquisition selections and lessen the cycle time for early acquisition and new technology addition. This research helps in analyzing sequential decisions in an evolving …

Investigating New Accident Causation, Risk Assessment, And Mitigation Strategy Selection Tools In The Petroleum Industry, Mohammad A. Alkazimi

Doctoral Dissertations

"The inherent complexity of the processes and the volatile nature of petroleum products compel the petroleum industry to continually seek and develop tools and techniques to identify, evaluate, and mitigate potential risks that can negatively impact their process operations. Additionally, government agencies and nonprofit professional societies guide the petroleum industry with regulatory guidelines, standards, and recommended best practices. The industry and these agencies and societies work to improve operational management, to ensure safe working conditions, and to minimize risk of all kinds, so that if failures occur, damage is contained within tolerable limits (Health and Safety Executives, 2013).

The currently …

Computing And The Electrical Transport Properties Of Coupled Quantum Networks, Casey Andrew Cain

Doctoral Dissertations

In this dissertation a number of investigations were conducted on ballistic quantum networks in the mesoscopic range. In this regime, the wave nature of electron transport under the influence of transverse magnetic fields leads to interesting applications for digital logic and computing circuits. The work specifically looks at characterizing a few main areas that would be of interest to experimentalists who are working in nanostructure devices, and is organized as a series of papers. The first paper analyzes scaling relations and normal mode charge distributions for such circuits in both isolated and open (terminals attached) form. The second paper compares …

Nmr T₁ Studies Of Colloidal Unimolecular Polymer (Cup) Surface Water, Yousef Abobaker Dawib

Doctoral Dissertations

"This dissertation is subdivided into three topics: Experimental study of colloidal unimolecular polymer (CUP) hydration; probing of polymer chain dynamics by ¹³C solid state NMR technique; and the anticorrosive effect of 5-mercapto-1, 3, 4-thiadiazole-2(3H)-thione (MTT) derivatives.

The states of water in colloidal unimolecular polymer system were investigated by low field proton NMR. Bound and free water fractions were determined using spin-lattice relaxation measurements. A model equation was used to analyze the inversion recovery data.

The proton cross polarization and the pulse sequence for total spinning sideband suppression CP-TOSS NMR method were developed to determine the chain mobility of polymers …

Reliability-Based Optimization Design Of Geosynthetic Reinforced Embankment Slopes, Michelle (Mingyan) Deng

Doctoral Dissertations

"This study examines the optimization design of geosynthetic reinforced embankment slopes (GRES) considering both economic benefits and technical safety requirements. In engineering design, cost is always a big concern. To minimize the cost, engineers tend to seek an optimal combination of design parameters among the considered alternatives while ensuring the optimal solution is safe. Reliability-based optimization (RBO) is such a technique that provides engineers the optimal design with the minimum cost while all technical design requirements are satisfied. The research goal of this study is to implement a mathematical formulation algorithm of the RBO technique in GRES design. To achieve …

Shape Based Classification And Functional Forecast Of Traffic Flow Profiles, Wasim Kayani

Doctoral Dissertations

This dissertation proposes a methodology for traffic flow pattern analysis, its validation, and forecasting. The shape of the daily traffic flows are directly related to the commuter’s traffic behavior which merit analysis based on their shape characteristics. As a departure from the traditional approaches, this research proposed a methodology based on shape for traffic flow analysis. Specifically, Granulometric Size Distributions (GSDs) were used to achieve classification of daily traffic flow patterns. A mathematical morphology method was used that allows the clustering of shapes. The proposed methodology leads to discovery of interesting daily traffic phenomena such as five normal daily traffic …

Performance Analysis And Modelling Of Hybrid Photovoltaic-Thermal Solar Panels, Nicole C. Annis

Doctoral Dissertations

A photovoltaic-thermal (PVT) panel was constructed, tested, and modelled using both MATLAB and TRNSYS. During the experimental testing, which took place on the Missouri University of Science and Technology campus in Rolla, Missouri; two identical PVT panels were tested alongside two PV panels to gather an electrical baseline for comparison. Approximately 69 days’ worth of data were of data were collected during the summer of 2014. The PV electrical, PVT electrical, PVT thermal and PVT combined (electrical and thermal) efficiencies were 3.5-5.6%, 3.4-5.4%, 20.9-11.6%, and 24.3-17.0%, respectively.

A MATLAB program was developed using existing equations for one-dimensional, quasi-steady model of …

Accuracy Of Theory For Calculating Electron Impact Ionization Of Molecules, Hari Chaluvadi

Doctoral Dissertations

The study of electron impact single ionization of atoms and molecules has provided valuable information about fundamental collisions. The most detailed information is obtained from triple differential cross sections (TDCS) in which the energy and momentum of all three final state particles are determined. These cross sections are much more difficult for theory since the detailed kinematics of the experiment become important. There are many theoretical approximations for ionization of molecules. One of the successful methods is the molecular 3-body distorted wave (M3DW) approximation. One of the strengths of the DW approximation is that it can be applied for any …

Modelling Of Interconnects In 3dic Based On Layered Green Functions, Siming Pan

Doctoral Dissertations

As traditional CMOS scaling pace gradually slows down, three-dimensional (3D) integration offers another dimension of in the ”More-than-Moore” era. In this dissertation, a number of investigations were conducted to better model interconnects in 3D integrated circuit (IC), to evaluate electrical behavior including delay, power consumption, signal integrity (SI), and power integrity (PI) for 3D ICs. Partial Element Equivalent Circuit (PEEC) method with layered Green’s function is studied here, since it consumes less computational resources and provides better physical insight to model the interconnects in 3DIC for high-speed digital circuits. The work is organized as a series of papers. The first …

Describing Local Community Acceptance With Discrete Choice Theory For Enhanced Community Engagement, Sisi Que

Doctoral Dissertations

This research sought to facilitate improved community (stakeholder) analysis by providing further insight on the determinants of local community acceptance using discrete choice theory. Specifically, the goals were to: (1) Identify, classify, and verify the important project characteristics and key demographic factors which affect local community acceptance of a mining project; (2) Account for the large number of relevant factors inherent in discrete choice experiments for mining community acceptance evaluation; and (3) Examine discrete choice models to select the most appropriate model for mining community consultation. The research will test the hypotheses that various discrete choice models can describe the …

Small Signal Modeling And Analysis Of Microgrid Systems, Md. Rasheduzzaman

Doctoral Dissertations

This dissertation focuses on small-signal modeling and analysis of inverter based microgrid systems. The proposed microgrid consists of two microsources placed on two different buses. The buses are connected using a distribution feeder with some impedance. The proposed microgrid can operate with the grid support, or without the grid support. When operated without the grid support, the standalone system’s microsources participate in controlling the system voltage and frequency. For a non-inertia source, such as the inverter, the load perturbations play an important role in system dynamics. In paper-I, such complex system was studied.

In the grid-tied mode, the microsources share …

Investigation Of Robust Optimization And Evidence Theory With Stochastic Expansions For Aerospace Applications Under Mixed Uncertainty, Harsheel R. Shah

Doctoral Dissertations

One of the primary objectives of this research is to develop a method to model and propagate mixed (aleatory and epistemic) uncertainty in aerospace simulations using DSTE. In order to avoid excessive computational cost associated with large scale applications and the evaluation of Dempster Shafer structures, stochastic expansions are implemented for efficient UQ. The mixed UQ with DSTE approach was demonstrated on an analytical example and high fidelity computational fluid dynamics (CFD) study of transonic flow over a RAE 2822 airfoil.

Another objective is to devise a DSTE based performance assessment framework through the use of quantification of margins and …

Seismological Investigation Of The Okavango Rift, Botswana, Youqiang Yu

Doctoral Dissertations

The mechanisms of rifting have been intensively investigated using geological and geophysical techniques beneath mature rift zones. However, current understanding on the earliest stages of rifting is seriously limited. Here we employ recently archived data from 17 broadband seismic stations traversing northern Botswana to conduct the first shear wave splitting and mantle transition zone (MTZ) studies within the Okavango Rift Zone (ORZ). The ORZ is an incipient continental rift situated at the terminal of the southwestern branch of the East African Rift System. The resulting normal MTZ thickness and consistently rift-parallel fast polarizations imply an absence of significant thermal anomalies …

Pulsed Inductive Plasma Studies By Spectroscopy And Internal Probe Methods, Warner C. Meeks

Doctoral Dissertations

The broad effort of the Missouri Plasmoid Experiment is to elucidate the energy conversion processes in a pulsed inductive discharge due to the presence of plasma. The test article is a 440 to 490 kHz theta-pinch (or solenoidal) geometry coil with a stored energy of around 80 joules. In this work experimental hydrogen, helium, argon and xenon data at back-fill pressures of 10 to 100 mTorr (1.3 to 133.3 Pa) are obtained and interpreted. Spectral and internal probe studies were performed on MPX Mk.I and Mk.II devices, respectively. IR spectra were acquired in the Mk.I device for argon and xenon. …

Unmanned Aircraft Systems Image Collection And Computer Vision Image Processing For Surveying And Mapping That Meets Professional Needs, James Preston Peterson Ii

Doctoral Dissertations

"Unmanned Aerial Systems (UAS) are rapidly blurring the lines between traditional and close range photogrammetry, and between surveying and photogrammetry. UAS are providing an economic platform for performing aerial surveying on small projects. The focus of this research was to describe traditional photogrammetric imagery and Light Detection and Ranging (LiDAR) geospatial products, describe close range photogrammetry (CRP), introduce UAS and computer vision (CV), and investigate whether industry mapping standards for accuracy can be met using UAS collection and CV processing. A 120-acre site was selected and 97 aerial targets were surveyed for evaluation purposes. Four UAS flights of varying heights …

Numerical And Field Data Analysis Of Drill Stem Vibration, Mohammed Fayez Al Dushaishi

Doctoral Dissertations

"Drill stem vibration is a major cause of premature failure of drill stem components and drilling inefficiency. In severe cases, drill stem vibration may lead to wellbore instability that could lead to increased operational cost. Drill stem vibrations are affected by design decisions and the drilling environment. Examples are; bottom hole assembly configurations, selection of operational parameters, and frequent changes in lithology. Vibration modeling, analysis of vibration data, and specialized vibration reduction tools are methods in use to prevent and mitigate severe vibrations.

A drill stem vibration model was created using nonlinear strain formulation which couples the axial, lateral and …

Process Design, Dynamics, And Techno-Economic Analysis Of A Sustainable Coal, Wind, And Small Modular Nuclear Reactor Hybrid Energy System, Kyle Lee Buchheit

Doctoral Dissertations

"The availability of cheap electricity is one of the biggest factors for improving quality of life. With the debate on the effects of carbon dioxide emissions continuing, several countries have either implemented or are considering the reduction of emissions through various economic means. The inclusion of a monetary penalty on carbon emissions would increase the prices of electricity produced by carbon-based sources. The push for large-scale renewable sources of energy has met problems with regards to energy storage and availability. The proposed coal, wind, and nuclear hybrid energy system would combine a renewable energy source, wind, with traditional and stable …

Analysis Of Production And Pressure Data To Characterize The Performance Of Oil And Gas Reservoirs, Abuagila Ramadan Elgmati

Doctoral Dissertations

"Production data analysis is an important tool for estimating important reservoir parameters. In particular, determining the average reservoir pressure (p_av) and tracking its change with time is critical to analyzing and optimizing reservoir performance. The traditional method for determining p_av involves pressure buildup tests. A direct method for estimating (p_av) from flowing pressures and rate data is available. However, the method is for an idealized case that assumes constant production rate during pseudo steady-state (PSS) flow, which is not generally true for real wells. This research extends that approach so that it can …

Privacy-Preserving Query Processing Over Encrypted Data In Cloud, Yousef M. Elmehdwi

Doctoral Dissertations

"The query processing of relational data has been studied extensively throughout the past decade. A number of theoretical and practical solutions to query processing have been proposed under various scenarios. With the recent popularity of cloud computing, data owners now have the opportunity to outsource not only their data but also data processing functionalities to the cloud. Because of data security and personal privacy concerns, sensitive data (e.g., medical records) should be encrypted before being outsourced to a cloud, and the cloud should perform query processing tasks on the encrypted data only. These tasks are termed as Privacy-Preserving Query Processing …

Synthesis And Characterization Of Vanadium Oxide Nanomaterials, Tyler M. Fears

Doctoral Dissertations

"This dissertation focuses on the synthesis and characterization of vanadium oxide nanomaterials and neutron-transparent Li-ion battery electrolytes.

Vanadium oxide gels were synthesized via the epoxide-assisted gelation of VOCl₃ using epichlorohydrin in ethanol. This represents the first epoxide-assisted gelation developed for vanadium oxide gels and serves as a potential economical replacement for the fabrication of vanadium oxide gels via the hydrolysis of vanadium alkoxides. Though epoxide-assisted gelation has been demonstrated for a number of transition metal oxides, the gelation mechanism observed here for VOCl₃ appears to be unique.

While investigating the electrochemical and structural properties of lithium vanadates, it …

Quantification Of Information Flow In Cyber Physical Systems, Li Feng

Doctoral Dissertations

"In Cyber Physical Systems (CPSs), traditional security mechanisms such as cryptography and access control are not enough to ensure the security of the system since complex interactions between the cyber portion and physical portion happen frequently. In particular, the physical infrastructure is inherently observable; aggregated physical observations can lead to unintended cyber information leakage. Information flow analysis, which aims to control the way information flows among different entities, is better suited for CPSs than the access control security mechanism. However, quantifying information leakage in CPSs can be challenging due to the flow of implicit information between the cyber portion, the …

Methods And Algorithms For Service Selection And Recommendation (Preference And Aggregation Based), Kenneth Kofi Fletcher

Doctoral Dissertations

"In order for service users to get the best service that meets their requirements, they prefer to personalize their non-functional attributes, such as reliability and price. However, the personalization makes it challenging because service providers have to deal with conflicting non-functional attributes when selecting services for users. In addition, users may sometimes want to explicitly specify their trade-offs among non-functional attributes to make their preferences known to service providers. Typically, users' service search requests with conflicting non-functional attributes may result in a ranked list of services that partially meet their needs. When this happens, it is natural for users to …