Digital Commons Network^™

The Onchocerciasis Vaccine For Africa-Tova-Initiative., Peter J Hotez, Maria Elena Bottazzi, Bin Zhan, Benjamin L Makepeace, Thomas R Klei, David Abraham, David W Taylor, Sara Lustigman

Department of Microbiology and Immunology Faculty Papers

No abstract provided.

A Biomechanical Analysis Of One-Third Tubular Plates For The Treatment Of Benign Lesions In The Distal Femur, Justin Brantley

Biomedical Engineering ETDs

The purpose of this study was to evaluate the use of one-third tubular plates for the treatment of benign defects in the medial distal metaphysis of the femur. Benign cysts are a common occurrence in long bones, and are of concern in load-bearing bones, such as the tibia and femur. These space-occupying growths are removed by curettage of the affected region. Numerous post-curettage management options have been described in the literature, which generally include filling the defect with either synthetic or biological materials. Unfortunately, complications, such as infectious disease transmission, thermal injury, and a robust inflammatory have all been reported …

Structural Influences On The Photochemistry And Photophysical Properties Of P-Phenylene Ethynylenes: Aggregation Effects And Solvent Interactions, Eric Harris Hill

Nanoscience and Microsystems ETDs

Compounds based on the p-phenylene ethynylene backbone with pendant charged groups, known as conjugated polyelectrolytes, have been of particular interest in recent years due to their solubility in water, sensing properties, and biocidal activity against bacteria, viruses, and fungi. A series of oligomers based on these polymers were synthesized (OPEs), and several interesting questions about their photophysical and biocidal properties were raised by earlier experimental observations, which are addressed by this dissertation. The study initially focuses on the influence of the backbone length and presence of carboxyester substituents on the photophysical properties of the OPEs. Next, the photochemistry of the …

Il-1Α Signaling Is Critical For Leukocyte Recruitment After Pulmonary Aspergillus Fumigatus Challenge, Alayna K. Caffrey, Margaret M. Lehmann, Julianne M. Zickovich, Vanessa Espinosa, Kelly M. Shepardson, Christopher P. Watschke, Kimberly M. Hilmer, Arsa Thammahong, Bridget M. Barker, Amariliz Rivera, Robert A. Cramer, Joshua J. Obar

Dartmouth Scholarship

Aspergillus fumigatus is a mold that causes severe pulmonary infections. Our knowledge of how A. fumigatus growth is controlled in the respiratory tract is developing, but still limited. Alveolar macrophages, lung resident macrophages, and airway epithelial cells constitute the first lines of defense against inhaled A. fumigatus conidia. Subsequently, neutrophils and inflammatory CCR2+ monocytes are recruited to the respiratory tract to prevent fungal growth. However, the mechanism of neutrophil and macrophage recruitment to the respiratory tract after A. fumigatus exposure remains an area of ongoing investigation. Here we show that A. fumigatus pulmonary challenge induces expression of the inflammasome-dependent cytokines …

The Changing World In Microcosm: The Dying Languages Of Liberia, Sierra Leone, And Guinea, George Tucker Childs

Applied Linguistics Faculty Publications and Presentations

Observers have become increasingly aware of how the world is changing due to the forces of globalization, be it in the form of neo-colonialism, the scramble for natural resources, or the various extractive industries. The recent alarm over Ebola illustrated another pernicious fallout of increased communication and travel. The effect of globalization has also been great on indigenous peoples and their cultures, in particular on what many consider to be an integral component of culture, the local languages.

I report on recent research devoted to the documentation of endangered languages in Sierra Leone, Guinea, and Liberia (the Ebola countries). Most …

Measles Outbreak Was Inevitable But Can Be Halted, Uab Doctor Says, Jim Bakken

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No abstract provided.

Mri Is The Most Effective Initial Diagnostic Study For Osteomyelitis Of The Foot In Diabetic Patients, Anthony M. Provenzano B.A.

Clinical Research in Practice: The Journal of Team Hippocrates

What is the best initial diagnostic study that should be used for a suspected osteomyelitis diagnosis? A critical review and clinical application of: Kapoor A, Page S, LaValley M, Gale DR, Felson DT. Magnetic resonance imaging for diagnosing foot osteomyelitis: a meta-analysis. Arch Intern Med. 2007;167(2):125-132. doi:10.1001/archinte.167.2.125.

Towards Sustainability In The Oil And Gas Sector: Benchmarking Of Environmental, Health, And Safety Efforts, Jennifer Schneider, Salim Ghettas, Nacer Merdaci, Mervin Brown, Joseph Martyniuk, Waleed Alshehri, Anthony Trojan

Journal of Environmental Sustainability

The environmental, social and climate change issues that face the world today have all industries considering how they will address sustainability in the future. The purpose of this paper is to evaluate the maturity of environmental, health and safety (EHS) efforts and progress toward sustainability in the oil and gas sector. Ten major oil companies have been analyzed based on public information including their published annual reports. Companies refer to voluntary initiatives when reporting their performance yet the assessment suggests that the sector overall continues to make progress and is maturing in its sustainability efforts. Many management system gaps were …

The Statesman, V. 58, I. 16, Stony Brook University

Stony Brook Statesman-Sucolian

v. 58, i. 16

Noise-Induced Switching And Extinction In Systems With Delay, Ira Schwartz, Lora Billings, Thomas Carr, M. Dykman

Department of Mathematics Faculty Scholarship and Creative Works

We consider the rates of noise-induced switching between the stable states of dissipative dynamical systems with delay and also the rates of noise-induced extinction, where such systems model population dynamics. We study a class of systems where the evolution depends on the dynamical variables at a preceding time with a fixed time delay, which we call hard delay. For weak noise, the rates of interattractor switching and extinction are exponentially small. Finding these rates to logarithmic accuracy is reduced to variational problems. The solutions of the variational problems give the most probable paths followed in switching or extinction. We show …

Validating Estimates Of Prevalence Of Non-Communicable Diseases Based On Household Surveys: The Symptomatic Diagnosis Study, Spencer L. James, Minerva Romero, Dolores Ramírez-Villalobos, Sara Gómez

Dartmouth Scholarship

Easy-to-collect epidemiological information is critical for the more accurate estimation of the prevalence and burden of different non-communicable diseases around the world. Current measurement is restricted by limitations in existing measurement systems in the developing world and the lack of biometry tests for non-communicable diseases. Diagnosis based on self-reported signs and symptoms (“Symptomatic Diagnosis,” or SD) analyzed with computer-based algorithms may be a promising method for collecting timely and reliable information on non-communicable disease prevalence. The objective of this study was to develop and assess the performance of a symptom-based questionnaire to estimate prevalence of non-communicable diseases in low-resource areas.

Medical School Watercooler Newsletter - January 25, 2015, Lindsey Lyle

Watercooler Newsletter

This is the January 25, 2015 edition of the Frederick P. Whiddon College of Medicine's Newsletter - Watercooler.

Contents Include:

Going the Distance: Running for a Purpose

USA Center for Healthy Communities Hosts Faculty Forum

USA Medical Student Co-Authors Research Article Published in the Lancet

Mobile Medical Museum 2015 Lecture Series Starts Feb. 5

Galapagos Seabirds' Lice Community: Host Hetero-Specific Interactions And Parasite Evolution, Jose Luis Rivera

Dissertations

My dissertation focused on understanding the factors behind host-parasite specificity and parasite diversification, using Galapagos seabirds and their ectoparasites as the study system. This system comprised the seabird hosts (magnificent and great frigatebirds, Nazca, blue-footed and red-footed boobies) and nine species of ectoparasitic lice (one Pectinopygus ischnoceran louse species infecting each host, two species of Colpocephalum amblyceran lice, one on each frigatebird species, and two shared amblyceran lice, Eidmanniella albescens found on Nazca and blue-footed boobies and Fregatiella aurifasciata found on the two frigatebirds). Using as focal species Eidmanniella albescens and Fregatiella aurifasciata, which infect multiple hosts, I analyzed how …

A Comparison Of Sexual Health And Sexual Pressure Among Young African American And Caucasian Women, Ann Gakumo

Journal of Health Disparities Research and Practice

Introduction. Condom self-efficacy, positive attitudes toward condom use, condom negotiation skills, HIV knowledge, and self-esteem have been associated with decreased HIV risk behavior among young women, but few studies have examined racial disparities that may exist in these social health indicators. Moreover, sexual pressure (inclusive of both coercive and non-coercive pressures to engage in unwanted or unprotected sex) has been understudied in women of different racial groups.

Study Purpose. The purpose of this study was to compare racial similarities and disparities in indicators of sexual health and sexual pressure in an urban sample of young African American and Caucasian women …

Project Thanks: A Socio-Ecological Framework For An Intervention Involving Hiv Positive African American Women With Comorbidities, Meena Mahadevan, Ndidiamaka Amutah, Lauren Juliette Ramos, Emily Rose Raines, Jerome King, Jodyann Mcintosh, Constance Leverett

Journal of Health Disparities Research and Practice

HIV-positive individuals are living longer today as a result of continuing advances in treatment but are also facing an increased risk for chronic diseases such as diabetes, and hypertension. These conditions result in a larger burden of hospitalization, outpatient, and emergency room visits. Impoverished African American women may represent an especially high-risk group due to disparities in health care, racial discrimination, and limited resources. This article describes an intervention that is based on the conceptual framework of the socio-ecological model. Project THANKS uses a community-based participatory, and empowerment building approach to target the unique personal, social, and environmental needs of …

Sexual Decision Making In The Absence Of Choice: The African American Female Dating Experience., Michele Peake Andrasik, Hong V. Nguyen, William H. George, Kelly F. Kajumulo

Journal of Health Disparities Research and Practice

Although links between low mate availability and increased HIV and STI risk for African American women have been documented in the literature, we know little about the impact of limited mate choices on the quality of relationships between Black men and women and how these relationship dynamics impact risk for young Black women. We conducted a qualitative study with African American female young adults (N=12) to explore the perceived impact of structural forces on African American female young adults’ dating and sexual behavior. Participants reported (1) perceptions of Black men as untrustworthy and manipulative, (2) the limited and often negative …

Do Masculinity And Perceived Condom Barriers Predict Heterosexual Hiv Risk Behaviors Among Black Substance Abusing Men?, A, Kathleen Burlew, Jerika Wilson, Latrice Montgomery, Bridgette Peteet, Candace Johnson, Mary Hatch-Maillette

Journal of Health Disparities Research and Practice

Although HIV prevention during substance abuse treatment is ideal, existing HIV risk-reduction interventions are less effective among Black and other ethnic minority substance abusers. The Sexual Health Model (SHM) and the Person, Extended Family and Neighborhood-3 model (PEN-3) both highlight the importance of increasing our understanding of the relationship of sociocultural factors to sexual-decision making as a step towards developing more HIV prevention interventions for ethnic minorities. However, few studies examine sociocultural factors in the sexual decision-making process of Black substance abusing men. This secondary analysis of data collected in an evaluation of Real Men Are Safe (REMAS), a HIV …

Harbor Notes, January 23, 2015, Jessica Blais

Harbor Notes

The January 23, 2015, issue of Harbor Notes.

The Leishmania Years At Unl (Or, My Life As A Cell Biologist, 1966-1981), John J. Janovy Jr.

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Slides for a talk during which Professor Janovy discussed the methods he used in researching Leishmania during the years 1966-1981. Includes lists of references.

Ethics In The Field: Contemporary Challenges, Lisa C. Depaoli

Journal of Ecological Anthropology

No abstract provided.

Rift Valley Fever Virus Infection In Golden Syrian Hamsters, Dionna Scharton, Arnaud J. Van Wettere, Kevin W. Bailey, Zachary Vest, Jonna B. Westover, Venkatraman Siddharthan, Brian B. Gowen

Animal, Dairy, and Veterinary Science Faculty Publications

Rift Valley fever virus (RVFV) is a formidable pathogen that causes severe disease and abortion in a variety of livestock species and a range of disease in humans that includes hemorrhagic fever, fulminant hepatitis, encephalitis and blindness. The natural transmission cycle involves mosquito vectors, but exposure can also occur through contact with infected fluids and tissues. The lack of approved antiviral therapies and vaccines for human use underlies the importance of small animal models for proof-of-concept efficacy studies. Several mouse and rat models of RVFV infection have been well characterized and provide useful systems for the study of certain aspects …

Prevention, Not Prejudice: The Role Of Federal Guidelines In Hiv-Criminalization Reform, Sarah J. Newman

Northwestern University Law Review

Thirty-four states and two U.S. territories have criminal statutes that specifically impose criminal liability for HIV transmission, exposure, or nondisclosure. With possible sentences ranging up to thirty years, these statutes have even provided the basis for convicting HIV positive individuals who never actually transmitted the virus. To address the unreasonable prosecutions of these individuals, Representative Barbara Lee of California introduced the Repeal Existing Policies that Encourage and Allow Legal HIV Discrimination Act (REPEAL Act) to the U.S. House of Representatives on September 23, 2011. If passed, the REPEAL Act would require a systematic review of these statutes and the development …

Regulating Cyber-Security, Nathan Alexander Sales

Northwestern University Law Review

The conventional wisdom is that this country’s privately owned critical infrastructure—banks, telecommunications networks, the power grid, and so on—is vulnerable to catastrophic cyber-attacks. The existing academic literature does not adequately grapple with this problem, however, because it conceives of cyber-security in unduly narrow terms: most scholars understand cyber-attacks as a problem of either the criminal law or the law of armed conflict. Cyber-security scholarship need not run in such established channels. This Article argues that, rather than thinking of private companies merely as potential victims of cyber-crimes or as possible targets in cyber-conflicts, we should think of them in administrative …

Elephant (Elephas Maximus) Health And Management In Asia: Variations In Veterinary Perspectives, David Miller, Bradford Jackson, Heidi S. Riddle, Christopher Stremme, Dennis Schmitt, Thaddeus Miller

College of Agriculture

There is a need to identify strategic investments in Asian elephant (Elephas maximus) health that will yield maximal benefits for overall elephant health and conservation. As an exploratory first step, a survey was administered to veterinarians from Asian elephant range countries at a workshop and via email to help prioritize health-related concerns that will mostly benefit elephants. Responses were received from 45 veterinarians from eight countries that had a range of experience with captive and wild elephants. The occurrence of medical conditions and responses to treatment varied among responses. However, injuries, parasitism, and gastrointestinal disease were reported as the most …

Fourteen Uab Honors Students To Showcase Community Projects At Clinton Global Initiative University Summit, Staff

Browse All News

No abstract provided.

2015-January-16-Dr. Mckenzie To Bring Expertise To Jcchc, University Marketing And Communications, East Tennessee State University

ETSU News

No abstract provided.

Uab Students To Showcase High-Impact Community Projects At Clinton Global Initiative University Summit, Staff

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No abstract provided.

Cluster Of Human Infections With Avian Influenza A (H7n9) Cases: A Temporal And Spatial Analysis, Yi Zhang, Zhixiong Shen, Chunna Ma, Chengsheng Jiang, Cindy Feng, Nivedita Shankar, Peng Yang, Wenjie Sun, Quanyi Wang

Marine Science

Objectives: This study aims to describe the spatial and temporal characteristics of human infections with H7N9 virus in China using data from February 2013 to March 2014 from the websites of every province’s Population and Family Planning Commission. Methods: A human infection with H7N9 virus dataset was summarized by county to analyze its spatial clustering, and by date of illness onset to analyze its space-time clustering using the ESRI® Geographic Information System (GIS) software ArcMap™ 10.1 and SatScan. Results: Based on active surveillance data, the distribution map of H7N9 cases shows that compared to the rest of China, the areas …

A Case Of Cutaneous Larva Migrans Presenting In A Pregnant Patient., Kasie Kudrewicz, Kylee N Crittenden, Alison Himes

Women’s Health Articles

Cutaneous larva migrans (CLM) is a pruritic dermatitis caused by migration of animal hookworm larvae into the skin. We present a case of CLM in a 31-year-old pregnant woman. The treatment of CLM relies on antihelminthic agents, such as thiabendazole, albendazole, and ivermectin. This case was interesting in that the standard treatment options previously mentioned were contraindicated owing to the patient's pregnancy. Cryotherapy with liquid nitrogen resulted in complete resolution of her lesion and symptoms.

Predictors And Outcomes Of Mycobacterium Tuberculosis Bacteremia Among Patients With Hiv And Tuberculosis Co-Infection Enrolled In The Actg A5221 Stride Study., John A. Crump, Xingye Wu, Michelle A. Kendall, Prudence D. Ive, Johnstone J. Kumwenda, Beatriz Grinsztejn, Ute Jentsch, Susan Swindells

Journal Articles: Infectious Diseases

BACKGROUND: We evaluated predictors and outcomes of Mycobacterium tuberculosis bacteremia among participants undergoing baseline mycobacterial blood culture in the ACTG A5221 STRIDE study, a randomized clinical trial comparing earlier with later ART among HIV-infected patients suspected of having tuberculosis with CD4-positive T-lymphocyte counts (CD4 counts)/mm(3). We conducted a secondary analysis comparing participants with respect to presence or absence of M. tuberculosis bacteremia.

METHODS: Participants with a baseline mycobacterial blood culture were compared with respect to the presence or absence of M. tuberculosis bacteremia. Baseline predictors of M. tuberculosis bacteremia were identified and participant outcomes were compared by mycobacteremia status.

RESULTS: …